Presentation
Intermediate stages like viral seeds and cell culture bank management, bulk vaccine manufacture, and finished product processing are also separately presented in terms of Production and Quality Control/Quality Assurance requirements, under the Adminitracion [ncbi.nlm.nih.gov]
Collection includes both citations and many full-text, downloadable documents from mid-1900s to present. AULIMP - Air University Library Index to Military Periodicals. [dtic.mil]
Reference is made to different research strategies used to obtain anti-AHF vaccines in the past and anti-arenaviral diseases in the present. [doi.org]
Entire Body System
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Fever
Human Diseases: Epidemiology, Treatment, Pathogenesis, and Diagnosis 73 Downloads 36 Citations Keywords Endemic Area Hemorrhagic Fever Progressive Extension Argentine Hemorrhagic Fever These keywords were added by machine and not by the authors. [dx.doi.org]
Weissenbacher MC, Laguens RP, Coto CE (1987) Argentine hemorrhagic fever. Curr Top Microbiol Immunol 134:79–116 PubMed Google Scholar 6. [doi.org]
KEYWORDS: Arenaviridae; Arenavirus vaccines; Argentinian hemorrhagic fever; Attenuated viral vaccines; Junin virus [ncbi.nlm.nih.gov]
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High Fever
As the disease progresses, the victim may develop a high fever, dehydration, hypotension, flushed skin, abnormally slow heartbeat, bleeding from the gums and internal tissues, hematuria, and hematemesis. [medical-dictionary.thefreedictionary.com]
As the disease progresses, the person may develop a high fever, dehydration, hypotension, flushed skin, abnormally slow heartbeat, or bleeding from the gums and internal tissues. [diseaseinfosearch.org]
Their symptoms vary, but most often include high fever, dizziness and fatigue. Some people will develop internal bleeding and neurological complications, such as delirium and seizures. [ncnp.org]
Body systems harmed by Argentine hemorrhagic fever Severe cases of AHF may progress to: Shock Pulmonary edema Diffuse mucosal hemorrhaging Meningoencephalitis with convulsions As the disease progresses, the patient may develop a high fever, dehydration [naturalpedia.com]
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Fatigue
[…] likely means of dissemination: Solid, liquid, or aerosol Primary route of entry: Absorption, inhalation, ingestion General signs and symptoms: Vary by type of viral hemorrhagic fever (VHF), but initial signs and symptoms often include marked fever, fatigue [labce.com]
Their symptoms vary, but most often include high fever, dizziness and fatigue. Some people will develop internal bleeding and neurological complications, such as delirium and seizures. [ncnp.org]
Symptoms often include: Fever Fatigue Dizziness Muscle aches Loss of strength Exhaustion People with severe cases often show signs of bleeding. This may be under the skin, in internal organs, or from body openings such as the mouth, eyes, or ears. [hopkinsmedicine.org]
Specific signs and symptoms vary by the type of VHF, but initial signs and symptoms often include: Fever Fatigue Dizziness Muscle aches Loss of strength Exhaustion Patients with severe cases of VHF often show signs of bleeding under the skin, in internal [southernnevadahealthdistrict.org]
Gastrointestinal
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Nausea
Initially, it is characterized by chills, fever, headache, myalgia, anorexia, nausea, vomiting, and a general feeling of malaise. [medical-dictionary.thefreedictionary.com]
Symptoms of the virus may include chills, fever, headache, dizziness, chest pain, back pain, abdominal pain, sore throat, nausea, vomiting, and a general feeling of malaise (tiredness and feelings of not being well, being uncomfortable and weak). [diseaseinfosearch.org]
Initial side effects of AHF may include: Fever Malaise Dizziness Myalgias/muscle pain Skin dysesthesia/abnormal sense of touch Oral ulcerations Llymphadenopathy Chest pain Back pain Abdominal pain Sore throat Headache Nausea Vomiting Cough Photophobia [naturalpedia.com]
These sorrel formulations may cause nausea or vomiting when taken with the prescription drugs metronidazole (Flagyl ) or disulfiram (Antabuse ). Avoid if pregnant or breastfeeding. [simplygoodnaturalfoods.com]
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Vomiting
Initially, it is characterized by chills, fever, headache, myalgia, anorexia, nausea, vomiting, and a general feeling of malaise. [medical-dictionary.thefreedictionary.com]
Symptoms of the virus may include chills, fever, headache, dizziness, chest pain, back pain, abdominal pain, sore throat, nausea, vomiting, and a general feeling of malaise (tiredness and feelings of not being well, being uncomfortable and weak). [diseaseinfosearch.org]
Initial side effects of AHF may include: Fever Malaise Dizziness Myalgias/muscle pain Skin dysesthesia/abnormal sense of touch Oral ulcerations Llymphadenopathy Chest pain Back pain Abdominal pain Sore throat Headache Nausea Vomiting Cough Photophobia [naturalpedia.com]
These sorrel formulations may cause nausea or vomiting when taken with the prescription drugs metronidazole (Flagyl ) or disulfiram (Antabuse ). Avoid if pregnant or breastfeeding. [simplygoodnaturalfoods.com]
Cardiovascular
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Hypotension
As the disease progresses, the victim may develop a high fever, dehydration, hypotension, flushed skin, abnormally slow heartbeat, bleeding from the gums and internal tissues, hematuria, and hematemesis. [medical-dictionary.thefreedictionary.com]
As the disease progresses, the person may develop a high fever, dehydration, hypotension, flushed skin, abnormally slow heartbeat, or bleeding from the gums and internal tissues. [diseaseinfosearch.org]
[…] systems harmed by Argentine hemorrhagic fever Severe cases of AHF may progress to: Shock Pulmonary edema Diffuse mucosal hemorrhaging Meningoencephalitis with convulsions As the disease progresses, the patient may develop a high fever, dehydration, hypotension [naturalpedia.com]
Musculoskeletal
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Myalgia
Initially, it is characterized by chills, fever, headache, myalgia, anorexia, nausea, vomiting, and a general feeling of malaise. [medical-dictionary.thefreedictionary.com]
Initial side effects of AHF may include fever, malaise, dizziness, and myalgias/muscle pain. Treatment with convalescent-phase plasma has been used with success in some patients with AHF. [naturalpedia.com]
Skin
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Flushing
[…] may include: Fever Malaise Dizziness Myalgias/muscle pain Skin dysesthesia/abnormal sense of touch Oral ulcerations Llymphadenopathy Chest pain Back pain Abdominal pain Sore throat Headache Nausea Vomiting Cough Photophobia Conjunctival redness Facial flushing [naturalpedia.com]
As the disease progresses, the victim may develop a high fever, dehydration, hypotension, flushed skin, abnormally slow heartbeat, bleeding from the gums and internal tissues, hematuria, and hematemesis. [medical-dictionary.thefreedictionary.com]
As the disease progresses, the person may develop a high fever, dehydration, hypotension, flushed skin, abnormally slow heartbeat, or bleeding from the gums and internal tissues. [diseaseinfosearch.org]
To save her from being mummified alive, they tried to flush out her abdominal cavity, according to TASS. [edition.cnn.com]
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Eczema
Use cautiously with a history of eczema. Avoid if pregnant or breastfeeding. Thyme : Thyme has been used medicinally for thousands of years. [simplygoodnaturalfoods.com]
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Petechiae
Dizziness Myalgias/muscle pain Skin dysesthesia/abnormal sense of touch Oral ulcerations Llymphadenopathy Chest pain Back pain Abdominal pain Sore throat Headache Nausea Vomiting Cough Photophobia Conjunctival redness Facial flushing Small axillary petechiae [naturalpedia.com]
Neurologic
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Headache
Initially, it is characterized by chills, fever, headache, myalgia, anorexia, nausea, vomiting, and a general feeling of malaise. [medical-dictionary.thefreedictionary.com]
Symptoms of the virus may include chills, fever, headache, dizziness, chest pain, back pain, abdominal pain, sore throat, nausea, vomiting, and a general feeling of malaise (tiredness and feelings of not being well, being uncomfortable and weak). [diseaseinfosearch.org]
The incubation time of the disease is between 10 and 12 days, after which the first symptoms appear: fever, headaches, weakness, loss of appetite and will. [wikidoc.org]
Initial side effects of AHF may include: Fever Malaise Dizziness Myalgias/muscle pain Skin dysesthesia/abnormal sense of touch Oral ulcerations Llymphadenopathy Chest pain Back pain Abdominal pain Sore throat Headache Nausea Vomiting Cough Photophobia [naturalpedia.com]
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Confusion
Short and intermittent patient contact by staff in protective clothing, with potentially confused patients, is the norm. [doi.org]
But the condition can quickly progress to shock, which is marked by falling blood pressure and body temperature, confusion, clotting abnormalities and bleeding into the skin. Blood poisoning is a medical emergency and can be fatal if left untreated. [simplygoodnaturalfoods.com]
Treatment
Treatments, management plans for Argentine hemorrhagic fever Patients diagnosed with viral hemorrhagic fevers (VHF) receive supportive therapy, but generally, there is no other treatment or established cure for VHFs. [naturalpedia.com]
Human Diseases: Epidemiology, Treatment, Pathogenesis, and Diagnosis 73 Downloads 36 Citations Keywords Endemic Area Hemorrhagic Fever Progressive Extension Argentine Hemorrhagic Fever These keywords were added by machine and not by the authors. [dx.doi.org]
AHF has had significant morbidity since its emergence in the 1950s, with a case-fatality rate of the illness without treatment between 15% and 30%. The use of a live attenuated vaccine has markedly reduced the incidence of AHF. [ncbi.nlm.nih.gov]
The initial introduction of treatment serums in the 1970s reduced this lethality. [wikidoc.org]
The initial introduction of treatment serums in the 1970s reduced this lethality. The Candid #1 vaccine for AHF was created in 1985 by Argentine virologist Dr. Julio Barrera Oro. [en.wikipedia.org]
Prognosis
Usually, the prognosis is complete recovery. See also Arenavirus, Bolivian hemorrhagic fever, Lassa fever. [medical-dictionary.thefreedictionary.com]
Natural History, Complications, and Prognosis AHF is a grave acute disease which may progress to recovery or death in 1 to 2 weeks. [wikidoc.org]
Etiology
Important achievements have been made in: (a) improvement of methods for the etiological diagnosis; (b) implementation and validation of therapeutical measures; (c) development of vaccines to protect against AHF. [ncbi.nlm.nih.gov]
In this report, we describe the development of an enzyme linked immunosorbent assay for the etiologic confirmation of the disease, based on recombinant antigens expressed in insect cells. [nora.nerc.ac.uk]
Summary Propagation of Junin virus, the etiological agent of Argentinian hemorrhagic fever, has been studied in a variety of cell cultures. [link.springer.com]
Epidemiology
Human Diseases: Epidemiology, Treatment, Pathogenesis, and Diagnosis 73 Downloads 36 Citations Keywords Endemic Area Hemorrhagic Fever Progressive Extension Argentine Hemorrhagic Fever These keywords were added by machine and not by the authors. [dx.doi.org]
A viral illness caused by the Junin arenavirus, named in 1953 after its city of isolation Epidemiology Transmitted by contact with rodent urine; 23 outbreaks have been recorded in the maize-producing region of Argentina Rodent vectors Akodon arenicola [medical-dictionary.thefreedictionary.com]
[…] ratio is 15%, but treatment reduces the mortality rate to 3 and a white blood cell (WBC) count of 3 had a sensitivity and specificity of 87% and 88%, respectively, thus suggesting that the use of these criteria in a case definition would be helpful for epidemiological [academic.oup.com]
Descriptive epidemiology 2. Summary of clinical features 3. Potential use in Bioterrorism 4. [books.google.de]
Secure and accurate diagnostic methods are needed for the epidemiological surveillance of the disease. Current assays rely on antigens prepared from lysates of virus infected mammalian cells. [nora.nerc.ac.uk]
Pathophysiology
In humans, the pathophysiology of the Junin virus is yet to be fully understood. Known side effects of Argentine hemorrhagic fever AHF infection is often mild or subclinical. [naturalpedia.com]
Prevention
Different approaches to obtain an effective antigen to prevent AHF using complete live or inactivated virus, as well as molecular constructs, have reached diverse development stages. [ncbi.nlm.nih.gov]
Candid 1, the first vaccine for the prevention of illness caused by an arenavirus, is safe and highly efficacious. [jhu.pure.elsevier.com]
No FDA-approved preventive or treatment currently exists for this virus. [grantome.com]
Supportive therapy and antiviral drugs may also help prevent complications. A vaccine for the virus became available in 1990 and is therefore a method of prevention for contracting the virus. [diseaseinfosearch.org]