Because anthracosis results from prolonged exposure to coal dust or soot particles, diagnosis of this condition is largely based on anamnesis. Patients may report to have worked in coal mines, but any other occupation or living conditions associated with these risk factors may also hint at anthracosis. In one study, traditional indoor baking has been related with anthracosis [3]. The age at first exposure and its overall time should be taken into account. It is important to know if the patient smokes, since smoking may trigger or aggravate symptoms like chronic productive cough, dyspnea and reduced tolerance to exercise. In patients suffering from advanced anthracosis or anthracofibrosis, symptoms of right heart failure may develop [6]. These individuals may additionally suffer from fatigue, severe dyspnea even at rest, cyanosis, venous congestion and peripheral edema. Such severe cases of anthracosis are rare and the majority of patients is indeed asymptomatic.

• Inflammation

  The thoracotomy was performed and a mediastinal lymph node showing caseating granulomatous inflammation with anthracosis and parenchymal anthracosis were detected. [ncbi.nlm.nih.gov]

  This chemokine may be a key factor in the chronic inflammation of the macrophage, which is central to the pathophysiology of coal worker’s pneumoconiosis. [6] Other interesting areas that may become promising are the antioxidants selenium and glutathione [emedicine.medscape.com]

  European Respiratory Journal 1995 8: 834-842; DOI: Abstract The alveolar macrophage (AM) is a critically important cell playing a prominent role in lung inflammation via the production of oxygen radicals, enzymes, arachidonic acid metabolites, and also [erj.ersjournals.com]

• Cough

  Those lung diseases cause people to cough and be short of breath. [msdmanuals.com]

  A 66-year-old woman was admitted to our clinic with the symptoms of dry cough, hoarseness, malaise, anorexia, night sweats and with the multiple mediastinal lymphadenopathy. [ncbi.nlm.nih.gov]

  Symptoms include worsening cough and dyspnea. About 15 percent of coal workers who have simple anthracosis develop complicated anthracosis. [beltina.org]

  The most common symptoms of pneumoconiosis are cough and shortness of breath. The risk is generally higher when people have been exposed to mineral dusts in high concentrations and/or for long periods of time. [lung.org]

• Sputum

  Sputum may be dark to black (melanoptysis). Black sputum (melanoptysis) is seen with inhalation of black carbon particles as is the case with CWP but other causes of a black sputum also needs to be considered. Read more on sputum color. [healthhype.com]

  Pulmonary tuberculosis diagnostic work up which included bronchoalveolar lavage, sputum smears and cultures, or histologic examination of lung biopsies was performed on all patients. [ncbi.nlm.nih.gov]

  Relation of Anthracosis and Tuberculosis Active tuberculosis was found in 30% of patients (52 of 172) of whom 22 had positive sputum smears; 42 of 163 (25%) had positive cultures. [journals.lww.com]

  Symptoms can include cough, with or without mucous (sputum) production, or chest tightness. Many patients complain of shortness of breath. Patients may first notice getting more breathless or winded with activity, like walking or climbing stairs. [lung.org]

  Victoria Infirmary,Newcastle Upon TyneHospitals, Newcastle uponTyne, UK Royal Victoria Infirmary,Newcastle Upon TyneHospitals, Queen VictoriaRoad, Newcastle upon Tyne,NE1 4LP, UK [email protected] A diagnosis of tuberculosis was entertainedand sputum [dokumen.tips]

• Dyspnea

  Symptoms include worsening cough and dyspnea. About 15 percent of coal workers who have simple anthracosis develop complicated anthracosis. [beltina.org]

  Majority of anthracosis patients are asymptomatic, whereas some develop chronic cough, dyspnea and intolerance to exercise. [symptoma.com]

  Dyspnea (38.7%) and productive cough (35.3%) were among the most common chief complaints. The abnormal bronchoscopic findings were seen most frequently in the right middle lobe bronchus. [ncbi.nlm.nih.gov]

  […] bluish tint of skin receiving insufficient oxygen or circulation to cough up blood or blood-stained sputum to breathe both too fast and too deep to breathe both too slow and too shallow two-pronged plastic device for deliviering oxygen into the nose dyspnea [quizlet.com]

  The patients with anthracosis presented with symptoms ranging from cough (76.65%), hemoptysis (46.6%), fever (26.6%), dyspnea (90%) and malaise (73.3%). [lungindia.com]

• Pneumonia

  […] and liver and kidney damage less severe but longer lasting form of pneumonia caused by Mycoplasma pneumoniae bacteria another term for Mycoplasma pneumonia condition that is the result of inhaling environmental particles that become toxic, such as coal [quizlet.com]

  Chest X-rays or CT scans may show your health-care provider: nodules ("spots") or masses areas of inflammation pneumonia excess fluid in or around the lungs Sometimes additional, more invasive testing is necessary to diagnose pneumoconiosis. [lung.org]

  The constant irritation of the bronchi coal dust causes the development of chronic bronchitis, catarrh, and the deposition of masses of coal in the interstitial tissue - desquamative interstitial pneumonia with subsequent outcome in cirrhosis of the lungs [carbohealth.com]

  Doctors commonly misdiagnose the early stages in which miners can become prone to bronchitis or pneumonia. It’s not uncommon for a miner to learn he “has the spots” from an x-ray or scan to assess another ailment such as back pain. [theguardian.com]

  Association of anthracosis with pneumonia is not clear. [lungindia.com]

• Productive Cough

  Dyspnea (38.7%) and productive cough (35.3%) were among the most common chief complaints. The abnormal bronchoscopic findings were seen most frequently in the right middle lobe bronchus. [ncbi.nlm.nih.gov]

  Chronic productive cough, dyspnea, hemoptysis, chest pain, fever and general weakness 1-2. [radiopaedia.org]

  It is important to know if the patient smokes, since smoking may trigger or aggravate symptoms like chronic productive cough, dyspnea and reduced tolerance to exercise. [symptoma.com]

  More commonly, workers exposed to coal dust develop industrial bronchitis, clinically defined as chronic bronchitis (i.e. productive cough for 3 months per year for at least 2 years) associated with workplace dust exposure. [en.wikipedia.org]

• Chest Pain

  After taking antituberculosis drugs, the patient's chest pain was relieved and she recovered. The patient achieved an excellent outcome following the use of less invasive methods than mediastinoscopy. [ncbi.nlm.nih.gov]

  Chronic productive cough, dyspnea, hemoptysis, chest pain, fever and general weakness 1-2. [radiopaedia.org]

  Anthracosis symptoms (cough, shortness of breath, chest pain, fatigue) are progressive in nature it's cool buy prednisone 10mg. [carbohealth.com]

  Symptoms may include: Coughing Shortness of breath Chest pain Chest tightness Abnormal breathing pattern The symptoms of occupational lung diseases may resemble other medical conditions or problems. Always consult your doctor for a diagnosis. [hopkinsmedicine.org]

  pain with each breath another term for pleurisy testing the gases present in the blood x-ray of the lung after a radiopaque substance has been inserted into the trachea or bronchial tube injection of dye into a blood vessel for the purpose of taking [quizlet.com]

• Cyanosis

  These individuals may additionally suffer from fatigue, severe dyspnea even at rest, cyanosis, venous congestion and peripheral edema. Such severe cases of anthracosis are rare and the majority of patients is indeed asymptomatic. [symptoma.com]

  […] spasms of the bronchi (bronchospasms) abnormal enlargement of the bronchi, possibly due to infection malignant tumor originating in the bronchi adult respiratory distress syndrome acute respiratory failure in adults characterized by tachypnea, dyspnea, cyanosis [quizlet.com]

If the medical history of a patients indicates a chronic exposure to coal dust or soot particles, anthracosis should be considered before confirming diagnosis of chronic obstructive pulmonary disease, asthma, tuberculosis or idiopathic pulmonary fibrosis [7]. The gold standard for the diagnosis of anthracosis is bronchoscopy, a technique that allows visualization of black depositions on respiratory mucous membranes and smooth narrowing of the bronchial tubes. Computed tomography scans often reveal enlargement and calcification of regional lymph nodes. Further characteristic findings include diffuse calcification, atelectasis, emphysema and pleural effusion [8] [9]. Mass lesions may require biopsy and histopathological analysis.

Pulmonary function tests, particularly spirometry, should be carried out to assess the extent of lung damage.

Of note, anthracosis possibly facilitates mycobacterial infections and large numbers of anthracosis patients also suffer from tuberculosis [5] [10]. Here, interferon-γ release assays, bacterial cultures and molecular biological confirmation of Mycobacteria spp. are the diagnostic measures of choice. Sputum samples obtained during bronchoscopy may be used for the latter.

Causative treatment for anthracosis is not available. Thus, therapy is palliative and aims at preventing exacerbation.

In most cases, the source of coal dust or soot particles may easily be identified. If it persists, exposure should be reduced as far as possible. Unfortunately, job changes are often not an option. However, shifting the affected worker to an area with less exposure to volatile matter may be possible.

Patients should be strongly advised not to smoke.

Rehabilitation programs may improve dyspnea, tolerance to exercise, and overall quality of life. Exercise is an important part of such programs but should start slowly.

Severe cases of anthracosis or anthracofibrosis, i.e., those presenting a very low arterial oxygen saturation, may require continuous oxygen therapy. Nocturnal oxygen desaturation may occur and blood gas analyses conducted at daytime may thus underestimate the risk for hypoxia. If desaturation at night is a problem, oxygen therapy should be applied while the patient is sleeping.

Patients may additionally benefit from bronchodilators.

If response to therapy is not satisfactory, patients should be considered for lung transplantation.

In some countries, occupational rights may entitle affected workers to compensation [11]. Thus, they should be advised to invoke these rights, possibly after seeking legal counseling.

Prognosis depends on the severity of disease. Although the condition is not reversible, mild cases do not necessarily affect the quality of life. Anthracofibrosis has a poor diagnosis.

Anthracosis is a typical occupational disease of coal miners, although it has been reported in patients that have never been working below ground [3].

In general, a young age at first exposure, prolonged exposure, i.e., several years of working underground or in any other environment loaded with high amounts of soot particles, and smoking are the main risk factors for this disease. There is a clear correlation between the aforementioned parameters and the severity of anthracosis.

Additionally, the size of coal dust or soot particles affects the development of anthracosis. Both are generally estimated to measure between 1 and 100 µm, i.e., although many particles are retained at bronchial tube level, the smaller share of such particles may penetrate into the bronchioles and possibly even into the alveoli.

Coal miners may work with distinct types of carbonaceous rocks that may contain more volatile material than others. In general, the older the coal, the more compact it is. Anthracite, for instance, comprises small amounts of volatile matter and thus exposure to it bears much lower risks of anthracosis than the same amount of exposure to lignite. Also, certain types of jobs within coal mines may involve greater exposure to volatile matter than others.

Definitive diagnosis of anthracosis requires bronchoscopy. Since many patients suffering from mild to moderate anthracosis remain asymptomatic, black depositions on the respiratory mucous membranes are often incidental findings. Furthermore, there is no clear definition for the terms healthy respiratory tract and anthracosis. In smokers, this may be a very challenging question. Therefore, the overall prevalence of anthracosis may only be roughly estimated. In a large study comprising more than 14,000 bronchoscopies conducted in Iran, about 5% of all patients were found to show signs of anthracosis [4]. About one third of those patients suffered from anthracofibrosis. Of note, considerable differences in anthracosis prevalence between distinct geographical regions may exist. The true number of patients affected by anthracosis presumably depends on the occupation and life-style of the population, as well as on industry and air pollution of the respective country.

Due to the etiology of the disease, anthracosis is very rarely diagnosed in children. The mean age of symptom onset is 63 years [5]. Although there are more men among coal miners than women, anthracosis also affect females. In fact, many studies show even higher prevalence rates in women than in men [1].

Inhalation of coal dust or soot particles initially leads to asymptomatic deposition on the mucous membranes of the respiratory tract. To a certain degree, this phenomenon can be observed in any smoker and in individuals living in urban environments.

If foreign bodies entering the respiratory tract cannot be removed by means of ciliary movement, macrophages will try to remove them. When only small quantities of particles are present, this process leads to subsequent excretion of particles in the mucus or removal by means of the lymphatic system. However, macrophages accumulate on the mucous membranes if coal dust or soot particles cannot be removed efficiently due to excessive amounts that exceed the self-cleaning capacities of the respiratory tract. These macrophages release pro- and anti-inflammatory mediators and trigger fibroblast proliferation. Matrix metalloproteinases, tissue inhibitors of metalloproteinases, and distinct cytokines may be released in this process. Unfortunately, growth of fibrous tissue further complicates removal of foreign bodies. In most cases though, inhalation of coal dust or soot particles continues for extensive periods and more dust accumulates in the respiratory tract.

Fibrosis does not only restrict the airways but may also contribute to the compression of vasculature and lymphatic vessels. This may lead to atelectasis and emphysema, and may also cause ischemic necrosis. All these processes worsen pulmonary gas exchange and arterial oxygen saturation and may ultimately provoke respiratory failure.

Anthracosis patients are particularly susceptible to infections with Mycobacterium spp. Tuberculosis is a comorbidity that aggravates the aforementioned pathophysiological processes.

Implementation and application of measures for occupational safety largely contribute to prevention of anthracosis. This is not restricted to coal mining but also applies to any other profession that involves significant exposure to dust. Individuals performing such jobs should undergo regular examinations and thoracic radiographies.

Similarly, measures to reduce air pollution in general may be helpful to avoid anthracosis.

Smoking is not recommended by any means.

Anthracosis is a type of pneumoconiosis, a term referring to any chronic pulmonary disease caused by inhalation of considerable amounts of dust. While pneumoconiosis may be develop in individuals who chronically inhale asbestos, silica, or cotton, patients suffering from anthracosis have been exposed to coal dust or soot particles for prolonged periods of time. Thus, anthracosis is commonly seen in coal miners, and the condition is often referred to as coal worker's pneumoconiosis or black lung disease. Since anthracosis is an occupational disease, its diagnosis may have legal consequences wherein patients may be possibly entitled to financial compensation.

Deposition of coal dust on the mucous membranes of the respiratory tract may be an incidental finding. Majority of anthracosis patients are asymptomatic, whereas some develop chronic cough, dyspnea and intolerance to exercise [1]. Symptoms typically manifest in those individuals that have either been exposed to coal dust or soot for very long periods of time or those that have inhaled large amounts of dust in shorter time ranges. Smoking exacerbates anthracosis.

If ciliary movement is unable to remove coal dust or soot particles from the airways by ciliary movement, macrophages will attempt to remove these particles. Activation of macrophages results in the release of pro-inflammatory cytokines and induction of fibroblast proliferation. Due to this effect, severe cases of anthracosis are often associated with progressive massive fibrosis [2]. Because the particles mainly deposit in the bronchial tubes, this condition is also known as bronchial anthracofibrosis.

Pulmonary function tests can help assess the extent of the disease. Diagnostic imaging, particularly computed tomography scans, allows for an evaluation of pulmonary tissue and lymph nodes. Fibrosis and calcification are also common findings.

Therapy is palliative and is aimed at symptom relief and prevention of further exacerbation. The most important therapeutic measures are avoidance of coal dust or soot particle exposure and smoking cessation.

Anthracosis refers to a chronic pulmonary disease characterized by deposition of coal dust or soot particles on the mucous membranes of the respiratory tract.

Causes

Usually, any inhaled small particle is transported back upwards by means of the ciliary movement of the mucous membranes. Prolonged exposure to coal dust or soot particles, however, exceeds the self-cleaning capacities of the lungs and results in the aforementioned condition.

Coal miners inhale large amounts of coal dust that may be deposited on the mucous membranes. Similarly, anyone continuously exposed to smoke may develop this disease. Immune cells try to remove the inhaled particles and induce chronic inflammation and pulmonary fibrosis.

Smoking and air pollution exacerbate the disease.

Symptoms

Most patients remain asymptomatic for years. Symptoms such as productive cough, breathing difficulties and intolerance to exercise typically manifest in patients aged 60 years and older. Severe cases of anthracosis may lead to right heart failure.

Diagnosis

The patient's medical history is of the utmost importance in the diagnosis of anthracosis and the choice of treatment. This condition is confirmed by performing bronchoscopy and visualizing black depositions on mucous membranes of the respiratory tract. Pulmonary function tests and computed tomography scans are helpful to assess the extent of lung damage. The latter also serves to rule out differential diagnoses.

Treatment

There is no causative treatment for anthracosis. If at all possible, the patient should avoid the source of coal dust or soot particles. Any reduction of exposure to this matter also prevents exacerbation of the disease. If a job change is not an option, it may be possible to change to a position that involves less exposure to dust.

Smokers should stop smoking.

Exercise programs may help to relieve breathing difficulties and intolerance to exercise. They should be realized under professional supervision.

If the pulmonary gas exchange is strongly restricted, continuous oxygen therapy may be required. In some patients, blood oxygen saturation only drops at night and thus, oxygen supplementation is only necessary while sleeping.

Additional medication may provide some relief by widening the bronchial tubes. However, if this is not the case and the patient is at acute risk of respiratory failure, they may be considered for lung transplantation.

Of note, in some countries, occupational rights may entitle anthracosis patients to compensation.

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2. Laney AS, Petsonk EL, Hale JM, Wolfe AL, Attfield MD. Potential determinants of coal workers' pneumoconiosis, advanced pneumoconiosis open link open link, and progressive massive fibrosis among underground coal miners in the United States, 2005-2009. Am J Public Health. 2012; 102 Suppl 2:S279-283.
3. Qorbani M, Yunesian M, Baradaran HR. Indoor smoke exposure and risk of anthracosis. Iran J Med Sci. 2014; 39(6):571-576.
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8. Kuempel ED, Wheeler MW, Smith RJ, Vallyathan V, Green FH. Contributions of dust exposure and cigarette smoking to emphysema severity in coal miners in the United States. Am J Respir Crit Care Med. 2009; 180(3):257-264.
9. Ghanei M, Aslani J, Peyman M, Asl MA, Pirnazar O. Bronchial anthracosis: a potent clue for diagnosis of pulmonary tuberculosis. Oman Med J. 2011; 26(1):19-22.
10. Mirsadraee MH, Asnashari AK, Attaran DM. Tuberculosis in patients with anthracosis of lung underlying mechanism or superimposed disease. Iran Red Crescent Med J. 2011; 13(9):670-673.
11. Office of Workers' Compensation Programs, Labor. Black Lung Benefits Act: standards for chest radiographs. Final rule. Fed Regist. 2014; 79(74):21606-21615.