Presentation
In S cells, a novel iron-binding intermediate (band D) was identified that was not present in R cells and may be a "sensitivity factor" to gallium. [ncbi.nlm.nih.gov]
In S cells, a novel iron-binding intermediate (band D) was identified that was not present in R cells and may be a “sensitivity factor” to gallium. [jpet.aspetjournals.org]
Presented at the American Society of Hematology 41st Annual Meeting. New Orleans, LA December 3–7, 1999. (abstract 2685). Google Scholar 41. [link.springer.com]
Entire Body System
- Fatigue
Fatigue Fatigue is very common, and can be due to the cancer itself or the chemotherapy. Other potential contributing factors include anemia, insomnia, depression and other medications, such as pain medications. [livestrong.com]
See All 2 Answers 2 Answers A Side effects of Eloxatin (oxaliplatin) may include: nausea or vomiting; constipation; diarrhea; loss of appetite; muscle or back pain; swelling at the site of the injection; change in taste; dizziness; fatigue; hair loss; [sharecare.com]
Additional side effects include fatigue, headaches, water retention etc. Prolonged and repeated administration of antineoplastic agents may have permanent negative effects on vital organs such as heart, kidneys, lungs or liver. [ic.steadyhealth.com]
Other side effects of these drugs are, fatigue, headaches, and water retention. The long-term use of these drugs can damage some vital organs, like the heart, kidneys, liver, and the lungs. [buzzle.com]
Some of the general adverse reactions after this drug is taken could be fatigue and headache. The level of these two can vary from patient to patient depending on the immune system. [castorlifecare.com]
Gastrointestinal
- Nausea
As control of vomiting has improved, attention has shifted to control of nausea, a related but distinct and equally important problem. Additional efforts will be necessary to understand mechanisms of nausea and to identify optimal remedies. [ncbi.nlm.nih.gov]
Toxicity includes immunosuppression with increased risk of infection and nausea and vomiting. [quizlet.com]
See All 2 Answers 2 Answers A Side effects of Eloxatin (oxaliplatin) may include: nausea or vomiting; constipation; diarrhea; loss of appetite; muscle or back pain; swelling at the site of the injection; change in taste; dizziness; fatigue; hair loss; [sharecare.com]
- Abdominal Pain
Call your doctor or midwife if you have any of these side effects: Vaginal bleeding or spotting Nausea Fatigue or lightheadedness Cramping abdominal pain 1 Answer A Potential benefits of methotrexate for ectopic pregnancy include the following: Can end [sharecare.com]
Side effects include nausea, vomiting, diarrhea, abdominal pain, stomatitis, edema, paresthesias, and hyperbilirubinemia. Often the hands and feet become dry and painful. [quizlet.com]
pain Cyclophosphamide Hemorrhagic cystitis Vincristine Neurotoxicity Irinotecan Diarrhea (early and late), nausea and vomiting, cholinergic syndrome, myelosuppression Cytarabine Cerebral damage Nearly all antineoplastic drugs have side effects that patients [doctorlib.info]
Skin
- Alopecia
Other adverse effects included myalgias, arthralgias, alopecia, diarrhea, nausea, vomiting, mucositis, and peripheral neuropathy. Rare cases of cardiac and central neurotoxicity were also noted. [ncbi.nlm.nih.gov]
Fever, rash, cellulitis, pain at the injection site, sore throat, conjunctivitis, and alopecia also occur frequently. [quizlet.com]
Treatment
It is used in combination in many protocols of cancer treatment. [pharmacorama.com]
Malignant melanoma cells are particularly well known for their unresponsiveness to chemotherapy; only about 30% of tumors exhibit a transient clinical response to treatment. [ncbi.nlm.nih.gov]
011Investigated for use/treatment in cancer/tumors (unspecified).DB05996Glembatumumab vedotinInvestigated for use/treatment in melanoma.DB06021AV-412Investigated for use/treatment in cancer/tumors (unspecified).DB06040FilanesibInvestigated for use/treatment [drugbank.ca]
Prognosis
BACKGROUND: Although patients with neuroendocrine tumors typically exhibit an indolent clinical course, the pace of disease accelerates and the prognosis deteriorates once objective progression of disease begins. [ncbi.nlm.nih.gov]
Hence, the need to take into consideration the prognosis of the disease in assessing the extent of benefit is another sensible distinction to be made. [esmoopen.bmj.com]
As overt HF induced by chemotherapy has such a worse prognosis, there is a stringent need to improve our ability to detect CTRCD at a subclinical level. [romanianjournalcardiology.ro]
Regulatory T cells and CD20 + B cells in pediatric very severe aplastic anemia: possible clinical markers for evaluating the therapeutic efficacy and prognosis. Hematology. 2018 Jul 11. 1-5. [Medline]. Brodsky RA. Acquired Aplastic Anemia. [medscape.com]
Etiology
The Drug Etiology of Agranulocytosis and Aplastic Anemia. New York: Oxford University Press; 1991. Issaragrisil S, Sriratanasatavorn C, Piankijagum A, Vannasaeng S, Porapakkham Y, Leaverton PE, et al. Incidence of aplastic anemia in Bangkok. [medscape.com]
Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium for Early Detection of Lung Cancer., Guida F, Sun N, Bantis LE, et al. Assessment of Lung Cancer Risk on the Basis of a Biomarker Panel of Circulating Proteins. [emedicine.medscape.com]
The most recognized clinical pattern consists of self-limiting dyspnea of uncertain etiology, in some cases involving bronchoconstriction [ 5 – 8 ]. [annonc.oxfordjournals.org]
Epidemiology
Hence the foundations of teratology, which once were largely morphological, have extended into genetics, biochemistry, molecular biology, reproductive physiology, epidemiology, and several aspects of veteri nary and clinical medicine. [books.google.com]
Surveillance Epidemiology and End Results (SEER) stat fact sheets. http://seer.cancer.gov/statfacts/html/all.html. Accessed March 15, 2010. [ajpb.com]
Surveillance, Epidemiology, and End Results Program. Available at http://seer.cancer.gov/statfacts/html/lungb.html. Accessed: April 12, 2019. Jonnalagadda S, Smith C, Mhango G, Wisnivesky JP. [emedicine.medscape.com]
Surveillance, Epidemiology, and End Results Program. SEER Stat Fact Sheets: Testis Cancer. National Cancer Institute. Available at http://seer.cancer.gov/statfacts/html/testis.html. Accessed: September 5, 2019. American Cancer Society. [medscape.com]
Since the 1970s, epidemiological studies conducted with nurses handling AD have shown an increase in risk of cancers5 6 such as leukemias5 and/or reprotoxic effects. [bmjopen.bmj.com]
Pathophysiology
Pathophysiology, diagnosis, and treatment of paroxysmal nocturnal hemoglobinuria: a review. Eur J Haematol. 2015 Sep. 95 (3):190-8. [Medline]. Brodsky RA, Mukhina GL, Li S, Nelson KL, Chiurazzi PL, Buckley JT, et al. [medscape.com]
Cardiotoxicity associated with cancer therapy: Pathophysiology and prevention. Rev Port Cardiol. 2013;32(5):395-409 22. Florescu M, Cinteza M, Vinereanu D. Chemotherapy-induced Cardiotoxicity. [romanianjournalcardiology.ro]
Long-term cardiovascular toxicity in children, adolescents, and young adults who receive cancer therapy: pathophysiology, course, monitoring, management, prevention, and research directions a scientific statement from the american heart association. [revistas.uis.edu.co]
A delayed-type hypersensitivity reaction involving immunological and non-immunological mechanisms has been proposed as a possible pathophysiological mechanism [ 45 ]. [annonc.oxfordjournals.org]
Prevention
[…] that are used to treat various cancers Associated cancers: Cancers of the breast, lung, ovary, liver, and bladder; cancers of the hematopoietic system Most important routes of exposure: Inhalation, skin contact, ingestion, needle stick injury Uses: Prevent [carexcanada.ca]
Hormones and hormone modulators block or interfere with these receptor sites to prevent growth of the cancer and cause cell death. [nurseslabs.com]
Inhibiting or preventing the growth or development of malignant cells. an′ti·ne′o·plas′tic n. antineoplastic [-nē′ōplas′tik] Etymology: Gk, anti + neos, new, plasma, something formed 1 pertaining to a substance, procedure, or measure that prevents the [medical-dictionary.thefreedictionary.com]
Centers for Disease Control and Prevention. National Institute for Occupational Safety and Health. [oncnursingnews.com]
It also helps prevent the HBV from multiplying and infecting new liver cells. [castorlifecare.com]