Collection includes both citations and many full-text, downloadable documents from mid-1900s to present. AULIMP - Air University Library Index to Military Periodicals. [dtic.mil]

Despite differences in GP1 recognition, we find that both antibodies present a key tyrosine residue, albeit on different chains, that inserts into a central pocket on JUNV GP1 and effectively mimics the contacts made by the host TfR1. [kclpure.kcl.ac.uk]

Intermediate stages like viral seeds and cell culture bank management, bulk vaccine manufacture, and finished product processing are also separately presented in terms of Production and Quality Control/Quality Assurance requirements, under the Adminitracion [ncbi.nlm.nih.gov]

Reference is made to different research strategies used to obtain anti-AHF vaccines in the past and anti-arenaviral diseases in the present. [doi.org]

• Fever

  Human Diseases: Epidemiology, Treatment, Pathogenesis, and Diagnosis 73 Downloads 36 Citations Keywords Endemic Area Hemorrhagic Fever Progressive Extension Argentine Hemorrhagic Fever These keywords were added by machine and not by the authors. [dx.doi.org]

  Argentine hemorrhagic fever (n.) hemorrhagic fever with neurological signs; caused by the Junin virus Synonyms: VHF viral hemorrhagic fever hemorrhagic fever viral haemorrhagic fever haemorrhagic fever 2. hemorrhagic (adj.) of or relating to a hemorrhage [synonym.com]

  KEYWORDS: Arenaviridae; Arenavirus vaccines; Argentinian hemorrhagic fever; Attenuated viral vaccines; Junin virus [ncbi.nlm.nih.gov]

  Detailed Synonyms for Argentine hemorrhagic fever in English Argentine hemorrhagic fever: the Argentine hemorrhagic fever – hemorrhagic fever with neurological signs; caused by the Junin virus 1 Related Definitions for "Argentine hemorrhagic fever": Related [interglot.com]

  Weissenbacher MC, Laguens RP, Coto CE (1987) Argentine hemorrhagic fever. Curr Top Microbiol Immunol 134:79–116 PubMed Google Scholar 6. [doi.org]

• Fatigue

  […] likely means of dissemination: Solid, liquid, or aerosol Primary route of entry: Absorption, inhalation, ingestion General signs and symptoms: Vary by type of viral hemorrhagic fever (VHF), but initial signs and symptoms often include marked fever, fatigue [labce.com]

  Their symptoms vary, but most often include high fever, dizziness and fatigue. Some people will develop internal bleeding and neurological complications, such as delirium and seizures. [ncnp.org]

  Symptoms often include: Fever Fatigue Dizziness Muscle aches Loss of strength Exhaustion People with severe cases often show signs of bleeding. This may be under the skin, in internal organs, or from body openings such as the mouth, eyes, or ears. [hopkinsmedicine.org]

  Specific signs and symptoms vary by the type of VHF, but initial signs and symptoms often include: Fever Fatigue Dizziness Muscle aches Loss of strength Exhaustion Patients with severe cases of VHF often show signs of bleeding under the skin, in internal [southernnevadahealthdistrict.org]

• High Fever

  As the disease progresses, the victim may develop a high fever, dehydration, hypotension, flushed skin, abnormally slow heartbeat, bleeding from the gums and internal tissues, hematuria, and hematemesis. [medical-dictionary.thefreedictionary.com]

  As the disease progresses, the person may develop a high fever, dehydration, hypotension, flushed skin, abnormally slow heartbeat, or bleeding from the gums and internal tissues. [diseaseinfosearch.org]

  Junin is also on the U.S. government's list of potential bioterror weapons -- along with other viruses that cause hemorrhagic fever. Their symptoms vary, but most often include high fever, dizziness and fatigue. [ncnp.org]

  Body systems harmed by Argentine hemorrhagic fever Severe cases of AHF may progress to: Shock Pulmonary edema Diffuse mucosal hemorrhaging Meningoencephalitis with convulsions As the disease progresses, the patient may develop a high fever, dehydration [naturalpedia.com]

• Collapse

  […] professor at the University of California, San Francisco, said there have been other instances of formaldehyde ingestion, which "has caused deaths, usually preceded by very severe corrosive damage to the stomach and the small intestine, followed by collapse [edition.cnn.com]

• Nausea

  Initially, it is characterized by chills, fever, headache, myalgia, anorexia, nausea, vomiting, and a general feeling of malaise. [medical-dictionary.thefreedictionary.com]

  Symptoms of the virus may include chills, fever, headache, dizziness, chest pain, back pain, abdominal pain, sore throat, nausea, vomiting, and a general feeling of malaise (tiredness and feelings of not being well, being uncomfortable and weak). [diseaseinfosearch.org]

  Initial side effects of AHF may include: Fever Malaise Dizziness Myalgias/muscle pain Skin dysesthesia/abnormal sense of touch Oral ulcerations Llymphadenopathy Chest pain Back pain Abdominal pain Sore throat Headache Nausea Vomiting Cough Photophobia [naturalpedia.com]

  These sorrel formulations may cause nausea or vomiting when taken with the prescription drugs metronidazole (Flagyl®) or disulfiram (Antabuse®). Avoid if pregnant or breastfeeding. [simplygoodnaturalfoods.com]

• Vomiting

  Initially, it is characterized by chills, fever, headache, myalgia, anorexia, nausea, vomiting, and a general feeling of malaise. [medical-dictionary.thefreedictionary.com]

  Symptoms of the virus may include chills, fever, headache, dizziness, chest pain, back pain, abdominal pain, sore throat, nausea, vomiting, and a general feeling of malaise (tiredness and feelings of not being well, being uncomfortable and weak). [diseaseinfosearch.org]

  Initial side effects of AHF may include: Fever Malaise Dizziness Myalgias/muscle pain Skin dysesthesia/abnormal sense of touch Oral ulcerations Llymphadenopathy Chest pain Back pain Abdominal pain Sore throat Headache Nausea Vomiting Cough Photophobia [naturalpedia.com]

  These sorrel formulations may cause nausea or vomiting when taken with the prescription drugs metronidazole (Flagyl®) or disulfiram (Antabuse®). Avoid if pregnant or breastfeeding. [simplygoodnaturalfoods.com]

• Hypotension

  As the disease progresses, the victim may develop a high fever, dehydration, hypotension, flushed skin, abnormally slow heartbeat, bleeding from the gums and internal tissues, hematuria, and hematemesis. [medical-dictionary.thefreedictionary.com]

  As the disease progresses, the person may develop a high fever, dehydration, hypotension, flushed skin, abnormally slow heartbeat, or bleeding from the gums and internal tissues. [diseaseinfosearch.org]

  […] systems harmed by Argentine hemorrhagic fever Severe cases of AHF may progress to: Shock Pulmonary edema Diffuse mucosal hemorrhaging Meningoencephalitis with convulsions As the disease progresses, the patient may develop a high fever, dehydration, hypotension [naturalpedia.com]

• Myalgia

  Initially, it is characterized by chills, fever, headache, myalgia, anorexia, nausea, vomiting, and a general feeling of malaise. [medical-dictionary.thefreedictionary.com]

  Initial side effects of AHF may include fever, malaise, dizziness, and myalgias/muscle pain. Treatment with convalescent-phase plasma has been used with success in some patients with AHF. [naturalpedia.com]

• Flushing

  […] may include: Fever Malaise Dizziness Myalgias/muscle pain Skin dysesthesia/abnormal sense of touch Oral ulcerations Llymphadenopathy Chest pain Back pain Abdominal pain Sore throat Headache Nausea Vomiting Cough Photophobia Conjunctival redness Facial flushing [naturalpedia.com]

  As the disease progresses, the victim may develop a high fever, dehydration, hypotension, flushed skin, abnormally slow heartbeat, bleeding from the gums and internal tissues, hematuria, and hematemesis. [medical-dictionary.thefreedictionary.com]

  As the disease progresses, the person may develop a high fever, dehydration, hypotension, flushed skin, abnormally slow heartbeat, or bleeding from the gums and internal tissues. [diseaseinfosearch.org]

  To save her from being mummified alive, they tried to flush out her abdominal cavity, according to TASS. [edition.cnn.com]

• Petechiae

  Dizziness Myalgias/muscle pain Skin dysesthesia/abnormal sense of touch Oral ulcerations Llymphadenopathy Chest pain Back pain Abdominal pain Sore throat Headache Nausea Vomiting Cough Photophobia Conjunctival redness Facial flushing Small axillary petechiae [naturalpedia.com]

  AHF leads to severe compromise of the vascular, neurological and immune systems and has a mortality rate between 20 and 30%.[3] Symptoms of the disease are conjunctivitis, purpura, petechiae and occasionally sepsis. [en.wikipedia.org]

• Dermatitis

  Boguniewicz M, Leung DYM: Recent insights into atopic dermatitis and implications for management of infectious complications. [karger.com]

  Avoid topical preparations in areas of skin breakdown or injury or in atopic patients due to multiple reports of contact dermatitis. [simplygoodnaturalfoods.com]

• Skin Rash

  rash, stomach discomfort, stomach ulcers, and vomiting. [simplygoodnaturalfoods.com]

• Eczema

  Use cautiously with a history of eczema. Avoid if pregnant or breastfeeding. Thyme : Thyme has been used medicinally for thousands of years. [simplygoodnaturalfoods.com]

• Headache

  Initially, it is characterized by chills, fever, headache, myalgia, anorexia, nausea, vomiting, and a general feeling of malaise. [medical-dictionary.thefreedictionary.com]

  Symptoms of the virus may include chills, fever, headache, dizziness, chest pain, back pain, abdominal pain, sore throat, nausea, vomiting, and a general feeling of malaise (tiredness and feelings of not being well, being uncomfortable and weak). [diseaseinfosearch.org]

  The incubation time of the disease is between 10 and 12 days, after which the first symptoms appear: fever, headaches, weakness, loss of appetite and will. [wikidoc.org]

  Initial side effects of AHF may include: Fever Malaise Dizziness Myalgias/muscle pain Skin dysesthesia/abnormal sense of touch Oral ulcerations Llymphadenopathy Chest pain Back pain Abdominal pain Sore throat Headache Nausea Vomiting Cough Photophobia [naturalpedia.com]

• Confusion

  The symptoms of the disease can be confusing; the condition can be mistaken for a different one, especially during the first week when it can resemble a flu. [en.wikipedia.org]

  But the condition can quickly progress to shock, which is marked by falling blood pressure and body temperature, confusion, clotting abnormalities and bleeding into the skin. Blood poisoning is a medical emergency and can be fatal if left untreated. [simplygoodnaturalfoods.com]

  Short and intermittent patient contact by staff in protective clothing, with potentially confused patients, is the norm. [doi.org]

• Irritability

  Use cautiously with gastrointestinal irritation or peptic ulcer disease due to anecdotal reports of gastrointestinal irritation. [simplygoodnaturalfoods.com]

Treatments, management plans for Argentine hemorrhagic fever Patients diagnosed with viral hemorrhagic fevers (VHF) receive supportive therapy, but generally, there is no other treatment or established cure for VHFs. [naturalpedia.com]

AHF has had significant morbidity since its emergence in the 1950s, with a case-fatality rate of the illness without treatment between 15% and 30%. The use of a live attenuated vaccine has markedly reduced the incidence of AHF. [ncbi.nlm.nih.gov]

The initial introduction of treatment serums in the 1970s reduced this lethality. [wikidoc.org]

Treatment may include hydration, rest, warmth, and adequate nutrition. Supportive therapy and antiviral drugs may also help prevent complications. [diseaseinfosearch.org]

The initial introduction of treatment serums in the 1970s reduced this lethality. The Candid #1 vaccine for AHF was created in 1985 by Argentine virologist Dr. Julio Barrera Oro. [en.wikipedia.org]

Usually, the prognosis is complete recovery. See also Arenavirus, Bolivian hemorrhagic fever, Lassa fever. [medical-dictionary.thefreedictionary.com]

Natural History, Complications, and Prognosis AHF is a grave acute disease which may progress to recovery or death in 1 to 2 weeks. [wikidoc.org]

In this report, we describe the development of an enzyme linked immunosorbent assay for the etiologic confirmation of the disease, based on recombinant antigens expressed in insect cells. [nora.nerc.ac.uk]

Important achievements have been made in: (a) improvement of methods for the etiological diagnosis; (b) implementation and validation of therapeutical measures; (c) development of vaccines to protect against AHF. [ncbi.nlm.nih.gov]

Summary Propagation of Junin virus, the etiological agent of Argentinian hemorrhagic fever, has been studied in a variety of cell cultures. [link.springer.com]

Human Diseases: Epidemiology, Treatment, Pathogenesis, and Diagnosis 73 Downloads 36 Citations Keywords Endemic Area Hemorrhagic Fever Progressive Extension Argentine Hemorrhagic Fever These keywords were added by machine and not by the authors. [dx.doi.org]

A viral illness caused by the Junin arenavirus, named in 1953 after its city of isolation Epidemiology Transmitted by contact with rodent urine; 23 outbreaks have been recorded in the maize-producing region of Argentina Rodent vectors Akodon arenicola [medical-dictionary.thefreedictionary.com]

Weekly Epidemiological Record = Relevé épidémiologique hebdomadaire, 57 (‎29)‎, 219 - 220. https://apps.who.int/iris/handle/10665/224066 Revue Weekly Epidemiological Record = Relevé épidémiologique hebdomadaire, 57 (‎29)‎: 219 - 220 [apps.who.int]

[…] ratio is >15%, but treatment reduces the mortality rate to 3 and a white blood cell (WBC) count of 3 had a sensitivity and specificity of 87% and 88%, respectively, thus suggesting that the use of these criteria in a case definition would be helpful for epidemiological [academic.oup.com]

In humans, the pathophysiology of the Junin virus is yet to be fully understood. Known side effects of Argentine hemorrhagic fever AHF infection is often mild or subclinical. [naturalpedia.com]

Different approaches to obtain an effective antigen to prevent AHF using complete live or inactivated virus, as well as molecular constructs, have reached diverse development stages. [ncbi.nlm.nih.gov]

No FDA-approved preventive or treatment currently exists for this virus. [grantome.com]

Supportive therapy and antiviral drugs may also help prevent complications. A vaccine for the virus became available in 1990 and is therefore a method of prevention for contracting the virus. [diseaseinfosearch.org]

Candid 1, the first vaccine for the prevention of illness caused by an arenavirus, is safe and highly efficacious. [jhu.pure.elsevier.com]