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Aortic Dilation


  • Dilation of the aortic root or ascending aorta was present in 28.0% and 41.6% of patients, respectively. Moderate or severe aortic root or ascending aortic dilation (z-score 4) was present in 8.2% and 13.7%, respectively.[ncbi.nlm.nih.gov]
  • Early-onset osteoarthritis is present in almost all patients. We present the case of a non-syndromic young boy with SMAD3 mutation isolated from the dilated aortic root and ascending aorta without osteoarthritis.[ncbi.nlm.nih.gov]
  • When it is present, magnetic resonance imaging visualizes the entire aorta and allows quantification of the site and degree of dilation.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: The present study highlighted the intrinsic abnormality of the mechanical property of the aortic wall as a feature of aortopathy in TOF.[ncbi.nlm.nih.gov]
  • METHODS: We performed a retrospective review of 642 patients who presented with bicuspid aortic valves between 1994 and 2014. Of these patients, 210 (33%) had aortic dilation (z score 3) by echocardiogram.[ncbi.nlm.nih.gov]
Heart Murmur
  • The majority of people sent for a heart scan and found to have bicuspid aortic valve are sent for the scan due to the presence of a heart murmur . Patients may be sent for a heart scan due to some unrelated reason and found to have a bicuspid valve.[myheart.net]
  • Presentation See also the separate Heart Auscultation, Heart Murmurs in Children and Pulse Examination articles. AR is diagnosed by the presence of a characteristic diastolic murmur, exaggerated arterial pulsations and low diastolic pressure.[patient.info]
  • Aortic root dilation may be an additional finding that suggests the patient with Turner syndrome is also at risk.[ncbi.nlm.nih.gov]
  • RATIONALE AND OBJECTIVES: Previous work suggests that ascending aortic (AsAo) dilation can be asymmetric and is potentially related to valve-related blood flow abnormalities.[ncbi.nlm.nih.gov]
  • TIMP-1, -2, and -3 were significantly decreased, and MMP2 activity was significantly increased in less dilated samples, suggesting that this normal-looking tissue was in the early stages of ECM degradation.[ncbi.nlm.nih.gov]
  • Inhibition of miR-29 in vivo abrogates aortic dilation in mice, suggesting that miR-29 may represent a novel molecular target to augment matrix synthesis and maintain vascular wall structural integrity.[ncbi.nlm.nih.gov]
  • Although several risk factors correlate with AD in rTOF, the rate of aortic growth is slow, suggesting that rTOF patients may not require frequent aortic imaging. Copyright 2012 Elsevier Ireland Ltd. All rights reserved.[ncbi.nlm.nih.gov]


  • I had been having chest pains and skipped beats and skipped beats with pain, i went to a cardio for the full workup. My bp was a little high resting 130/90 and a little high on the stress test..this runs in my family.[medhelp.org]


  • Both proper perioperative treatment and close monitoring are required for the successful surgery.[ncbi.nlm.nih.gov]
  • This study examines the use of the angiotensin-converting enzyme inhibitor enalapril for treatment of these patients.[ncbi.nlm.nih.gov]
  • Guidelines are needed regarding the follow-up and treatment of these patients and their families.[ncbi.nlm.nih.gov]
  • Groenink and colleagues randomly assigned 117 patients to remain on their medication and not receive further treatment. Another 116 patients were treated with losartan at a starting dose of 50 mg daily.[medpagetoday.com]
  • Condition or disease Intervention/treatment Aortic Valve Stenosis Other: diagnosed as bicuspid aortic valve Detailed Description: The growth rate of ascending aorta was calculated as annual growth rate using baseline and the last echocardiography.[clinicaltrials.gov]


  • Prognosis [ 2 ] Patients with acute severe AR have a poor prognosis without intervention, due to their haemodynamic instability. Patients with chronic severe AR and symptoms also have a poor long-term prognosis.[patient.info]
  • Treatment and prognosis As with other aortic aneurysms, increasing size results in an increased risk of rupture with the risk of rupture of 7% per year in patients with an aneurysm 6.0 cm 5.[radiopaedia.org]
  • Prognosis and risk factors in patients with asymptomatic aortic stenosis and their modulation by atorvastatin (20 mg). Am J Cardiol. 2008 Sep 15;102(6):743-8. doi: 10.1016/j.amjcard.2008.04.060. Epub 2008 Jul 2.[clinicaltrials.gov]
  • Aortopathies: etiologies, genetics, differential diagnosis, prognosis and management . Am J Med 2013 ; 126 : 670 – 8 . 10 Hypertrophic cardiomyopathy: the genetic determinants of clinical disease expression .[academic.oup.com]
  • , even a normally functioning BAV can progress and damage gradually to reveal abnormal folding and creasing throughout the cardiac cycle, with more turbulent flow, as well as restricted motion (12) Aortopathy and coarctation have implications on the prognosis[escardio.org]


  • Although the etiology and optimal management of aortic dilation associated with BAV remain the subject of debate, recent data have suggested that L-R and R-N cusp fusion phenotypes represent distinct pathological entities.[ncbi.nlm.nih.gov]
  • Etiology True aneurysms can result from a wide variety of conditions: atherosclerosis (uncommon) connective tissue diseases Marfan syndrome Ehlers-Danlos syndrome Loeys-Dietz syndrome aortitis syphilis Takayasu disease rheumatoid arthritis ankylosing[radiopaedia.org]
  • Etiology Causes include 1 : senile / atherosclerotic ectasia / hypertension aneurysm of the ascending aorta aortic dissection ( Stanford type A / DeBakey type I and II ) aortic valve aortic valve stenosis subvalvular aortic stenosis aortic valve regurgitation[radiopaedia.org]
  • This anatomic distinction is important because the etiology, natural history, and treatment of thoracic aneurysms vary for each of these segments.[emedicine.medscape.com]


  • Presents revisions by a new authorship of experts in infectious disease, genetics and epidemiology, sports medicine, neurology, cardiac surgery, cardiac anesthesiology, and more.[books.google.ro]
  • Epidemiology [ 2 ] Rheumatic heart disease is the most common cause of AR throughout the world. In developed countries, congenital and degenerative valve abnormalities are the most common cause and the peak age of presentation is 40-60 years.[patient.info]
  • "Low prevalence of abdominal aortic aneurysm among 65-year-old Swedish men indicates a change in the epidemiology of the disease." Circulation 124.10 (2011): 1118-1123. CONTINUE SCROLLING FOR RELATED SLIDESHOW[medicinenet.com]
  • Moreover, recent USA data from 2006–2007 of isolated descending thoracic aorta aneurysms found 23% of ideal candidate (uncomplicated, elective descending aortic aneurysms) underwent to TEVAR, the remaining 77% underwent open surgical repair. [18] Epidemiology[en.wikipedia.org]
Sex distribution
Age distribution


  • We used cardiovascular MR to understand the pathophysiology better by examining the links between 3-dimensional flow abnormalities, aortic function, and aortic dilation.[ncbi.nlm.nih.gov]
  • Further studies are needed to help define the genetic and pathophysiologic basis as well as the clinical implications of this association in a larger group of HCM patients. Published on behalf of the European Society of Cardiology.[ncbi.nlm.nih.gov]
  • BACKGROUND: The clinical spectrum and underlying pathophysiology of isolated congenital complete heart block (CCHB) remain incompletely understood.[ncbi.nlm.nih.gov]
  • Additionally, it is important to understand the pathophysiologic basis of this association in order to determine the appropriate surveillance and monitoring.[academic.oup.com]
  • The study by Tzemos et al. ( 15 ) in this issue of the Journal provides an integrating view of the aforementioned pathophysiological factors in BAV patients.[content.onlinejacc.org]


  • Interestingly, SOX9 over-expression prevented the cytokine-mediated reduction of FBLN5 expression and transcription.[ncbi.nlm.nih.gov]
  • Abstract Despite variable clinical results, beta blockers have become the primary therapy for prevention of aortic dilation in patients with the Marfan syndrome.[ncbi.nlm.nih.gov]
  • Therapeutic methods to decrease risk, such as those directed toward prevention of bacterial endocarditis, blood pressure control, and perhaps prophylactic beta blockade or surgical reconstruction, may need to be considered.[ncbi.nlm.nih.gov]
  • New therapies that inhibit these miRNAs may prevent aortic dilation. Copyright 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.[ncbi.nlm.nih.gov]
  • We may have a drug that prevents the dissection of the aorta and that is an important advancement. This is an inexpensive drug at this time and it is important for healthcare."[medpagetoday.com]

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