METHODS: The author conducted a search of the literature using Medline (Ovid, 1946-present) and PubMed (1966-2013) for English-language studies that included the following search terms: 'testosterone' or 'androgen' combined with 'women', 'therapy' or [ncbi.nlm.nih.gov]

However, the next presentation from CALGB/Alliance (S2-05) showed different results. [bcaction.org]

Post-webinar follow-up: For those who were unable to catch the live show, it is now possible to listen to the entire presentation and watch Dr. Denmeade’s slide presentation if you click here for the Youtube link. [prostatecancerinfolink.net]

• Virilization

  Each of the subjects had male-gender behavior but incomplete virilization. [ncbi.nlm.nih.gov]

  Androgen-related side effects include virilization, elevated transaminases, blood lipid abnormalities, hepatic tumors, and liver and spleen peliosis. These effects have not been prospectively studied in DC. [bloodjournal.org]

• Congestive Heart Failure

  If initial screening reveals evidence of congestive heart failure or valvular or other structural heart disease, an echocardiogram should be obtained. [ahajournals.org]

  This may lead to congestive heart failure (the inability of your heart to pump enough blood for your body) if you have heart, liver, or kidney disease. [everydayhealth.com]

  heart failure Other: No active peptic ulcer disease No regular use of antacid or H2 blockers No known or predicted achlorhydria No concurrent use of terfenadine, astemizole, omeprazole, or cisapride No second malignancy unless curatively treated No history [clinicaltrials.gov]

• Anorexia

  […] deficiency or other causes of chronic fatigue like Lyme disease orchronic fatigue syndrome; psychiatric disorders such as major depressive disorder; or other potential etiological conditions or pre-disposing factors which have been implicated including: anorexia [bumc.bu.edu]

  Megestrol acetate for treatment of anorexia-cachexia syndrome. Cochrane Database Syst Rev. 2005;(2):CD004310. Beaumont H, Augood C, Duckitt K, Lethaby A. Danazol for heavy menstrual bleeding. Cochrane Database Syst Rev. 2007;(3):CD001017. [aetna.com]

• Loss of Appetite

  Anti-androgen medications can cause a variety of common side effects including nausea, diarrhea, constipation, loss of appetite, dizziness, headache and trouble sleeping. [livestrong.com]

  […] of appetite, continuing mood or mental changes purple or red spots on body or inside the mouth or nose sore throat swelling, pain, or tenderness of abdomen vomiting of blood Some side effects may occur that usually do not need medical attention. [mayoclinic.org]

  Nausea, loss of appetite and bloating Headaches Increased appetite and weight increase (uncommon) Mood changes including depression and reduced libido Melasma (facial pigmentation) Hair loss (it is more common for hair fall to occur when the medication [dermnetnz.org]

• Hirsutism

  It is effective for 70% of those with hirsutism. Several different regimes are prescribed with doses ranging from 25 to 200 mg daily. [dermnetnz.org]

  Voice change and mild hirsutism were observed in most of the women receiving nandrolone decanoate, and these secondary effects constitute a real disadvantage to its use in females. [ncbi.nlm.nih.gov]

  All males reported priapism; females reported hirsutism and hoarseness of voice. In summary, patients with DC and BMF may achieve transfusion-independence when treated with androgens. [bloodjournal.org]

  These characteristics are extremely unlikely to develop if dosage is monitored appropriately and if testosterone levels are maintained within the normal range for young adult women of reproductive age aggression or irritability hirsutism – excess hair [betterhealth.vic.gov.au]

• Alopecia

  […] serious abnormalities to develop in an unborn baby and termination of pregnancy is likely to be advised if a woman becomes pregnant while using testosterone) are breastfeeding suffer from acne have hirsutism (excessive body or facial hair) suffer from alopecia [betterhealth.vic.gov.au]

  The typical side effects related to the estrogentestosterone preparations are alopecia, acne, and hirsutism, although these are dose and duration dependent and are not common. 34 Controlled studies 32, 35, 48, 51 have found low incidence of deep voice [aafp.org]

  […] should also be avoided in women who have or have had breast or uterine cancer, have high cholesterol or heart disease, or have liver disease. 2 A study using combined estrogen and testosterone preparations for treatment showed uncommon side effects of alopecia [uspharmacist.com]

  Most commonly reported side effects are androgen skin effects (increased sebum secretion, greasy skin and hair, scalp itching, alopecia, hirsutism) (Tables 2 and 3 ). [eje.bioscientifica.com]

• Mood Swings

  These side effects range from hot flashes and loss of bone density to mood swings, weight gain, and erectile dysfunction. [pcf.org]

  Men who take ADT complain about a lot of side effects, from weight gain to mood swings, impotence and hot flashes. Many also complained about memory loss or trouble thinking. [nbcnews.com]

  The main side effects are: erectile problems (impotence) hot flushes and sweating feeling tired and weak breast tenderness tumour flare Side effects of long term treatment are: weight gain memory problems mood swings and depression bone thinning (osteoporosis [cancerresearchuk.org]

  Low energy levels, mood swings, irritability, poor concentration, reduced muscle strength and low sex drive can be symptoms of androgen deficiency (low testosterone). Symptoms often overlap with those of other illnesses. [andrologyaustralia.org]

• Aggressive Behavior

  Behaviors (P=0.031) on the CBCL. [ncbi.nlm.nih.gov]

  Common side effects that are not dangerous to most and may be considered beneficial in some cases may include: Acne Aggressive behavior Oily skin Increased body hair growth Increased sex drive Gynecomastia Hypertension Headache Weight gain Hot flushes [drugdangers.com]

  Symptoms included abnormally large genitalia (penis and clitoris), advanced bone age, early puberty and aggressive behavior. Young boys may even develop enlarged breasts. A doctor should be contacted right away if these symptoms occur. [drugwatch.com]

  Enlarged genitalia, early development of pubic hair, increased erections or libido, and aggressive behavior are signs and symptoms of early puberty and accidental exposure. [uspharmacist.com]

• Tremor

  If you are taking Lexapro, Effexor, Zoloft, or Paxil, call your healthcare provider if you are having difficulty sleeping, dry mouth, nervousness or tremors in your hands. Call immediately if you have feelings of depression or thoughts of suicide. [oncolink.org]

• Testosterone Increased

  One of the studies showed a two-fold increase in heart attacks in those on testosterone who were over the age of 65. The second study showed a connection between testosterone and increased risk of both stroke and heart attack. [drugdangers.com]

  Body builders in particular are known for their use of synthetic hormones to rapidly increase muscle mass. “Testosterone can help increase muscle mass in a much faster fashion. [drugwatch.com]

  […] dose Transdermal Increase frequency, satisfaction, orgasm 43, 47 Increase desire, orgasm 32 Increase frequency and pleasure 48 TABLE 5 Benefits of Testosterone Treatment for Women* Indication Possible benefit Formulations Bone strength Increase bone [aafp.org]

  Ajayi AA. 1995 Testosterone increases platelet thromboxane A2 receptor density. Circulation. 91:2740-2747. 52. [mastersmensclinic.com]

• Hematocrit Increased

  Very few side effects were observed, including a tendency for weight increase and an increase in hemoglobin and hematocrit, although these were reversible a few months later (data not shown), thus indicating good patient compliance to the allocated treatment [care.diabetesjournals.org]

• Hepatocellular Carcinoma

  Lopez Sandoval R, Guadalupe Cantu J (1979) Androgenic therapy and hepatocellular carcinoma, report of a case. Rev Gastroenterol Mex 44 (1): 35–40 Google Scholar 10. [link.springer.com]

  The case of a young man with hypogonadism, who was treated for five years withmethyltestosterone and who developed hepatocellular carcinoma, is discussed. He received a course of 5-fluorouracil via the hepatic artery. [ncbi.nlm.nih.gov]

Androgen deprivation therapy (ADT) has been the core treatment of advance-staged disease since the discovery of prostate cancer's androgen dependence in 1941 by Huggins et al. [1] Options for initial medical treatment include gonadotropin-releasing hormone [ncbi.nlm.nih.gov]

BAT) is a paradoxical treatment for castrate-resistant prostate cancer whereby testosterone levels are rapidly alternated between supraphysiologic and near-castrate concentrations. [jhu.pure.elsevier.com]

Older patients with AML have a poor prognosis, owing in part to low tolerance to intensive chemotherapy regimens. [medpagetoday.com]

A single study demonstrated that androgen priming in a small group of patients (n=85) using chemotherapy regimens that are now outdated altered the prognosis 13. [uroweb.org]

View Article PubMed Google Scholar Souhami L, Bae K, Pilepich M, Sandler H: Timing of salvage hormonal therapy in prostate cancer patients with unfavorable prognosis treated with radiotherapy: a secondary analysis of Radiation Therapy Oncology Group 85 [ro-journal.biomedcentral.com]

We’ve found, paradoxically, that patients who have the shortest time to their nadir PSA value after hormone therapy may actually have a worse prognosis. [harvardprostateknowledge.org]

The clinical evaluation must include investigations for one or more etiological factors such as hypogonadism, which is found in 5% to 15% of men with osteoporosis. [ncbi.nlm.nih.gov]

Pathophysiologic Facts About Androgen Insufficiency There are five major categories or types of etiology of androgen insufficiency: Gonadal (chemo- or radiation-therapy, oophorectomy), Adrenal (adrenal failure or insufficiency), Hypothalamic-Pituitary [bumc.bu.edu]

[…] the role of androgens in neuron growth, axonal regeneration and β-amyloid protein accumulation, they write in the Journal of Clinical Oncology : “There are a number of plausible mechanisms to explain a neuropathic effect of androgen deficiency in the etiology [news-medical.net]

(Unpublished) Abstract Periodontitis is a multifactorial disease with microbial dental plaque as the etiological agent. [d-scholarship.pitt.edu]

A karyotype is recommended for cases of primary hypogonadism of unknown etiology to rule out Klinefelter's syndrome. [aetna.com]

In epidemiological studies, low T is associated with obesity, inflammation, atherosclerosis and the progression of atherosclerosis. Longitudinal epidemiological studies showed that low T is associated with an increased cardiovascular mortality. [ncbi.nlm.nih.gov]

Institution: University of Pittsburgh Schools and Programs: Graduate School of Public Health > Epidemiology Degree: PhD - Doctor of Philosophy Thesis Type: Doctoral Dissertation Refereed: Yes Uncontrolled Keywords: epidemiology; health services research [d-scholarship.pitt.edu]

Clinical biologic pathophysiologies of women’s sexual dysfunction. J Sex Med 2: 4, 2005. [link.springer.com]

Pathophysiologic Facts About Androgen Insufficiency There are five major categories or types of etiology of androgen insufficiency: Gonadal (chemo- or radiation-therapy, oophorectomy), Adrenal (adrenal failure or insufficiency), Hypothalamic-Pituitary [bumc.bu.edu]

It has been demonstrated that interventions such as hormone therapies may favorably influence some of the pathological conditions in aging men by preventing the preventable and delaying the inevitable. [ncbi.nlm.nih.gov]

Thomas Hugh Jones, consultant physician and endocrinologist 1 Barnsley Hospital NHS Foundation Trust, Barnsley S75 2EP, UK hugh.jones{at}nhs.net Should be monitored, and primary and secondary prevention optimised Accumulating evidence suggests that androgen [bmj.com]