Anorchia or vanishing testis syndrome is a rare condition characterized by the complete absence of one or both testes in a phenotypical male. Clinical examination can be inconclusive and specific hormonal studies are required to confirm the diagnosis.
Anorchia, also known as embryonic testicular regression is characterized by the unilateral or bilateral absence of functioning testicular tissue in an individual who has 46, XY karyotype and is phenotypically male   . The congenital form has an incidence of one in twenty thousand  while an acquired form has been identified based on the presence of testicular tissue in the postnatal period but which disappears later . Anorchia has also been reported in one out of 175 cases with cryptorchidism . It is known to have a familial tendency    . The etiology of the condition is still being debated with several proposed theories ranging from genetic to 46, XY abnormal gonads  to vascular occlusion during embryonic testicular descent .
Most patients with anorchia present with normal male external sexual characteristics but may also present with microphallus , ambiguous external genitals , and feminine appearance of external genitalia . Cases of neonatal testicular torsion as a presenting symptom has been reported by various authors  . Individuals with bilateral anorchia typically develop normally but the onset of puberty is either delayed or absent depending on the extent of functioning testicular tissue in the body. Therefore secondary sexual characteristics may develop partially or not at all. Other organ anomalies like renal ectopia can also be present in these individuals   along with low bone density.
Entire Body System
Pediatric disorders of sex development. In: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams Textbook of Endocrinology. 13th ed. Philadelphia, PA: Elsevier; 2016:chap 23. Ali O, Donohoue PA. Hypofunction of the testes. [nlm.nih.gov]
This is followed by studies on the temporal variation of testosterone and plasma gonadotrophins in man; interactions between steroids and gonadotropins; gonadotrophins and plasma testosterone in senescence; androgen secretion in male hypogonadism; and [books.google.com]
Discussions on the current methods for the diagnosis and treatment of male hypogonadism, male infertility and male sexual dysfunction follow, with detailed descriptions of types of androgen replacement and the benefits and risks of such treatment. [books.google.ro]
hypogonadism in recruits and soldiers]. 61 Tomov T...Ankov V 7010789 1980 152 [Hypothalamo-hypophyseal-thyroid axis in recruits and soldiers with male hypogonadism]. 61 Tomov T...Ankov V 6777988 1980 153 A gonadotrophin responsive testosterone producing [malacards.org]
hypogonadism and infertility 9.1 Definitions and classification of disorders 9.2 Normal male endocrinology 9.2.1 The male gamete: spermatogenesis, maturation, function 9.2.2 Endocrine and local testicular regulation 9.2.3 Testicular hormones 9.3 Evaluation [oxfordmedicine.com]
STUDY DESIGN: Patients were divided into two groups according to the absence (group A, n 29) or the presence (group B, n 26) of palpable intrascrotal or inguinal mass at first clinical examination. [ncbi.nlm.nih.gov]
Physical examination may reveal microphallus or normal external male genitalia with bilateral or unilateral palpable intrascrotal or inguinal masses or no palpable masses. [symptoma.com]
STUDY DESIGN Patients were divided into two groups according to the absence (group A, n 29) or the presence (group B, n 26) of palpable intrascrotal or inguinal mass at first clinical examination. [unboundmedicine.com]
Study design Patients were divided into two groups according to the absence (group A, n 29) or the presence (group B, n 26) of palpable intrascrotal or inguinal mass at first clinical examination. [scinapse.io]
Zenaty et al  reported palpable intrascrotal or inguinal masses at first examination in 26/55 (47%) patients included in a multicenter study. [journals.plos.org]
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disease 0 references male infertility due to gonadal dysgenesis 1 reference stated in Monarch Disease Ontology release 2018-06-29sonu retrieved 28 July 2018 MonDO ID MONDO:0017967 46,XY disorder of gonadal development 1 reference stated in Monarch Disease [wikidata.org]
Cromie WJ: Cryptorchidism and malignant testicular disease, in Hadziselimovic F (ed): Cryptorchidism: Management and Implications. New Yeok, Springer-Verlag, 1983; 83. 228. [auanet.org]
A clinician should suspect anorchia if a patient presents with complaints of delayed puberty and has masculine external genitals but no palpable testes. A thorough family history must be elicited as other family members are also likely to have complete or partial gonadal abnormalities with 46, XY karyotype . Physical examination may reveal microphallus  or normal external male genitalia with bilateral or unilateral palpable intrascrotal   or inguinal masses  or no palpable masses .
Confirmation of the diagnosis requires hormonal evaluation such as gonadotrophin-releasing hormone (GnRH), follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone, inhibin B levels and provocation test with human chorionic gonadotrophin (hCG). In bilateral anorchia, low levels of testosterone along with elevated FSH levels and an absence of a rise in levels of testosterone after hCG     is noticed. hCG provocation test is not required in 46, XY patients with elevated FSH and undetectable levels of anti-müllerian (AMH) and inhibin B as this scenario is diagnostic for anorchia .
Although ultrasonography can be performed as part of the workup, it cannot distinguish between testis and inguinal lymphadenopathy. Magnetic resonance imaging (MRI) is more useful for detecting testicular tissue especially if cryptorchidism is suspected. But imaging studies may not be required if hCG provocation fails to cause a rise in plasma testosterone levels .
Some authors have suggested surgical exploration for the testicular tissue as the most definitive method of diagnosis  especially in unilateral anorchia . However, others  suggest that surgery is unnecessary in the workup of bilateral anorchia if endocrine tests confirm the absence of functioning testicular tissue.
In most cases, testosterone treatment stimulates the penile growth. [ncbi.nlm.nih.gov]
(August 2017) Treatment Treatment includes androgen (testosterone) supplementation to artificially initiate puberty, testicular prosthetic implantation, and psychological support. [en.wikipedia.org]
[…] includes: Artificial (prosthetic) testicle implants Male hormones (androgens) Psychological support The outlook is good with treatment. [nlm.nih.gov]
Prognosis - Anorchia Prognosis is good with treatment. Treatment - Anorchia Treatment includes androgen (testosterone) supplementation to artificially initiate puberty, testicular prosthetic implantation, and psychological support. [checkorphan.org]
Expectations (prognosis) Prognosis is good with treatment. Complications Complications include infertility, psychological problems related to gender, and occasional face, neck, or back abnormalities. [health.am]
Bone density Surgery to look for male reproductive tissue Testosterone levels (low) Ultrasound or MRI X,Y karyotype Treatment Treatment includes: Artificial (prosthetic) testicle implants Male hormones (androgens) Psychological support Expectations (prognosis [coordinatedhealth.com]
Abstract Hypogonadism affecting the male pediatric population is uncommon, with that attributed to multiple unrelated etiologies being exceedingly rare. [ncbi.nlm.nih.gov]
Disorders of sexual development: etiology, evaluation, and medical management. In: Wein AJ, Kavoussi LR, Partin AW, Peters CA, eds. Campbell-Walsh Urology. 11th ed. Philadelphia, PA: Elsevier; 2016:chap 150. Updated by: Sovrin M. [nlm.nih.gov]
The etiology of the condition is still being debated with several proposed theories ranging from genetic to 46, XY abnormal gonads to vascular occlusion during embryonic testicular descent. [symptoma.com]
[…] thyroid hormones 3.1.3 Clinical assessment of the thyroid patient 3.1.4 Thyroid function tests and the effects of drugs 3.1.5 Nonthyroidal illness 3.1.6 Thyroid imaging: nuclear medicine techniques 184.108.40.206 Thyroid imaging: nonisotopic techniques 3.1.7 Epidemiology [oxfordmedicine.com]
A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Am J Clin Nutr 1982;36:936–42.CrossrefGoogle Scholar 6. Roelants M, Hauspie R, Hoppenbrouwers K. [degruyter.com]
Provided by Review Date: 9/7/2008 Reviewed By: Linda Vorvick, MD, Seattle Site Coordinator, Lecturer, Pathophysiology, MEDEX Northwest Division of Physician Assistant Studies, University of Washington School of Medicine; and Louis S. [assets.aarp.org]
Update Date: 9/7/2008 Updated by: Linda Vorvick, MD, Seattle Site Coordinator, Lecturer, Pathophysiology, MEDEX Northwest Division of Physician Assistant Studies, University of Washington School of Medicine; and Louis S. [pacificschoolserver.org]
Images Review Date: 9/7/2008 Reviewed By: Linda Vorvick, MD, Seattle Site Coordinator, Lecturer, Pathophysiology, MEDEX Northwest Division of Physician Assistant Studies, University of Washington School of Medicine; and Louis S. [lutheranhealthcare.org]
Hypothalamic dysfunction (hypothalamic syndromes) 2.4.2 Craniopharyngiomas 2.4.3 Perisellar tumours including cysts, hamartomas, and vascular tumours 2.4.4 Lymphocytic hypophysitis and other inflammatory conditions of the pituitary 2.5 Pineal physiology and pathophysiology [oxfordmedicine.com]
Increased production of androgen precursors by the adrenal cortex may have prevented eunuchoidism without stimulating secondary sexual development. [jamanetwork.com]
Prevention - Anorchia Not supplied. Diagnosis - Anorchia Not supplied. Prognosis - Anorchia Prognosis is good with treatment. [checkorphan.org]
Among her publications on health sociology are "Crisis Prevention and Management during SARS Outbreak, Singapore", Emerging Infectious Diseases, 10, 2: 364-368, 2004, with HP Lee; "Traditional Healing Systems and the Ethos of Science," Social Science [books.google.ro]
It usually includes: Bracing Medication Physical therapy Preventing the condition from getting worse by treating the underlying condition causing the muscle weakness Surgery (sometimes) Your health care provider can tell you more about your condition [mclaren.org]
Undescended testes usually descend into the scrotum during the first months after birth; if the testicle fails to descend into the scrotum, a surgical replacement or removal is necessary in order to relocate or remove the testicle and prevent a transformation [drelist.com]
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- Lodh B, Kanwar V, Kaku Singh AK, Singh SR. Unfused crossed renal ectopia with ipsilateral anorchia- a rare entity. J. Clin. Diagn Res. 2013 Sep; 7(9): 2029-2030
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- Belgorosky A, Rivarola MA. Sex hormone-binding globulin response to human chorionic gonadotropin stimulation in children with cryptorchidism, anorchia, male pseudohermaphroditism, and micropenis. J Clin Endocrinol Metab. 1982;54: 698-704.