In males, the presenting symptom is a slow growing testicular mass. Most cases follow a benign clinical course. In females it may present with estrogenic or androgenic manifestations. The vast majority of cases have a benign clinical course. [codes.iarc.fr]

Abstract A case of a 17-year-old patient diagnosed with bilateral androblastoma of the ovary is presented. The patient was admitted because of secondary amenorrhea, hirsutism and acne. [ncbi.nlm.nih.gov]

Signs and symptoms[edit] Due to excess testosterone secreted by the tumour, one-third of adult females present with a recent history of progressive masculinization. [en.wikipedia.org]

While they can present at any age, they typically present <30 years old, with a mean age of 14 years. In ~30-50% of patients, the presenting symptoms are related to clinical signs of androgenic activity 6. [radiopaedia.org]

• Virilization

  The signs of either virilism or masculinism decreased. Hormonal examination showed a normal level of testosteron. [i-lib.ugm.ac.id]

  Androblastomas occur in the TESTIS or the OVARY causing precocious masculinization in the males, and defeminization, or virilization (VIRILISM) in the females. In some cases, the Sertoli cells produce ESTROGENS. [connects.catalyst.harvard.edu]

  Androblastomas occur in the TESTIS or the OVARY causing precocious masculinization in the males, and defeminization, or virilization (VIRILISM) in the females. [rgd.mcw.edu]

• Pain

  This was associated with pain in five patients. In three patients the pain was severe due to torsion, causing an acute abdominal emergency. [semanticscholar.org]

  This was associated with pain in five patients. In three patients the pain was severe due to torsion, causing an acute abdominal emergency. Slight virilization was observed in one patient only. [ncbi.nlm.nih.gov]

  Pain Center If you are one of the millions of Americans who suffer from pain, you know that it can take a toll on your life - both physically and emotionally. But, you do not have to accept chronic pain as a normal part of life in all cases. [excelahealth.org]

  Cervical facet joint pain Thoracic facet joint pain Lumbar facet joint pain Sacroiliac joint pain Baastrup syndrome Diffuse idiopathic skeletal hyperostosis SPINAL TRAUMA Fractures of the condyles (C0) Fractures of the atlas (C1) Traumatic occipitocervical [play.google.com]

• Ascites

  Ascites & hydrothorax when present in any other conditions is called Pseudo Meigs' syndrome. [gradestack.com]

  In 20-40% of cases, such tumors are associated with abdominal ascites in the triad of ovarian neoplasm, ascites, and pleural effusions (Meigs syndrome). Once the neoplasm is removed, the ascites and pleural effusion resolves. [prep4usmle.com]

  During surgery, ~200 ml yellow ascites was noted and cytological examination of the ascites showed no tumor cells. The mass was a cyst that originated from the right ovary with a 5-mm rupture (Fig. 1). [spandidos-publications.com]

• Swelling

  Gynecomastia preceded the clinical appearace of testicular swelling by 3 months, suggesting that the 2 tumors developed contemporaneously and that, in theory, the Sertoli cell tumor is probably dependent on the germ cell tumor. [ncbi.nlm.nih.gov]

  Although there is only a painless local swelling distant metastases in different organs may already be present. [urologie.insel.ch]

  NAME: International Journal of Clinical Medicine, Vol.7 No.9, September 13, 2016 ABSTRACT: Sertoli-Leydig cell tumor of the ovary is a kind of sex cord-stromal tumor, which occurs between teens and twenties with symptoms including abdominal pain and swelling [scirp.org]

  Other symptoms that a patient may experience are abdominal pain and swelling. Diagnosis and Staging Ovarian tumors are diagnosed by a physician during a pelvic exam or other physical examination. [knowcancer.com]

• Severe Pain

  Signs and symptoms of a rupture may include: Light-headedness Rapid heart rate Sudden, severe pain in your abdomen, chest, or back Complications - Aortic Aneurysm Complications from aortic aneurysms may be life-threatening and may include: Aortic dissection [nhlbi.nih.gov]

• Deepening of Voice

  Authors M Jha Paropkar Maternity and Women Hospital, Thapathali, Kathmandu B Shakya Paropkar Maternity and Women Hospital, Thapathali, Kathmandu Keywords: amenorrhoea, androblastoma, breast atrophy, deepening of voice, hirsutism Abstract Androblastoma [nepjol.info]

  […] of voice, due to enlargement of the voice box Cessation of menses Decrease in size of breasts Redistribution of fat Broadening of the shoulders Acne of the face and chest Loss of sexual desire Increased musculature Abdominal pain may occur in some cases [dovemed.com]

• Pleural Effusion

  In 20-40% of cases, such tumors are associated with abdominal ascites in the triad of ovarian neoplasm, ascites, and pleural effusions (Meigs syndrome). Once the neoplasm is removed, the ascites and pleural effusion resolves. [prep4usmle.com]

  If lung metastases are present there may be pleural effusions causing breathlessness. Effusions may require drainage. [healthengine.com.au]

  If pleural effusion is present, positive cytology must be present to allot a case to stage IV. Parenchymal liver metastasis equals stage IV. [emedicine.medscape.com]

• Abdominal Mass

  The most frequent presenting sign was the finding of an abdominal mass. This was associated with pain in five patients. In three patients the pain was severe due to torsion, causing an acute abdominal emergency. [semanticscholar.org]

  เพิ่มขึ้น, ท้องอืด ระยะเวลาอาจเป็นเดือนหรือปี อาการ secondary symptom: anorexia, N/V, urinary frequency or urgency Most common physical finding : abdominal mass (60% of ovarian tumors) ลักษณะก้อน movable mass, above pelvic brim, bimanual palpation ได้ระหว่าง [sites.google.com]

  Hormonally inactive tumors often have a nonspecific presentation such as an abdominal mass and/or pain. The majority of patients present with stage I disease. Most tumors are unilateral (>90% of cases) and confined to the ovaries. [radiopaedia.org]

• Pelvic Mass

  (Am J Surg Pathol 1985;9:543) Estrogenic hormonal manifestations are rare Diagnosis May be suspected clinically in a young patient presenting with a combination of virilization, elevated testosterone levels and ovarian / pelvic mass on imaging studies [pathologyoutlines.com]

  Case report A 13-year-old female presented to the Shandong Provincial Hospital affiliated to Shandong University (Jinan, Shandong, China) with a 7-day history of abdominal distension, a 3-day history of abdominal pain and a pelvic mass. [spandidos-publications.com]

• Body Hair Increased

  Symptoms This tumor secretes male hormones which causes secondary sex changes in women including: deepening of the voice increased facial and body hair increased size of the clitoris male pattern baldness Signs and tests ultrasound of the ovaries CT scan [health.am]

• Breast Atrophy

  Authors M Jha Paropkar Maternity and Women Hospital, Thapathali, Kathmandu B Shakya Paropkar Maternity and Women Hospital, Thapathali, Kathmandu Keywords: amenorrhoea, androblastoma, breast atrophy, deepening of voice, hirsutism Abstract Androblastoma [nepjol.info]

  Synopsis usually unilateral ovarian tumor may release male sex steroid hormones and produce defeminization (breast atrophy, amenorrhea, loss of hair and sterility) to masculinization (hirsutism, voice change and hypertrophy of the clitoris). possible [humpath.com]

  atrophy and menstrual irregularity or amenorrhea (Am J Surg Pathol 1985;9:543) Estrogenic hormonal manifestations are rare Diagnosis May be suspected clinically in a young patient presenting with a combination of virilization, elevated testosterone levels [pathologyoutlines.com]

  atrophy, and clitoral hypertrophy. [emedicine.medscape.com]

• Irritability

  Vasospasm (irritation by the leaked blood causing narrowing of the blood vessels) is a common complication following a ruptured aneurysm. This can lead to further brain damage. [stroke.org]

  Dental-Insights patient 25 years old. suffering from 6 days complain left eye redness with irritation. treatment continue. Moxiflox drop moxiflox ointment Lubricant oint lubricant drop ? Plz suggest Dr. Shadab Aalam [curofy.com]

  Blood is very irritating to the brain and surrounding membranes and causes significant pain. [medicinenet.com]

  These include: overweight or obesity a sedentary lifestyle a diet high in red or processed meats smoking tobacco regularly consuming too much alcohol a history of irritable bowel disease (IBD) having type 2 diabetes Brain Some factors increase the risk [medicalnewstoday.com]

• Amenorrhea

  The patient was admitted because of secondary amenorrhea, hirsutism and acne. [ncbi.nlm.nih.gov]

  […] ovary Disease definition Malignant Sertoli-Leydig cell tumor of ovary is a rare malignant sex cord stromal tumor of ovary (see this term) occuring typically in young women and characterized by manifestations of androgen excess (hirsutism, hair loss, amenorrhea [orpha.net]

• Clitoromegaly

  Additional signs include acne and hirsutism, voice deepening, clitoromegaly, temporal hair recession, and an increase in musculature. Serum testosterone level is high. Cause[edit] The exact cause of Sertoli–Leydig cell tumour is not known. [en.wikipedia.org]

  Signs and Symptoms (Pathophysiology) Symptoms can include infrequent or no menstrual periods, the development of facial hair, a hoarse voice, increased muscle mass, acne, and clitoromegaly. [knowcancer.com]

  A 14 year old female admitted with abdominal distension, change in voice, male pattern balding and clitoromegaly in the dept. of Ob/Gy A.V.B.R.H. (Acharya Vinoba Bhave Rural Hospital) Sawangi, Wardha. [ijrcog.org]

• Adnexal Mass

  Appears as a complex mass in posterior cul-de-sac; complex hypoechoic adnexal mass with sepatations, irregular margins & fluid-debris levels; Ovaries are often difficult to recognize separate from the mass; usually bilateral but may be unilateral if an [quizlet.com]

  On physical examination, the obstetrician palpates a right adnexal mass. Ultrasonographic evaluation confirms the presence of a solid mass in the right ovary. The ovary is removed and sent to pathology. [prep4usmle.com]

  […] diagnosis) (Eur J Gynaecol Oncol 2017;38:214) Intraoperative frozen section evaluation is helpful to confirm the clinical suspicion and guide the surgical management Radiology description Ultrasound, pelvic CT or MRI can show a solid or solid and cystic adnexal [pathologyoutlines.com]

• Pelvic Pain

  Read More Endometriosis If you’ve experienced pelvic pain, you may wonder if it’s a result of period cramps or something else. [sharecare.com]

  pain or a pelvic mass, rarely with ascites and tumor rupture Androgenic hormonal symptoms (virilization) are common and present in approximately 50% of patients; they include hirsutism, clitoromegaly, breast atrophy and menstrual irregularity or amenorrhea [pathologyoutlines.com]

• Metrorrhagia

  The few cases reported were characterized by metrorrhagia suggesting the hyperestrogenic state. An additional case of Sertoli cell tumor is reported in which the clinical picture is of secondary ammenorrhea followed by metrorrhagia. [gynecologiconcology-online.net]

In addition, every medical doctor should always try to perform thorough medical workup of his patients in order to avoid overlooking tiny, but sometimes crucial, aspects leading to diagnosis. [hindawi.com]

• Ovarian Mass

  Analytical, diagnostic and therapeutic context of Sertoli-Leydig Cell Tumor RESULTS: A 33-year-old woman with abrupt cessation of menses, progressive hirsutism, and weight gain because of a unilateral ovarian mass identified sonographically and an increased [wikigenes.org]

  In this report, we present an extremely rare case of ovarian GAB with JGCT in an elderly patient. A 65-year-old woman presented with an abdominal mass. [mdpi.com]

  Female adnexal tumor of probable wolffian origin arises primarily in the broad ligament but may present as an ovarian mass. The architecture varies from cystic, to a slitlike glandular or a sievelike pattern. [emedicine.medscape.com]

• Pleural Effusion

  In 20-40% of cases, such tumors are associated with abdominal ascites in the triad of ovarian neoplasm, ascites, and pleural effusions (Meigs syndrome). Once the neoplasm is removed, the ascites and pleural effusion resolves. [prep4usmle.com]

  If lung metastases are present there may be pleural effusions causing breathlessness. Effusions may require drainage. [healthengine.com.au]

  If pleural effusion is present, positive cytology must be present to allot a case to stage IV. Parenchymal liver metastasis equals stage IV. [emedicine.medscape.com]

Treatment[edit] The usual treatment is surgery. The surgery usually is a fertility-sparing unilateral salpingo-oophorectomy. [en.wikipedia.org]

Treatment Surgery is done to remove one or both ovaries. If the tumor is advanced stage, chemotherapy or radiation therapy may be done after surgery. Outlook (Prognosis) Early treatment results in a good outcome. [stlukes-stl.com]

Androblastoma of an ovary - treatment [medicine-for-you.com]

[…] to advances in diagnosis and treatment. [rarediseases.info.nih.gov]

The prognosis is generally good as the tumour tends to grow slowly and usually is benign: 25% are malignant. [en.wikipedia.org]

prognosis compared with those with poor health Age of the individual: Older individuals generally have poorer prognosis than younger individuals Whether the tumor is occurring for the first time, or is a recurrent tumor. [dovemed.com]

Outlook (Prognosis) Prognosis of SLCT depends on the stage and degree of differentiation of the tumor. Since these tumors are typically benign and their growth is slow, outlook is generally very positive. [knowcancer.com]

Wegener granulomatosis - Autoimmune etiology and clinical course. Diabetes - disease and management information, including diagnosis, typical treatment plans and diabetes supplies. [netdoc.com]

[…] blood CF cerebrospinal fluid CI chemically induced CH chemistry CL classification CO complications CN congenital DI diagnosis DG diagnostic imaging DH diet therapy DT drug therapy EC economics EM embryology EN enzymology EP epidemiology EH ethnology ET etiology [decs.bvs.br]

English: BS blood supply BL blood CF cerebrospinal fluid CI chemically induced CH chemistry CL classification CO complications CN congenital DI diagnosis DG diagnostic imaging DH diet therapy DT drug therapy EC economics EM embryology EN enzymology EP epidemiology [decs.bvs.br]

Testicular tumors: epidemiologic, etiologic and pathologic features. Cancer. 1973; 32: 1186 Scopus (350) PubMed Crossref Google Scholar Teilum G. Classification of testicular and ovarian androblastoma and Sertoli cell tumors. [goldjournal.net]

Sertoli–Leydig cell tumor group Epidemiology Sertoli-Leydig cell tumors are uncommon benign tumors, accounting for less than 0.5% of all ovarian tumors. [emedicine.medscape.com]

Definition / general Sex cord stromal tumor of testis composed of cells expressing, to a varying degree, features of fetal, prepubertal or adult Sertoli cells Terminology Also called androblastoma Epidemiology < 1% of testicular tumors Occurs in normally [pathologyoutlines.com]

All patients were reported between 2004 and 2013 in the Surveillance, Epidemiology, and End Results (SEER) database. [ncbi.nlm.nih.gov]

Signs and Symptoms (Pathophysiology) Symptoms can include infrequent or no menstrual periods, the development of facial hair, a hoarse voice, increased muscle mass, acne, and clitoromegaly. [knowcancer.com]

[…] germline DICER1 mutation occur at a younger age (Gynecol Oncol 2017;147:521) Nearly all pediatric Sertoli-Leydig cell tumors are moderately or poorly differentiated, are DICER1 syndrome associated and often show a retiform pattern or heterologous elements Pathophysiology [pathologyoutlines.com]

Prevention There are no known ways to prevent ovarian cancer of any kind, as the cause is unknown. References Choong S, Fuller P, et al. Sertoli-Leydig cell tumor of the ovary, a rare cause of precocious puberty in a 12-month-old infant. [wkhs.com]

Prevention There are no known ways to prevent ovarian cancer of any kind, as the cause is unknown. [azkrmc.com]

Prevention There are no known ways to prevent ovarian cancer of any kind, as the cause is unknown. References: Choong S, Fuller P, et al. Sertoli-Leydig cell tumor of the ovary, a rare cause of precocious puberty in a 12-month-old infant. [wnyurology.com]