As such, many men are presenting to healthcare practitioners for the first time. [ncbi.nlm.nih.gov]

• Fatigue

  Without it, a person can become fatigued very easily. The more fatigued a person feels the less likely they are to be active. Individuals may lose their sex drive as testosterone levels begin to drop. [drbartnof.com]

  This therapy could boost libido, alleviate depression and fight fatigue. Hormone replacement therapy may pose risks to prostate cancer patients. [thanyapura.com]

  MAIN MESSAGE: Physicians should consider hypoandrogenism if male patients complain of loss of libido, erectile dysfunction, weakness, fatigue, lethargy, loss of motivation, or mood swings. [ncbi.nlm.nih.gov]

  While these symptoms are signs of andropause, they may also be symptoms of other conditions like adrenal fatigue and poor thyroid health. [bodylogicmd.com]

  Fatigue : This is one of the classic symptoms of low testosterone. Lethargy, lack of sleep and general tiredness can make it difficult to deal with fatigue. 7. [thehealthsite.com]

• Infertility

  Loss of sexual drive may include reduced sexual desire, erectile dysfunction, infertility, fewer unprompted erections (especially during sleep), and smaller testes. [health.in4mnation.com]

  These may include: Infertility Enlarged prostate leading to difficulty urinating Blood clots Worsening heart failure At this time, it is unclear whether TRT increases the risk of heart attack, stroke, or prostate cancer. [medlineplus.gov]

  Boosting Testosterone without Hormones Zinc is involved in almost every aspect of male reproduction, including testosterone metabolism, sperm formation, and sperm motility. 1 A prime example of the usefulness of zinc was illustrated in a study of 37 infertile [foreverhealth.com]

  The following are some symptoms of low testosterone: diminished sex drive, reduced muscle bulk and strength, night sweats, infertility, fewer spontaneous erections, depression, loss of body hair, swollen breasts, palpitations, shrunken testes, height [livescience.com]

• Male Hypogonadism

  It is imperative that male hypogonadism be evaluated and treated with hormonal replacement to avoid the development of frailty and effects on sexual health. This article will review the diagnosis and management of andropause. [ncbi.nlm.nih.gov]

• Coronary Atherosclerosis

  Testosterone treatment in elderly individuals with chronic heart failure might improve insulin sensitivity and various cardiorespiratory and muscular outcomes. [28] But no consistent relationship between coronary atherosclerosis and level of testosterone [ijem.in]

• Vascular Disease

  Disordered erectile function is not generally an endocrine problem but rather vascular, neurologic, and psychogenic in origin. It also may be the first sign of systemic vascular disease. [ncbi.nlm.nih.gov]

  […] attacks and destroys the testes such as variations of systemic lupus erythematosis, subtle genetic abnormalities which permit normal adult development but lead to premature testicular failure, generalized vascular diseases such as diabetes, chemotherapy [diagnose-me.com]

  Atherosclerotic vascular disease can result in erectile dysfunction due to decreased blood flow, as can damage to the nerves controlling erection. [sciencebasedmedicine.org]

• Osteopenia

  Assessment of bone density at 2-year intervals is advisable in hypogonadal men and serum testosterone measurements should be obtained in all men with osteopenia. [ijem.in]

  Fractures, one complication of osteopenia and osteoporosis, may suggest andropause as well. [ncbi.nlm.nih.gov]

• Skin Patch

  Skin patches: People who wear a patch containing testosterone receive the hormone through the skin. The patch allows a slow, steady release of testosterone into the blood stream. [medbroadcast.com]

  Locations The testosterone may be applied to the: Inside lining of the cheek (buccal mucosa) Inside of the nose (nasal mucosa) As a skin patch As a skin gel (including the back, chest, shoulders, arms, and thighs) As a topical solution placed in the axilla [mazemenshealth.com]

• Loss of Libido

  The majority identified irritability (72.5%), loss of energy (66.5%), and loss of libido (60.7%) as symptoms. [ncbi.nlm.nih.gov]

  Symptoms of Andropause: Loss of libido and potency Erectile dysfunction Nervousness Depression Fatigue Loss of muscle mass Loss of memory Inability to concentrate Insomnia Increased breast tissue (caused by higher than normal estrogen levels) Hot flushes [pharmaceutical.co.nz]

  These male menopause symptoms include: Erectile Dysfunction Night Sweats in Men Muscle Loss Low Libido or Sex Drive Depression Weight Gain Urinary Problems Hot Flashes in Men Gynecomastia (male breasts) Hair Loss Sleep Apnea Fatigue Irritability The imbalance [bodylogicmd.com]

  Shocking as it may be to some men, male menopause, or andropause, is becoming more widely recognized and accepted by physicians for the changes many middle-aged men experience — from energy loss to depression to loss of libido to sexual dysfunction. [health.howstuffworks.com]

• Fear

  Ignorance and fear of the andropause condition abounds in the general public and amongst health professionals. There is a paucity of information in the literature about the symptoms and condition of the andropause. [ncbi.nlm.nih.gov]

  Interpersonal: A longing for intimacy and fear of getting close. Physical: Increased fatigue, short-term memory loss and weight gain. Spiritual: Great restlessness and a longing to follow soul's calling. [menstuff.org]

  […] formation (ill at ease) anemia joint stiffness and muscle pain increased aging of the heart and brain decreased memory and intelligence increased dementia and Alzheimer's disease less muscle, more fat tiredness depression, mood changes excitability fear [healthandbodywellnessmd.com]

  Recent evidence suggests that the fear of prostate cancer is perhaps exaggerated, since prostatic disease is estrogen-dependent rather than testosterone-dependent. [andrology.com]

  Men are now freer to discuss their sexual performance problems with their doctors, wives and friends without fear of being ridiculed or ignored. [completehealthinstitute.com]

• Stroke

  The agency will now require producers to conduct clinical trials to determine more definitively whether the products increase the risk of heart attacks and strokes. [nytimes.com]

  Together, these data support endocrine dyscrasia and the subsequent loss of cell cycle control as an important etiological event in the development of neurodegenerative diseases including AD, stroke and Parkinson's disease. Published by Elsevier Inc. [ncbi.nlm.nih.gov]

  The findings, released in August 2015, showed that men who restored testosterone to normal levels with testosterone therapy were at a reduced risk of heart attack or stroke. [bodylogicmd.com]

  These may include: Infertility Enlarged prostate leading to difficulty urinating Blood clots Worsening heart failure At this time, it is unclear whether TRT increases the risk of heart attack, stroke, or prostate cancer. [medlineplus.gov]

• Confusion

  Bio-identical testosterone must not be confused with synthetic derivatives or "anabolic steroids", which when used by athletes and body builders have caused disastrous effects. [healthandbodywellnessmd.com]

  Confused about when to test in saliva, blood, and urine? Click here to learn more. [zrtlab.com]

  Overactivity of the autonomic system can occur in diabetic patients and it is important not to confuse symptoms of diabetic autonomic neuropathy with that of the Andropause. [amazon.com]

  Confusion also exists because of the subset of testosterone that is measured. [ncbi.nlm.nih.gov]

• Sexual Dysfunction

  Most significant in this population are the side effects of hot flashes, anemia, gynecomastia, depression, cognitive decline, sarcopenia, a decreased overall quality of life, sexual dysfunction, and osteoporosis with subsequent bone fractures. [ncbi.nlm.nih.gov]

  A male experiencing andropause may have a number of symptoms related to the condition and is at risk of sexual dysfunction, weight gain, low energy, and cardiovascular and cholesterol issues. [camelbackhealth.com]

• Prostatic Disease

  Increased risk of prostate disease and heart disease is also associated with increased estrogens in men. Once a man has gained more than 20 pounds of excess body fat, he is very likely to actually have excessive estrogen. [yourhormones.com]

  Prostate Cancer Risk Of greatest concern when supplementing testosterone is an increase in prostatic disease, namely benign prostatic hyperplasia or the development of, or increased occurrence of, prostatic carcinoma. [ncbi.nlm.nih.gov]

  Recent evidence suggests that the fear of prostate cancer is perhaps exaggerated, since prostatic disease is estrogen-dependent rather than testosterone-dependent. [andrology.com]

  After initiation of testosterone treatment, patients should be monitored for prostate disease at 3-6 months, 12 months, and at least annually thereafter. [ijem.in]

• Enlargement of the Prostate

  It is perhaps this event that is most responsible for the many symptoms of male menopause, and possibly even enlarged prostates and prostate cancer. [obrienrx.com]

  Many men are concerned about their prostate and for good reason. By the time men turn 60, 20 percent of them have an enlarged prostate (begin prostatic hypertrophy or BPH). [coreonehealth.com]

  It also increases your risk of enlargement of the prostate and even prostate cancer. [healthrenewal.co.za]

However, low testosterone can also be indicative of an underlying pituitary disorder; therefore, careful workup should be performed to distinguish between benign and pathologic conditions in individual men. [ncbi.nlm.nih.gov]

Given this result, one wonders how careful a workup was done before prescribing testosterone replacement. After all, there are multiple forms of hypogonadism, primary and secondary. [sciencebasedmedicine.org]

• Testosterone Decreased

  It is estimated that testosterone decreases about 3 to 5% every year after the age of 30. [camelbackhealth.com]

  As men age, their testosterone level dips, triggering many physical and psychological symptoms. “It’s part of the natural ageing process. Once men cross 30, testosterone decreases about 10% every decade. Andropause is similar to menopause. [timesofindia.indiatimes.com]

  This is part of the natural aging process and it is estimated that testosterone decreases about 10% every decade after men reach the age of 30. Andropause is a condition that is associated with the decrease in the male hormone testosterone. [medbroadcast.com]

• Testosterone Increased

  The potential for CV risks from testosterone therapy led the FDA to issue a requirement in 2015 that testosterone pharmaceutical labels include warning information about the possibility of an increased risk of heart attacks and stroke. [en.wikipedia.org]

  New evidence suggests that a similar phenomenon occurs in men as their testosterone levels diminish with age. Research thus far point to a strong association between low-testosterone levels and an increase in cardiovascular risk in men. [charlesevansmd.com]

  The probability of symptoms increased with decreased levels of testosterone ( Figure 1 ). [doi.org]

  But supraphysiological testosterone levels induce an increase in LDL-C and decrease of HDL-C levels and may increase the risk of cardiovascular disease. [ijem.in]

• Androgens Decreased

  There are two terms used to describe this condition – PADAM (partial androgen decrease of aging men) and ADAM (androgen decrease of aging men). [hgh10.com]

  decrease below a particular threshold. [ijem.in]

  This decrease in growth hormone is called somatopause (similar to the decrease in androgens being called andropause). [mazemenshealth.com]

  Increased estrogen rather than decreased androgen action is associated with longer androgen receptor CAG repeats. J Clin Endocrinol Metab 2009;94: 277-84. 51. Huhtaniemi IT, Pye SR, Holliday KL, Thomson W, O'Neill TW, et al. [doi.org]

• Androgens Increased

  Androgens were first discovered in 1936. Androgens increase protein synthesis within cells which results in a buildup of cellular tissue especially in the muscle. [tomwhitewellness.com]

  Androgens increase lean body mass and affect body weight as well. Androgens are required to maintain bone density in men. [mazemenshealth.com]

AAG Health & Wellness Hormone replacement therapy clinic specializing in testosterone & human growth hormone treatment for andropause. [curlie.org]

Almost all PCPs (91.5%) agreed that prostate cancer is a contraindication to treatment while around one-third (33.9%) agreed that breast cancer was a contraindication. [ncbi.nlm.nih.gov]

This article presents an overview of the etiology and pathophysiology of hypogonadism, and offers guidelines for the evaluation of men who should have further testing. The pros and cons of various testosterone formulations are discussed. [ncbi.nlm.nih.gov]

Gettingovertestosterone: Postulating a fresh start for etiologic studies of prostate cancer. J Natl Cancer Inst 2008;100:158-9. 33. Thompson IM, Ankerst DP, Chi C, Goodman PJ, Tangen CM, Lucia MS, et al. [ijem.in]

Prospective epidemiological and clinical evidence in humans supports the premise that rebalancing the ratio of circulating gonadotropins:sex steroids reduces the incidence of AD. [ncbi.nlm.nih.gov]

This article presents an overview of the etiology and pathophysiology of hypogonadism, and offers guidelines for the evaluation of men who should have further testing. The pros and cons of various testosterone formulations are discussed. [ncbi.nlm.nih.gov]

PATHOPHYSIOLOGY Decreasing levels of bioavailable testosterone due to :  Decrease rate of production by testes  Reduction in size and weight of testes  Critical illness  Increassed leval of stress  Testicular trauma  Genetic and metabolic disorder [slideshare.net]

Traish and Abraham Morgentaler, Benefits and Risks of Testosterone Therapy in Men With Testosterone Deficiency, Sex Differences in Cardiovascular Physiology and Pathophysiology, 10.1016/B978-0-12-813197-8.00018-X, (321-354), (2019). John T. [doi.org]

Your plan can include some of the nutrients discussed for boosting testosterone, preventing its conversion to estrogen, and improving how your body metabolizes hormones. [foreverhealth.com]

Ideally, supplementation with HPG hormones should mimic closely the serum concentrations of all HPG hormones in reproductive men and cycling women to prevent dyotic signaling and attempted neuron division. [ncbi.nlm.nih.gov]

Every person responds differently to hormone treatment modalities, especially bHRT, thus consistent monitoring is necessary to achieve optimal symptom relief and chronic disease prevention. [hoodtocoasthealthcare.com]