Presentation
In this report, we describe an adolescent female exposed to unknown illicit substances and sexual abuse who presented with psychosis, anorexia, seizures, and ataxia. [ncbi.nlm.nih.gov]
Anorexia is generally present in typhus fever from the beginning of the attack, and may persist until its close. [thesaurus.com]
Entire Body System
- Weight Loss
The single exception is that the weight of the patient with the atypical variant is within or above the normal range, despite significant weight loss. [sciencedaily.com]
Overall, there is an indication that weight loss is of primary importance and it begins to take precedence over other important life roles and responsibilities. [eatingdisorder.org]
There are two types of anorexia, restricting type where calories are restricted by which weight loss can be achieved. Purging type of anorexia weight loss is done by using diuretics and emetics. [imedpub.com]
It is important to note that weight loss or a lack of weight gain rarely calms body anxieties; Disturbance in how the person experiences their weight and shape. [nedic.ca]
Rapid or severe weight loss can cause life-threatening problems. [msdmanuals.com]
- Asymptomatic
For asymptomatic relatives who have the HLA-DQ2 or HLA-DQ8 celiac disease-susceptibility haplotype on molecular genetic testing and negative antibody results, tTG IgA testing should be performed at three- to five-year intervals to screen for the development [ncbi.nlm.nih.gov]
Nutritional and gastrointestinal disorders that can predispose to osteoporosis include undiagnosed and untreated coeliac disease (both symptomatic and asymptomatic people),[4][59] Crohn's disease,[60] ulcerative colitis,[60] cystic fibrosis,[60] surgery [en.wikipedia.org]
[…] puberty, fatigue, aphthous stomatitis, elevated transaminases, neurologic problems, or dental enamel hypoplasia.(...) it has become clear that symptomatic and diagnosed celiac disease is the tip of the iceberg; the remaining 90% or more of children are asymptomatic [en.m.wikipedia.org]
Gastrointestinal
- Nausea
Nausea, vomiting, or anorexia was observed with the first course in 7 of 19 patients. [ncbi.nlm.nih.gov]
An increase in pressure within the skull may cause anorexia, nausea, or vomiting, as may infections in the mouth or badly fitting dentures. [britannica.com]
Vomiting is not common except in those cases which follow upon an error of diet, but there is generally some nausea and anorexia. Anorexia is generally present in typhus fever from the beginning of the attack, and may persist until its close. [thesaurus.com]
Musculoskeletal
- Osteoporosis
Osteoporosis Elderly woman with osteoporosis showing a curved back from compression fractures of her back bones. [en.wikipedia.org]
Several more severe medical complications for anorexia include: Irregular heartbeats Low blood sugar Loss of bone mass Kidney and liver damage Osteoporosis Insomnia Anemia Infertility Depression Electrolyte imbalances Cathartic colon from laxative abuse [mccallumplace.com]
[…] follow-up studies show an average mortality resulting from complications of the illness of roughly 5-6% Typically appears between 12 and 17 years of age, but occurrences in younger children are well-documented Very high rates of reduced bone density and osteoporosis [uclahealth.org]
This can make you more likely to develop a condition called osteoporosis. This is more likely if weight has been low for a year or more in children and young people, or 2 years or more in adults. [www2.hse.ie]
Psychiatrical
- Anxiety Disorder
Myths and Facts Recovery Is Possible What To Look For Anxiety Disorders Behavioral Disorders Eating Disorders Mental Health and Substance Use Disorders Mood Disorders Obsessive-Compulsive Disorder Personality Disorders Psychotic Disorders Suicidal Behavior [mentalhealth.gov]
Children with anxiety disorders or obsessional traits are also more likely to become anorexic. [childmind.org]
Mood disorders are more common in the binge/purge subtype than in the restrictive subtype.12 About half of anorexia patients have comorbid anxiety disorders, including obsessive-compulsive disorder and social phobia.12 Bulimia Nervosa: 1.5% of American [anad.org]
[…] applied to a variety of childhood disorders,[55] including depressive disorders and various anxiety disorders. [en.wikipedia.org]
- Obsessive Thoughts
Genetic scientists have pinpointed genes linking anorexia to depression, anxiety, and obsessive-compulsive disorder. [psycom.net]
A vicious cycle Once a person starts losing weight, a low weight and lack of nutrients may contribute to brain changes in a way that reinforces the behaviors and obsessive thoughts related to anorexia nervosa. [medicalnewstoday.com]
Psychological features include: Distorted body image and poor insight Self-evaluation almost exclusively in terms of their shape and weight Pre-occupation or obsessive thoughts about food and weight OCD (obsessive compulsive disorder) behaviors Perfectionism [psychologistanywhereanytime.com]
- Behavior Disorder
Myths and Facts Recovery Is Possible What To Look For Anxiety Disorders Behavioral Disorders Eating Disorders Mental Health and Substance Use Disorders Mood Disorders Obsessive-Compulsive Disorder Personality Disorders Psychotic Disorders Suicidal Behavior [mentalhealth.gov]
Outpatient treatment places the patient in an environment that could enable disordered eating behaviors. Family and friends may lack an objective viewpoint and cannot look at the disorder without bias. [rehabs.com]
disorders in the 1960s was also seen as a prototype of behavior therapy. [en.wikipedia.org]
- Delusion
[…] abilities Often explained with a mix of spiritual and material beliefs Perfectionism, secondary benefits 1694 20 Nervous atrophy Fasting caused by an “ill and morbid state of the spirits” A psychological etiology was supposed 1858 28 Hypocondriacal delusion [ncbi.nlm.nih.gov]
Interventions particularly related to these conditions include exploring reality testing, changing delusions and hallucinations, examining factors which precipitate relapse, and managing relapses.[41] Schizophrenia[edit] Several meta-analyses suggested [en.wikipedia.org]
- Abnormal Behavior
behaviors surrounding food Developing food rituals such as rearranging food on the plate or excessive chewing In women, missed period for 3 or more cycles Dry mouth Low blood pressure Fatigue Confusion Slowed thinking Abnormal heart rhythm Wearing layers [psychguides.com]
Neurologic
- Irritability
And we get kind of grumpy and irritable and start foraging and do whatever we can to find food,” Bulik says. [scientificamerican.com]
Common complications of AN include: anxiety, mood swings, depression irritable weak, lack of energy dizzy, headaches low blood pressure stomach or intestinal problems low body temperature loss of bone density hair loss or thinning soft, fine hair that [keltyeatingdisorders.ca]
[…] disorder consisting of loss of appetite due to emotional states, such as anxiety, irritation, anger, and fear. [medical-dictionary.thefreedictionary.com]
Sufferers can feel depressed, irritable, hopeless and moody as a result. All of these things are symptoms of malnutrition. There are also many physical symptoms of malnutrition other than loss of weight. [mirror-mirror.org]
- Seizure
In this report, we describe an adolescent female exposed to unknown illicit substances and sexual abuse who presented with psychosis, anorexia, seizures, and ataxia. [ncbi.nlm.nih.gov]
It caused problems with my digestive system, seizures and hallucinations.” [thesun.co.uk]
After a week of fasting she collapsed with a seizure and was rushed to hospital, where horrified doctors and nurses were astonished she was still alive. [dailymail.co.uk]
[…] problems with the heart and blood vessels – including poor circulation, an irregular heartbeat, low blood pressure, heart valve disease, heart failure, and swelling in the feet, hands or face (oedema) problems with the brain and nerves – including fits (seizures [nhs.uk]
- Agitation
She felt "agitated" and worried she would miss meals she needed for her recovery, and discharged herself, the inquest heard. [bbc.com]
Individual may become inattentive, forgetful, or agitated and psychotic [meddean.luc.edu]
If a patient is highly agitated, especially when attempting to eat, then a major tranquilliser that does not have the disinhibiting effects of an anxiolytic drug may be useful. [nps.org.au]
- Asthenia
To what extent structural alterations, with their associated reduced cardiac output, are responsible for symptoms such as asthenia is difficult to establish because these patients generally tend to deny any symptoms of their disease. [revespcardiol.org]
- Stroke
Info Sex Addiction Sexual Abuse Sexual Harassment Shingles Shopping Addiction Shyness Siblings Single Dads Single Moms Single Parents Singles Skin Cancer Skin Picking Sleep Apnea Sleep Walking Smoking Social Anxiety Social Security Spina Bifida Stress Stroke [anorexia.supportgroups.com]
[…] recommended for osteoporosis by itself.[118] Raloxifene, while effective in decreasing vertebral fractures, does not affect the risk of nonvertebral fracture.[91] And while it reduces the risk of breast cancer, it increases the risk of blood clots and strokes [en.wikipedia.org]
Urogenital
- Dysmenorrhea
"[63] Emerging evidence suggests a possible role for CBT in the treatment of attention deficit hyperactivity disorder (ADHD);[80] hypochondriasis;[81] coping with the impact of multiple sclerosis;[82] sleep disturbances related to aging;[83] dysmenorrhea [en.wikipedia.org]
- Sexual Dysfunction
Partners may become more anxious to conceive, increasing sexual dysfunction.[17] Marital discord often develops, especially when they are under pressure to make medical decisions. [en.wikipedia.org]
Workup
The patient's diagnosis was delayed until a metabolic workup was initiated, revealing hyperhomocysteinemia, low normal plasma methionine, and methylmalonic aciduria. [ncbi.nlm.nih.gov]
The routine protocol for patients with anorexia nervosa at our institution includes an electrocardiogram, a full ionogram with measurements of sodium, potassium, calcium and magnesium, as well as a complete biochemical workup and exhaustive hormone study [revespcardiol.org]
See Workup for more detail. [emedicine.medscape.com]
Treatment
Maudsley Family-Based Treatment (FBT) for anorexia is successful for between 50 and 80% of adolescents. To improve this success rate, various approaches to augmenting the treatment have been proposed. [ncbi.nlm.nih.gov]
Compulsory treatment Someone with anorexia may refuse treatment even though they're ill and their life is at risk. In these cases, doctors may decide as a last resort, to admit the person to hospital for compulsory treatment. [www2.hse.ie]
You can read more about these different treatment options on our approach to eating disorder treatment page. [priorygroup.com]
Compulsory treatment Occasionally, someone with anorexia may refuse treatment even though they're seriously ill and their life is at risk. [nhs.uk]
Prognosis
The prognosis depends on a number of factors. [radiopaedia.org]
Abstract Chemotherapy frequently causes anorexia in cancer patients, which has been associated with poor disease prognosis. [ncbi.nlm.nih.gov]
Early detection may improve prognosis[7]. [patient.info]
Early intervention has a better prognosis. The disease and treatment are relatively long lasting and long term, but most individuals will get better. [healthychildren.org]
Etiology
For example, some clinicians first hypothesized hormonal etiology, 37 while others doubted a hormonal etiology. [ncbi.nlm.nih.gov]
Etiology of Eating Disorders The etiology of all eating disorders cannot be tracked back to a single event, but consist of a complex interaction between biological, psychological and social factors. [lecturio.com]
Related content: Mini Quiz: Etiology of Anorexia Nervosa Recent brain research in anorexia nervosa has focused on reward pathways, with the hypothesis that these pathways might disturb food approach mechanism in anorexia nervosa. [psychiatrictimes.com]
The etiology of anorexia nervosa is unknown. Other than being female, few risk factors have been identified. In Western society, obesity is considered unattractive and unhealthy, and the desire to be thin is pervasive, even among children. [msdmanuals.com]
In fact, many proponents of this approach would consider ‘family problems’ as part of the etiology of the AN. No doubt, this view might contribute to parents feeling themselves to blame for their child’s illness. [maudsleyparents.org]
Epidemiology
Related Journals of Anorexia Journal of Obesity & Eating Disorders, Journal of Hypertension: Open Access, Journal of Diabetes & Metabolism, Journal of Nutritional Disorders & Therapy, Epidemiology: Open Access, World Review of Nutrition and Dietetics, [imedpub.com]
Recent epidemiological studies show that 2% of babies in ordinary paediatric clinics suffer from infantile anorexia. In the first part of this paper we present a case study from our hospital clinical activity. [ncbi.nlm.nih.gov]
[…] six-year-long project involved the study of 17,000 anorexia nervosa cases from around the world Researchers found the disease has "very strong" links with metabolism More patients are being recruited for an expanded study Head of the QIMR Berghofer genetic epidemiology [abc.net.au]
American Journal of Epidemiology, 169(4), 415-427. Marques, L., Alegria, M., Becker, A. E., Chen, C.-n., Fang, A., Chosak, A., & Diniz, J. B. (2011). [anad.org]
We would also like to thank the research nurses and data collectors at the Department of Medical Epidemiology and Biostatistics who worked on ANGI. [nature.com]
Pathophysiology
This book covers the clinical features and symptoms, neurobiology, pathophysiology, and current and potential future treatment options for both anorexia and bulimia nervosa. [intechopen.com]
To accomplish this, we applied reward tasks that were closely associated with brain dopamine response to find evidence of dopaminergic involvement in the pathophysiology of anorexia nervosa. [psychiatrictimes.com]
The DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat. Genet. 44, 981–990 (2012).. 39. Teslovich, T. [nature.com]
(See Workup, Treatment, and Medication.) [17] Pathophysiology A typical case of anorexia nervosa involves a young person (teenager or young adult) who is mildly overweight or of normal weight and who begins a diet and exercise plan to lose weight. [emedicine.medscape.com]
Prevention
Treatment with LA16001 was revealed to prevent body weight loss, and all three extracts were demonstrated to improve food intake. [ncbi.nlm.nih.gov]
They may include: Depression, anxiety and other mood disorders Personality disorders Obsessive-compulsive disorders Alcohol and substance misuse Self-injury, suicidal thoughts or suicide attempts Prevention There's no guaranteed way to prevent anorexia [mayoclinic.org]
[…] your weight be/become seriously overweight/underweight be/become clinically/morbidly obese achieve/facilitate/promote/stimulate weight loss slim down to 70 kilos/ ( British English ) 11 stone/ ( especially North American English ) 160 pounds combat/prevent [oxfordlearnersdictionaries.com]
In 2017 the parliamentary and health service ombudsman published a damning report that highlighted the need for greater investment in these services to prevent further lives being lost. [theguardian.com]