The present review summarizes the literature, from the early descriptions pointing toward an immunologic basis of PA and up to the present recognition that PA is a cutaneous sign for autoimmune disorders, in general, and the presence of antiphospholipid [ncbi.nlm.nih.gov]

In the present case, the prothrombotic state was yet asymptomatic but the presence of primary anetoderma has directly led to the search for antiphospholipid antibodies. [kosmetischemedizin-online.de]

The day before the admission he presented purpura of the skin of the right ankle, of the bottom and of the knees. [ispub.com]

• Inflammation

  A follow-up biopsy at this time showed minimal lymphocytic inflammation but almost complete absence of elastic tissue in the mid-reticular dermis. [vgrd.org]

  On routine stains the skin looks relatively normal, perhaps with some signs of inflammation. [dermnetnz.org]

  Janoff A, Scherer J: Mediators of inflammation in leukocyte lysosomes: IX. Elastinolytic activity in granules of human polymorphonuclear leukocytes. J Exp Med 1968;128:1137-1155.Crossref 21. [deepdyve.com]

  Tgfb1 lethargy Smad3 limb grasping Smad2 liver fibrosis Tgfbr2 liver hypoplasia Smad2, Smad3 liver inflammation Tgfb1, Tgfbr2 lung inflammation Tgfb1, Tgfbr2 lymph node inflammation Tgfb1 male infertility Tgfb1 malocclusion Smad4, Tgfb1 mandible hypoplasia [rgd.mcw.edu]

  Conditions and Treatments mitral valve stenosis, critical limb ischemia, chest pain, angina, acute coronary syndrome, inflammation of the heart valve, heart muscle disease, arterial occlusive disease, carotid stenosis, renal artery stenosis, aortic valve [nyulangone.org]

• Dyspnea

  A previously healthy 34-year-old male was transported to the emergency department with dyspnea, diaphoresis, pallor, and urticarial wheals on his face, arms, and torso after the administration of the third dose of anthrax vaccine. [medscienceresearch.com]

• Urticaria

  Anetodermic lesions developed two years ago without preceding urticaria pigmentosa lesions. In skin biopsy perivascular mast cell and eosinophil infiltrations were observed. [odermatol.com]

  Several months later, the erythema and urticaria was noted to have resolved, leaving soft, pendulous plaques with overlying finely wrinkled skin. [vgrd.org]

  In the past, cases of primary anetoderma were divided into the Jadassohn-Pellizari type, in which the lesions are preceded by erythema or urticaria, and the Schweninger-Buzzi type, in which there are no preceding inflammatory lesions. [bmcdermatol.biomedcentral.com]

  September 01, 2011 Serum concentration of dehydroepiandrosterone sulfate (DHEA-S) in patients suffering from acute urticaria. September 01, 2011 Analysis of 6 cases of drug-induced pemphigus. [medscape.com]

• Subcutaneous Mass

  Usually the lesions manifested as soft, wrinkled, protuberant lesions with a firm underlying subcutaneous mass. [medcomhk.com]

  She presented with a soft, wrinkled pedunculated lesion overlying a firm subcutaneous mass on her right anterior shoulder. [thedoctorsdoctor.com]

• Blister

  Rubbing that is too frequent or forceful will cause blisters as opposed to calluses to form. Cause [ edit ] Normally, a callus will form on any part of the skin exposed to excess friction over a long period of time. [en.wikipedia.org]

  “Pemphigus is a rare autoimmune disease characterized by flaccid blisters and erosions on skin and mucous epithelia. [medscienceresearch.com]

• Localized Scleroderma

  […] juvenile rheumatoid arthritis Smad3 kidney disease Tgfb1, Tgfbr1, Tgfbr2 Laryngotracheal Stenosis, Progressive, with Short Stature and Arthropathy Smad4 leiomyoma Smad3, Tgfbr1 Lipoyltransferase 1 Deficiency Tgfbr2 liver cirrhosis Smad3, Tgfb1, Tgfbr1 localized [rgd.mcw.edu]

• Osteoporosis

  […] ductal carcinoma Tgfb1, Tgfbr2 papilloma Tgfb1 Paraquat Lung Smad7, Tgfb1 Parasitic Liver Diseases Smad4 Peritoneal Fibrosis Tgfb1 Peyronie's disease Tgfb1 pleural disease Tgfb1 pneumonia Tgfb1 Posterior Leukoencephalopathy Syndrome Tgfb1 Postmenopausal Osteoporosis [rgd.mcw.edu]

• Irritability

  Allergies, irritants, your genetic makeup, and certain diseases and immune system problems can cause rashes, hives, and other skin conditions. Many skin problems, such as acne, also affect your appearance. [icdlist.com]

  People with poor circulation or sensation should check their skin often for signs of rubbing and irritation so they can minimize any damage. [en.wikipedia.org]

  Although Piguet and Bolgert proposed that mechanical irritation (trauma) was an inciting factor and some authors support this hypothesis,3,6,10 there were no history of trauma on the lesions in most of the cases including our patient. [medcomhk.com]

  The multiple clinical sequelae associated with epidermal barrier impairments inherent to AD include dry skin, pruritus, increased skin sensitivity to irritants and allergens, eczematous skin changes, staphylococcal skin and anterior nares colonization [read.qxmd.com]

• Hyperactivity

  […] heart inflammation Tgfb1 hemopericardium Tgfbr1, Tgfbr2 hemorrhagic ascites Tgfbr2 hemothorax Tgfbr1, Tgfbr2 hepatic necrosis Tgfb1, Tgfbr2 hepatic steatosis Smad4 holoprosencephaly Smad2, Smad3 hunched posture Tgfb1 hydrocephaly Tgfb1 hydroureter Smad4 hyperactivity [rgd.mcw.edu]

• Renal Insufficiency

  Other common associated manifestations include livedo reticularis, thrombocytopenia, valvular heart disease, and nephropathy with renal insufficiency, hypertension, and proteinuria. [semanticscholar.org]

• Kidney Failure

  […] of chorioallantoic fusion Smad2, Tgfb1 failure of ejaculation Tgfb1 failure of primitive streak formation Smad2, Smad4 failure to gastrulate Smad2, Smad4 fused somites Smad2, Smad3, Smad4 gastric necrosis Tgfb1 gastric polyps Smad4 gastric ulcer Tgfb1 [rgd.mcw.edu]

The specific diagnostic workup and treatments for corns may differ substantially from other forms of calluses. Prevention [ edit ] Corns and calluses are easier to prevent than to treat. [en.wikipedia.org]

Am J Dermatopathol 36:449–464 CrossRef PubMed Google Scholar Girardi M, Kay J, Elston DM et al (2011) Nephrogenic systemic fibrosis: clinicopathological definition and workup recommendations. [link.springer.com]

We describe a striking case of primary anetoderma and review the classification, differential diagnosis, causes, and treatment. [ncbi.nlm.nih.gov]

Established lesions can be excised for definitive treatment, but this leaves permanent scars. [altmeyers.org]

Three recent studies have reported clinical and histopathological improvement using laser therapy as an alternative treatment modality.(4,5,6) TREATMENT: After establishing the diagnosis, the patient was sent for laboratory screening to evaluate for potential [aocd-grandrounds.org]

Mycosis fungoides: disease evolution and prognosis of 309 Dutch patients. Arch Dermatol 136: 504510. ‎ Seite 22 - M, et al. Transformation of mycosis fungoides: clinicopathological and prognostic features of 45 cases. [books.google.de]

This classification does not predict prognosis and is therefore no longer used. There have been many theories proposed to describe the mechanism of development of anetoderma, but at this time this remains unknown. [dermnetnz.org]

The two types of primary anetoderma can coexist in the same patient, and the prognosis and histopathology are identical in both. Thus this differentiation is of historical interest only. [dvkeywords.blogspot.com]

This classification is only of historical interest, because the two types of lesions can co-exist in the same patient; the prognosis and the histopathology are also the same. [dermaamin.com]

Abstract Anetoderma is a rare disease of unknown etiology, today classified as a subtype of the circumscribed elastotic disorders. [onlinelibrary.wiley.com]

[…] that the biopsy demonstrates a loss of elastic fibers along with vascular inflammation, there are multiple etiologies that might be possible in this case. [vgrd.org]

The progressive positivization of autoimmunity of this patient seems to be triggered by HSP or to be linked to the etiology of the purpura. [ispub.com]

All of these studies returned as unremarkable, ruling against an autoimmune etiology. [aocd-grandrounds.org]

Anetoderma is a rare benign condition of diverse etiology whose characteristic is the diminution or absence of the dermal elastic fibers. Classified as primary and secondary, the latter associated with tumors, inflammatory, and infectious diseases. [pubfacts.com]

Definition / general Benign disorder of focal loss of dermal elastic tissue, causing focal flaccid or saclike skin Either primary (idiopathic) arising in normal skin, or secondary arising at site of previous skin lesions Terminology Greek: Anetos means slack Epidemiology [pathologyoutlines.com]

▪ ANETODERMA History Epidemiology The lesions in anetoderma usually occur in young adults between the age of 15 and 30 years of age and more frequently in women than men. Anetoderma is rare, but the incidence is unknown. [dermaamin.com]

These findings suggest that in addition to elastolytic overactivity, altered reassembly of elastic fibers may also play a significant role in the pathogenesis anetoderma. [4] Epidemiology Frequency The exact incidence of anetoderma is unknown, but secondary [emedicine.medscape.com]

Pharmaco-epidemiological data indicate that 30% of anthrax vaccine recipients experience mild local reactions. With large numbers of military personnel being vaccinated, emergency physicians may encounter more vaccine-related adverse reactions.” [medscienceresearch.com]

Case Overview anetoderma Member Rated 0 Patient case no. 2362 Date added 14 June 2003 Patient details Age --Undetermined-- Localisation Upper limbs / Folds / axillae Primary Lesions Anetoderma Pathophysiology Symptoms Asymptomatic, Diagnosis anetoderma [dermquest.com]

[…] such as whole-exome sequencing will identify even more single-gene disorders and even allow us to classify them according to their patient-specific mutations. 3 Recently, studies in rare inherited skin disorders have also led to new insight into the pathophysiology [accessmedicine.mhmedical.com]

Moreover, the pathophysiology, as well as a temporary relationship between APA, SLE development and onset of anetoderma, have not been well established. [medicaljournals.se]

A familial form that manifests as primary anetoderma has also been described. [1] Pathophysiology The exact cause of anetoderma is unknown. [emedicine.medscape.com]

Specifically, impairments of the SC permeability barrier, antimicrobial barrier, and immunologic barrier contribute markedly to the fundamental pathophysiology of AD. [read.qxmd.com]

Your skin Holds body fluids in, preventing dehydration Keeps harmful microbes out, preventing infections Helps you feel things like heat, cold, and pain Keeps your body temperature even Makes vitamin D when the sun shines on it Anything that irritates [icdlist.com]

Prevention [ edit ] Corns and calluses are easier to prevent than to treat. When it is usually not desirable to form a callus, minimizing rubbing and pressure will prevent callus formation. [en.wikipedia.org]

Colchicine has been shown to prevent the development of new primary anetoderma lesions. In secondary anetoderma, control of the causative dermatoses should theoretically prevent the development of new lesions (Kineston DP et al 2008). [altmeyers.org]

SHOWING 1-10 OF 76 REFERENCES Antiphospholipid syndrome associated recurrent pregnancy loss: treatment with heparin and low-dose aspirin is superior to low-dose aspirin alone APLASA study update: primary thrombosis prevention in asymptomatic aPL( ) patients [semanticscholar.org]