Argyria is a rare skin condition that develops following contact with silver salts.
The disease is related to the following processes: Poison and has an incidence of about 0 / 100.000.
Argyria is an uncommon skin condition that develops following acute or chronic contact with silver salts. In even more rare circumstances, it may develop after oral consumption of silver containing salts.
Argyria presents with either localized or systemic grayish-blue discoloration of skin and mucus membranes. Some people may develop argyria after use of medications that contain silver but others may develop internal organ discoloration after chronic exposure to silver salts while working in the mining industry  . If silver salts are ingested orally, then the deposits may also occur in other organs of the body. In the past silver salts were used in certain sutures and dental procedures and were reported to cause argyria. Some people have also developed bluish-silver discoloration following acupuncture around ear lobes containing silver earrings .
It is difficult to predict who will develop argyria because there is a great variability in exposure and formation of the skin discoloration. Some people who have had prolonged exposure and have had no problems but others have had acute short-term exposure and developed significant skin discoloration.
Globally, the most common cause of argyria is exposure of workers to silver in the heavy metal industry (eg. silver refining, mining or metal alloy manufacture), where the individual is constantly exposed to silver particles. Other occupations where one may become exposed to silver include contact with electroplating solutions, adding metallic film on china and glassware and during photographic processing. There are also a few dietary supplements sold for the treatment of AIDS, cancer, diabetes and herpes infections that also contain silver salts. There are also several reports of argyria following use of silver salts for irrigation of nasal mucus membrane and urethra, in wound dressings, eye drops and prolonged use of an anti-smoking aid that contains silver acetate.
The common causes of argyria include the following:
There is a great individual variability as to who and when argyria develops. Some people develop severe argyria after short-term exposure to silver salts and some people work for many years and only develop minor skin discoloration. However, in general, argyria is more likely to develop when one is exposed to high concentrations of silver for prolonged time period  .
The incidence of argyria is not known because many individuals never come to medical attention. Overall, this skin disorder is rare chiefly because silver agents are no longer used as pharmaceutical and in the heavy metals industry; safe guards have been put in place to avoid skin contact and inhalation. Over the years, dysfunction of several organs has been reported after silver exposure   .
Following skin contact, some individuals will only develop localized skin patches of argyria. Such localized dermatosis may be seen after short term use of nasal or eye drops containing colloidal silver. Others may develop argyria following acupuncture near the ear. Systemic manifestations of argyria are usually seen after oral consumption of silver salts. In the remote past, colloidal silver suspensions were often used to treat a variety of gastrointestinal tract disorders like stomach upset, gastroesophageal reflux disease (GERD), peptic ulcer disease and gastritis. In addition, colloidal silver was also used to treat rhinitis, sinusitis and nasal congestion. In such cases, small amounts of silver were continuously absorbed into the systemic circulation resulting in deposition in internal organs. Argyria may also occur in people who work in the silver mining industry and in individuals who work in jewellery industry where they are frequently polishing silver. There are also reports that argyria may occur in professionals who polish artificial pearls.
In these cases, inhalation of silver dust particles is the route of transmission. There are isolated reports that argyria may have a genetic predisposition. Even though silver salts precipitate all over the body, the pigmentary changes are usually observed on the sun-exposed areas. The exact reason for this is not known but experts believe that the silver salts once bound to protein in the skin, are chemically oxidized by light waves that result in the discoloration. Others suggest that silver plus UV light stimulates production of melanin, which then is responsible for the skin darkening. The healthy adult does not have huge amount of silver ions in the body. It is estimated that in most humans the silver concentration in the body varies from 800-1,000 micrograms. The exact amount of silver known to cause argyria is not known, but the literature indicates that exposure to more than 4 grams may initiate the process. Silver is not an innocuous metal and at doses ranging from 50-500 mg/kg, this metal can induce multiple organ failure and death.
The prognosis for patients with argyria depends on the extent of the silver deposition  . In individuals with just skin and mucus membrane involvement, the prognosis is good. These individuals only have a cosmetic problem, which unfortunately is permanent. For individuals who have silver depositions in organs like the kidney, brain, liver or pancreas, the prognosis is variable. Organ dysfunction can occur and progress. Because of lack of good treatment, the only way to prevent progression of disease is prevention of additional silver exposure.
Because argyria is a rare skin disorder a detailed history about silver exposure is required. It is important to delve into any past occupational history of metal exposure or use of dietary supplements containing silver. Some individuals may be using silver containing nose drops that are known to produce pigmentation on the nail lunula and nose. In burn patients, prolonged use of silver sulfadiazine may also induce scar-localized argyria.
On physical the findings depend on how long the silver containing products have been used. In acute cases, there may be no obvious findings. After prolonged use, one may visualize a greyish brown stain on the gums as the first sign of argyria. Over time, some patients may show diffuse grayish patches on the skin. The cutaneous pigmentation may appear bluish gray, metallic or dirty silver. The skin pigmentation is often more obvious in the sun-exposed areas like the neck, face, nose, hands and fingers. In the very rare patient, the patient’s entire skin may appear a dull blue or gray color.
Besides the skin, one may notice discoloration of the nail beds, sclera and mucus membranes. When the abdomen is explored at surgery or during post mortem examination, it may also reveal bluish discoloration of the liver, spleen, small bowel and mesentery. In extremely rare cases, some individuals may have black tears (melanodacryorrhea).
Even though some patients may develop skin discoloration after a few months, the majority of individual develop argyria after a few years.
Plain X-rays may sometimes reveal heavy deposits of silver but the concentration can be measured by using x-ray fluorescence. However, this technique is not useful for assessing silver deposition in bone or internal organs.
Silver levels can be measured in blood but the testing is not readily available in all medical laboratories. If organ dysfunction is suspected, a total blood count, renal and liver function, blood glucose, and creatine kinase levels should be ordered.
The definitive procedure to confirm argyria is a skin biopsy. Histology will reveal black brown granules either singly or in aggregates located in the basement membrane zone surrounding sweat glands. The silver granules also deposit around nerves and pilosebaceous glands. Silver granules have a strong affinity for elastic fibers where they often appear as refractile particles under dark field illumination.
Electron microscopy may be performed to look for specific location of silver granules. In early cases of argyria, the granules may appear in macrophages and fibroblasts. In chronic cases, the granules may be extracellular.
If the patient has neurological deficits, one may require a comprehensive neurological exam, nerve conducting tests and EMG studies. A CT scan may be ordered if a patient has seizure to rule out any mass. The role of lumbar puncture in a patient with argyria is non-productive.
In general, the treatment of argyria is strictly for cosmetic reasons. The skin disorder rarely causes any symptoms but most people do not like the dark grayish cosmetic appearance and would like something done. Over the years many depigmentation solutions or bleaching agents have been developed, but none of them have proven to be effective. Isolated case reports reveal that 5% hydroquinone may decrease the number of silver granules in the upper layers of skin, around sweat glands and also lower the number of melanocytes. Hydroquinone reverses the depigmentation by inhibiting the oxidation of tyrosine to 3, 4-dihydroxyphenylalanine and inhibits melanocyte metabolic process. The agent does not actually cause reversal of most skin lesions but prevents the lesions from getting darker. Unfortunately, it does not work in everyone. Treatments like dermabrasion and use of chemical peels do not work and are more likely to induce complications.
Various types of chelating agents have been used in the past to remove silver, but none has proven to be effective. For most people, the best treatment of the skin discoloration is wearing garments to hide the pigmentation and use of sunscreen. Because argyria can worsen with sun exposure, it is highly recommended that sunscreens be applied liberally anytime the individual ventures out of the home. Use of opaque cosmetics has been suggested as means to prevent further darkening of skin and also an aid for masking the skin pigmentation.
Some cosmetic surgeons have used the Nd:YAG laser to treat the discoloration. However, there are only isolated reports of benefit. Laser is prohibitively expensive, requires many sessions and can also cause complications that may worsen the skin discoloration. Because the silver particles are in the dermis, the intensity of laser required is high and this can be painful. Thus, some type of analgesia is also required during treatment. Laser is a last resort treatment and should only be undertaken for isolated patches. Laser is not recommended for treatment of large body areas, as the laser can be very painful.
Both sulfur and selenium compounds have been used to chelate to free silver and modify its toxicity. Once silver binds to selenium, the salt is insoluble and unable to penetrate tissues. Thus, this reduces the effect of free silver from interfering with enzymatic activity in various tissues. Binding of silver to sulfur also results in similar insoluble complexes, but repeated doses are required.
The ideal treatment of argyria is prevention. This means preventing skin exposure and oral consumption of silver salts. The consumer should be educated about preventive measures such as wearing proper garments and masks when working with silver.
It should be understood that current belief is that mild to moderate exposure to silver may not seriously affect human health. However, if the silver deposits in critical organs like the liver, pancreas, kidney or brain, adverse effects are likely. It is believed that toxicity of silver is often prevented because of binding to endogenous substance like sulfur and selenium.
Argyria is an uncommon skin condition that develops due to exposure to chemical compounds of the element silver, or to silver dust. Argyria presents with either localized or systemic grayish-blue discoloration of skin and mucus membranes.
Silver exposure is usually occupational but may also occur through the ingestion of colloidal silver, acupuncture, earrings and medications. Some people develop severe argyria after short-term exposure to silver salts and some people develop minor skin discoloration after many years.
In general, the treatment of argyria is strictly for cosmetic reasons. The skin disorder rarely causes any symptoms.