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Argentinian Hemorrhagic Fever

Argentine Hemorrhagic Fever


Presentation

  • Collection includes both citations and many full-text, downloadable documents from mid-1900s to present. AULIMP - Air University Library Index to Military Periodicals.[dtic.mil]
  • Intermediate stages like viral seeds and cell culture bank management, bulk vaccine manufacture, and finished product processing are also separately presented in terms of Production and Quality Control/Quality Assurance requirements, under the Adminitracion[ncbi.nlm.nih.gov]
  • Despite differences in GP1 recognition, we find that both antibodies present a key tyrosine residue, albeit on different chains, that inserts into a central pocket on JUNV GP1 and effectively mimics the contacts made by the host TfR1.[kclpure.kcl.ac.uk]
  • Reference is made to different research strategies used to obtain anti-AHF vaccines in the past and anti-arenaviral diseases in the present.[ncbi.nlm.nih.gov]
Fever
  • Human Diseases: Epidemiology, Treatment, Pathogenesis, and Diagnosis 73 Downloads 36 Citations Keywords Endemic Area Hemorrhagic Fever Progressive Extension Argentine Hemorrhagic Fever These keywords were added by machine and not by the authors.[dx.doi.org]
  • KEYWORDS: Arenaviridae; Arenavirus vaccines; Argentinian hemorrhagic fever; Attenuated viral vaccines; Junin virus[ncbi.nlm.nih.gov]
  • Argentine hemorrhagic fever (n.) hemorrhagic fever with neurological signs; caused by the Junin virus Synonyms: VHF viral hemorrhagic fever hemorrhagic fever viral haemorrhagic fever haemorrhagic fever 2. hemorrhagic (adj.) of or relating to a hemorrhage[synonym.com]
  • Weissenbacher MC, Laguens RP, Coto CE (1987) Argentine hemorrhagic fever. Curr Top Microbiol Immunol 134:79–116 PubMed Google Scholar 6.[doi.org]
  • References American Hemorrhagic Fevers: Global Status includes separate sections on Argentine hemorrhagic fever, Brazilian hemorrhagic fever, Bolivian hemorrhagic fever, Venezuelan hemorrhagic fever, and Whitewater Arroyo virus infection.[books.google.de]
High Fever
  • As the disease progresses, the victim may develop a high fever, dehydration, hypotension, flushed skin, abnormally slow heartbeat, bleeding from the gums and internal tissues, hematuria, and hematemesis.[medical-dictionary.thefreedictionary.com]
  • As the disease progresses, the person may develop a high fever, dehydration, hypotension, flushed skin, abnormally slow heartbeat, or bleeding from the gums and internal tissues.[diseaseinfosearch.org]
  • Body systems harmed by Argentine hemorrhagic fever Severe cases of AHF may progress to: Shock Pulmonary edema Diffuse mucosal hemorrhaging Meningoencephalitis with convulsions As the disease progresses, the patient may develop a high fever, dehydration[naturalpedia.com]
  • Their symptoms vary, but most often include high fever, dizziness and fatigue. Some people will develop internal bleeding and neurological complications, such as delirium and seizures.[ncnp.org]
Fishing
  • Argentine (adj.) of or relating to or characteristic of Argentina or its people Synonyms: Argentinian 4. argentine (n.) any of various small silver-scaled salmon-like marine fishes Synonyms: soft-finned fish genus Argentina Argentina malacopterygian Antonyms[synonym.com]
Nausea
  • Initially, it is characterized by chills, fever, headache, myalgia, anorexia, nausea, vomiting, and a general feeling of malaise.[medical-dictionary.thefreedictionary.com]
  • Symptoms of the virus may include chills, fever, headache, dizziness, chest pain, back pain, abdominal pain, sore throat, nausea, vomiting, and a general feeling of malaise (tiredness and feelings of not being well, being uncomfortable and weak).[diseaseinfosearch.org]
  • Initial side effects of AHF may include: Fever Malaise Dizziness Myalgias/muscle pain Skin dysesthesia/abnormal sense of touch Oral ulcerations Llymphadenopathy Chest pain Back pain Abdominal pain Sore throat Headache Nausea Vomiting Cough Photophobia[naturalpedia.com]
Vomiting
  • Initially, it is characterized by chills, fever, headache, myalgia, anorexia, nausea, vomiting, and a general feeling of malaise.[medical-dictionary.thefreedictionary.com]
  • Symptoms of the virus may include chills, fever, headache, dizziness, chest pain, back pain, abdominal pain, sore throat, nausea, vomiting, and a general feeling of malaise (tiredness and feelings of not being well, being uncomfortable and weak).[diseaseinfosearch.org]
  • Initial side effects of AHF may include: Fever Malaise Dizziness Myalgias/muscle pain Skin dysesthesia/abnormal sense of touch Oral ulcerations Llymphadenopathy Chest pain Back pain Abdominal pain Sore throat Headache Nausea Vomiting Cough Photophobia[naturalpedia.com]
Hypotension
  • As the disease progresses, the victim may develop a high fever, dehydration, hypotension, flushed skin, abnormally slow heartbeat, bleeding from the gums and internal tissues, hematuria, and hematemesis.[medical-dictionary.thefreedictionary.com]
  • As the disease progresses, the person may develop a high fever, dehydration, hypotension, flushed skin, abnormally slow heartbeat, or bleeding from the gums and internal tissues.[diseaseinfosearch.org]
  • […] systems harmed by Argentine hemorrhagic fever Severe cases of AHF may progress to: Shock Pulmonary edema Diffuse mucosal hemorrhaging Meningoencephalitis with convulsions As the disease progresses, the patient may develop a high fever, dehydration, hypotension[naturalpedia.com]
Flushing
  • […] may include: Fever Malaise Dizziness Myalgias/muscle pain Skin dysesthesia/abnormal sense of touch Oral ulcerations Llymphadenopathy Chest pain Back pain Abdominal pain Sore throat Headache Nausea Vomiting Cough Photophobia Conjunctival redness Facial flushing[naturalpedia.com]
  • As the disease progresses, the victim may develop a high fever, dehydration, hypotension, flushed skin, abnormally slow heartbeat, bleeding from the gums and internal tissues, hematuria, and hematemesis.[medical-dictionary.thefreedictionary.com]
  • As the disease progresses, the person may develop a high fever, dehydration, hypotension, flushed skin, abnormally slow heartbeat, or bleeding from the gums and internal tissues.[diseaseinfosearch.org]
  • To save her from being mummified alive, they tried to flush out her abdominal cavity, according to TASS.[edition.cnn.com]
Petechiae
  • Dizziness Myalgias/muscle pain Skin dysesthesia/abnormal sense of touch Oral ulcerations Llymphadenopathy Chest pain Back pain Abdominal pain Sore throat Headache Nausea Vomiting Cough Photophobia Conjunctival redness Facial flushing Small axillary petechiae[naturalpedia.com]
Myalgia
  • Initially, it is characterized by chills, fever, headache, myalgia, anorexia, nausea, vomiting, and a general feeling of malaise.[medical-dictionary.thefreedictionary.com]
  • Initial side effects of AHF may include fever, malaise, dizziness, and myalgias/muscle pain. Treatment with convalescent-phase plasma has been used with success in some patients with AHF.[naturalpedia.com]
Confusion
  • Short and intermittent patient contact by staff in protective clothing, with potentially confused patients, is the norm.[doi.org]

Treatment

  • Treatments, management plans for Argentine hemorrhagic fever Patients diagnosed with viral hemorrhagic fevers (VHF) receive supportive therapy, but generally, there is no other treatment or established cure for VHFs.[naturalpedia.com]
  • AHF has had significant morbidity since its emergence in the 1950s, with a case-fatality rate of the illness without treatment between 15% and 30%. The use of a live attenuated vaccine has markedly reduced the incidence of AHF.[ncbi.nlm.nih.gov]
  • The initial introduction of treatment serums in the 1970s reduced this lethality.[wikidoc.org]
  • Treatment may include hydration, rest, warmth, and adequate nutrition. Supportive therapy and antiviral drugs may also help prevent complications.[diseaseinfosearch.org]
  • The initial introduction of treatment serums in the 1970s reduced this lethality. The Candid #1 vaccine for AHF was created in 1985 by Argentine virologist Dr. Julio Barrera Oro.[en.wikipedia.org]

Prognosis

  • Usually, the prognosis is complete recovery. See also Arenavirus, Bolivian hemorrhagic fever, Lassa fever .[medical-dictionary.thefreedictionary.com]
  • Natural History, Complications, and Prognosis AHF is a grave acute disease which may progress to recovery or death in 1 to 2 weeks.[wikidoc.org]

Etiology

  • In this report, we describe the development of an enzyme linked immunosorbent assay for the etiologic confirmation of the disease, based on recombinant antigens expressed in insect cells.[nora.nerc.ac.uk]
  • Important achievements have been made in: (a) improvement of methods for the etiological diagnosis; (b) implementation and validation of therapeutical measures; (c) development of vaccines to protect against AHF.[ncbi.nlm.nih.gov]
  • Summary Propagation of Junin virus, the etiological agent of Argentinian hemorrhagic fever, has been studied in a variety of cell cultures.[link.springer.com]

Epidemiology

  • Human Diseases: Epidemiology, Treatment, Pathogenesis, and Diagnosis 73 Downloads 36 Citations Keywords Endemic Area Hemorrhagic Fever Progressive Extension Argentine Hemorrhagic Fever These keywords were added by machine and not by the authors.[dx.doi.org]
  • A viral illness caused by the Junin arenavirus, named in 1953 after its city of isolation Epidemiology Transmitted by contact with rodent urine; 23 outbreaks have been recorded in the maize-producing region of Argentina Rodent vectors Akodon arenicola[medical-dictionary.thefreedictionary.com]
  • […] ratio is 15%, but treatment reduces the mortality rate to 3 and a white blood cell (WBC) count of 3 had a sensitivity and specificity of 87% and 88%, respectively, thus suggesting that the use of these criteria in a case definition would be helpful for epidemiological[academic.oup.com]
  • Descriptive epidemiology 2. Summary of clinical features 3. Potential use in Bioterrorism 4.[books.google.de]
  • Secure and accurate diagnostic methods are needed for the epidemiological surveillance of the disease. Current assays rely on antigens prepared from lysates of virus infected mammalian cells.[nora.nerc.ac.uk]
Sex distribution
Age distribution

Pathophysiology

  • In humans, the pathophysiology of the Junin virus is yet to be fully understood. Known side effects of Argentine hemorrhagic fever AHF infection is often mild or subclinical.[naturalpedia.com]

Prevention

  • Different approaches to obtain an effective antigen to prevent AHF using complete live or inactivated virus, as well as molecular constructs, have reached diverse development stages.[ncbi.nlm.nih.gov]
  • No FDA-approved preventive or treatment currently exists for this virus.[grantome.com]
  • Supportive therapy and antiviral drugs may also help prevent complications. A vaccine for the virus became available in 1990 and is therefore a method of prevention for contracting the virus.[diseaseinfosearch.org]
  • Candid 1, the first vaccine for the prevention of illness caused by an arenavirus, is safe and highly efficacious.[jhu.pure.elsevier.com]
  • Information is updated on features and field performance of Candid #1 vaccine, a live attenuted vaccine currently used to prevent AHF. This vaccine was developed through a joint international effort that envisioned it as an orphan drug.[ncbi.nlm.nih.gov]

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