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Anemia due to Vitamin B6 Deficiency

Pyridoxine Deficiency Anemia


Presentation

  • Deficiency of this vitamin typically presents symptoms involving damage of the nerves in the feet and hands. Dermatitis, inflammation in the mouth, and cracked lips can also occur.[stop-being-tired.com]
  • Sadly, very few children presenting with autistic symptoms receive adequate testing for B 12 deficiency. Infants and young children are often misdiagnosed.[pharmacytimes.com]
  • Snapshot A 24-year-old woman presents to her primary care physician due to fatigue, nightsweats, cough, and fever. She reported to being in her usual state of health until a few weeks after returning from her trip to Mexico.[medbullets.com]
  • VITAMIN B6 INTRODUCTION Vitamin B6 also called pyridoxine is a watersoluble vitamin that is naturally present in many foods, added to others, and available as a dietary supplement.[slideshare.net]
  • The autosomal recessive form is typically severe in presentation. Genetic syndromes: Rarely, sideroblastic anemia may be part of a congenital syndrome and present with associated findings, such as ataxia, myopathy, and pancreatic insufficiency.[en.wikipedia.org]
Anemia
  • NIH: National Heart, Lung, and Blood Institute Anemia (Medical Encyclopedia) Anemia - B12 deficiency (Medical Encyclopedia) Anemia caused by low iron -- infants and toddlers (Medical Encyclopedia) Anemia of chronic disease (Medical Encyclopedia) Anemia[icdlist.com]
  • Gastric bypass surgery undertaken to produce weight loss can cause this form of vitamin-deficiency anemia as well. Pernicious anemia.[everydayhealth.com]
  • Anemia and vitamin B6 Gaby has much more to say on vitamin B6 and anemia. As you will see from the quotes below, suboptimal vitamin B6 intake can be involved surprisingly often in cases of anemia.[mossnutrition.com]
Colic
  • Irritability or gastric symptoms of B 12 deficiency can be easily mistaken for colic or gastroenteritis.[pharmacytimes.com]
Heart Rate Irregular
  • If you develop anemia due to low B-6 levels, you may experience symptoms such as heart rate irregularities, fatigue, pale skin, dizziness, headache, difficulty breathing or cold extremities.[livestrong.com]
Compulsive Behavior
  • Both autistic and brain-injured B 12 - deficient children have obsessive-compulsive behaviors and difficulty with speech, language, writing, and comprehension. B 12 deficiency can also cause aloofness and withdrawal.[pharmacytimes.com]
Seizure
  • Rarely, deficiency or dependency causes seizures in infants. Seizures, particularly in infants, may be refractory to treatment with anticonvulsants. Normocytic, microcytic, or sideroblastic anemia can also develop.[merckmanuals.com]
  • Marked deficiency causes irritability, weakness, depression, dizziness, peripheral neuropathy, and seizures. In infants and children typical manifestations are diarrhea, anemia, and seizures.[icd9data.com]
  • Seizure Disorders – B-6/P5P deficiency can cause certain types of seizures. A number of the decarboxylases for neurotransmitter synthesis are P5P-dependent.[metabolichealing.com]
  • Seizures Seizures are the common symptoms found in infants who suffer from the deficiency of vitamin B6.Children and infants who have fast metabolism usually get seizures but there is no test that can be carried out to measure the level of deficiency[searchhomeremedy.com]
  • Seizures Deficiency of vitamin B6 causes seizures in infants. However, infants and children have good metabolism they get seizures but no test can find out the level of deficiency they suffer from.[ayurtimes.com]
Peripheral Neuropathy
  • Vitamin B 6 deficiency is also associated with skin problems scaling on the lips and cracks at the corners of the mouth swollen tongue depression and confusion PMS morning sickness weakened immune function anemia peripheral neuropathy Peripheral neuropathy[about-natural-remedies.net]
  • Symptoms can include peripheral neuropathy, a pellagra-like syndrome, anemia, and seizures, which, particularly in infants, may not resolve when treated with anticonvulsants.[merckmanuals.com]
  • Marked deficiency causes irritability, weakness, depression, dizziness, peripheral neuropathy, and seizures. In infants and children typical manifestations are diarrhea, anemia, and seizures.[icd9data.com]
  • Signs and symptoms include stomatitis, glossitis, dermatitis, peripheral neuropathy, irritability, seizures, and anemia.[icd10data.com]
  • A delay in treatment can result in an incomplete recovery of lost functions. b) Peripheral neuropathy Peripheral neuropathy is also a usual presentation of vitamin B12 deficiency.[brainblogger.com]

Workup

Microcytic Anemia
  • While this may be correct in some cases, P5P deficiency can also cause microcytic anemia.[metabolichealing.com]
  • Congenital forms often present with normocytic or microcytic anemia while acquired forms of sideroblastic anemia are often normocytic or macrocytic.[en.wikipedia.org]
  • CURRENT RESEARCHES Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and[slideshare.net]
  • Iron, of course, is typically associated with microcytic anemia whereas folate and vitamin B12 are typically associated with macrocytic anemia.[mossnutrition.com]
Thrombocytosis
  • Three forms exist and include refractory anemia with ringed sideroblasts (RARS), refractory anemia with ringed sideroblasts and thrombocytosis (RARS-T), and refractory cytopenia with multilineage dysplasia and ringed sideroblasts (RCMD-RS).[en.wikipedia.org]

Treatment

  • His main research interests are obesity treatment and nutrition for cancer prevention and treatment.[books.google.com]
  • […] of pyridoxine deficiency Treatment of pyridoxine-responsive sideroblastic anemia, but not other types of sideroblastic anemia [7] Treatment of certain inborn types of seizures in infants (pyridoxine-dependent epilepsy) [8] Vitamin B6 is POSSIBLY EFFECTIVE[nutrientsreview.com]
  • Seizures, particularly in infants, may be refractory to treatment with anticonvulsants. Normocytic, microcytic, or sideroblastic anemia can also develop.[merckmanuals.com]
  • Treatment may include vitamin B 12 shots (injections) and folic acid pills.[hopkinsmedicine.org]
  • Some complications improve with appropriate treatment, but others – such as problems with the nervous system – can be permanent. Page last reviewed: 16/05/2016 Next review due: 01/05/2019[nhs.uk]

Prognosis

  • Therapeutic phlebotomy can be used to manage iron overload. [17] Prognosis [ edit ] Sideroblastic anemias are often described as responsive or non-responsive in terms of increased hemoglobin levels to pharmacological doses of vitamin B 6. 1- Congenital[en.wikipedia.org]

Etiology

  • Etiology Dietary vitamin B 6 deficiency , though rare, can develop because extensive processing can deplete foods of vitamin B 6 .[merckmanuals.com]
  • Oral administration of high-dose vitamin B 12 (1 to 2 mg daily) is as effective as intramuscular administration in correcting the deficiency, regardless of etiology.[aafp.org]
  • Yet, the etiology of late-onset depression is unclear and evidence is currently lacking to suggest whether supplemental B vitamins (including vitamin B 6 ) could relieve depressive symptoms.[lpi.oregonstate.edu]

Epidemiology

  • In an epidemiological study, Tufts University researchers identified trends of vitamin B6 status in a sample of the United States population based on measures of plasma pyridoxal 5'- phosphate (PLP) levels in the bloodstream.[sciencedaily.com]
  • […] homeostasis through glycogen degradation and gluconeogenesis. 5 Inverse associations have been shown between plasma PLP and chronic or acute disease, including rheumatoid arthritis, cardiovascular disease, deep vein thrombosis, and cancer. 4-16 A number of epidemiologic[labcorp.com]
  • Epidemiology Frequency United States Idiopathic pyridoxine deficiency is very rare.[emedicine.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • This vitamin is unique in that either deficiency or excess can cause peripheral neuropathy. [1, 2, 3, 4, 5] Pathophysiology After absorption, pyridoxine, pyridoxamine, and pyridoxal are transported into hepatic cells by facilitated diffusion.[emedicine.medscape.com]

Prevention

  • His main research interests are obesity treatment and nutrition for cancer prevention and treatment.[books.google.com]
  • Preventing re-blockage of blood vessels after angioplasty. Evidence on the benefits of vitamin B6 for preventing the re-blockage of blood vessels after angioplasty is inconsistent.[webmd.com]
  • How to prevent and overcome the deficiency of vitamin B6 How to prevent and even treat it? The easiest way is, to consume natural food sources that contain lots of vitamin B6. Additionally still consult a doctor.[healthfame.com]
  • Can pernicious anemia/ vitamin B-12 deficiency be prevented? The autoimmune process that causes pernicious anemia cannot be prevented.[medicinenet.com]

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