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Arcanobacterium Infection

Presentation

[…] rash is present; usually maculopapular, but may be scarlatiniform.3 The rash begins peripherally on extensor surfaces of the extremities and spreads centrally sparing the face, palms, and soles. [accesspediatrics.mhmedical.com]

The patient presented fever which ranged from 37.6 to 38.5 °C. A throat culture was obtained; in the bacteriological culture, A. Haemolyticum was identified. [ncbi.nlm.nih.gov]

Patients present with a sore throat, pharyngeal erythema, fever, exanthema, and swollen lymph nodes. [statpearls.com]

One week after the last debridement, the patient presented to the emergency department with fever, hypotension, and severe left foot pain. [liebertpub.com]

The various clinical presentations include chronic wound infection, ankle joint infection, foot ulcer and osteomyelitis. [jacmjournal.org]

Entire Body System

  • Falling

    The droplets can fall onto hands and then get into eyes and noses. [healthychildren.org]

  • Intravenous Drugs

    European Journal of Clinical Microbiology & Infectious Diseases (1995) 14:1085–1088 Google Scholar Chandrasekar PH, Molinari JA:Corynebacterium hemolyticum bacteremia with fatal neurologic complication in an intravenous drug addict. [link.springer.com]

    Eur J Clin Microbiol Infect Dis. 1995, 14 (12): 1085-1088. 10.1007/BF01590944 Article CAS PubMed Google Scholar Chandrasekar PH, Molinari JA: Corynebacterium hemolyticum bacteremia with fatal neurologic complication in an intravenous drug addict. [ann-clinmicrob.biomedcentral.com]

Musculoskeletal

  • Fracture

    Journal of Infectious Diseases (1990) 162:780–781 Google Scholar Procek J, Hlava H: Pyogenic Corynebacterium as a pathogen in osteomyelitis following a fracture. [link.springer.com]

Workup

Microbiology

  • Listeria Monocytogenes

    Otherwise, A. haemolyticum can be mis-identified as group B Streptococcus or Listeria monocytogenes. [liebertpub.com]

Treatment

There may be variations in treatment that your pediatrician may recommend based on individual facts and circumstances. [healthychildren.org]

In this particular case, treatment failure with amoxicillin/clavulanic acid before entrance warned about the possibility of treatment failure with any β-lactam. [elsevier.es]

High doses of penicillin, with or without gentamicin, it is recommended for the treatment of deep infections. Palabras clave : Arcanobacterium haemolyticum; Infections; Review; Microbiology; Diagnosis; Treatment. [scielo.isciii.es]

[…] an adequate clinical response within 10 days of treatment. [ncbi.nlm.nih.gov]

Prognosis

Its treatment consists of supportive care and antibiotics, resulting in a good prognosis without any long-term sequelae when recognized and treated promptly. [statpearls.com]

Etiology

The natural history of the disease may be self-limiting or require antibiotic treatment.[3] Etiology Cultures of A. haemolyticum can be detected as a part of normal skin flora and pharynx of healthy individuals. [statpearls.com]

Epidemiology

Medicine, Biology Microbiology Research Journal International 2018 The observed increase in the number of Corynebacterium species isolated from urine samples over the years indicates the important role of these bacteria in the urinary tract infection epidemiology [semanticscholar.org]

Objectives: Describe the epidemiology of Arcanobacterium haemolyticum in various populations. Outline the evaluation of Arcanobacterium haemolyticum. Review the management of patients with Arcanobacterium haemolyticum. [statpearls.com]

EPIDEMIOLOGY Man is the primary environmental reservoir. Although it has been identified as a commensal of the human pharyngeal flora, isolation from the nasopharyngeal microbiota of asymptomatic patients is infrequently reported. [antimicrobe.org]

Prevention

Infection prevention measures were implemented in a bundled approach, involving education, better aseptic wound care conditions and hygienic precautions. [journalofhospitalinfection.com]

Organisms are not typically observed.8 Treatment and Prevention No prospective randomized study has established efficacy of antimicrobial treatment for A haemolyticum infection.1,3 In infected patients without antibiotic therapy, symptoms can last for [accesspediatrics.mhmedical.com]

Patients should be educated on symptoms and methods of prevention such as hand washing, covering mouth when coughing, sharing utensils, social distancing, and etc. when symptomatic. [statpearls.com]

In cases where the site of infection may prevent adequate drug penetration, such as endocarditis and osteomyelitis, macrolides or clindamycin in combination with rifampin might be preferable to beta-lactam antibiotics. [antimicrobe.org]

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