We think that the CYP 2D6 inhibitor sertraline might have played a role in increasing the plasma concentration and toxicity of aripiprazole in the presented patient. [ncbi.nlm.nih.gov]

We report a 12-year-old boy who presented with diabetic ketoacidosis (DKA) due to Aripiprazole use. [care.diabetesjournals.org]

• Developmental Disorder

  BACKGROUND: Autism spectrum disorders (ASD) include Autistic Disorder, Asperger's Disorder and Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS). Irritability related to ASD has been treated with antipsychotics. [ncbi.nlm.nih.gov]

  Description of the condition Before 2013, autism spectrum disorders (ASD) represented pervasive developmental disorders of variable severity, defined as autistic disorder, Asperger's disorder and pervasive developmental disorder ‐ not otherwise specified [doi.org]

  Background: Autism spectrum disorders (ASD) include autistic disorder, Asperger's disorder and pervasive developmental disorder - not otherwise specified (PDD-NOS). [cochrane.org]

• Hyperthermia

  Consciousness change, modest elevation of creatine kinase, and leukocytosis were the most consistent findings; hyperthermia accounts for only some of the cases. [ncbi.nlm.nih.gov]

  Neither patient experienced any of the classic sympathomimetic symptoms of amphetamine toxicity (eg, hyperthermia, hypertension, tachypnea, hyperreflexia, tremor, or mydriasis). 12 A study by Matteucci et al reviewed 47 cases reported to the California [doi.org]

  Serious Reactions hypersensitivity rxn anaphylaxis neuroleptic malignant syndrome extrapyramidal sx tardive dyskinesia dystonia stroke TIA syncope hypotension, orthostatic seizures hyperglycemia diabetes mellitus dysphagia, severe aspiration hyperthermia [online.epocrates.com]

  […] patients to hyperthermia. [pdr.net]

• Hypothermia

  Hypothermia appears to occur more frequently during initiation of antipsychotic therapy or after dose increases. [pdr.net]

• Overeating

  However, there was a significant difference in the early dropout rate in terms of lack of efficacy favouring AOM over PP (OR: 0.394; 95% CI: 0.185-0.841). [ncbi.nlm.nih.gov]

  Concentrations of aripiprazole in the formulation containing 1:1 Ora-Plus and Ora-Sweet were unchanged over the study period with no signs of degradation over 91 days. [ijpc.com]

• Constipation

  The patient had a history of poor feeding since infancy and had been treated for gastro-oesophageal reflux disease (GERD), constipation and multiple food allergies. [ncbi.nlm.nih.gov]

  In those studies, Abilify's most common side effects were fidgeting, restlessness, insomnia, constipation, fatigue, and blurred vision. Earlier this month, the FDA approved Abilify to treat schizophrenia in teens aged 13-17. [webmd.com]

  Side Effects The following are some of the adverse events that were experienced in clinical trials by 2% or more of subjects receiving aripiprazole: Headache Anxiety Nausea Vomiting Constipation Insomnia Lightheadedness Somnolence (sleepiness) Akathisia [centerwatch.com]

  Common side effects of Abilify include headaches, sedation, insomnia, agitation, anxiety, nausea, vomiting, and constipation. [everydayhealth.com]

• Hypersalivation

  17.0-17.0 nausea / Early / 8.0-15.0 vomiting / Early / 3.0-14.0 dizziness / Early / 3.0-10.0 dyspepsia / Early / 9.0-9.0 fever / Early / 4.0-9.0 pharyngitis / Delayed / 3.0-9.0 appetite stimulation / Delayed / 3.0-7.0 restlessness / Early / 1.0-6.0 hypersalivation [pdr.net]

• Sialorrhea

  […] weight gain anxiety insomnia nausea/vomiting lightheadedness dizziness somnolence sedation akathisia injection site rxn (IM use) constipation incontinence blurred vision extrapyramidal sx tremor xerostomia cough restlessness fatigue arthralgia/myalgia sialorrhea [online.epocrates.com]

• Angioedema

  […] or not part of patient’s presenting symptoms. 1 76 77 78 Prescribe in smallest quantity consistent with good patient management to reduce risk of overdosage. 1 77 Sensitivity Reactions Allergic and sensitivity reactions (e.g., anaphylactic reaction, angioedema [drugs.com]

  […] agranulocytosis / Delayed / Incidence not known torsade de pointes / Rapid / Incidence not known toxic epidermal necrolysis / Delayed / Incidence not known laryngospasm / Rapid / Incidence not known Stevens-Johnson syndrome / Delayed / Incidence not known angioedema [pdr.net]

• Motor Restlessness

  restlessness) No siginficant differences were found in incidence of discontinuation due to adverse events experienced by the aripiprazole group compared to the placebo group. [centerwatch.com]

• Delusion

  […] no improvement in symptoms and a gradual further exacerbation of auditory delusions. [ncbi.nlm.nih.gov]

  Case study : The patient, who had a history of acquired brain injury, was receiving treatment for his psychotic illness characterized by persecutory delusions, second person auditory hallucinations, self-neglect and challenging behaviours. [informahealthcare.com]

  According to the dopamine theory of schizophrenia, overactivity of the mesolimbic pathway may trigger positive symptoms (hallucinations, delusions). [psychopharmacologyinstitute.com]

• Behavior Disorder

  TS is often associated with behavioral problems, such as ADHD and obsessive-compulsive disorder [ 35 ], and is more difficult to treat than other TDs. [bmcpsychiatry.biomedcentral.com]

  Glutamatergic postsynaptic density protein dysfunctions in synaptic plasticity and dendritic spines morphology: relevance to schizophrenia and other behavioral disorders pathophysiology, and implications for novel therapeutic approaches. [ncbi.nlm.nih.gov]

  Moreover, aripiprazole appears to inhibit marble-burying behavior, an animal model of obsessive compulsive disorder, via its action on 5-HT1ARs. Low-dose systemic aripiprazole ( 62, 63 ]. [doi.org]

• Auditory Hallucination

  Case study : The patient, who had a history of acquired brain injury, was receiving treatment for his psychotic illness characterized by persecutory delusions, second person auditory hallucinations, self-neglect and challenging behaviours. [informahealthcare.com]

  Jan 25, 2019 (Started Nov 01, 2017) Effectiveness Slight (for visual hallucinations) Effectiveness Slight (for ruminating thoughts) Effectiveness Slight (for hallucinations) Effectiveness Slight (for bipolar disorder) Effectiveness Slight (for auditory [patientslikeme.com]

• Euphoria

  Bipolar I disorder is a specific type of bipolar disorder characterized by manic or mixed episodes of feelings of extreme irritability or euphoria. Bipolar I disorder is the most severe form of the illness marked by extreme manic episodes. [tevapharm.com]

  […] management of bipolar disorder in children and young people, and in collaboration with the child or young person's parents or carers. 1.11.5 When diagnosing bipolar disorder in children or young people take account of the following: mania must be present euphoria [nice.org.uk]

• Polyuria

  Since that time he began to gain weight and had complaints of polyuria and polydipsia. His present condition was attributed to Aripiprazole, which was discontinued. [care.diabetesjournals.org]

  […] risk of hyperglycemia and diabetes; in some cases, hyperglycemia concomitant with use of atypical antipsychotics has been associated with ketoacidosis, hyperosmolar coma, or death; monitor patients for symptoms of hyperglycemia including polydipsia, polyuria [reference.medscape.com]

  […] diabetes, has hypertension, had dyslipidemia Labs to monitor after starting an atypical antipsychotic Measure BMI monthly for 3 months, then quarterly, BP, fasting plasma glucose, fasting lipids within 3 months and then annually monitor for rapid onset of polyuria [quizlet.com]

• Akathisia

  Compared with placebo, aripiprazole caused more movement disorders, as measured on the Simpson Angus Scale (SAS), on the Barnes Akathisia Scale (BAS) and by participant-reported akathisia (high quality evidence), with more people requiring treatment with [ncbi.nlm.nih.gov]

  Aripiprazole is generally well tolerated relative to other antipsychotic medications, although commonly reported side effects include worsening extrapyramidal symptoms and motoric activation similar to akathisia. [dx.doi.org]

• Insomnia

  One reason it was effective may be that the insomnia induced by daytime APZ was effective in treating the patient's daytime sleepiness. Another reason may be APZ increases histamine release which controls sleep-wake cycles. [ncbi.nlm.nih.gov]

  Abilify side effects in children are stuffy nose, fatigue, insomnia, headache, nausea, vomiting, weight gain, uncontrolled movement, and increased saliva or drooling. [rxight.com]

• Headache

  Aripiprazole can cause side effects including headache, insomnia, agitation, nervousness, lightheadedness, dizziness, somnolence, akathisia, and weight gain. Neutropenia is a less frequent side effect of aripiprazole. [ncbi.nlm.nih.gov]

  Abilify side effects in children are stuffy nose, fatigue, insomnia, headache, nausea, vomiting, weight gain, uncontrolled movement, and increased saliva or drooling. [rxight.com]

  Adverse effects to aripiprazole therapy may include headache, nausea, somnolence and blurred vision. Compliance Statement B : For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. [ltd.aruplab.com]

• Agitation

  OBJECTIVES: To evaluate the effects of intramuscular aripiprazole in the treatment of psychosis-induced aggression or agitation (rapid tranquillisation). [ncbi.nlm.nih.gov]

  Agitation improved significantly after 45 minutes among patients receiving 9.75 mg of IM aripiprazole, compared with 105 minutes in the IM haloperidol group. [mdedge.com]

  Agitation Associated with Schizophrenia or Bipolar Mania (Intramuscular Injection) The recommended dose for the treatment of agitation is 9.75 mg. How Aripiprazole Works The mechanism of action of aripiprazole is unknown. [web.archive.org]

• Extrapyramidal Symptoms

  There were no significant differences in adverse sexual events, extrapyramidal symptoms, or akathisia between the 2 groups. [ncbi.nlm.nih.gov]

  Aripiprazole is generally well tolerated relative to other antipsychotic medications, although commonly reported side effects include worsening extrapyramidal symptoms and motoric activation similar to akathisia. [dx.doi.org]

  The “atypical” antipsychotics have a lower propensity to cause extrapyramidal symptoms (EPS), but the molecular basis for this is not fully understood nor is the impact of inverse agonism upon their clinical properties. [jpet.aspetjournals.org]

As the development of persistent hiccups may result in extensive medical workup, clinicians should be aware of drug-associated causes including aripiprazole. © The Author(s) 2014. KEYWORDS: antipsychotic; aripiprazole; hiccups [ncbi.nlm.nih.gov]

• Hyperprolactinemia

  AIM: Aripiprazole (ARP) is a popular antipsychotic drug that has demonstrated ameliorative effects on hyperprolactinemia. [ncbi.nlm.nih.gov]

  Aripiprazole (ARI) is beneficial for antipsychotic-associated hyperprolactinemia but has been reported to decrease PRL secretion. [doi.org]

The place in therapy for this treatment is likely to be as an alternative treatment option to the currently available second-generation prolonged-release depot antipsychotics for maintenance treatment of schizophrenia. [nice.org.uk]

Drug treatment is the first-line treatment for acute mania with the initial aim of rapid control of agitation, aggression and dangerous behaviour. [ncbi.nlm.nih.gov]

[…] as maintenance treatment in patients with schizophrenia The trial is designed into three treatment phases. [druglib.com]

Areas covered: This paper reviews the current treatment guidelines for the treatment of bipolar disorder and examines the rationale behind the use of aripiprazole in combination with mood stabilizers for acute and long-term treatment of bipolar disorder [doi.org]

Tomotaka Suzuki, Masayuki Takase, Toshihiro Moriyama, Hiroyuki Watanabe, Toyoaki Hirata, Makoto Asano and Masaomi Iyo, Impact of dopamine supersensitivity psychosis in treatment-resistant schizophrenia: An analysis of multi-factors predicting long-term prognosis [doi.org]

Given that these medications have substantially improved the long-term prognosis of schizophrenia and that schizophrenia is a disease with significant morbidity, continued use of antipsychotics is clearly still necessary. [ncbi.nlm.nih.gov]

DISCUSSION: The exact etiology of hiccups is unknown but likely involves dopamine and/or γ-butyric acid. [ncbi.nlm.nih.gov]

It is further questionable whether the complexities of treating bipolar disorder (with its unknown etiology and well-known heterogeneity in response to treatment) are accurately portrayed as a reliable, mechanical thermostat. [journals.plos.org]

Recently, one large epidemiological study has confirmed this risk. [ncbi.nlm.nih.gov]

The epidemiology of social anxiety disorder in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. J Clin Psychiatry. 2005;66:1351–61. PubMed CrossRef Google Scholar 69. [doi.org]

Epidemiology of DSM-5 bipolar I disorder: Results from the national epidemiologic survey on alcohol and related conditions - III. Blanco C, Compton WM, Saha TD et al. J Psychiatr Res 84 (2017) 310-317. National Institute of Mental Health. [globenewswire.com]

Although pathophysiological mechanisms are poorly understood, imaging of the present case points toward an involvement of the retinal pigmentary epithelium. [ncbi.nlm.nih.gov]

Abstract Recent imaging studies have indicated that the pathophysiology of schizophrenia is closely related to white matter abnormalities and microglial activation. [schres-journal.com]

E‐mail: [email protected] Abstract The activation of the inflammatory/immunological response system is suggested to be related to the pathophysiology of schizophrenia. [doi.org]

Its efficacy and non-inferiority to oral aripiprazole have been demonstrated in preventing relapse in patients with schizophrenia. [ncbi.nlm.nih.gov]

Lamotrigine, olanzapine, and quetiapine have bimodal efficacy in preventing both mania and depression, although lamotrigine’s efficacy is more robust in preventing depression and olanzapine’s efficacy is greater in preventing mania. [doi.org]