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Aniline Poisoning

Poisoning by Aniline


Presentation

  • A comprehensive textbook of adult emergency medicine for trainee doctors - covers all the problems likely to present to a trainee in the emergency department.[books.google.com]
  • Overview Chronic toxic encephalopathy Etiology : chronic or repeated high-dose exposure (e.g,, inhalation) to organic solvents or heavy metals cerebral, cerebellar, and brain stem atrophy Presentation Mental conditions (e.g., personality changes) Multifocal[amboss.com]
  • He has presented 61 scientific papers and has published 33 peer-reviewed journal articles and 15 book chapters on poisoning-related topics.[pharmacy.ucsf.edu]
  • “It was extremely toxic,” says Alison Matthews David, author of Fashion Victims: The Dangers of Dress Past and Present. “Especially if you inhale it. It goes straight to your brain.” One of the first symptoms was neuromotor problems, like trembling.[news.nationalgeographic.com]
Fatigue
  • In case of poisoning A. in the lungs cases, there are complaints of weakness, fatigue, dizziness, headache; blueness of the lips, ears, nail phalanxes; in the blood metgemoglobin killed Ganza.[medicalency.com]
  • […] or inhalation of styrene released from disposed packaging materials, cigarette smoke, automobile emissions, or manufacturing of automobile parts, fiberglass, plastic pipes, and insulation for wiring and appliances Effects (mainly due to inhalation) Fatigue[amboss.com]
  • Symptoms of hypoxia such as dyspnea, fatigue and headache appear when the concentration reaches 20 to 45%. "Administration of methylene blue is indicated in symptomatic patients with methemoglobin levels greater than 30%."[haz-map.com]
Anemia
  • : Hemolytic anemia after aniline and aniline-related drugs such as dapsone and primaquine is thought to be mediated by active/reactive metabolite formed during the hepatic clearance of the parent compounds.[flipper.diff.org]
  • For chronic poisoning aniline characterized by headaches, deterioration of sleep, lethargy, fatigue, palpitations, sievetest skin, often with yellowish shade, toxic hepatitis, anemia. Carcinogenic effect aniline is not. First aid and treatment.[medicalency.com]
  • "Historically, most work-related episodes of methemoglobinemia and hemolytic anemia have been due to exposure to aromatic nitro and amino compounds.[haz-map.com]
Sepsis
  • Significant updating of following topics - acute coronary syndrome management, trauma, sepsis management, imaging, arrhythmias. Expansion of administration section - especially patient safety. Changes to drug overdose sections in toxicology section.[books.google.com]
Hypotension
  • Acute exposure to skin, airways or gastrointestinal tract may cause cyanosis, methaemoglobinaemia, headache, shallow respiration, dizziness, confusion, stupor, hypotension, lethargy, convulsions and coma, jaundice, pain on urination, haemolysis and anaemia[ihcworld.com]
Headache
  • […] coal-tar benzol cold curing compounding room containing crimson antimony cyanosis described dipping room disease dizziness employed exhaust exposed exposure floor footwear gastric juice German girls gloves golden antimony golden sulphide grain handle headache[books.google.com]
  • References: [2] [4] Pyrethroid Sources of exposure : skin contact with, ingestion of, or inhalation of insecticides (e.g., malaria control); permethrin treatment of scabies, head and pubic lice Effects Headaches, dizziness, fatigue, coma Nausea Irritation[amboss.com]
  • This enzyme is responsible for the biosynthesis of prostoglandins, which are involved in the dilation of blood vessels that causes the pain experienced in a headache.[ch.ic.ac.uk]
  • In acute poisoning aniline in mild cases, victims complain of weakness, dizziness, headache pain ; marked blueness of the lips, ears, nail phalanxes; in the blood metgemoglobin killed Ganza.[medicalency.com]
  • These cases have been characterized by marked cyanosis, sometimes accompanied by vertigo and weakness, digestive disorders, headache and somnolence.[jamanetwork.com]
Dizziness
  • […] acute Akron aniline fumes aniline oil aniline poisoning benzine poisoning buffing carbon disulphide carbon tetrachloride chloroform chronic coal-tar benzol cold curing compounding room containing crimson antimony cyanosis described dipping room disease dizziness[books.google.com]
  • References: [2] [4] Pyrethroid Sources of exposure : skin contact with, ingestion of, or inhalation of insecticides (e.g., malaria control); permethrin treatment of scabies, head and pubic lice Effects Headaches, dizziness, fatigue, coma Nausea Irritation[amboss.com]
  • In acute poisoning aniline in mild cases, victims complain of weakness, dizziness, headache pain ; marked blueness of the lips, ears, nail phalanxes; in the blood metgemoglobin killed Ganza.[medicalency.com]
  • Acute exposure to skin, airways or gastrointestinal tract may cause cyanosis, methaemoglobinaemia, headache, shallow respiration, dizziness, confusion, stupor, hypotension, lethargy, convulsions and coma, jaundice, pain on urination, haemolysis and anaemia[ihcworld.com]
  • Continued exposure may lead to difficult breathing, dizziness, stupor, unconsciousness, convulsions may occur but appear to be uncommon. Cardiac effects: heart blocks, arrhythmias, and shock.[flipper.diff.org]
Confusion
  • Acute exposure to skin, airways or gastrointestinal tract may cause cyanosis, methaemoglobinaemia, headache, shallow respiration, dizziness, confusion, stupor, hypotension, lethargy, convulsions and coma, jaundice, pain on urination, haemolysis and anaemia[ihcworld.com]
  • […] amounts of aniline for short periods of time decreases the ability of blood to carry oxygen .Lack of oxygen causes effects ranging from severe headache, nausea, sometimes vomiting, to dryness of throat and loss of appetite Central nervous symptoms: confusion[flipper.diff.org]
  • Arsenic also was odorless and tasteless and easily confused with flour or sugar and other cooking essentials. By the 1830s, morbid descriptions of murders with arsenic terrified the public and became a staple of the British popular press.[crosscut.com]
Vertigo
  • These cases have been characterized by marked cyanosis, sometimes accompanied by vertigo and weakness, digestive disorders, headache and somnolence.[jamanetwork.com]
  • […] eye contact, and ingestion of disinfectants, tobacco smoke, or embalming fluid (an aqueous solution stabilized with methanol ; formalin ) Effects Irritation of the skin ( contact dermatitis ), mucous membranes, eyes, and respiratory tract Headache, vertigo[amboss.com]
  • […] for short periods of time decreases the ability of blood to carry oxygen .Lack of oxygen causes effects ranging from severe headache, nausea, sometimes vomiting, to dryness of throat and loss of appetite Central nervous symptoms: confusion, ataxia, vertigo[flipper.diff.org]
Stupor
  • Acute exposure to skin, airways or gastrointestinal tract may cause cyanosis, methaemoglobinaemia, headache, shallow respiration, dizziness, confusion, stupor, hypotension, lethargy, convulsions and coma, jaundice, pain on urination, haemolysis and anaemia[ihcworld.com]
  • Continued exposure may lead to difficult breathing, dizziness, stupor, unconsciousness, convulsions may occur but appear to be uncommon. Cardiac effects: heart blocks, arrhythmias, and shock.[flipper.diff.org]

Workup

Heinz Bodies
  • It is known that ascorbic acid promotes the rate of hydroxylation of aniline to p -aminophenol 2, which is a potent agent in the production of Heinz bodies not only in vivo but also in vitro 3, and ascorbic acid is able to produce Heinz bodies in vitro[nature.com]
Heinz Bodies
  • It is known that ascorbic acid promotes the rate of hydroxylation of aniline to p -aminophenol 2, which is a potent agent in the production of Heinz bodies not only in vivo but also in vitro 3, and ascorbic acid is able to produce Heinz bodies in vitro[nature.com]

Treatment

  • Important factors in treatment are discussed. These include, gastric lavage, the administration of methylene blue and exchange transfusion. The possibility of a late haemolytic reaction being a complication of methylene blue treatment is mentioned.[unboundmedicine.com]
  • Also has boxes featuring controversial areas of treatment. Practical and clinically orientated. Major changes to resuscitation guidelines. Complete rewriting of ENT section.[books.google.com]
  • We have found that in rats poisoned with aniline the formation of Heinz bodies is promoted by treatment with ascorbic acid.[nature.com]
  • Most organic solvents do not have an antidote; therefore, treatment is generally supportive. For an overview of other types of substance toxicity (e.g., with organophosphates ), see the learning card on poisoning.[amboss.com]

Prognosis

  • ., memory impairment) Grading Clinical features Diagnosis Prognosis Stage I Difficulty concentrating Poor memory Mood changes History Psychopathological findings Complete recovery within 2 years if no further exposure occurs.[amboss.com]

Etiology

  • Overview Chronic toxic encephalopathy Etiology : chronic or repeated high-dose exposure (e.g,, inhalation) to organic solvents or heavy metals cerebral, cerebellar, and brain stem atrophy Presentation Mental conditions (e.g., personality changes) Multifocal[amboss.com]

Prevention

  • Reduction of the amount of prostoglandin, therefore, helps prevent headaches and other pain. How it's made Paracetamol is one of the most common drugs used in the world, and is manufactured in huge quantities.[ch.ic.ac.uk]
  • (ERG, 2016) Protective Clothing Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact.[cameochemicals.noaa.gov]
  • Prevention of poisoning: go on contact method of obtaining aniline; transportation of aniline in railway tanks and send it to the consuming shops for pipelines; sealing and mechanization of processes associated with the use of aniline, effective ventilation[medicalency.com]
  • View Images This 1910 British Fire Prevention Committee experiment demonstrates the flammability of flannelette fabric. The garment on the left was fireproofed, while the one on the right was not.[news.nationalgeographic.com]

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