The present data suggest that those prostate cancer patients who have even marginally elevated adrenal androgens may especially benefit from combined androgen blockade. [ncbi.nlm.nih.gov]

• Weakness

  HY-I0352 Epiandrosterone Agonist >98.0% Epiandrosterone is a steroid hormone with weak androgenic activity. [medchemexpress.com]

  PURPOSE OF REVIEW: The adrenal gland is considered a source of weak androgens, such as dehydroepiandrosterone, dehydroepiandrosterone sulfate, and androstenedione. [ncbi.nlm.nih.gov]

  ENGLISH: There are enzymes in within the follicle and the sebaceous glands that turn weak androgens into tissue-specific androgens such as DHT. One enzyme I refer to is one form of 5-alpha-reductase. [anagen.net]

  It is inactivated by 3α-hydroxysteroid dehydrogenase in skeleta muscules so it is considered a weak androgen. [drugbank.ca]

• Male Hypogonadism

  We hypothesise that serum androgen concentrations observed in female androgen excess and male hypogonadism are metabolically disadvantageous, promoting adipose and liver lipid accumulation, central fat mass expansion and insulin resistance. © 2017 The [ncbi.nlm.nih.gov]

  The DDDs are based on use in substitution therapy in male hypogonadism. The DDDs for patches (e.g. testosterone) are given in amount delivered. [whocc.no]

  Objective/s This article outlines the aetiology, clinical features, investigation and management of male hypogonadism and discusses the more controversial area of LOH. [racgp.org.au]

  This condition is also commonly known as male hypogonadism if the cause is deficiency in testicular production of reproductive hormones. Androgen deficiency affects 1 in 200 men under 60 years old. [my.clevelandclinic.org]

  The FDA has approved testosterone use only for men with “male hypogonadism” including low interest, osteoporosis, depressed mood, low energy, etc. There are no FDA approved pharmaceutical treatments for women with sexual dysfunction. [bumc.bu.edu]

• Precocious Puberty

  Cyproterone acetate • Direct antiantiandrogenic action • Progesterone like activity – inhibits LH causing antiandrogenic action • Competes with dihydroteststerone for intracellular receptor Uses: • Precocious puberty in Boys • Inappropriate sexual behaviour [slideshare.net]

  In both males and females, too much testosterone can lead to precocious puberty and result in infertility. In women, high blood levels of testosterone may also be an indicator of polycystic ovary syndrome. [yourhormones.info]

• Hypertension

  Chronic inflammation and adipocyte dysfunction may alter endothelial function leading to hypertension. [ncbi.nlm.nih.gov]

• Jaundice

  They can: Cause acne Increase liver enzymes; this can cause yellow skin ( jaundice ) and liver damage Because of the side effects of androgens, their use has been limited. They are normally used only in people who rely on blood transfusions. [aamds.org]

  Of the five, bilirubin is usually the last to become elevated, so relying on a bilirubin test or waiting to see if the patient develops jaundice may mean that liver problems will become advanced before they are detected. [harvardprostateknowledge.org]

  Androgens – Adverse Effects • Virilization: – may occur in women receiving relatively high doses for prolonged periods, such as for estrogen-dependent mammary carcinoma • Cholestatic Jaundice – may be produced by steroids possessing a 17-alkyl substituted [slideshare.net]

  Jaundice. Worms or other parasites in the alimentary canal. Typhoid. Burn injuries. A defective perspiratory mechanism. What are the symptoms of Leucoderma? The problems usually start with a small white spot, which later develops into patches. [findhealthclinics.com]

• No Pubic Hair

  The conversion of 3H-testosterone and the uptake of 3H-testosterone and 3H-5alpha-dihydrotestosterone were investigated in pubic skin and pubic hair follicles of a XXY-man with inadequate pubic hair. [ncbi.nlm.nih.gov]

  […] loss or thinning of hair increase in pubic hair growth infection, pain, redness, or other irritation at site of injection nervousness stomach pain trouble in sleeping For males only Decrease in testicle size infection, pain, redness, swelling, sores, [mayoclinic.org]

  The child may have reduced development of pubic hair, growth of the penis and testes, and deepening of the voice. [yourhormones.info]

  Common symptoms of this disorder in women include: infertility masculine characteristics early appearance of pubic hair severe acne Treatment for high testosterone depends on the cause, but generally includes medication or lifestyle changes. [healthline.com]

  Because the development of pubic and underarm hair, in women as well as in men, depends upon testosterone, most AIS women have no pubic or underarm hair, but some have sparse hair. [isna.org]

• Somnolence

  Step 1: Modify Lifestyle Factors That Affect Testosterone Levels Some other factors might be influencing your experience as well, entirely unrelated to testosterone levels: are you taking other medications that could produce somnolence or a sense of weakness [lifeextensionitaly.wordpress.com]

• Clitoromegaly

  For example, some can be born with female-appearing genitals but may have an enlarged clitoris (clitoromegaly) or fusion of certain areas of the labia. [rarediseases.org]

  In contrast, severe forms result in female external genitalia with clitoromegaly and partial labial fusion with internal testes. PAIS results from missense changes in the AR gene. [invitae.com]

  […] or bifid scrotum) Grade 4 PAIS Ambiguous genitals, severely ‘under-masculinized’ (phallic structure that is indeterminate between a penis and a clitoris) Grade 5 PAIS Essentially female genitals (including separate urethral and vaginal orifices, mild clitoromegaly [aissg.org]

Detailed history and clinical examination, hormonal workup, and radiological evaluation are the cornerstone for diagnosing hyperandrogenism with hirsutism and virilization in a female. 1. Roman S. Adrenocortical carcinoma. [dx.doi.org]

Workup in androgen excess Laboratory evaluation should be part of the workup for every woman who seeks treatment for signs or symptoms of androgen excess, such as hirsutism. [emedicine.medscape.com]

• Dyslipidemia

  Adiposity, impaired glucose metabolism, dyslipidemia and estrogen levels may mediate the observed associations. Regarding testosterone therapy in women, there have been no large prospective studies on cardiovascular outcomes. [ncbi.nlm.nih.gov]

  Sensitization to insulin in adolescent girls to normalize hirsutism, hyperandrogenism, oligomenorrhea, dyslipidemia, and hyperinsulinism after precocious pubarche. J Clin Endocrinol Metab. 2000 Oct. 85(10):3526-30. [Medline]. [emedicine.medscape.com]

In contrast, Snail mRNA levels are repressed by androgen treatment similar to DRAIC RNA levels. However, while antiandrogen treatment seems not to change Snail mRNA levels, antiandrogen treatments induce DRAIC RNA levels. [ncbi.nlm.nih.gov]

[…] used in the treatment of endometriosis and symptomatic treatment of severe pain and tenderness associated with benign fibrocystic breasts.DB13943Testosterone cypionateAn androgen used to treat low or absent testosterone.DB13944Testosterone enanthateAn [drugbank.ca]

Abstract Purpose Elderly patients with acute myeloid leukemia (AML) have a poor prognosis, and innovative maintenance therapy could improve their outcomes. [ncbi.nlm.nih.gov]

Prognosis Prognosis for patients with CAIS is favorable if support and counseling are appropriate. Adults have normal female gender identity. Patients are infertile and have an increased risk of osteoporosis if hormone replacement is inadequate. [orpha.net]

The second study found that even triple-negative breast cancers (TNBCs), which are without known hormone drivers and carry the poorest prognosis, are dependent on androgen receptor activation. [sciencedaily.com]

Despite the fact that in younger women exhibits more aggressive features and a worse prognosis, BC can be considered a prevalently post-menopausal disease (2). [frontiersin.org]

PCOS is the most common endocrine condition in women, but its etiology remains unknown. [ncbi.nlm.nih.gov]

The etiology of EOC remains elusive; however, experimental and epidemiologic data suggest a role for hormone-related exposures in ovarian carcinogenesis and risk factor differences by histologic phenotypes and developmental pathways. [cancerres.aacrjournals.org]

Inflammation appears to be a crucial etiological factor of prostate cancer. [mayo.edu]

Pathophysiologic Facts About Androgen Insufficiency There are five major categories or types of etiology of androgen insufficiency: Gonadal (chemo- or radiation-therapy, oophorectomy), Adrenal (adrenal failure or insufficiency), Hypothalamic-Pituitary [bumc.bu.edu]

[…] and Women's Health Team, Villejuif, France. 12 Hellenic Health Foundation, Athens, Greece. 13 WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and [ncbi.nlm.nih.gov]

The etiology of EOC remains elusive; however, experimental and epidemiologic data suggest a role for hormone-related exposures in ovarian carcinogenesis and risk factor differences by histologic phenotypes and developmental pathways. [cancerres.aacrjournals.org]

Our understanding of the epidemiology and economic impact of these disorders has expanded, emphasizing their critical importance. These are but a few highlights of how the terrain has changed in a relatively brief period of time. [link.springer.com]

Summary Epidemiology The estimated incidence is between 1/20,000 and 1/99,000 live male births. Clinical description The typical presentation is primary amenorrhea in an adolescent female. [orpha.net]

Abstract The physiological and pathophysiological roles of sex hormones have been well documented and the modulation of their effects is applicable in many current treatments. [ncbi.nlm.nih.gov]

Research Design and Methods: We conducted a secondary analysis of the Diabetes Prevention Program (DPP) and the Diabetes Prevention Program Outcomes Study (DPPOS). [ncbi.nlm.nih.gov]

This prevents androgens from encouraging prostate cancer cell growth. Spironolactone Spironolactone (Aldactone) is a type of anti-androgen that’s been used for 30 years to treat hormonal acne and excessive body hair. [healthline.com]

[…] compared to women. an·dro·gen ( an'drō-jen ), Generic term for an agent, usually a hormone (for example, androsterone, testosterone), which stimulates activity of the accessory male sex organs, encourages development of male sex characteristics, or prevents [medical-dictionary.thefreedictionary.com]

" 23 Apr. 2019 These breakouts are linked to hormones called androgens (male hormones that are present in both guys and girls), which produce excess oil so normal creams will only heal existing acne — not prevent it from occurring. — Kelsey Castañon [merriam-webster.com]