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Aortic Valve Calcification

Calcified Aortic Valve


Presentation

  • Mild tricuspid regurgitation was present in 41% of patients vs. 26% of controls (P 0.042), and aortic valve calcification was present in 40% of patients, compared with 18% of controls (P 0.003).[ncbi.nlm.nih.gov]
Turkish
  • PATIENTS AND METHODS: Our study consisted of 305 Turkish patients of European descent (139 male, 166 female; mean plus or minus age, 68 plus or minus 9 years) referred to our echocardiography laboratory for aortic valve evaluation between June 2, 2003[ncbi.nlm.nih.gov]
Heart Disease
  • OBJECTIVE: Treatment with ergot-derived dopamine agonists, pergolide, and cabergoline has been associated with an increased frequency of valvular heart disease in Parkinson's disease.[ncbi.nlm.nih.gov]
  • Aortic valve calcification may be an early sign that you have heart disease, even if you don't have any other heart disease symptoms. Calcification and stenosis generally affects people older than age 65.[mayoclinic.org]
  • Dana Cramariuc, Department of Heart Disease, Haukeland University Hospital, 5021 Bergen, Norway; cramariuc_dana{at}yahoo.com Abstract Objective Sex differences in risk factors of aortic valve calcification (AVC) by echocardiography have not been reported[heart.bmj.com]
Osteopenia
  • BACKGROUND: The use of oral calcium supplementation among the elderly for prevention and treatment of osteoporosis and osteopenia is increasing. The incidence of aortic valve disease and coronary artery disease also is increasing.[ncbi.nlm.nih.gov]
Decreased Renal Function
  • Recently, mechanisms of calcific valve degeneration have been further elucidated and many of the pathways involved could be amplified in patients with decreased renal function.[ncbi.nlm.nih.gov]
Dizziness
  • […] become more severe and cause: chest pain brought on by physical activity (angina) – caused by your heart having to work harder shortness of breath – at first you may only notice this when you exercise, but later you may experience this even when resting dizziness[nhs.uk]
  • Symptoms According to the Cleveland Clinic, a calcified heart valve will lead to valve diseases, which have symptoms such as shortness of breath, fatigue, coughing, heart palpitations, chest pain or tightness and dizziness.[livestrong.com]
  • However the symptoms associated with more severe aortic stenosis may include: Chest pain (angina) or tightness with activity Feeling faint or dizzy Shortness of breath, especially with activity Tiredness Treatment If the narrowing (stenosis) is mild then[patient.info]
  • Most of them are diagnosed because of their symptoms of Syncope (dizziness, fainting), Angina (chest pain) and Congestive Heart Failure (shortness of breath, leg swelling, weakness) or because of an obvious and loud systolic murmur.[heartsurgeryinfo.com]
  • Dizziness, fainting, or loss of consciousness. Signs of heart failure, such as fatigue and shortness of breath with activity. Palpitations (an uncomfortable feeling that your heart is beating rapidly or irregularly).[northshore.org]

Workup

  • Further workup revealed distal segmental right lower lobe pulmonary embolus and he was appropriately started on rivaroxaban for pulmonary embolus.[journal.frontiersin.org]
Calcified Aortic Valve
  • OBJECTIVES: To assess the procedural and short-term clinical outcome of performing balloon-expandable TAVR in patients with extremely calcified aortic valves.[ncbi.nlm.nih.gov]
Lymphocytic Infiltrate
  • Abstract Aortic valve stenosis is a complex inflammatory process, akin to arterial atherosclerosis, involving lymphocytic infiltrates, macrophages, foam cells, endothelial activation and dysfunction, increased cellularity and extracellular matrix deposition[ncbi.nlm.nih.gov]
Foam Cell
  • Abstract Aortic valve stenosis is a complex inflammatory process, akin to arterial atherosclerosis, involving lymphocytic infiltrates, macrophages, foam cells, endothelial activation and dysfunction, increased cellularity and extracellular matrix deposition[ncbi.nlm.nih.gov]
  • Previous pathologic studies demonstrated that foam cells which represent early atherosclerotic lesions can be found in subjects already during adolescence on the endothelium of the epicardial coronary arteries, the ventricular surface of the posterior[cardiovascularultrasound.biomedcentral.com]

Treatment

  • OBJECTIVES: This study evaluated the impact of AVC load, absolute and relative to aortic annulus size (AVCdensity), on overall mortality in patients with AS under conservative treatment and without regard to treatment.[ncbi.nlm.nih.gov]

Prognosis

  • Natural history, epidemiology, and prognosis of aortic stenosis. . Accessed April 18, 2017. Zakkar M, et al. Aortic stenosis: Diagnosis and management. BMJ. 2016;355:1. Dweck M, et al.[mayoclinic.org]
  • See: Statistics from Altmetric.com aortic valve calcification aortic valve stenosis sex prognosis echocardiography Introduction Sex differences in aortic stenosis (AS) have been pointed out both at the valvular and left ventricular (LV) level. 1 From[heart.bmj.com]
  • Although no effective treatment for alkaptonuria exists, prognosis is relatively good (1). However, complications are unavoidable. Arthropathy may be severely debilitating, and cardiovascular or renal impairment can involve vital prognosis.[ctsnet.org]
  • Congestive heart failure [ edit ] Congestive heart failure (CHF) carries a grave prognosis in people with AS.[en.wikipedia.org]
  • Surgical treatment has greatly improved the outlook (prognosis) in most people who have more severe stenosis. Surgery to widen or to replace the valve has a very good success rate.[patient.info]

Etiology

  • Therefore, clarification of the etiology of calcification is urgently needed to develop drug therapies and prevention methods.[ncbi.nlm.nih.gov]
  • Mohler III, University of Pennsylvania Translational Research Center, 3400 Civic Center Boulevard, Building, 421, Room 11-103, Philadelphia, Pennsylvania 19104-5159 Key Words aortic valve calcification endothelial progenitor cell The etiology of calcific[onlinejacc.org]
  • Classification and etiology There are numerous other predisposing factors and causes of aortic stenosis.[radiopaedia.org]

Epidemiology

  • Arfan a ; b ; c Affiliations: Department of Neurology, Erasmus MC, Rotterdam, the Netherlands Department of Epidemiology, Harvard T.H.[content.iospress.com]
  • BACKGROUND: Previous epidemiologic studies have shown that low-density lipoprotein is an independent risk factor for prevalent aortic valve calcification (AVC); however, to our knowledge, the interactions between plasma lipoprotein concentrations and[ncbi.nlm.nih.gov]
  • Natural history, epidemiology, and prognosis of aortic stenosis. . Accessed April 18, 2017. Zakkar M, et al. Aortic stenosis: Diagnosis and management. BMJ. 2016;355:1. Dweck M, et al.[mayoclinic.org]
  • ., a cardiologist and associate professor of medicine and epidemiology at the Johns Hopkins University School of Medicine who is a senior author of the study.[hopkinsmedicine.org]
Sex distribution
Age distribution

Pathophysiology

  • The scope of the present review is to summarize the clinical data and the pathophysiological mechanisms potentially involved in the link between renal function decline and the progression of aortic valve disease.[ncbi.nlm.nih.gov]

Prevention

  • CHOP deficiency prevents oxLDL-induced VIC osteoblastic differentiation via preventing VIC-derived ABs releasing. 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.[ncbi.nlm.nih.gov]

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