In males, the presenting symptom is a slow growing testicular mass. Most cases follow a benign clinical course. In females it may present with estrogenic or androgenic manifestations. The vast majority of cases have a benign clinical course. [codes.iarc.fr]

Abstract A case of a 17-year-old patient diagnosed with bilateral androblastoma of the ovary is presented. The patient was admitted because of secondary amenorrhea, hirsutism and acne. [ncbi.nlm.nih.gov]

Signs and symptoms[edit] Due to excess testosterone secreted by the tumour, one-third of adult females present with a recent history of progressive masculinization. [en.wikipedia.org]

While they can present at any age, they typically present <30 years old, with a mean age of 14 years. In ~30-50% of patients, the presenting symptoms are related to clinical signs of androgenic activity 6. [radiopaedia.org]

• Virilization

  The signs of either virilism or masculinism decreased. Hormonal examination showed a normal level of testosteron. [i-lib.ugm.ac.id]

  Androblastomas occur in the TESTIS or the OVARY causing precocious masculinization in the males, and defeminization, or virilization (VIRILISM) in the females. In some cases, the Sertoli cells produce ESTROGENS. [finto.fi]

  Androblastomas occur in the TESTIS or the OVARY causing precocious masculinization in the males, and defeminization, or virilization (VIRILISM) in the females. [rgd.mcw.edu]

• Pain

  This was associated with pain in five patients. In three patients the pain was severe due to torsion, causing an acute abdominal emergency. [semanticscholar.org]

  This was associated with pain in five patients. In three patients the pain was severe due to torsion, causing an acute abdominal emergency. Slight virilization was observed in one patient only. [ncbi.nlm.nih.gov]

  Pain Center If you are one of the millions of Americans who suffer from pain, you know that it can take a toll on your life - both physically and emotionally. But, you do not have to accept chronic pain as a normal part of life in all cases. [excelahealth.org]

  Cervical facet joint pain Thoracic facet joint pain Lumbar facet joint pain Sacroiliac joint pain Baastrup syndrome Diffuse idiopathic skeletal hyperostosis SPINAL TRAUMA Fractures of the condyles (C0) Fractures of the atlas (C1) Traumatic occipitocervical [play.google.com]

• Weakness

  A form of long QT syndrome characterized by ventricular arrhythmia, muscle weakness, and developmental abnormalities which include micrognathia, low-set ears and deformities… Used to indicate that either or both of two items or options may be valid. [tititudorancea.com]

  The junctions where these arteries come together may develop weak spots. These weak spots can balloon out and fill with blood, creating the outpouchings of blood vessels known as aneurysms. [medicinenet.com]

  These include: smoking high blood pressure a family history of brain aneurysms In some cases, an aneurysm may develop because there was a weakness in the walls of the blood vessels at birth. [nhs.uk]

  For example, a weak area of a vessel in your chest and abdomen may require a type of surgery called an endovascular stent graft. [healthline.com]

• Infertility

  Female infertility If you've been trying unsuccessfully to get pregnant, you may be wondering whether infertility is an issue. Discover the signs of infertility and the latest treatments. [sharecare.com]

  Key Words: infertility - androblastoma - cytostatics - ovarian tumor - virilization File : 13.pdf Sitasi (tidak ada sitasi) Referensi 1. C. Westhoff, and M.C. Randal, Ovarian cancer screening: Potential effect on mortality, 1991 2. E.C. [i-lib.ugm.ac.id]

  The incidence is greater in industrialized countries, nulliparous or treated for infertility for a long time. The tumor cells derive from cells that have penetrated deeply the covering mezothel cells (“epithelial”) of the ovary. [myhealth-guide.org]

  Children may suffer from precocious pseudopuberty including uni- or bilateral asymmetric gynecomastia and adults from erectile dysfunction, decreased libido, or infertility [7]. 2. [hindawi.com]

• Anemia

  Anemia, however, was related to a better survival, especially in patients with a Dukes' B carcinoma. Clinicopathological staging according to Dukes' is closely related to survival. [ncbi.nlm.nih.gov]

  Potential symptoms may include: Anemia, and symptoms that go along with anemia such as fatigue, shortness of breath, weakness, and a rapid heart rate. [verywellhealth.com]

  Biochemical examinations were normal except iron deficiancy anemia. Tumor markers were normal. [ispub.com]

  환아에서 고위험군 분류에 따른 조혈모세포이식에 대한 생존이득 Clinical Pediatric Hematology-Oncology 18/2 :86-91,2011 소아신경모세포종에서 세차례의 고용량화학요법 후 자가조혈모세포이식 Clinical Pediatric Hematology-Oncology 18/2 :97-102,2011 Epidemiology and Clinical Long-term Outcome of Childhood Aplastic Anemia [yuhs.or.kr]

  Case report: An 18-year-old female Egyptian patient was admitted with hematochezia and remarkable anemia. [dovepress.com]

• Deepening of Voice

  Authors M Jha Paropkar Maternity and Women Hospital, Thapathali, Kathmandu B Shakya Paropkar Maternity and Women Hospital, Thapathali, Kathmandu Keywords: amenorrhoea, androblastoma, breast atrophy, deepening of voice, hirsutism Abstract Androblastoma [nepjol.info]

  […] of voice, due to enlargement of the voice box Cessation of menses Decrease in size of breasts Redistribution of fat Broadening of the shoulders Acne of the face and chest Loss of sexual desire Increased musculature Abdominal pain may occur in some cases [dovemed.com]

• Abdominal Pain

  Abdominal pain: Like gas and bloating, abdominal pain is nonspecific and can have many possible causes. When pain is present, it may be noted in the region known for pain with appendicitis, McBurney's point. [verywellhealth.com]

  Other symptoms that a patient may experience are abdominal pain and swelling. Diagnosis and Staging Ovarian tumors are diagnosed by a physician during a pelvic exam or other physical examination. [knowcancer.com]

  In the current study, a 13‑year‑old female was diagnosed with a stage Ⅰc ovarian Sertoli‑Leydig cell tumor following abdominal pain and distension. [spandidos-publications.com]

• Hirsutism

  The patient was admitted because of secondary amenorrhea, hirsutism and acne. [ncbi.nlm.nih.gov]

  Patients with functioning tumors have signs of virilization such as hirsutism, deep voice and clitoral enlargement [uaz.edu.mx]

  Sertoli-Leydig cell tumor of the ovary Disease definition Malignant Sertoli-Leydig cell tumor of ovary is a rare malignant sex cord stromal tumor of ovary (see this term) occuring typically in young women and characterized by manifestations of androgen excess (hirsutism [orpha.net]

• Alopecia

  […] ovarian Sertoli-Leydig cell tumor in a 13-year-old female: A case report. 62 Zhang H...Mu YL 26893701 2016 8 Steroid cell tumor: A rare virilizing ovarian tumor. 62 Das A...Singh AS 26458674 2015 9 [Virilizing ovarian tumor: a rare cause of androgenetic alopecia [malacards.org]

• Headache

  Migraine headache, meningitis, tumor, and stroke all may cause neurologic symptoms. [medicinenet.com]

  Symptoms Ruptured aneurysm A sudden, severe headache is the key symptom of a ruptured aneurysm. This headache is often described as the "worst headache" ever experienced. [mayoclinic.org]

  Symptoms include: a sudden agonising headache – it's been described as a "thunderclap headache", similar to a sudden hit on the head, resulting in a blinding pain unlike anything experienced before a stiff neck sickness and vomiting pain on looking at [nhs.uk]

  But as an aneurysm enlarges, it can produce headaches or localized pain. If an aneurysm gets very large, it may produce pressure on the normal brain tissue or adjacent nerves. [stroke.org]

• Irritability

  Vasospasm (irritation by the leaked blood causing narrowing of the blood vessels) is a common complication following a ruptured aneurysm. This can lead to further brain damage. [stroke.org]

  Dental-Insights patient 25 years old. suffering from 6 days complain left eye redness with irritation. treatment continue. Moxiflox drop moxiflox ointment Lubricant oint lubricant drop ? Plz suggest Dr. Shadab Aalam [curofy.com]

  Blood is very irritating to the brain and surrounding membranes and causes significant pain. [medicinenet.com]

  These include: overweight or obesity a sedentary lifestyle a diet high in red or processed meats smoking tobacco regularly consuming too much alcohol a history of irritable bowel disease (IBD) having type 2 diabetes Brain Some factors increase the risk [medicalnewstoday.com]

• Seizure

  Common signs and symptoms of a ruptured aneurysm include: Sudden, extremely severe headache Nausea and vomiting Stiff neck Blurred or double vision Sensitivity to light Seizure A drooping eyelid Loss of consciousness Confusion 'Leaking' aneurysm In some [mayoclinic.org]

  Medications may be used to control high blood pressure and prevent blood vessel spasm, seizure, agitation, and pain. What is the outcome of brain aneurysm? Brain aneurysms are deadly. [medicinenet.com]

  […] following symptoms might occur: a sensation that the bowels are full bloody stool rectal bleeding stomach pain unexplained weight loss Brain or skull The following symptoms may develop if adenocarcinoma develops in the skull: headaches nausea vomiting seizures [medicalnewstoday.com]

• Amenorrhea

  The patient was admitted because of secondary amenorrhea, hirsutism and acne. [ncbi.nlm.nih.gov]

  […] ovary Disease definition Malignant Sertoli-Leydig cell tumor of ovary is a rare malignant sex cord stromal tumor of ovary (see this term) occuring typically in young women and characterized by manifestations of androgen excess (hirsutism, hair loss, amenorrhea [orpha.net]

• Clitoromegaly

  Additional signs include acne and hirsutism, voice deepening, clitoromegaly, temporal hair recession, and an increase in musculature. Serum testosterone level is high. Cause[edit] The exact cause of Sertoli–Leydig cell tumour is not known. [en.wikipedia.org]

  Signs and Symptoms (Pathophysiology) Symptoms can include infrequent or no menstrual periods, the development of facial hair, a hoarse voice, increased muscle mass, acne, and clitoromegaly. [knowcancer.com]

  A 14 year old female admitted with abdominal distension, change in voice, male pattern balding and clitoromegaly in the dept. of Ob/Gy A.V.B.R.H. (Acharya Vinoba Bhave Rural Hospital) Sawangi, Wardha. [ijrcog.org]

In addition, every medical doctor should always try to perform thorough medical workup of his patients in order to avoid overlooking tiny, but sometimes crucial, aspects leading to diagnosis. [hindawi.com]

Treatment[edit] The usual treatment is surgery. The surgery usually is a fertility-sparing unilateral salpingo-oophorectomy. [en.wikipedia.org]

Treatment Surgery is done to remove one or both ovaries. If the tumor is advanced stage, chemotherapy or radiation therapy may be done after surgery. Outlook (Prognosis) Early treatment results in a good outcome. [stlukes-stl.com]

Androblastoma of an ovary - treatment [medicine-for-you.com]

[…] to advances in diagnosis and treatment. [rarediseases.info.nih.gov]

The prognosis is generally good as the tumour tends to grow slowly and usually is benign: 25% are malignant. [en.wikipedia.org]

prognosis compared with those with poor health Age of the individual: Older individuals generally have poorer prognosis than younger individuals Whether the tumor is occurring for the first time, or is a recurrent tumor. [dovemed.com]

Outlook (Prognosis) Prognosis of SLCT depends on the stage and degree of differentiation of the tumor. Since these tumors are typically benign and their growth is slow, outlook is generally very positive. [knowcancer.com]

Wegener granulomatosis - Autoimmune etiology and clinical course. Diabetes - disease and management information, including diagnosis, typical treatment plans and diabetes supplies. [netdoc.com]

[…] blood CF cerebrospinal fluid CI chemically induced CH chemistry CL classification CO complications CN congenital DI diagnosis DG diagnostic imaging DH diet therapy DT drug therapy EC economics EM embryology EN enzymology EP epidemiology EH ethnology ET etiology [decs.bvs.br]

English: BS blood supply BL blood CF cerebrospinal fluid CI chemically induced CH chemistry CL classification CO complications CN congenital DI diagnosis DG diagnostic imaging DH diet therapy DT drug therapy EC economics EM embryology EN enzymology EP epidemiology [decs.bvs.br]

Testicular tumors: epidemiologic, etiologic and pathologic features. Cancer. 1973; 32: 1186 Scopus (350) PubMed Crossref Google Scholar Teilum G. Classification of testicular and ovarian androblastoma and Sertoli cell tumors. [goldjournal.net]

Sertoli–Leydig cell tumor group Epidemiology Sertoli-Leydig cell tumors are uncommon benign tumors, accounting for less than 0.5% of all ovarian tumors. [emedicine.medscape.com]

Definition / general Sex cord stromal tumor of testis composed of cells expressing, to a varying degree, features of fetal, prepubertal or adult Sertoli cells Terminology Also called androblastoma Epidemiology < 1% of testicular tumors Occurs in normally [pathologyoutlines.com]

All patients were reported between 2004 and 2013 in the Surveillance, Epidemiology, and End Results (SEER) database. [ncbi.nlm.nih.gov]

Signs and Symptoms (Pathophysiology) Symptoms can include infrequent or no menstrual periods, the development of facial hair, a hoarse voice, increased muscle mass, acne, and clitoromegaly. [knowcancer.com]

[…] germline DICER1 mutation occur at a younger age (Gynecol Oncol 2017;147:521) Nearly all pediatric Sertoli-Leydig cell tumors are moderately or poorly differentiated, are DICER1 syndrome associated and often show a retiform pattern or heterologous elements Pathophysiology [pathologyoutlines.com]

Prevention There are no known ways to prevent ovarian cancer of any kind, as the cause is unknown. References Choong S, Fuller P, et al. Sertoli-Leydig cell tumor of the ovary, a rare cause of precocious puberty in a 12-month-old infant. [wkhs.com]

Prevention There are no known ways to prevent ovarian cancer of any kind, as the cause is unknown. [azkrmc.com]

Prevention There are no known ways to prevent ovarian cancer of any kind, as the cause is unknown. Choong S, Fuller P, et al. Sertoli-Leydig cell tumor of the ovary, a rare cause of precocious puberty in a 12-month-old infant. [stjosepheureka.myhospitalwebsite.com]

Prevention There are no known ways to prevent ovarian cancer of any kind, as the cause is unknown. References: Choong S, Fuller P, et al. Sertoli-Leydig cell tumor of the ovary, a rare cause of precocious puberty in a 12-month-old infant. [whc-shreveport.com]