Reticulolinear aplasia cutis congenita on the face and neck is a distinctive cutaneous manifestation in several syndromes linked to band Xp22. Pathophysiology The exact pathophysiology of aplasia cutis congenita (ACC) is unclear. [emedicine.medscape.com]

A female infant was born with an extensive defect of the skin, a skull defect, imperforate hymen, and some other anomalies. She died soon after birth probably due to asphyxia and dehydration. [ncbi.nlm.nih.gov]

The newborn had multifocal aplasia cutis congenita involving the head, trunk, and limbs with cerebral ischemic changes demonstrated by imaging. The newborn had a monochorionic twin fetus papyraceus. The array cytogenetic analysis was normal. [ncbi.nlm.nih.gov]