The present data suggest that those prostate cancer patients who have even marginally elevated adrenal androgens may especially benefit from combined androgen blockade. [ncbi.nlm.nih.gov]

• Precocious Puberty

  Cyproterone acetate • Direct antiantiandrogenic action • Progesterone like activity – inhibits LH causing antiandrogenic action • Competes with dihydroteststerone for intracellular receptor Uses: • Precocious puberty in Boys • Inappropriate sexual behaviour [slideshare.net]

  In both males and females, too much testosterone can lead to precocious puberty and result in infertility. In women, high blood levels of testosterone may also be an indicator of polycystic ovary syndrome. [yourhormones.info]

• Chordee

  In childhood, genital abnormalities consisted of a clitoral-like phallus surrounded by a chordee, non-fused labial-scrotal folds and a urogenital sinus. The testes were in the inguinal canals, or rarely, in the labial-scrotal folds. [ncbi.nlm.nih.gov]

Detailed history and clinical examination, hormonal workup, and radiological evaluation are the cornerstone for diagnosing hyperandrogenism with hirsutism and virilization in a female. 1. Roman S. Adrenocortical carcinoma. [dx.doi.org]

Workup in androgen excess Laboratory evaluation should be part of the workup for every woman who seeks treatment for signs or symptoms of androgen excess, such as hirsutism. [emedicine.medscape.com]

In contrast, Snail mRNA levels are repressed by androgen treatment similar to DRAIC RNA levels. However, while antiandrogen treatment seems not to change Snail mRNA levels, antiandrogen treatments induce DRAIC RNA levels. [ncbi.nlm.nih.gov]

[…] used in the treatment of endometriosis and symptomatic treatment of severe pain and tenderness associated with benign fibrocystic breasts.DB13943Testosterone cypionateAn androgen used to treat low or absent testosterone.DB13944Testosterone enanthateAn [drugbank.ca]

Abstract Purpose Elderly patients with acute myeloid leukemia (AML) have a poor prognosis, and innovative maintenance therapy could improve their outcomes. [ncbi.nlm.nih.gov]

Prognosis Prognosis for patients with CAIS is favorable if support and counseling are appropriate. Adults have normal female gender identity. Patients are infertile and have an increased risk of osteoporosis if hormone replacement is inadequate. [orpha.net]

The second study found that even triple-negative breast cancers (TNBCs), which are without known hormone drivers and carry the poorest prognosis, are dependent on androgen receptor activation. [sciencedaily.com]

Despite the fact that in younger women exhibits more aggressive features and a worse prognosis, BC can be considered a prevalently post-menopausal disease (2). [frontiersin.org]

Numerous studies indicate that the steroid hormones have been implicated in the etiology and/or progression of epithelial ovarian cancer and support a role for androgens, including: 1) androgen receptor (AR) is present in primate ovaries at almost all [ncbi.nlm.nih.gov]

The etiology of EOC remains elusive; however, experimental and epidemiologic data suggest a role for hormone-related exposures in ovarian carcinogenesis and risk factor differences by histologic phenotypes and developmental pathways. [cancerres.aacrjournals.org]

Pathophysiologic Facts About Androgen Insufficiency There are five major categories or types of etiology of androgen insufficiency: Gonadal (chemo- or radiation-therapy, oophorectomy), Adrenal (adrenal failure or insufficiency), Hypothalamic-Pituitary [bumc.bu.edu]

Hyperandrogenism and androgen excess: physiology, etiology, differential diagnosis, management. In: Lobo RA, Gershenson DM, Lentz GM, Valea FA, eds. Comprehensive Gynecology. 7th ed. Philadelphia, PA: Elsevier; 2017:chap 40. [nlm.nih.gov]

[…] and Women's Health Team, Villejuif, France. 12 Hellenic Health Foundation, Athens, Greece. 13 WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and [ncbi.nlm.nih.gov]

The etiology of EOC remains elusive; however, experimental and epidemiologic data suggest a role for hormone-related exposures in ovarian carcinogenesis and risk factor differences by histologic phenotypes and developmental pathways. [cancerres.aacrjournals.org]

Our understanding of the epidemiology and economic impact of these disorders has expanded, emphasizing their critical importance. These are but a few highlights of how the terrain has changed in a relatively brief period of time. [link.springer.com]

Summary Epidemiology The estimated incidence is between 1/20,000 and 1/99,000 live male births. Clinical description The typical presentation is primary amenorrhea in an adolescent female. [orpha.net]

Abstract The physiological and pathophysiological roles of sex hormones have been well documented and the modulation of their effects is applicable in many current treatments. [ncbi.nlm.nih.gov]

Research Design and Methods: We conducted a secondary analysis of the Diabetes Prevention Program (DPP) and the Diabetes Prevention Program Outcomes Study (DPPOS). [ncbi.nlm.nih.gov]

This prevents androgens from encouraging prostate cancer cell growth. Spironolactone Spironolactone (Aldactone) is a type of anti-androgen that’s been used for 30 years to treat hormonal acne and excessive body hair. [healthline.com]

Special medication known as 5aR inhibitors can prevent the enzyme from converting androgen into DHT. [hairtransplantmentor.com]

Antiandrogen drugs such as bicalutamide and enzalutamide bind with androgen receptor to prevent them from activating genes that drive cancer progression. [eurekalert.org]