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Antineoplastic Agent
Antineoplastic Drugs

Presentation

In S cells, a novel iron-binding intermediate (band D) was identified that was not present in R cells and may be a "sensitivity factor" to gallium. [ncbi.nlm.nih.gov]

In S cells, a novel iron-binding intermediate (band D) was identified that was not present in R cells and may be a “sensitivity factor” to gallium. [jpet.aspetjournals.org]

Presented at the American Society of Hematology 41st Annual Meeting. New Orleans, LA December 3–7, 1999. (abstract 2685). Google Scholar 41. [link.springer.com]

Entire Body System

  • Anemia

    Late clonal diseases of treated aplastic anemia. Semin Hematol. 2000 Jan. 37(1):91-101. [Medline]. Nakao S. Immune mechanism of aplastic anemia. Int J Hematol. 1997 Aug. 66(2):127-34. [Medline]. [medscape.com]

    Other potential contributing factors include anemia, insomnia, depression and other medications, such as pain medications. [livestrong.com]

    The main toxicity was grade 1 to 3 anemia in 16 (62%) pts, with hemolysis noted in 9 pts. Although methemoglobinemia was observed in 19 pts, it was severe in only 3 pts. [ncbi.nlm.nih.gov]

    Hydroxyurea will not cure sickle cell anemia. [askchampkart.fr]

    Hydrea used alone or radiation therapy to Dizziness 500 mg tb, buy hydrea shelf life It is also used to control the painful crises of sickle cell anemia. Hydrea pills hydrea gelule. [galenored.com]

  • Fatigue

    Fatigue Fatigue is very common, and can be due to the cancer itself or the chemotherapy. Other potential contributing factors include anemia, insomnia, depression and other medications, such as pain medications. [livestrong.com]

    See All 2 Answers 2 Answers A Side effects of Eloxatin (oxaliplatin) may include: nausea or vomiting; constipation; diarrhea; loss of appetite; muscle or back pain; swelling at the site of the injection; change in taste; dizziness; fatigue; hair loss; [sharecare.com]

    Additional side effects include fatigue, headaches, water retention etc. Prolonged and repeated administration of antineoplastic agents may have permanent negative effects on vital organs such as heart, kidneys, lungs or liver. [ic.steadyhealth.com]

    Other side effects of these drugs are, fatigue, headaches, and water retention. The long-term use of these drugs can damage some vital organs, like the heart, kidneys, liver, and the lungs. [buzzle.com]

    Some of the general adverse reactions after this drug is taken could be fatigue and headache. The level of these two can vary from patient to patient depending on the immune system. [castorlifecare.com]

  • Congestive Heart Failure

    Measurement of intake and output, daily weight measurement, and observation for signs of surface edema or congestive heart failure are essential parts of patient care. Care of the patient with edema must include meticulous skin care. [medical-dictionary.thefreedictionary.com]

    Congestive heart failure in patients treated with doxorubicin: a retrospective analysis of three trials. Cancer 2003; 97:2869–79 21. Adãoa R, Keulenaerb G, Leite-Moreiraa A, Brás-Silvaa C. [romanianjournalcardiology.ro]

    Although the acute cardiac effects of hypotension, tachycardia, and dysrhythmias are usually not clinically significant, long-term effects leading to congestive heart failure can be life-threatening and necessitate discontinuance of drug therapy. [doctorlib.info]

    It may cause acute and delayed cardiotoxicity including arrhythmias and congestive heart failure. Care must be taken to avoid extravasation because it is a potent vesicant. doxorubicin liposome (Doxil). [quizlet.com]

    Cardiovascular complications, such as ischaemic heart disease, venous thromboembolism, congestive heart failure, pulmonary embolism, myocardial infarction and cerebrovascular failure. [en.wikipedia.org]

  • Unconsciousness

    Side Effects: Chest pain or discomfort lightheadedness, dizziness or fainting shortness of breath slow or irregular heartbeat unconsciousness unusual tiredness Ask for Price Product Price : Get Latest Price Product Details: Packaging Size 1x28 Packaging [castorlifecare.com]

Gastrointestinal

  • Nausea

    As control of vomiting has improved, attention has shifted to control of nausea, a related but distinct and equally important problem. Additional efforts will be necessary to understand mechanisms of nausea and to identify optimal remedies. [ncbi.nlm.nih.gov]

    Toxicity includes immunosuppression with increased risk of infection and nausea and vomiting. [quizlet.com]

    See All 2 Answers 2 Answers A Side effects of Eloxatin (oxaliplatin) may include: nausea or vomiting; constipation; diarrhea; loss of appetite; muscle or back pain; swelling at the site of the injection; change in taste; dizziness; fatigue; hair loss; [sharecare.com]

  • Abdominal Pain

    Call your doctor or midwife if you have any of these side effects: Vaginal bleeding or spotting Nausea Fatigue or lightheadedness Cramping abdominal pain 1 Answer A Potential benefits of methotrexate for ectopic pregnancy include the following: Can end [sharecare.com]

    Side effects include nausea, vomiting, diarrhea, abdominal pain, stomatitis, edema, paresthesias, and hyperbilirubinemia. Often the hands and feet become dry and painful. [quizlet.com]

    pain Cyclophosphamide Hemorrhagic cystitis Vincristine Neurotoxicity Irinotecan Diarrhea (early and late), nausea and vomiting, cholinergic syndrome, myelosuppression Cytarabine Cerebral damage Nearly all antineoplastic drugs have side effects that patients [doctorlib.info]

Cardiovascular

  • Heart Failure

    (rare) and heart failure (rare). [en.wikipedia.org]

    In patients with symptomatic heart failure (HF) from cancer treatment, the mortality rate has been reported to be as high as 60% at two years7,8. [romanianjournalcardiology.ro]

    Measurement of intake and output, daily weight measurement, and observation for signs of surface edema or congestive heart failure are essential parts of patient care. Care of the patient with edema must include meticulous skin care. [medical-dictionary.thefreedictionary.com]

    Although the acute cardiac effects of hypotension, tachycardia, and dysrhythmias are usually not clinically significant, long-term effects leading to congestive heart failure can be life-threatening and necessitate discontinuance of drug therapy. [doctorlib.info]

    It may cause acute and delayed cardiotoxicity including arrhythmias and congestive heart failure. Care must be taken to avoid extravasation because it is a potent vesicant. doxorubicin liposome (Doxil). [quizlet.com]

Musculoskeletal

  • Muscle Cramp

    Common side effects:Nausea, Vomiting, Loss of appetite, Fatigue, Insomnia (difficulty in sleeping), Diarrhoea, Muscle cramp Ask for Price Product Price : Get Latest Price International Brand Name Daclatasvir Brand Name Ledifos Generic Name Sofosbuvir [castorlifecare.com]

    Adverse Effects Use of cancer cell-specific agents may result to these adverse effects: Imatinib: GI upset, muscle cramps, heart failure, fluid retention, skin rash. [nurseslabs.com]

Skin

  • Alopecia

    Other adverse effects included myalgias, arthralgias, alopecia, diarrhea, nausea, vomiting, mucositis, and peripheral neuropathy. Rare cases of cardiac and central neurotoxicity were also noted. [ncbi.nlm.nih.gov]

    Fever, rash, cellulitis, pain at the injection site, sore throat, conjunctivitis, and alopecia also occur frequently. [quizlet.com]

  • Blister

    Packaging Size : Blister of 1 Tablet read more... Sris Pharmaceuticals Mettakanigudem, Hyderabad Plot No. 108, Sree Rams, Vokshith Enclave, Mettakanigudem, Hyderabad - 500055, Dist. [dir.indiamart.com]

    Treating shingles (herpes zoster), cold sores (fever blisters or herpes labialis), and treating, suppressing, or reducing transmission of genital herpes in patients with healthy immune systems. [castorlifecare.com]

  • Hyperpigmentation

    Serpentine supravenous hyperpigmentation occurs predominately in men who are receiving treatment for solid tumors. Serpentine supravenous hyperpigmentation is an uncommon sequelae of antineoplastic therapy. [ncbi.nlm.nih.gov]

Psychiatrical

  • Withdrawn

    […] liquid until the required volume is withdrawn. [osha.gov]

Neurologic

  • Dysesthesia

    Oxaliplatin monotherapy has frequently been associated with adverse reactions from upper respiratory tract, mainly of laryngeal dysesthesia, which is a form of neurosensory effect [ 77 ]. Pulmonary toxicity is rare following oxaliplatin monotherapy. [annonc.oxfordjournals.org]

Treatment

It is used in combination in many protocols of cancer treatment. [pharmacorama.com]

Malignant melanoma cells are particularly well known for their unresponsiveness to chemotherapy; only about 30% of tumors exhibit a transient clinical response to treatment. [ncbi.nlm.nih.gov]

011Investigated for use/treatment in cancer/tumors (unspecified).DB05996Glembatumumab vedotinInvestigated for use/treatment in melanoma.DB06021AV-412Investigated for use/treatment in cancer/tumors (unspecified).DB06040FilanesibInvestigated for use/treatment [drugbank.ca]

Prognosis

BACKGROUND: Although patients with neuroendocrine tumors typically exhibit an indolent clinical course, the pace of disease accelerates and the prognosis deteriorates once objective progression of disease begins. [ncbi.nlm.nih.gov]

Hence, the need to take into consideration the prognosis of the disease in assessing the extent of benefit is another sensible distinction to be made. [esmoopen.bmj.com]

As overt HF induced by chemotherapy has such a worse prognosis, there is a stringent need to improve our ability to detect CTRCD at a subclinical level. [romanianjournalcardiology.ro]

Regulatory T cells and CD20 + B cells in pediatric very severe aplastic anemia: possible clinical markers for evaluating the therapeutic efficacy and prognosis. Hematology. 2018 Jul 11. 1-5. [Medline]. Brodsky RA. Acquired Aplastic Anemia. [medscape.com]

Etiology

The Drug Etiology of Agranulocytosis and Aplastic Anemia. New York: Oxford University Press; 1991. Issaragrisil S, Sriratanasatavorn C, Piankijagum A, Vannasaeng S, Porapakkham Y, Leaverton PE, et al. Incidence of aplastic anemia in Bangkok. [medscape.com]

Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium for Early Detection of Lung Cancer., Guida F, Sun N, Bantis LE, et al. Assessment of Lung Cancer Risk on the Basis of a Biomarker Panel of Circulating Proteins. [emedicine.medscape.com]

The most recognized clinical pattern consists of self-limiting dyspnea of uncertain etiology, in some cases involving bronchoconstriction [ 5 – 8 ]. [annonc.oxfordjournals.org]

Epidemiology

Hence the foundations of teratology, which once were largely morphological, have extended into genetics, biochemistry, molecular biology, reproductive physiology, epidemiology, and several aspects of veteri nary and clinical medicine. [books.google.com]

Surveillance Epidemiology and End Results (SEER) stat fact sheets. http://seer.cancer.gov/statfacts/html/all.html. Accessed March 15, 2010. [ajpb.com]

Surveillance, Epidemiology, and End Results Program. Available at http://seer.cancer.gov/statfacts/html/lungb.html. Accessed: April 12, 2019. Jonnalagadda S, Smith C, Mhango G, Wisnivesky JP. [emedicine.medscape.com]

Surveillance, Epidemiology, and End Results Program. SEER Stat Fact Sheets: Testis Cancer. National Cancer Institute. Available at http://seer.cancer.gov/statfacts/html/testis.html. Accessed: September 5, 2019. American Cancer Society. [medscape.com]

Since the 1970s, epidemiological studies conducted with nurses handling AD have shown an increase in risk of cancers5 6 such as leukemias5 and/or reprotoxic effects. [bmjopen.bmj.com]

Pathophysiology

Pathophysiology, diagnosis, and treatment of paroxysmal nocturnal hemoglobinuria: a review. Eur J Haematol. 2015 Sep. 95 (3):190-8. [Medline]. Brodsky RA, Mukhina GL, Li S, Nelson KL, Chiurazzi PL, Buckley JT, et al. [medscape.com]

Cardiotoxicity associated with cancer therapy: Pathophysiology and prevention. Rev Port Cardiol. 2013;32(5):395-409 22. Florescu M, Cinteza M, Vinereanu D. Chemotherapy-induced Cardiotoxicity. [romanianjournalcardiology.ro]

Long-term cardiovascular toxicity in children, adolescents, and young adults who receive cancer therapy: pathophysiology, course, monitoring, management, prevention, and research directions a scientific statement from the american heart association. [revistas.uis.edu.co]

A delayed-type hypersensitivity reaction involving immunological and non-immunological mechanisms has been proposed as a possible pathophysiological mechanism [ 45 ]. [annonc.oxfordjournals.org]

Prevention

[…] that are used to treat various cancers Associated cancers: Cancers of the breast, lung, ovary, liver, and bladder; cancers of the hematopoietic system Most important routes of exposure: Inhalation, skin contact, ingestion, needle stick injury Uses: Prevent [carexcanada.ca]

Hormones and hormone modulators block or interfere with these receptor sites to prevent growth of the cancer and cause cell death. [nurseslabs.com]

Inhibiting or preventing the growth or development of malignant cells. an′ti·ne′o·plas′tic n. antineoplastic [-nē′ōplas′tik] Etymology: Gk, anti + neos, new, plasma, something formed 1 pertaining to a substance, procedure, or measure that prevents the [medical-dictionary.thefreedictionary.com]

Centers for Disease Control and Prevention. National Institute for Occupational Safety and Health. [oncnursingnews.com]

It also helps prevent the HBV from multiplying and infecting new liver cells. [castorlifecare.com]

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