Symptoma

Antitubercular Agent

Agents Antitubercular

In the present review, we have collated published reports on this versatile core to provide an insight so that its complete therapeutic potential can be utilized for the treatment of tuberculosis. [ncbi.nlm.nih.gov]

[…] live in institutions immigrants from Latin america, southeast asia, Africa Mantoux Test ( PPD) Multiple puncture test (Tine) Given ID in the forearm (read results in 48-72 hrs 10 mm or greater induration positive reaction. ( doesn't mean disease is present [quizlet.com]

The student will also take part in the University Graduate School and Faculty Doctoral Research Development Programme (DRDP) including transferable skills (eg presentation skills, scientific writing and employability skills) which aid in their future [westminster.ac.uk]

Nanomaterials, in the present scenario, have opened new avenues in medicine, diagnosis, and therapeutics. In view of this, the current study aims to determine the efficacy of phytogenic metal nanoparticles to inhibit mycobacteria. [dovepress.com]

Therefore in the present investigation, we studied the synergistic effect of some plant extracts/phytochemicals along with the Isoniazid and rifampicin. The M. tuberculosis H37Ra was used as model organism. [omicsonline.org]

  • Fatigue

    Patient Monitoring INH Prophylaxis Seen Q month & assess for s/s of liver damage or other toxic effects, anorexia, n/v, fatigue, weakness, paresthesias of hands/feet, persistent dark urine, icterus, rash, elevated temp Routine LFTs (Q mo) for patients [slideshare.net]

    Clinical signs of liver toxicity can include nausea, vomiting, fatigue, abdominal pain and loss of appetite. [livestrong.com]

    […] right away if you have any of the following symptoms: Fever for 3 or more days Pain in the lower abdomen Itchiness or a rash Nausea, vomiting, or no appetite Yellowish skin or eyes Dark or brown urine Tingling, burning, or numbness of the hands and feet Fatigue [webmd.com]

    CNS: Fatigue, drowsiness, headache, ataxia, confusion, dizziness, inability to concentrate, generalized numbness, pain in extremities, muscular weakness. Special Senses: Visual disturbances, transient low-frequency hearing loss, conjunctivitis. [robholland.com]

    […] serum aspartate aminotransferase) at least once per month, especially if signs of hepatitis (anorexia, malaise, fatigue, nausea, and jaundice). May result from metabolite, acetylhydrazine. [cyto.purdue.edu]

  • Nausea

    Common adverse events in clinical trials included nausea, arthralgia, and headache. Serious adverse events included elevated serum transaminase levels and rate-corrected QT-interval prolongation. [ncbi.nlm.nih.gov]

    Peripheral neuropathy and CNS toxicity Causes vitamin B6 (pyridoxine) deficiency Causes decreased GABA synthesis Drug-induced hepatitis Most frequent major toxic effect, potentially fatal - loss of appetite, nausea, vomiting, jaundice increased ALT [quizlet.com]

    Most common are rash (0.8%), fever (0.5%), and nausea and vomiting (1.5%). (GG8th90). Jaundice Most notable problem and has resulted in death. [cyto.purdue.edu]

    Thioacetazone may cause nausea, vomiting, diarrhoea and skin rashes. Cases of thrombocytopenia and aplastic anaemia are also recorded. Thioridazine- a study to know the effectiveness of Thioridazine treatment was carried out. [onlymyhealth.com]

    Clinical signs of liver toxicity can include nausea, vomiting, fatigue, abdominal pain and loss of appetite. [livestrong.com]

  • Abdominal Pain

    Clinical signs of liver toxicity can include nausea, vomiting, fatigue, abdominal pain and loss of appetite. [livestrong.com]

    Ethambutol HCl Adverse Effects Fever, malaise, dizziness, headache Dermatitis, pruritis Thrombocytopenia Common: N/V, anorexia, abdominal pain SEVERE: Optic neuritis, loss of acuity, loss of red-green discrimination Drug Interactions Aluminum salts may [slideshare.net]

    May be worsened by isoniazid and pyridoxine. · Other effects that have been observed -- pruritus, joint pain, gastrointestinal upset, abdominal pain, malaise, headache, dizziness, mental confusion, disorientation, and possible hallucination. [cyto.purdue.edu]

    The concentration increases during meningitis. (3) Adverse effects(3-5,7) Minor adverse effects • Gastrointestinal reactions: Nausea, anorexia, and abdominal pain can occur in patients treated with rifampin. [scielo.br]

  • Orthostatic Hypotension

    (tx for tuberculosis) Pyridoxine(B6) as prophylaxsis works in 2-3 wks of therapy orthostatic hypotension Give ac meals (tx for tuberculosis) causes optic neuritis. check visual acuity (tx for tuberculosis) SE: orange urine tears, saliva Nephyotoxicity [quizlet.com]

Bedaquiline is a novel agent with a unique mechanism of action and has the potential to meet a great need in patients with MDR TB who have no other treatment options. [ncbi.nlm.nih.gov]

In most susceptible cases, the patient undergoes 6 months of treatment. Treatment lasts for 9 months if the patient's sputum culture result is still positive after 2 months of therapy. [emedicine.medscape.com]

Indications for drug therapy Prevention & treatment of tuberculosis No prototype – each drug differs from the others TB: Highly contagious Reportable disease Treatment initiated by specialist Refer for initial work-up & treatment PCP ROLE: Follow patient [slideshare.net]

The currently use antitubercular drugs having toxic effect and long period of therapeutic treatment. Therefore, many researchers have synthesized various newer drugs and analogues of currently used drugs for tuberculosis treatment. [ssjournals.com]

Abstract Effective antituberculosis drugs have radically improved the prognosis of the patient with active tuberculosis. Surgical therapy is rarely needed, and sanatoria have largely vanished. [ncbi.nlm.nih.gov]

Single-center experience with drug-induced liver injury from India: causes, outcome, prognosis, and predictors of mortality. Am J Gastroenterol. 2010;105:2396–404. [tropicalgastro.com]

Patients with cholestatic hepatitis have a better prognosis. Acute cellular necrosis is indistinguishable from viral hepatitis, which is why extremely high aminotransferase levels can be found. [scielo.br]

Competing etiologies particularly acute viral hepatitis may need to be excluded. Risk factors for TB DILI Interactions between genetic, host and environmental factors contribute towards the development of TB DILI. [tropicalgastro.com]

The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and [ingentaconnect.com]

References [1] WHO Global tuberculosis control: epidemiology, strategy, financing: WHO report 2011 [2] World Health Organization Global tuberculosis control. [archbronconeumol.org]

Europe and United States: epidemiology, surveillance, and control. Clin Chest Med. 2009;30(4):637-65, vii. [ Links ] 59. Saukkonen JJ, Cohn DL, Jasmer RM, Schenker S, Jereb JA, Nolan CM, et al. [scielo.br]

Miliary tuberculosis: epidemiology, clinical manifestations, diagnosis, and outcome. Rev Infect Dis. 1990;12:583–90. 41. Trautner BW, Darouiche RO. Tuberculous pericarditis: optimal diagnosis and management. Clin Infect Dis. 2001;33:954–61. 42. [aafp.org]

The epidemiology of XDR-TB is currently not well studied, but it is believed that XDR-TB does not transmit easily in healthy populations, but is capable of causing epidemics in populations which are already stricken by HIV and therefore more susceptible [ijpsr.com]

The latest recommendations include the new MyPlate guide, the Dietary Guidelines for Americans 2010, new and expanded chapters, and a large variety of tables, boxes, and pathophysiology algorithms, all providing need-to-know information with ease. [books.google.com]

Encyclopedia Definition 1 Any agent that is active against Mycobacterium tuberculosis and can be used in the treatment of or in the prevention of tuberculosis. [tititudorancea.com]

Allium cepa (onion) possesses antibiotic activity against both Gram-positive and Gram-negative bacteria and can be used to prevent tuberculosis most effectively. [globaljournals.org]

In patients with latent TB, the goal of therapy is to prevent disease progression. Isoniazid View full drug information This is the drug of choice for use in preventive therapy and the primary drug for use in combination therapy for active TB. [emedicine.medscape.com]

Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report [On-line report]. Available online at . Centers for Disease Control and Prevention (2002 March 23, Reviewed). TB and HIV Coinfection. [labtestsonline.it]

Preventing or treating tuberculosis. 2. An agent used to prevent or treat tuberculosis. Synonym: antituberculotic [medical-dictionary.thefreedictionary.com]