Structurally, the most promising compounds (both urea and thiourea derivatives) presented smaller lateral chains and unsubstituted or para-substituted phenyl ring with a methyl group. [ncbi.nlm.nih.gov]

• Epilepsy

  Future discoveries by the ASP (now renamed the Epilepsy Therapy Screening) can be expected to make additional contributions to improving the health of persons with epilepsy. KEYWORDS: Anti-seizure; Anticonvulsant; Epilepsy; Screening; Seizure [ncbi.nlm.nih.gov]

• Fatigue

  Side effects can include fatigue, imbalance, and behavioral changes, which often dissipate after the first month of treatment. [healthcommunities.com]

  It curbs your pain and can help your fatigue and sleep problems. Gabapentin ( Neurontin ). Research shows this drug lessens pain and fatigue, and improves sleep. It's similar to pregabalin, and works in the same way. [webmd.com]

  About a third of the people on gabapentin experienced unpleasant side effects, mostly nausea and fatigue, and so did 10 percent of those on placebo. The beneficial effects disappeared when patients stopped taking the drug. [well.blogs.nytimes.com]

  Side Effects of Anticonvulsants Dizziness Drowsiness Fatigue Tremors Rash Weight Gain Long term use leads to liver damage Confusion Nausea or vomiting Common Anticonvulsant Drugs Neurontin Tegretol Topamax Dilantin Valpropate Stop suffering from the side [recoveryconnection.org]

  Side Effects of Anticonvulsants Dizziness Drowsiness Fatigue Tremors Rash Weight Gain Long term use leads to liver damage Confusion Nausea or vomiting Common Anticonvulsant Drugs Neurontin Tegretol Topamax Dilantin Valpropate Recovery Connection Addiction [recoveryconnection.com]

• Acute Intermittent Porphyria

  Posttraumatic epilepsy and acute intermittent porphyria: effects of phenytoin, carbamazepine, and clonazepam. Neurology 1978;28:824-8. 8. Lambrecht RW, Gildemeister OS, Pepe JA, Tortorelli KD, Williams A, Bonkovsky HL. [porphyria.eu]

• Transient Hypothyroidism

  Although both women received anticonvulsant therapy, transient hypothyroidism was observed only in the hypothyroid woman and was found after treatment with classic anticonvulsant agents (carbamazepine and sodium valproate) but not with gabapentin. [ncbi.nlm.nih.gov]

• Fever Followed by a Rash

  The syndrome begins with fever followed by a rash that can progress to erythema multiforme, toxic epidermal necrolysis, and multi-organ system involvement. [ncbi.nlm.nih.gov]

• Nausea

  All anticonvulsants have dose-dependent side effects on the central nervous system such as somnolence and nausea, but some agents have more specific side effects (e.g., gingival hyperplasia caused by phenytoin). [amboss.com]

  Common side effects include tingling sensations in the arms and legs, irregular eye movements, appetite loss, nausea, and others. [healthcommunities.com]

  We describe a 31-year-old woman sent to the emergency department with symptoms of high fever, peripheral lymphadenopathy, arthralgia, nausea, vomiting and a vesiculobullous eruption resembling measles. [ncbi.nlm.nih.gov]

  Headaches, chest pain, nausea, and fever are some of the side effects of this drug. [webmd.com]

  Nausea, vomiting, indigestion, headaches, confusion and drowsiness sometimes occur but usually subside in a few weeks. Dosages Recommended By Investigators. Comes in 250 and 500 mg capsules. Dose is primarily based on body weight. [anxieties.com]

• Constipation

  It can also lead to stomach pain, constipation, nausea, and trouble concentrating. Muscle Relaxants Although experts aren't sure why, muscle relaxants can treat a variety of fibromyalgia symptoms. Cyclobenzaprine ( Flexeril ). [webmd.com]

  ‘Patients should be warned of possible side effects of this anticonvulsant medication (eg, nausea, vomiting, headache, diplopia, constipation, confusion, ataxia).’ ‘Her eyesight was impaired by glaucoma and she was on anticonvulsant drugs.’ [en.oxforddictionaries.com]

  The most common side effects are constipation, mild nausea or vomiting, and mild dizziness, drowsiness, or lightheadedness. These problems usually go away as the body adjusts to the drug and do not require medical treatment. [faqs.org]

• Abdominal Pain

  Side effects are usually mild or moderate and include the following: Abdominal pain, nausea, vomiting Dizziness Double vision Drowsiness, fatigue Hyponatremia Loss of coordination, abnormal gait Zonisamide (Zonegram)—This drug is approved for use in adults [healthcommunities.com]

  Other general side effects of anticonvulsants that do not usually require medical attention include: mild coordination problems mild dizziness abdominal pain or cramping sinus pain sleeplessness or nightmares change in appetite mild feelings of anxiety [encyclopedia.com]

  These include nausea, abdominal pain, dizziness, sleepiness, irritability, anxiety or mood changes. These are usually not serious, but may worry some people and should be discussed with your doctor or pharmacist. [rch.org.au]

  Side effects for the drug are behavioral disturbances, nausea and drowsiness, hiccups, headache, rash, decrease in appetite, abdominal pain, and an unsteady walk. [dash.harvard.edu]

  Other adverse effects include somnolence, headaches, abnormal thinking, abdominal pain, pharyngitis, ataxia, confusion, psychosis, and skin rash. No changes in biochemical or hematologic parameters are reported. [emedicine.com]

• Shoulder Pain

  An 18-year-old man was admitted to our hospital for shoulder pain and further evaluation of decreased bone mineral density. He had been treated with anticonvulsants, including phenytoin, phenobarbital, valproic acid and zonisamide for seizures. [ncbi.nlm.nih.gov]

• Mucocutaneous Rash

  Anticonvulsant hypersensitivity syndrome is a disease characterized by multisystemic involvement, fever, lymphadenopathy, mucocutaneous rash, hypertransaminasemia and peripheral eosinophilia. [ncbi.nlm.nih.gov]

• Seizure

  […] to diminished potency and seizure recurrence. [ncbi.nlm.nih.gov]

• Nystagmus

  Symptoms seen in anticonvulsant toxicity can include confusion, nystagmus, ataxia lethargy, coma, respiratory depression, and death. [ncbi.nlm.nih.gov]

  constant rate of drug eliminated) Gingival hyperplasia Stevens-Johnson syndrome Hirsutism Drug-induced lupus erythematosus Osteopathies Megaloblastic anemia Nystagmus, diplopia, ataxia Peripheral neuropathy Teratogenic: fetal hydantoin syndrome Induction [amboss.com]

  Adverse reactions that may occur with the administration of an anticonvulsant drug include the following: • Drowsiness, weakness, dizziness • Headache, somnolence • Nystagmus (constant, involuntary movement of the eyeball) • Ataxia (loss of control of [basicmedicalkey.com]

  Overdoses of gabapentin have produced dizziness and diarrhoea, and those of lamotrigine lethargy, ataxia and nystagmus. [link.springer.com]

[…] or a delayed systemic hypersensitivity reaction after intake of a drug that they had also taken during a previous anticonvulsant DRESS which had occurred months or years earlier; in the fifth, a possible reaction was prevented thanks to the allergy workup [ncbi.nlm.nih.gov]

Initial emergency interventions by the interprofessional team include: Obtaining a thorough history and drug history whenever possible Recognition of toxidromes when present Stabilization including hemodynamic and airway support Laboratory workup including [statpearls.com]

Refer patients with intractable spells to a neurologist or an epileptologist for further workup, including video-electroencephalographic (EEG) monitoring, to characterize the etiology of their seizures. [emedicine.medscape.com]

• Lymphopenia

  Blood analysis showed an inflammatory syndrome, thrombocytopenia and moderate lymphopenia. A few days later, results indicated old immunisation for measles. [ncbi.nlm.nih.gov]

• Human Herpesvirus 6

  Human herpesvirus 6 (HHV6) antibody titers increased significantly within 15 days. There was a favourable outcome after discontinuation of the drugs and corticosteroid therapy. [ncbi.nlm.nih.gov]

• Hepatocellular Carcinoma

  Compounds 1 and 3 did not affect viability and morphology of human hepatocellular carcinoma cells (HepG2). Copyright 2015 Elsevier Masson SAS. All rights reserved. [ncbi.nlm.nih.gov]

Severe neurological and psychomotor deterioration combined with increased seizure activity showed a lack of response to the treatment. At the age of 29 mon the patient was in a pre-comatose stage at which time melatonin was added to treatment. [ncbi.nlm.nih.gov]

As has been the trend with prognosis in sICH, scores have been developed to stratify sICH patients’ risk of seizures. [ahajournals.org]

Prognosis Patients often recover fully from anticonvulsant toxicity. Cardiac and neurologic complications may lead to permanent debilitating conditions if resuscitation is not available. This can cause significant morbidity and mortality. [ncbi.nlm.nih.gov]

There is some evidence that initiating anticonvulsants after a single seizure may not result in improvement in the long term prognosis and may not reduce the risk of injury or mortality.1,2 Selection of an anticonvulsant is generally guided by the type [bpac.org.nz]

Kaplan, The Clinical Features, Diagnosis, and Prognosis of Nonconvulsive Status Epilepticus, The Neurologist, 10.1097/01.nrl.0000162954.76053.d2, 11, 6, (348-361), (2005). [doi.org]

Most evidence regarding the etiology points to a genetically related defect in the detoxification enzyme. Early recognition is important in order to discontinue drug therapy. Continuity of care assists in prevention of re-exposure. [ncbi.nlm.nih.gov]

The most common etiologic factors were hypoglycemia (14.6%), hypoxic ischemic encephalopathy (12.2%), and hypocalcemia (12.2%). [go.gale.com]

It is hoped that this will further our understanding of the initial stages of pregnancy and the etiology of various reproductive disorders. [news-medical.net]

Investigators have reported epidemiologic data and described the pathophysiology, diagnostic criteria, and management options. [ncbi.nlm.nih.gov]

Epidemiological and medical aspects of epilepsy in the elderly. Epilepsy Res 2006; 68:Suppl 1:S39-S48. [slideshare.net]

The epidemiology of epilepsy revisited. Curr Opin Neurol, 16 (2003), pp. 165-170 [4] P.M. Preux, M. Druet-Cabanac. Epidemiology and aetiology of epilepsy in sub-Saharan, Africa. Lancet Neurol, 4 (2005), pp. 21-31 [5] T.L. Mac, D.S. Tran, F. Quet, P. [elsevier.es]

Investigators have reported epidemiologic data and described the pathophysiology, diagnostic criteria, and management options. [ncbi.nlm.nih.gov]

Perhaps the greatest evidence that glutamate modulation might be important in the pathophysiology of mood disorders comes from the clinical use of the anticonvulsant lamotrigine. [dictionary.cambridge.org]

Treatment with antiepileptic drugs (AEDs) can alleviate spontaneous seizure activity without preventing the progression and development of epileptogenesis. [ncbi.nlm.nih.gov]

Preventing or arresting seizures. 2. An agent having such action. anticonvulsant A drug used to prevent or reduce the severity of epileptic attacks, or to prevent dangerous muscle contraction in electroconvulsive therapy. [medical-dictionary.thefreedictionary.com]