Presentation
The patient presented with weight loss and abdominal distension caused by antral and duodenal stenosis due to an inveterate peptic ulcer. [ncbi.nlm.nih.gov]
[…] turn 90deg and come back in Here, failure to come back in Exomphalos - adbo muscles fail to form properly "Bubble" = peritoneum + amnion Pyloric stenosis Congenital hypertrophy of pyloric smooth muscle M > F Stenosis develops due to thickened muscle Present [alancam.com]
It is present in almost all cases of established AG, is prominent in one third ( 10, 11 ) and, as shown in this study, can be present before complete loss of the oxyntic mucosa. [nature.com]
The details are presented in table 1. [intechopen.com]
Various types of smooth muscle proliferation may be present, possibly as a response to the production of basic fibroblastic growth factor. [epathologies.com]
Gastrointestinal
- Gastropathy
Less severe and more focal atrophy, which is usually limited to the antrum, may also occur in reactive gastropathy ( Fig. 15.14 ). [clinicalgate.com]
[…] aggressive - 5HT, sub P, polypeptide YY 25% Appendix (only one that affects "young") - 5HT, polypeptide YY 25% Colorectal - 5HT, polypeptide YY) In body or fundus 5HT Somatostatin Histamine Sx Gastritis Ulcer aSx Assoc Atrophic gastritis MEN-I HYPERTROPHIC GASTROPATHY [alancam.com]
The clinical importance of autoimmune gastropathy in type 1 diabetes remains undervalued. [care.diabetesjournals.org]
Hypertrophic Gastropathy Menetrier Disease Zollinger- Ellison Syndrome 56. [slideshare.net]
Antral Histology The antrum was biopsied in 31 cases ( Table 3 ), and 15 showed features of chemical–bile reflux gastropathy; 10 cases were classified as chronic gastritis; and 6 were classified as chronic active gastritis. [nature.com]
Cardiovascular
- Hypertension
[…] esophageal high pressure zone)上部食道高圧帯 Hydrops vesicae fellae (hydrops of gallbladder)胆嚢水腫 hyperalimentation高カロリー栄養法 hyperplastic polyp過形成性ポリープ hypertrophic pyloric stenosis肥厚性幽門狭窄 hypochondrium 季肋部 hypotonic duodenography低緊張性十二指腸造影[法] i idiopathic portal hypertension [tokyo-med.ac.jp]
Workup
Serum
- Gastrin Increased
Increased G cells in the antrum. Produce gastrin to stimulate the (missing) parietal cells. Notes: Compare with other types of gastric atrophy. DDx: Gastric neuroendocrine tumour. [librepathology.org]
Precautions High protein diet can lead to an increase in the level of gastrin 2 to 5 times of the normal level. Diabetic patients on insulin may give a false raised level of gastrin. [labpedia.net]
Absolute increase in serum gastrin level above the basal figure is preferred to percent change. 4 I.V. secretin normally diminishes gastrin, but serum gastrin increases in gastrinoma patients. [labcorp.com]
These effects are a consequence of the increased gastrin levels that result from the potent suppression of acid secretion induced by PPIs. [hon.ch]
Absolute increase in serum gastrin level above the basal figure is preferred to percent change.4 I.V. secretin normally diminishes gastrin, but serum gastrin increases in gastrinoma patients. [human-secretin.com]
- Hypoglycemia
الصفحة 100 - Nesidioblastosis: The pathologic basis of persistent hyperinsulinemic hypoglycemia in infants. Morphologic and quantitative analysis of seven cases based on specific immunostaining and electron microscopy - Heitz PU. [books.google.com]
Insulin-induced hypoglycemia. The smell of food, swallowing and chewing. Calcium. Amino acids like glycine, tryptophan, and phenylalanine. Normal Source 1 Age pg/mL Cord blood 20 to 290 0 to 4 days 120 to 183 Child ! [labpedia.net]
Certainly bypass procedures are notorious for the occurrence of proliferation of beta cells and the development of nesidioblastosis and hypoglycemia and you ought to check the fasting glucose and insulin level. [endotext.org]
Treatment
Significant updates on bariatric surgery, Barrett's esophagus, endoscopic ultrasound, endosonography, treatment of liver disease, and much more keep you current on the latest advances. [books.google.com]
Type 1 gNET is a recurrent gastric disease, and its preferred treatment is endoscopic resection and endoscopic follow-up. Not all type 1 g-NEN patients require SSA treatment. [tgh.amegroups.com]
Number of Tables: 0 ISSN: 0012-2823 (Print) eISSN: 1421-9867 (Online) For additional information: https://www.karger.com/DIG Abstract In this study we have performed a quantitative analysis of antral gastrin cells in 9 uraemic patients under dialytic treatment [karger.com]
Prognosis
Different g-NEN types have dramatically different prognosis and treatment strategies. [tgh.amegroups.com]
Rappel S et al: [Carcinoid tumors of the stomach in atrophic autoimmune gastritis: classification, differential diagnosis and prognosis.] Verh Dtsch Ges Pathol. 80:199-207, 1996. [humpath.com]
The prognosis is poor with the median survival of only 8 months reported in the literature. Chemotherapy has been attempted in a limited number of patients yet the rarity of these tumor does not allow for standard therapeutic protocols. [endocrinediseases.org]
J Clin Invest 93 : 1321 –1325, 1994 ↵ Rappel S, Altendorf-Hofmann A, Stolte M: Prognosis of gastric carcinoid tumours. Digestion 56 : 455 –462, 1995 View Abstract [care.diabetesjournals.org]
Prognosis of Gastric Carcinoma Depends on Depth of invasion Extent of Lymph Node involvement Distant metastases Histologic type Resection margins DNA Ploidy, P53 mutation Five year S.R of surgically treated early carcinoma is 90- 95% in advanced [slideshare.net]
Etiology
Etiology: autoimmune. Diagnosis based on serology for antibodies to: [2] Parietal cells. Intrinsic factor. [librepathology.org]
Etiology Patients receiving methyldopa treatment may develop Parietal Cell Antibodies (PCAs) and chronic autoimmune gastritis.The changes disappear upon cessation ofthedrug. [humpath.com]
[…] described by human and veterinary pathologists, but the organisms were dismissed as irrelevant contaminants. 3 Schindler claimed that the bacteriologic cause of chronic gastritis had not been proved convincingly in a single case. 1 Instead, a wide range of etiologic [clinicalgate.com]
Pathogenesis of Chronic GastritisMajor etiologic associations are: H.Pylori chronic infection Autoimmune (P. [slideshare.net]
Based on these results, they proposed that Helicobacter pylori is involved in the etiology of these diseases. The infection is usually asymptomatic but can cause peptic ulcer. [flipper.diff.org]
Epidemiology
One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 2008; 26:3063-3072 [endocrinediseases.org]
Review Article Epidemiology According to the United States Surveillance, Epidemiology, and End Results (SEER) database, gastric neuroendocrine neoplasms (g-NENs) accounted for 2.2% among all NENs for the period from 1950 to 1969 and up to 6% for the period [tgh.amegroups.com]
Atrophic body/fundic mucosa with loss of mucosal folds Intestinal metaplasia Polyps Laboratory Tests Circulating antibodies against H⁺/K⁺ATPase Circulating antibodies against IF High serum gastrin concentration Low serum pepsinogen Vitamin B12 deficiency Epidemiology [humpath.com]
Epidemiology of Gastric cancer Second most common tumor in the world High in Japan, Chile, Costa Rica, China, Colombia, Portugal, Russia and Bulgaria Four to six fold less common in USA, UK, Canada, Australia, New Zealand, France & Sweden Male to [slideshare.net]
Pathophysiology
A second outstanding feature of this volume is its success in balanc ing basic pathophysiology with practical considerations of clinical man agement. [books.google.com]
Pathophysiology [ edit ] Atrophic gastritis under low power. H&E stain. [en.wikipedia.org]
Pathophysiology Gastrin is a hormone produced by the antral cells (G- cells) in the stomach mucosa. Other sources of production are G cell of duodenum and delta cells of the pancreas. [labpedia.net]
Pathophysiology/Complications Abstract OBJECTIVE —Parietal cell antibodies (PCAs) are found in 20% of type 1 diabetic patients, denoting autoimmune gastritis and pernicious anemia, which may predispose to enterochromaffin-like (ECL) cell hyper/dysplasia [care.diabetesjournals.org]
Prevention
Risk factors and prevention of suicidal behavior 2012 MILITELLO, CARMELO AGING CLINICAL AND EXPERIMENTAL RESEARCH 3 Androgen profile in patients with pancreatic carcinoma 1992 SPERTI, COSIMO ; MILITELLO, CARMELO ; PASQUALI, CLAUDIO ; PEDRAZZOLI, SERGIO [research.unipd.it]
Although no specific treatment is available at this time to prevent the progression of AG, an accurate diagnosis can be important in clinical management decisions. References 1 Dixon MF, Genta RM, Yardley JH, Correa P. [nature.com]
Early diagnosis of autoimmune gastropathy is important for the prevention/treatment of iron deficiency anemia, pernicious anemia, ECL cell hyper/dysplasia, and carcinoid tumor. [care.diabetesjournals.org]