Presentation
In conclusion, the present study did not find an increased prevalence of GCA/PMR among a cohort of Israeli patients with AA/D. [ncbi.nlm.nih.gov]
Respiratoric
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Dyspnea with Sudden Onset
On presentation, these family members complained of dyspnea and sudden onset of severe pain in the chest, abdomen, or upper and lower extremities (Table 1). [ojrd.biomedcentral.com]
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Non-Cardiac Chest Pain
Spiral CT in acute non-cardiac chest pain. Clin Radiol 1999; 5438–45. 12. Yamaguchi T, Kuroki K, Ohyama Y, Ishikawa T. Pitfalls of CT diagnosis of aortic dissection: nonvisualized intimal flap in the ascending aorta or aortic arch. [journals.lww.com]
Cardiovascular
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Left Ventricular Dysfunction
One advantage of MRA over CTA is the ability to evaluate complications such as hemopericardium, left ventricular dysfunction, and valve regurgitation. [journals.lww.com]
Skin
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Flushing
[…] and Saline Flush to Saline Flush Alone in TEVAR and TAVI Procedures to Reduce Cerebral Ischemia Not yet recruiting NCT03998631 Phase 1 25 A Chinese Registry to Determine the Genetic Risk Factors and Serumal Biomarkers for Thoracic Aortic Aneurysm/Dissection [malacards.org]
Musculoskeletal
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Mid Back Pain
Abdominal aortic aneurysms often present with lumbar or abdominal mid-back pain. They can also have ischemic bowels, since, as their aneurysm expands, it results in an inadequate blood supply to the bowels, says York. [reliasmedia.com]
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Bilateral Arm Weakness
Our investigation revealed that both patients (VII-26 and VII-27) had complained of bilateral arm weakness, effort-induced shoulder pain, and general fatigue. [ojrd.biomedcentral.com]
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Short Arm
When blood is pumped out by the heart, it first travels through the ascending thoracic aorta (up the short arm of the candy cane), then down the descending thoracic aorta (first part of the long arm) into the abdominal aorta (the bottom of the candy cane [tadcoalition.org]
Neurologic
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Slurred Speech
Aortic aneurysm rupture can lead to stroke, which causes sudden weakness or numbness in a limb, slurred speech, or lack of vision and balance. If you think you or someone you know is experiencing any of these conditions, call 9-1-1 immediately. [heart.stonybrookmedicine.edu]
Workup
A good patient history and physical examination are essential, along with imaging studies, electrocardiography, and laboratory studies (see Workup). Acute aortic dissection can be treated surgically or medically. [emedicine.medscape.com]
Treatment
PARTICIPANTS: 360 088 treatment episodes of fluoroquinolone use (78%ciprofloxacin) and propensity score matched comparator episodes of amoxicillin use (n 360 088). [ncbi.nlm.nih.gov]
[…] to when treatment is ongoing. [bmj.com]
Treatment for an Aortic Aneurysm Surgical or interventional treatment of an aortic aneurysm or dissection will depend on the location and size of the aneurysm. [helios-gesundheit.de]
Prognosis
CT scanning may be used to confirm the diagnosis but is less helpful in complications and prognosis. [patient.info]
If the operation was successful, it neutralized the effect of diagnosis on prognosis (Figure 2). In the seminal Olmsted County study by Bickerstaff et al,1 a TAD incidence of 5.3 of 100 000/year is reported. [ahajournals.org]
If the operation was successful, it neutralized the effect of diagnosis on prognosis ( Figure 2 ). In the seminal Olmsted County study by Bickerstaff et al, 1 a TAD incidence of 5.3 of 100 000/year is reported. [circ.ahajournals.org]
Obstruction of branch vessels · DX o MRI if available is usually best for imaging ascending aorta o Contrast-enhanced CT can image arch and descending aorta o Transesophageal ultrasound, if available, especially for root and ascending aorta o Angiography · Prognosis [learningradiology.com]
Despite the phenotypic overlap of these syndromes, important differences in prognosis underline the importance of accurate diagnosis to optimize management strategies. [acc.org]
Etiology
BACKGROUND: Hereditary factors play an important etiologic role in thoracic aortic aneurysm and dissection (TAAD), with a number of genes proven to predispose to this condition. [ncbi.nlm.nih.gov]
Atherosclerosis is important for the etiology of descending aortic aneurysm and its histological features are similar to that of abdominal aortic aneurysm. Cystic medial necrosis is also important for the etiology of aortic dissection. [ci.nii.ac.jp]
Both twins had deep vein thrombosis of unclear etiology, possibly attributed entirely to immobility after surgery. [pediatrics.aappublications.org]
The University of Michigan is home to the International Registry of Aortic Dissection, and several research laboratories that are exploring the molecular etiologies of aortic diseases. [umcvc.org]
The Evaluation of the Clinical Performance of the Valiant Thoracic Stent Graft System in the Treatment of Descending Thoracic Aneurysms of Degenerative Etiology in Subjects Who Are Candidates for Endovascular Repair. [malacards.org]
Epidemiology
The results presented confer light to the importance of mortality statistics and the need for epidemiologic studies to understand unique trends in our own population. [ncbi.nlm.nih.gov]
Data from epidemiologic and non-clinical studies indicate an increased risk of aortic aneurysm and dissection after intake of fluoroquinolones. [gov.uk]
In Brazil, epidemiologic studies on aneurysms are scarce and the available literature is outdated. [bmcpublichealth.biomedcentral.com]
BP is supported by an investigator grant from the Strategic Research Area Epidemiology programme at Karolinska Institutet. MI is supported by an investigator grant from the Swedish Government Funds for Clinical Research (ALF). [bmj.com]
Pathophysiology
Genetic studies of human patients and murine models have yielded invaluable insights into the pathophysiology of aneurysm formation and progression in MFS. [ncbi.nlm.nih.gov]
Department of Pathophysiological and Experimental Pathology, Graduate School of Medical Sciences Kyushu University Higashi-ku, Fukuoka Japan [link.springer.com]
Animal studies aimed to clarify the pathophysiological mechanism of this association would also be valuable. Results of our study should be interpreted in light of both its strengths and limitations. [jamanetwork.com]
The integrity of the human aorta heavily depends on an intact extracellular matrix, and the pathophysiology of aortic aneurysm is known to involve excessive tissue breakdown through matrix metalloproteinases.910 Two recent observational studies have raised [bmj.com]
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Prevention
These poor outcomes are preventable by surgical repair; however, identifying at-risk individuals is difficult. [ncbi.nlm.nih.gov]