Presentation
The present data suggest that those prostate cancer patients who have even marginally elevated adrenal androgens may especially benefit from combined androgen blockade. [ncbi.nlm.nih.gov]
Entire Body System
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Precocious Puberty
Cyproterone acetate • Direct antiantiandrogenic action • Progesterone like activity – inhibits LH causing antiandrogenic action • Competes with dihydroteststerone for intracellular receptor Uses: • Precocious puberty in Boys • Inappropriate sexual behaviour [slideshare.net]
In both males and females, too much testosterone can lead to precocious puberty and result in infertility. In women, high blood levels of testosterone may also be an indicator of polycystic ovary syndrome. [yourhormones.info]
Urogenital
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Chordee
In childhood, genital abnormalities consisted of a clitoral-like phallus surrounded by a chordee, non-fused labial-scrotal folds and a urogenital sinus. The testes were in the inguinal canals, or rarely, in the labial-scrotal folds. [ncbi.nlm.nih.gov]
Treatment
In contrast, Snail mRNA levels are repressed by androgen treatment similar to DRAIC RNA levels. However, while antiandrogen treatment seems not to change Snail mRNA levels, antiandrogen treatments induce DRAIC RNA levels. [ncbi.nlm.nih.gov]
Prognosis
Abstract Purpose Elderly patients with acute myeloid leukemia (AML) have a poor prognosis, and innovative maintenance therapy could improve their outcomes. [ncbi.nlm.nih.gov]
Prognosis Prognosis for patients with CAIS is favorable if support and counseling are appropriate. Adults have normal female gender identity. Patients are infertile and have an increased risk of osteoporosis if hormone replacement is inadequate. [orpha.net]
The second study found that even triple-negative breast cancers (TNBCs), which are without known hormone drivers and carry the poorest prognosis, are dependent on androgen receptor activation. [sciencedaily.com]
Despite the fact that in younger women exhibits more aggressive features and a worse prognosis, BC can be considered a prevalently post-menopausal disease (2). [frontiersin.org]
Etiology
PCOS is the most common endocrine condition in women, but its etiology remains unknown. [ncbi.nlm.nih.gov]
The etiology of EOC remains elusive; however, experimental and epidemiologic data suggest a role for hormone-related exposures in ovarian carcinogenesis and risk factor differences by histologic phenotypes and developmental pathways. [cancerres.aacrjournals.org]
Hyperandrogenism and androgen excess: physiology, etiology, differential diagnosis, management. In: Lobo RA, Gershenson DM, Lentz GM, Valea FA, eds. Comprehensive Gynecology. 7th ed. Philadelphia, PA: Elsevier; 2017:chap 40. [nlm.nih.gov]
Epidemiology
[…] and Women's Health Team, Villejuif, France. 12 Hellenic Health Foundation, Athens, Greece. 13 WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and [ncbi.nlm.nih.gov]
The etiology of EOC remains elusive; however, experimental and epidemiologic data suggest a role for hormone-related exposures in ovarian carcinogenesis and risk factor differences by histologic phenotypes and developmental pathways. [cancerres.aacrjournals.org]
Cancer Epidemiology, Biomarkers & Prevention 16 2237 – 2246. ( doi:10.1158/1055-9965.EPI-07-0589 ). [jme.bioscientifica.com]
Our understanding of the epidemiology and economic impact of these disorders has expanded, emphasizing their critical importance. These are but a few highlights of how the terrain has changed in a relatively brief period of time. [link.springer.com]
Pathophysiology
Abstract The physiological and pathophysiological roles of sex hormones have been well documented and the modulation of their effects is applicable in many current treatments. [ncbi.nlm.nih.gov]
Prevention
Research Design and Methods: We conducted a secondary analysis of the Diabetes Prevention Program (DPP) and the Diabetes Prevention Program Outcomes Study (DPPOS). [ncbi.nlm.nih.gov]