Aphthous Stomatitis (Aphthae)


    Aphthous stomatitis is a pathological condition which consists in the appearance of benign and non-contagious ulcers in the oral cavity.

    Aphthous Stomatitis originates from this process: infectious.


    Regardless of the clinical form, ulcers always appear in the same location inside the mouth of the affected individual: the non-keratinized area of the mucosa. Therefore, parts such as tongue dorsum, gums, and hard palate mucosa, all keratinized structures, are never touched by ulceration.

    As previously stated, AS tends to affect healthy individuals who are present by no particular clinical condition. The ulcers generally appear during childhood or early adulthood, with 80% of the patients being younger than 30 years, and its frequency and severity tend to decrease with the passing of years. The condition might consist in isolated episodes which usually develop 2-4 times a year, but it might also show a continuous pattern that involves the constant formation of new lesions from older ones soon after healing. Lesions are generally characterized by a disproportionate pain lasting for 4-7 days. The appearance of ulcers is usually preceded by a prodrome of pain and burning which generally lasts for 1-2 days with no previous vesicles. Ulcers present as shallow and well-demarcated bodies with an oval or round shape at the center of which can be seen a yellow-gray pseudo-membrane associated with a red halo and a slightly raised margins of red color.

    The most common clinical form is the minor aphthous ulcer which accounts for around 80-85% of cases. The lesions tend to appear on the buccal mucosa and pharynx, on the floor of the mouth or the lateral and ventral positions of the tongue, with a diameter smaller than 1 cm. They heal within 10 days leaving no sign of scarring.

    Major aphthous ulcers, on the other hand, represents 10% of the cases of AS and generally sets in after puberty. The main aspect of this form is the tendency of presenting with marked clinical features, with a more intense prodrome and a longer appearance period that usually lasts for several weeks or months. Their size is greater than seen in the minor form, with a diameter generally larger than 1 cm. Major ulcers tend to appear on the soft palate, lips, and throat and might be associated with fever, malaise, dysphagia, and scars.

    Lastly, herpetiform aphthous ulcers represent the least common clinical form that accounts for around 5% of the cases of AS. The lesions are much smaller, with a diameter generally ranging between 1 and 3 mm, and they tend to appear in multiple clusters of small and painful ulcers throughout the inside of the month. After a while they tend to coalesce, to turn into lager ulcers which generally disappear after 2 weeks. For this last clinical form a gender-related predisposition has been observed, with lesions more frequently occurring in women than men, usually at a later stage than the one observed in the other forms.

    Jaw & Teeth
    Aphthous Stomatitis
    • Acrodynia (Pink disease): Oral and perioral ulceration, hypersalivation, gingivitis and early tooth loss are features of acrodynia caused by mercury poisoning, now rarely seen.[]
    Lesion of the Tongue
    • If there are lesions on the tongue, speaking and chewing can be uncomfortable, and ulcers on the soft palate, back of the throat, or esophagus can cause painful swallowing.[]
    • Pain is worst in the days immediately following the initial formation of the ulcer, and then recedes as healing progresses. [3] If there are lesions on the tongue, speaking and chewing can be uncomfortable, and ulcers on the soft palate , back of the[]
    Sore Mouth
    • Mouth Ulcer Treatment Aphthous stomatitis, aka mouth ulcers, can be very painful.[]
    • Mouth rinses, which have the steroid dexamethasone, are prescribed for multiple canker sores.[]
    • Called also chronic atrophic candidiasis and denture sore mouth . gangrenous stomatitis see noma . herpetic stomatitis herpes simplex involving the oral mucosa and lips, characterized by the formation of yellowish vesicles that rupture and produce ragged[]
    Tongue Ulcer
    • Symptoms may include: Ulcers in the mouth, usually inside the lips, on the cheeks, or on the tongue Ulcers that are covered with a yellow layer and have a red base No fever present (in most cases) Lesions usually heal in seven to 14 days Lesions tend[]
    • Symptoms include: Painful ulcers in the mouth, usually inside the lips, on the cheeks, or on the tongue Ulcers that are covered with a yellow layer and have a red base No fever present (in most cases) Lesions usually heal in seven to 14 days Lesion tend[]
    • Signs and symptoms may include: Ulcers in the mouth, usually inside the lips, on the cheeks, or on the tongue Ulcers that are covered with a yellow layer and have a red base No fever present (in most cases) Lesions usually heal in seven to 14 days Lesions[]
    • Symptoms may include: Ulcers in the mouth, usually inside the lips, on the cheeks, or on the tongue Ulcers that are covered with a yellow layer and have a red base For the full article:[]
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  • Entire body system
    Reiter's Syndrome
    • Moreover, recurrent aphthae is often erroneously confused with herpes simplex infection and it may have clinical and histological aspects in common with Behcet's, Stevens-Johnson, and Reiter's syndrome.[]
    • Seems like reiters syndrome will fUse many of the same...[]
    • Reiter's syndrome Ulcers Conjunctivitis Keratoderma blenorrhagica Other oculomucocutaneous syndromes: ulcerative colitis, herpes simplex, syphilis, lupus erythematosus and mixed connective tissue disease.[]
    • ., Reiter syndrome), and HIV/AIDS.[]
    • Non-oral symptoms of Behçet's syndrome may be present in 43 to 100 percent of patients with recurrent aphthous ulcers, depending on severity. 6 Reiter's syndrome is associated with oral ulcers, uveitis, conjunctivitis and HLA B27-positive arthritis following[]
    Relapsing Polychondritis
    • O’Duffy Mouth and genital ulcers with inflamed cartilage: MAGIC syndrome, Five patients with features of relapsing polychondritis and Behçet's disease Am J Med, 79 (1985), pp. 65-72 55 S.R.[]
    • The name stands for "mouth and genital ulcers with inflamed cartilage" (relapsing polychondritis).[]
    • The name stands for "mouth and genital ulcers with inflamed cartilage" ( relapsing polychondritis ). [9] PFAPA syndrome is a rare condition that tends to occur in children. [9] The name stands for "periodic fever , aphthae, pharyngitis (sore throat) and[]
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  • Workup

    The diagnosis of AS can generally be performed by using the following laboratory studies:

    • Complete blood cell count, usually employed to determine hemoglobin concentration and the levels of glucose-6-phosphate dehydrogenase and glycemia. 
    • Measurement of the levels of iron, folate, ferritin, and vitamins B-6 and B-12 [8]
    • Measurement of erythrocyte sedimentation rate
    • Laboratory tests like Tzanck test, viral culture, or skin biopsy. These tests are necessary to rule out the presence of simplex virus infection, especially in immunocompromised individuals diagnosed with HIV. 

    Because of the lack of definitive histological features and tests, diagnosis is invariably made by an exclusion process based on the clinical history and lesion presentation [9].


    Helicobacter Pylori
    • Lack of association between aphthous ulcers and Helicobacter pylori [Letter].[]
    • Am J Otolaryngol 21:389–393 PubMed Google Scholar Shimoyama T, Horie N, Kato T et al (2000) Helicobacter pylori in oral ulcerations.[]
    • Farmakis Outcome following treatment for Helicobacter pylori in patients with recurrent aphthous stomatitis 19 F.[]
    Human Herpesvirus 6
    • Bagg Detection of serum antibodies against cytomegalovirus, varicella zoster virus and human herpesvirus 6 in patients with recurrent aphthous stomatitis J Oral Pathol Med, 28 (1999), pp. 12-15 20 D.[]
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  • Treatment

    There is a variety of agents that are used to treat recurrent aphthous ulcers. These range from agents with palliative effects to those which shorten the healing time [10] [11] and prevent recurrence. Topical agents include:

    • Anti-inflammatory and immunomodulatory agents: These are used immediately, at the beginning of the treatment, and generally include a variety of different products such as topical gels, creams, ointments, and sprays. 
    • Adjuvant rinses: These have proven to reduce the presence of pathogens inside the mouth, and are thought to lower inflammatory levels and healing time. The most important products include chlorhexidine gluconate and diluted hydrogen peroxide.
    • Oral bioadherents: They are generally used to reduce pain, which sometimes might be very severe and disproportionate compared to the size of lesions. The mucoadhesives form a protective coating which alleviates pain. 

    Systemic agents include:

    • Colchicine: This medication is commonly used to treat gout and was originally extracted from the plants of the genus Colchicum.
    • Prednisone: This is a corticosteroid used as an alternative for Colchicine. 
    • Azathioprine: This is an immunosuppressive drug used in organ transplantation and autoimmune diseases.
    • Montelukast sodium: This is an active leukotriene receptor antagonist which has been reported having few adverse effects, especially when compared to steroids [12]. 
    • Thalidomide: This is an immunomodulatory drug especially used to treat individuals affected by HIV infection
    • Clofazimine: This is a fat-soluble iminophenazine dye used in multidrug therapy to treat leprosy. This drug is especially indicated in those showing the tendency of continuously experiencing the appearance of new lesions [13].

    There is no surgical approach to treat recurrent aphthous ulcers [14]. Diet modifications are strongly suggested, as outbreaks of AS might be caused by allergic stimuli whose frequency can be drastically reduced, for not saying eliminated at all, with finely chosen food changes [15] [16] [17].

    The mainstay for the treatment for AS is undoubtedly represented by the use of chlorhexidine gluconate mouthwashes and topical corticosteroids. These should be applied during prodrome, so that clinical signs can be reduced before their development. The corticosteroid dexamethasone 0.5 mg/5 mL is particularly effective in rinses, generally followed by the use of ointments like clobetasol ointment 0.05% or fluocinonide ointment 0.05% in mucosal protective paste. If topical corticosteroids turn out to be ineffective to treat ulcers, they may be replaced by prednisone which is usually administered in doses of 40 mg once a day in a 5 days treatment. Severe cases are best treated with systemic corticosteroids and immunosuppressants. Some agents can even be administered intralesionally, especially with betamethasone, dexamethasone, or triamcinolone.


    AS frequently tends to appear in healthy individuals, with no particular clinical consequences. However, in some cases it might be associated with a systemic disease like Behcet's syndrome or inflammatory bowel disease, in a clinical situation which might easily result into a significant morbidity or mortality.


    Behçet Disease
    • During the follow-up period, we observed the other cardinal signs of the Behçet's disease.[]
    • Anti-TNF agents for Behçet's disease: análisis of publisher data on 369 patients.[]
    • Behçet's disease is a triad of mouth ulcers, genital ulcers and anterior uveitis.[]
    • ’s disease and for disease shift from recurrent aphthous stomatitis to mucocutaneous type of Behçet’s disease.[]
    • It is imperative that these patients be evaluated to rule out Behçet disease as well as inflammatory bowel disease.[]
    Bullous Pemphigoid
    • Lupus erythematosus, bullous pemphigoid and pemphigus vulgaris are other diseases that may involve ulceration of the mouth.[]
    Celiac Disease
    • View Article PubMed Google Scholar Catassi C: [The global village of celiac disease].[]
    • Screening for celiac disease may also need to be ruled out.[]
    • NSGU is more likely than simple oral aphthosis to be associated with systemic illness, such as: Behcet syndrome Gluten-sensitive enteropathy (celiac disease) Inflammatory bowel disease Human immunodeficiency virus ( HIV ) infection .[]
    • Sometimes aphthous-like ulcerations can be the only sign of celiac disease.[]
    Crohn's Disease
    • Blood tests may include: Blood count, iron, B12 and folate studies Gluten antibody tests for celiac disease Faecal calprotectin test for Crohn disease Swabs for microbiology evaluate the presence of Candida albicans, Herpes simplex virus and Vincent's[]
    • Other conditions cause similar sores: Blood and immune system diseases, including HIV Vitamin and mineral deficiencies Allergies Trauma Crohn's disease Lupus Canker sores are often confused with cold sores.[]
    Erythema Multiforme
    • multiforme , and fixed drug eruption .[]
    • Erythema multiforme Erosions Erosions Target (iris) lesions 4.[]
    • Other examples of systemic conditions associated with aphthous-like ulceration include reactive arthritis (Reiter's syndrome), and recurrent erythema multiforme.[]
    • multiforme, ulceration associated with gastrointestinal disease, [11] [18] and recurrent intra-oral herpes simplex infection.[]
    Hand, Foot and Mouth Disease
    • Mouth ulcers can be caused by other conditions (such as contact dermatitis , herpes infection , hand-foot-and-mouth disease , and lupus) that may need treatment so they should always be seen by a physician for a diagnosis.[]
    • Oculomucocutaneous syndromes: (see table above) Other causes: (see table below) Other causes of oral ulcers Viral infections: Herpes simplex stomatitis, chickenpox and herpes zoster, hand, foot and mouth disease, herpangina (Coxsackie viruses), infectious[]
    • , foot and mouth disease Hereditary benign intraepithelial dyskeratosis Herpangina Herpes zoster Intraoral dental sinus Leukoedema Leukoplakia Lichen planus Linea alba Lupus erythematosus Melanocytic nevus Melanocytic oral lesion Molluscum contagiosum[]
    Herpes Labialis
    • Objectives Prevention Adult Caries Root Caries Gingivitis Periodontitis Tooth Changes with Aging Tooth Loss Oral Effects of Medications Gingival Hyperplasia Dental Erosions Xerostomia Alcohol & Tobacco Meth Mouth Common Oral Lesions Chapter Objectives Herpes[]
    • External links [ edit ] Aphthous stomatitis at DMOZ v t e Oral and maxillofacial pathology ( K00–K06, K11–K14 , 520–525, 527–529 ) Lips Cheilitis Actinic Angular Plasma cell Cleft lip Congenital lip pit Eclabium Herpes labialis Macrocheilia Microcheilia[]
    Lichen Planus
    • Planus Leukoplakia & Erythoplakia Oral Cancer Oral Cancer:Treatment Denture Problems Prophylaxis & Anticoagulation Chapter Objectives Coordination of Care Endocarditis Prophylaxis Conditions Procedures Dosing Implanted Devices Managing Anticoagulation[]
    • planus, epidermolysis bullosa acquisita Oral squamous cell carcinoma and other oral malignant primary or metastatic neoplasms Leukaemia and neutropenia Vasculitis , e.g.[]
    • ., lichen planus, pemphigus, pemphigoid) THE AUTHOR Dr. []
    • Association between psychological disorders and the presence of Oral lichen planus, Burning mouth syndrome and recurrent aphthous stomatitis.[]
    • Eversole Immunopathogenesis of oral lichen planus and recurrent aphthous stotamitis Semin Cutan Med Surg, 16 (1997), pp. 284-294 9 M.[]
    • Pemphigus Erosions Erosions Multiple flaccid bullae 6.[]
    • ., lichen planus, pemphigus, pemphigoid) THE AUTHOR Dr. []
    • Lupus erythematosus, bullous pemphigoid and pemphigus vulgaris are other diseases that may involve ulceration of the mouth.[]
    • Keratoacanthoma Malignant: Adenosquamous carcinoma Basaloid squamous carcinoma Mucosal melanoma Spindle cell carcinoma Squamous cell carcinoma Verrucous carcinoma Oral florid papillomatosis Oral melanosis Smoker's melanosis Pemphigoid Benign mucous membrane Pemphigus[]
    • Such deposits are characteristic for certain autoimmune-mediated vesiculo-bullous diseases, like Pemphigus vulgaris and Pemphigoid .[]
    • Aphthous stomatitis at DMOZ[]
    • Aphthous stomatitis is not contagious.[]
    • […] oraal , orale aften , afte , orale aftoïde ulcus , zweren aftoïd oraal , stomatitis aftoïd , aftoïde stomatitis , aften; oraal , aften; stomatitis , aften; ulcus , aphthosa; stomatitis , aphthosum; ulcus , oraal; aften , stomatitis; aften , stomatitis[]
    • […] aphthous stomatitis in Medicine aphthous stomatitis n.[]
    • The two main forms of stomatitis are herpes stomatitis, also known as a cold sore, and aphthous stomatitis, also known as a canker sore.[]
    Systemic Lupus Erythematosus
    • Behçet syndrome , systemic lupus erythematosus , and inflammatory bowel disease are systemic diseases associated with oral recurrent aphthous ulcers.[]
    • As previously stated, AS frequently affects healthy individuals, even though in some cases it might be associated with other pathological conditions such as Behcet's syndrome or systemic lupus erythematosus.[]
    • Rothfield The 1982 revised criteria for the classification of systemic lupus erythematosus Arthritis Rheum, 25 (1982), pp. 1271-1277 44 Criteria for diagnosis of Behçet's disease.[]
    Ulcerative Colitis
    • Gastrointestinal disease: pernicious anaemia, coeliac disease and dermatitis herpetiformis (rare in DH), Crohn's disease and ulcerative colitis.[]
    • Patients with an underlying deficiency state or systemic disease that could cause recurrent mouth ulcers e.g. iron, vitamin B12 or foliate deficience, coeliac disease, Crohn's disease, ulcerative colitis, Behcet's disease or Aids.[]
    • Colitis, Crohn's disease, Behçet's syndrome or serious anemia. 4- Treatment with systemic steroids, immunomodulatory agents, antibiotics, non-steroidal anti-inflammatory drugs (except occasional use for headaches) one month prior to the study entry.[]
    • Certain medical conditions may also cause canker sores, such as celiac disease , Crohn's disease , ulcerative colitis , Behcet's disease and HIV/AIDS .[]
    • ., celiac disease, Crohn’s disease, ulcerative colitis), some viral and bacterial infections, mechanical injuries and stress.[]
    Vitamin B12 Deficiency
    • Approaches to vitamin B12 deficiency.[]
    • The relationship to vitamin B12 deficiency has been the subject of many studies.[]
    • Although these studies found that 0–42% of those with recurrent ulcers suffer from vitamin B12 deficiency, an association with deficiency is rare.[]
    Wegener Granulomatosis
    • Wegener's granulomatosis Cytotoxic agents as methotrexate Irradiation of oral mucosa There are three main clinical types of RAS: Minor aphthous ulcers Major aphthous ulcers Herpetiform ulceration Age of onset Childhood or adolescence Childhood or adolescence[]
    • Wegener's granulomatosis: oral or nasal inflammation to the development of painful or painless oral ulcers or purulent or bloody nasal discharge. 45 4.[]
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  • Etiology

    Unfortunately, despite the clear clinical characterization that has been defined over the course of the years, the etiology of AS is still unknown, and no precise cause responsible for its appearance can be suggested. However, the most commonly accepted theory among experts is that AS must be a multifactorial condition which originates from immune-related events that cause the self-destruction of the oral epithelium. The destruction is mostly cell-mediated, with the intervention of cytokines like IL-2, IL-10, and in particular TNF-α, all well known inflammatory mediators playing a pivotal role in the functioning of the immune system.

    Of note, many individuals affected by AS show hematinic deficiencies, especially in terms of low levels of iron, folic acid, and vitamins B-6 and B-12 [1], which appear twice as frequently as in healthy individuals. Furthermore, the pathological condition seems to run in certain families, as suggested by the high appearance frequency in identical twins [2], and this tendency might underline the involvements of genetic factors in the etiology of AS.


    In America, AS appears to affect around 20% of the population, even though it seems to be particularly frequent in certain social groups, such as the students of professional schools. Strangely enough, the condition is more common among children with a high socioeconomic background [6]. Internationally, AP affects all populations in every continent, with an international frequency that ranges from 2 to 66% according to the particular country considered [3]. There is no evident gender-related predisposition, even though in particular social groups the pathology might be much more common in females than males. In America, around 1% of the children can be affected by recurrent AS, with an early onset which generally appears before the age of 5 years. The percentage of affected individuals tends to decrease after reaching the age of 30. In other individuals, the onset of AS might take place after puberty and generally tends to persist for the rest of their life, although less frequently. To sum up, AP primarily affects young individuals, but its incidence and severity tends to decrease over the years [4] [5] [6] [7].

    Sex distribution
    Age distribution


    Thanks to the clinical data gathered so far, it is now possible to categorize aphthous ulcers into three main clinical forms: recurrent aphthous ulcer minor, recurrent aphthous ulcer major, and herpetiform recurrent aphthous ulcer.

    The most common of these forms is recurrent aphthous ulcer minor, which appears as a discrete, shallow, and painful lesion usually smaller than 1 cm in diameter. There might be just one minor ulcer present in the mouth at a time, but frequently more than one is observed. This clinical form accounts for more than 80% of the AS cases.

    Recurrent aphthous ulcer major, on the other hand, is much less common than the minor form. It presents in an oval shape and its diameter is usually greater than 1 cm. In this form, there might be many lesions in the mouth at a time. These are large and deep ulcers with irregular borders that may coalesce after a while.

    Herpetiform recurrent aphthous ulcer is the least common form, with a frequency of around 5-10%. It is characterized by a reduced size that is usually no larger than 1 mm in diameter. For this reason, sometimes it is possible to observe the appearance of this clinical form with the development of tiny ulcers in clusters of tens or hundreds of units which might be localized in certain points or be spread throughout the oral soft mucosa.


    Outbreak of aphthae might be prevented with a gluten-free diet in celiac patients. Those who already have lesions in their mouth are advised to avoid hard and sharp foods, to prevent worsening the conditions of the already existing ulcers or the formation of new ones. Furthermore, affected individuals should also evade salt and hot spices, which might increase the already severe pain that  characterizes AS. In this regards, it is worth noting that the appearance of aphthae has been reported after the ingestion of cinnamon, nuts, and pineapples, which might act as inciting agents.

    According to some studies, there is an association between smoking and the occurrence of AS, which might be reduced by using tobacco. For example, the incidence of recurrent aphthous ulcer is significantly lower in smoking people than the incidence observed in non smokers [18] [19]. This tendency is explained with the capacity of tobacco to increase keratinization in the mucosa, which as a consequence might remain much less exposed to ulceration. In other words, nicotine that is locally absorbed, might work as a preventing agent against the formation of lesions.


    Aphthous stomatitis (AS) is also referred to as recurrent aphthous ulcers (RAU) or canker sores. This type of ulceration represents one of the most common mucosal lesions, usually found even in healthy individuals affected by no other pathological condition. Although AS is characterized by a clinically significant morbidity, its etiology remains generally unknown. The lesions consist of ulcers which appear on the mucous membranes inside the oral cavity for 7 to 10 days. Some lesions might even last for several weeks, leaving scars after the completion of the healing process.

    Generally speaking, the activity for idiopathic recurrent aphthous ulcers is self-limiting, but in some cases it might appear as a continuous process. Furthermore, similar lesions can be seen in the genital region. As previously stated, AS frequently affects healthy individuals, even though in some cases it might be associated with other pathological conditions such as Behcet's syndrome or systemic lupus erythematosus.

    Patient Information

    Aphthous stomatitis (canker sores, or aphthous ulcers) is a pathological condition characterized by the presence of small and painful ulcers inside the mouth which usually appears in childhood and tends to recur over the course of the years. This condition is common, but its origin is still unknown, even though it tends to run in families. However, many experts believe that this is a multifactorial pathology which might be favored or triggered by several factors such as oral injuries, stress and certain foods. Symptoms include pain and burning in the initial stage, that is then followed by a ulcer after a few days. Pain is disproportionally severe and usually lasts from 4 to 7 days. The lesions present as soft and loose formations, usually less than 1 cm in diameter, and frequently gather in clusters of two or more units. Ulcers tend to disappear by themselves within 7-10 days leaving no scar on the oral tissue affected. Treatment is palliative and based on general measures such as the use of corticosteroid combined with frequent rinses.


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    1. Kozlak ST, Walsh SJ, Lalla RV. Reduced dietary intake of vitamin B12 and folate in patients with recurrent aphthous stomatitis. J Oral Pathol Med. 2010 Feb 7.
    2. Miller MF, Garfunkel AA, Ram C, Ship II. Inheritance patterns in recurrent aphthous ulcers: twin and pedigree data. Oral Surg Oral Med Oral Pathol. 1977 Jun. 43(6):886-91.
    3. Axéll T, Henricsson V. The occurrence of recurrent aphthous ulcers in an adult Swedish population. Acta Odontol Scand. 1985 May. 43(2):121-5.
    4. Vincent SD, Lilly GE. Clinical, historic, and therapeutic features of aphthous stomatitis. Literature review and open clinical trial employing steroids. Oral Surg Oral Med Oral Pathol. 1992 Jul;74(1):79-86.
    5. Natah SS, Konttinen YT, Enattah NS, Ashammakhi N, Sharkey KA, Häyrinen-Immonen R. Recurrent aphthous ulcers today: a review of the growing knowledge. Int J Oral Maxillofac Surg. 2004 Apr;33(3):221-34.
    6. Kleinman DV, Swango PA, Niessen LC. Epidemiologic studies of oral mucosal conditions--methodologic issues. Community Dent Oral Epidemiol. 1991 Jun;19(3):129-40.
    7. Reichart PA. Oral mucosal lesions in a representative cross-sectional study ofaging Germans. Community Dent Oral Epidemiol. 2000 Oct;28(5):390-8.
    8. Rogers RS 3rd, Hutton KP. Screening for haematinic deficiencies in patients with recurrent aphthous stomatitis. Australas J Dermatol. 1986 Dec. 27(3):98-103.
    9. Scully C, Gorsky M, Lozada-Nur F. The diagnosis and management of recurrent aphthous stomatitis: a consensus approach. J Am Dent Assoc. 2003 Feb;134(2):200-7.
    10. Alidaee MR, Taheri A, Mansoori P, Ghodsi SZ. Silver nitrate cautery in aphthous stomatitis: a randomized controlled trial. Br J Dermatol. 2005 Sep. 153(3):521-5.
    11. Brice SL. Clinical evaluation of the use of low-intensity ultrasound in the treatment of recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997 Jan. 83(1):14-20.
    12. Femiano F, Buonaiuto C, Gombos F, Lanza A, Cirillo N. Pilot study on recurrent aphthous stomatitis (RAS): a randomized placebo-controlled trial for the comparative therapeutic effects of systemic prednisone and systemic montelukast in subjects unresponsive to topical therapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Mar. 109(3):402-7.
    13. de Abreu MA, Hirata CH, Pimentel DR, Weckx LL. Treatment of recurrent aphthous stomatitis with clofazimine. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Nov. 108(5):714-21.
    14. Arikan OK, Birol A, Tuncez F, Erkek E, Koc C. A prospective randomized controlled trial to determine if cryotherapy can reduce the pain of patients with minor form of recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Jan. 101(1):e1-5.
    15. Eversole LR, Shopper TP, Chambers DW. Effects of suspected foodstuff challenging agents in the etiology of recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol. 1982 Jul. 54(1):33-8.
    16. Hay KD, Reade PC. The use of an elimination diet in the treatment of recurrent aphthous ulceration of the oral cavity. Oral Surg Oral Med Oral Pathol. 1984 May. 57(5):504-7.
    17. Wright A, Ryan FP, Willingham SE, et al. Food allergy or intolerance in severe recurrent aphthous ulceration of the mouth. Br Med J (Clin Res Ed). 1986 May 10. 292(6530):1237-8.
    18. Axell T, Henricsson V. Association between recurrent aphthous ulcers and tobacco habits. Scand J Dent Res. 1985 Jun. 93(3):239-42.
    19. Bittoun R. Recurrent aphthous ulcers and nicotine. Med J Aust. 1991 Apr 1. 154(7):471-2.

    • Clinical, historic, and therapeutic features of aphthous stomatitis: Literature review and open clinical trial employing steroids - SD Vincent, GE Lilly - Oral surgery, oral medicine, oral pathology, 1992 - Elsevier
    • Burning mouth syndrome and peripheral neuropathy in patients with type 1 diabetes mellitus - PA Moore, J Guggenheimer, T Orchard - Journal of diabetes and its , 2007 - Elsevier
    • Aphthous ulceration - C Scully - New England Journal of Medicine, 2006 - Mass Medical Soc
    • Detection of Helicobacter pylori DNA in recurrent aphthous stomatitis tissue by PCR - MP Riggio, A Lennon, D Wray - Journal of oral pathology & , 2002 - Wiley Online Library
    • Association between Helicobacter pylori and recurrent aphthous stomatitis in children and adolescents - AMG Fritscher, K Cherubini, J Chies - Journal of oral , 2004 - Wiley Online Library
    • A double-blind study of topically applied 5% amlexanox in the treatment of aphthous ulcers - RO Greer, JE Lindenmuth, T Juarez - Journal of oral and , 1993 - Elsevier

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