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Andropause

Climacteric male


Presentation

  • As such, many men are presenting to healthcare practitioners for the first time.[ncbi.nlm.nih.gov]
  • Results of the author's own research in 302 men of the association of memory loss as a symptom in the andropause will be presented.[ncbi.nlm.nih.gov]
  • Abstract Age-related decline in serum testosterone level may present as a constellation of signs and symptoms of hypogonadism known as andropause.[ncbi.nlm.nih.gov]
  • Investigation is directed at the presenting complaints and measuring the serum bioavailable testosterone. Treatment is currently by testosterone replacement using one of a number of routes (parenteral, oral, transdermal).[ncbi.nlm.nih.gov]
  • OBJECTIVE: The present study investigated whether job demands modify the association between low levels of testosterone and andropause symptoms. STUDY DESIGN: Participants were Japanese middle-aged workers in a middle-size company.[ncbi.nlm.nih.gov]
Fatigue
  • Without it, a person can become fatigued very easily. The more fatigued a person feels the less likely they are to be active. Individuals may lose their sex drive as testosterone levels begin to drop.[drbartnof.com]
  • MAIN MESSAGE: Physicians should consider hypoandrogenism if male patients complain of loss of libido, erectile dysfunction, weakness, fatigue, lethargy, loss of motivation, or mood swings.[ncbi.nlm.nih.gov]
  • This therapy could boost libido, alleviate depression and fight fatigue. Hormone replacement therapy may pose risks to prostate cancer patients.[thanyapura.com]
  • The clinical picture of andropause syndrome is characterized by diminished sexual desire and erectile capacity, decrease in intellectual activity, fatigue, depression, decrease in lean body mass, skin alterations, decrease in body hair, decrease in bone[ncbi.nlm.nih.gov]
  • While these symptoms are signs of andropause, they may also be symptoms of other conditions like adrenal fatigue and poor thyroid health.[bodylogicmd.com]
Male Hypogonadism
  • It is imperative that male hypogonadism be evaluated and treated with hormonal replacement to avoid the development of frailty and effects on sexual health. This article will review the diagnosis and management of andropause.[ncbi.nlm.nih.gov]
  • Abstract Andropause or late-onset hypogondism (LOH) is a situation where a middle-aged or older man has low serum testosterone (T) in conjunction with diffuse symptoms reminiscent of those of genuine male hypogonadism (e.g. reduced sexual function, loss[ncbi.nlm.nih.gov]
  • The nonsexual benefits of testosterone replacement therapy (TRT) in male hypogonadism are well documented, but whether health care professionals (HCPs) and members of the general public are aware of these benefits is not known.[ncbi.nlm.nih.gov]
  • Abstract Age related male hypogonadism, or "andropause", is increasingly recognized as of frequent occurrence in older patients. Diagnosis requires both the presence of clinical symptoms and low testosterone levels.[ncbi.nlm.nih.gov]
  • OBJECTIVE: To compare the modalities of treatment for male hypogonadism available in Brazil.[ncbi.nlm.nih.gov]
Camping
  • Of 180 listed male workers, 170 attended this camp and 157 eligible men participated in the study.[ncbi.nlm.nih.gov]
  • Saad Andrologia. 2016; : n/a 35 Geranylgeraniol enhances testosterone production via the cAMP/protein kinase A pathway in testis-derived I-10 tumor cells Hsin-Jung Ho,Hitoshi Shirakawa,Risa Yoshida,Asagi Ito,Misato Maeda,Tomoko Goto,Michio Komai Bioscience[doi.org]
Sepsis
  • We report the case of a severely wounded serviceman with complete traumatic andropause, whose symptomatic temperature swings were initially mistaken for signs of occult sepsis.[ncbi.nlm.nih.gov]
Decreased Libido
  • Symptoms of late-onset hypogonadism include decreased libido, fatigue, depression, and erectile dysfunction. The condition may proceed unnoticed for many years because symptoms are often subtle.[britannica.com]
  • Erectile dysfunction , decreased libido, and loss of fertility are common examples of sexual issues that might occur due to andropause. Additionally, some men may experience a decrease in the size of their testes.[goodtherapy.org]
  • For example, feeling too weak or tired to engage in sex could be related to impaired cardiovascular health, feelings of insecurity, and decreased libido, all of which may be related to a testosterone deficiency.[womensinternational.com]
  • Approximately 40 % of men between 40 and 60 will experience some degree of lethargy, depression, increased irritability, mood swings, hot flushes, insomnia, decreased libido, weakness, loss of both lean body mass and bone mass (making them susceptible[andrology.com]
  • The gradual decline, most often fully realized between the ages of 50 and 55, can produce a variety of changes and effects on the male body: Erectile dysfunction (problems with erections) Decreased libido (low sex drive) Mood disturbances, including depression[completehealthinstitute.com]
Social Isolation
  • All these may eventually affect negatively the self-care capacity of patients making them require a long-term professional care, and lead to severe psychological and social isolation and increased mortality and change in quality of life.[ncbi.nlm.nih.gov]
Forgetful
  • Intriguingly, a recent animal study has demonstrated that induction of adult neurogenesis results in the loss of previously encoded memories while decreasing neurogenesis after memory formation during infancy mitigated forgetting.[ncbi.nlm.nih.gov]
  • But don’t forget to have your hormones tested before starting any hormone regimen. You also need to be committed to obtaining follow-up blood tests at least once a year.[foreverhealth.com]
  • Further andropause symptoms can include weight gain, pot or "beer bellies," mood swings and irritability, forgetfulness, enlarged male breasts and even ED or Erectile Dysfunction.[atlantamedicalinstitute.com]
Sexual Dysfunction
  • Most significant in this population are the side effects of hot flashes, anemia, gynecomastia, depression, cognitive decline, sarcopenia, a decreased overall quality of life, sexual dysfunction, and osteoporosis with subsequent bone fractures.[ncbi.nlm.nih.gov]
  • Such age-associated HPG hypofunctioning, which has been termed 'andropause', is thought to be responsible for a variety of symptoms experienced by elderly men, including sexual dysfunction and depression.[ncbi.nlm.nih.gov]
  • Abstract There are several problems facing aging men, especially sexual dysfunction, hypogonadism, and psychologic changes. This constellation of changes is sometimes referred to as "manopause" or "andropause."[ncbi.nlm.nih.gov]
  • Sexual dysfunction, hypogonadism and psychological changes are also commonly observed symptoms in this condition. Changes of similar kind can also be seen in young males with androgen deficiency.[ncbi.nlm.nih.gov]
  • A male experiencing andropause may have a number of symptoms related to the condition and is at risk of sexual dysfunction, weight gain, low energy, and cardiovascular and cholesterol issues.[camelbackhealth.com]

Workup

  • However, low testosterone can also be indicative of an underlying pituitary disorder; therefore, careful workup should be performed to distinguish between benign and pathologic conditions in individual men.[ncbi.nlm.nih.gov]
  • Given this result, one wonders how careful a workup was done before prescribing testosterone replacement. After all, there are multiple forms of hypogonadism, primary and secondary.[sciencebasedmedicine.org]
Testosterone Decreased
  • It is estimated that testosterone decreases about 3 to 5% every year after the age of 30.[camelbackhealth.com]
  • Once men cross 30, testosterone decreases about 10% every decade. Andropause is similar to menopause. One can see a decline in sexuality and energy due to the decrease in male hormones,” says clinical psychologist Seema Hingorrany.[timesofindia.indiatimes.com]
  • This is part of the natural aging process and it is estimated that testosterone decreases about 10% every decade after men reach the age of 30. Andropause is a condition that is associated with the decrease in the male hormone testosterone.[medbroadcast.com]
Androgens Decreased
  • There are two terms used to describe this condition – PADAM (partial androgen decrease of aging men) and ADAM (androgen decrease of aging men).[hgh10.com]
  • decrease, increases testosterone levels and improves sexual function in healthy aging males in a double-blind randomised clinical study Amanda Rao,Elizabeth Steels,Warrick J.[doi.org]
Androgens Increased
  • Androgens increase protein synthesis within cells which results in a buildup of cellular tissue especially in the muscle. The term “anabolic” generally refers to having a positive effect on growth in the body.[tomwhitewellness.com]
Hyperprolactinemia
  • None of the subjects had hypogonadism secondary to hyperprolactinemia or pituitary insufficiency. Causes of osteoporosis that could mask the clinical diagnosis of hypogonadism were not demonstrated by the general exams.[scielo.br]

Treatment

  • AAG Health & Wellness Hormone replacement therapy clinic specializing in testosterone & human growth hormone treatment for andropause.[curlie.org]
  • Only 123 (11.4%) had an idea about the treatment of andropause. The keenness to resort to treatment or seek medical advice was shown by 355 (47.3%).[ncbi.nlm.nih.gov]
  • Treatment is currently by testosterone replacement using one of a number of routes (parenteral, oral, transdermal). The object of treatment is improvement in the index clinical domains and biochemical normalization.[ncbi.nlm.nih.gov]
  • Almost all PCPs (91.5%) agreed that prostate cancer is a contraindication to treatment while around one-third (33.9%) agreed that breast cancer was a contraindication.[ncbi.nlm.nih.gov]
  • Low level of clinical suspicion secondary to inadequate knowledge about this clinical entity remains the major obstacle to appropriate treatment.[ncbi.nlm.nih.gov]

Etiology

  • This article presents an overview of the etiology and pathophysiology of hypogonadism, and offers guidelines for the evaluation of men who should have further testing. The pros and cons of various testosterone formulations are discussed.[ncbi.nlm.nih.gov]
  • Many with erectile failure, suffer silently regardless of its etiology. In this review, we suggest some practical guidelines for the management of these conditions.[ncbi.nlm.nih.gov]
  • We also investigate the multifactorial etiology of age-related physiological changes--the body undergoes changes in its structure, there is a loss of muscle strength and decline in physical functions.[ncbi.nlm.nih.gov]
  • Together, these data support endocrine dyscrasia and the subsequent loss of cell cycle control as an important etiological event in the development of neurodegenerative diseases including AD, stroke and Parkinson's disease. Published by Elsevier Inc.[ncbi.nlm.nih.gov]

Epidemiology

  • Prospective epidemiological and clinical evidence in humans supports the premise that rebalancing the ratio of circulating gonadotropins:sex steroids reduces the incidence of AD.[ncbi.nlm.nih.gov]
  • The results of older clinical and epidemiological studies are confronted with the most recently published data. The importance of type, doses and delivery route of hormones is discussed with respect to the cardiovascular safety of HRT.[ncbi.nlm.nih.gov]
  • In this review, the literature has been perused and the definition, epidemiology, pathophysiology, clinical features, diagnosis and treatment are outlined.[ncbi.nlm.nih.gov]
  • With the perspective provided by recent epidemiological findings, not least from the estrogen only arm of the Women's Health Initiative Study (WHI), European Menopause and Andropause Society (EMAS) supports research activities in symptomatic women with[ncbi.nlm.nih.gov]
  • Compelling epidemiologic evidence to support this assertion includes the increased prevalence of Alzheimer disease (AD) in women, the correlation of serum HPG hormones with disease and the decreased incidence, and delay in the onset of AD following hormone[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • This article presents an overview of the etiology and pathophysiology of hypogonadism, and offers guidelines for the evaluation of men who should have further testing. The pros and cons of various testosterone formulations are discussed.[ncbi.nlm.nih.gov]
  • In this review, the literature has been perused and the definition, epidemiology, pathophysiology, clinical features, diagnosis and treatment are outlined.[ncbi.nlm.nih.gov]
  • In this article we discuss the pathophysiology, definition and diagnostic difficulties of andropause in geriatric patients.[ncbi.nlm.nih.gov]
  • Fully 62% of the top 50 most prescribed drugs relate to the pathophysiology and metabolic effects of andropause.[orientalhealthsolutions.com]
  • Traish and Abraham Morgentaler, Benefits and Risks of Testosterone Therapy in Men With Testosterone Deficiency, Sex Differences in Cardiovascular Physiology and Pathophysiology, 10.1016/B978-0-12-813197-8.00018-X, (321-354), (2019). John T.[doi.org]

Prevention

  • With the increase in aging male population, life span in Iran, and focus on quality of life, andropause will become a major health issue that needs to be addressed in order to prevent disability.[ncbi.nlm.nih.gov]
  • Though this evidence is accumulating, the question of how to provide best clinical practice in an attempt to both alleviate the menopausal symptoms and prevent the more long-term postmenopausal degenerative diseases is still under debate.[ncbi.nlm.nih.gov]
  • The results parallel recent reports of the neuroprotective effects of estrogens in preventing dementia. Diabetes is associated with memory loss because of the additional insults to cognitive function of the brain secondary to ischemia.[ncbi.nlm.nih.gov]
  • To limit the age-related physiological decline in serum testosterone levels, we should be able to tackle the still unresolved important clinical issue--can hormone replacement therapy administered to elderly men improve their functional status, prevent[ncbi.nlm.nih.gov]
  • Ideally, supplementation with HPG hormones should mimic closely the serum concentrations of all HPG hormones in reproductive men and cycling women to prevent dyotic signaling and attempted neuron division.[ncbi.nlm.nih.gov]

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