We think that the CYP 2D6 inhibitor sertraline might have played a role in increasing the plasma concentration and toxicity of aripiprazole in the presented patient. [ncbi.nlm.nih.gov]

In both cases, the presentation of drowsiness, lethargy, and ataxia were more consistent with ingestion of an atypical antipsychotic than with amphetamines. [doi.org]

• Acutely Ill Patient

  CONCLUSIONS: These findings indicate that AOM 400 is efficacious across the spectrum of schizophrenia symptoms in acutely ill patients, with implications for both short-term and, by extension, long-term patient outcomes. [ncbi.nlm.nih.gov]

  Olanzapine versus aripiprazole for the treatment of agitation in acutely ill patients with schizophrenia. J Clin Psychopharmacol. 2008; 28:601-7. 95. Mallikaarjun S, Shoaf SE, Boulton DW et al. [drugs.com]

• Unable to Stand

  She was unable to stand or ambulate without falling. All vital signs were within normal limits. Acetaminophen and salicylate assays were negative. The initial UDS from admission tested positive only for amphetamines at 311 ng/mL. [doi.org]

• Pleural Effusion

  Chest X-ray and thoracic CT showed pulmonary edema and bilateral pleural effusion. [ncbi.nlm.nih.gov]

• Constipation

  The patient had a history of poor feeding since infancy and had been treated for gastro-oesophageal reflux disease (GERD), constipation and multiple food allergies. [ncbi.nlm.nih.gov]

  Common side effects of Abilify include headaches, sedation, insomnia, agitation, anxiety, nausea, vomiting, and constipation. [everydayhealth.com]

  Side Effects The following are some of the adverse events that were experienced in clinical trials by 2% or more of subjects receiving aripiprazole: Headache Anxiety Nausea Vomiting Constipation Insomnia Lightheadedness Somnolence (sleepiness) Akathisia [centerwatch.com]

  […] as reported by the FDA (December 2014), the most common side effects of Abilify in adults include insomnia, headache, restlessness, blurred vision, upper respiratory illness restlessness/need to move (akathisia), nausea, dizziness, vomiting, anxiety, constipation [rxight.com]

• Blepharospasm

  It proved to be effective in AEO with blepharospasm. In case 2 and case 3, the patients experienced AEO without blepharospasm, and a significant improvement was observed after aripiprazole treatment. [ncbi.nlm.nih.gov]

• Motor Restlessness

  restlessness) No siginficant differences were found in incidence of discontinuation due to adverse events experienced by the aripiprazole group compared to the placebo group. [centerwatch.com]

• Oligomenorrhea

  Participants had elevated prolactin ( 24 ng/mL) and were experiencing galactorrhea, amenorrhea, oligomenorrhea, or sexual dysfunction on a prolactin-elevating antipsychotic. [ncbi.nlm.nih.gov]

• Akathisia

  Compared with placebo, aripiprazole caused more movement disorders, as measured on the Simpson Angus Scale (SAS), on the Barnes Akathisia Scale (BAS) and by participant-reported akathisia (high quality evidence), with more people requiring treatment with [ncbi.nlm.nih.gov]

  Aripiprazole is generally well tolerated relative to other antipsychotic medications, although commonly reported side effects include worsening extrapyramidal symptoms and motoric activation similar to akathisia. [informahealthcare.com]

• Headache

  Aripiprazole can cause side effects including headache, insomnia, agitation, nervousness, lightheadedness, dizziness, somnolence, akathisia, and weight gain. Neutropenia is a less frequent side effect of aripiprazole. [ncbi.nlm.nih.gov]

  Abilify side effects in children are stuffy nose, fatigue, insomnia, headache, nausea, vomiting, weight gain, uncontrolled movement, and increased saliva or drooling. [rxight.com]

• Agitation

  OBJECTIVES: To evaluate the effects of intramuscular aripiprazole in the treatment of psychosis-induced aggression or agitation (rapid tranquillisation). [ncbi.nlm.nih.gov]

  Agitation Associated with Schizophrenia or Bipolar Mania (Intramuscular Injection) The recommended dose for the treatment of agitation is 9.75 mg. How Aripiprazole Works The mechanism of action of aripiprazole is unknown. [web.archive.org]

  [see CLINICAL STUDIES ] Agitation Associated with Schizophrenia or Bipolar Mania ABILIFY Injection is indicated for the acute treatment of agitation associated with schizophrenia or bipolar disorder, manic or mixed. [druglib.com]

• Stupor

  On the 25th day, atypical NMS occurred with rigidity, elevated creatine kinase, and stupor, which subsided with supportive therapy. He was discharged under treatment with aripiprazole 15 mg and fluoxetine 60 mg. [ncbi.nlm.nih.gov]

  Prolonged catatonic stupor successfully treated with aripiprazole in an adolescent male with schizophrenia: a case report. Clin Schizophr Relat Psychoses 2010; 4; 185–188. 60. [aepnya.eu]

• Mydriasis

  Neither patient experienced any of the classic sympathomimetic symptoms of amphetamine toxicity (eg, hyperthermia, hypertension, tachypnea, hyperreflexia, tremor, or mydriasis). 12 A study by Matteucci et al reviewed 47 cases reported to the California [doi.org]

As the development of persistent hiccups may result in extensive medical workup, clinicians should be aware of drug-associated causes including aripiprazole. The Author(s) 2014. KEYWORDS: antipsychotic; aripiprazole; hiccups [ncbi.nlm.nih.gov]

• Calcium Increased

  It exhibited no appreciable 5-HT2A or 5-HT2B agonism, whereas it antagonized 5-HT-stimulated calcium increase at either 5-HT2A or 5-HT2B receptor expressed in CHO cells (IC50s of 369 and 0.46 nM, respectively). [ncbi.nlm.nih.gov]

• Pleural Effusion

  Chest X-ray and thoracic CT showed pulmonary edema and bilateral pleural effusion. [ncbi.nlm.nih.gov]

Drug treatment is the first-line treatment for acute mania with the initial aim of rapid control of agitation, aggression and dangerous behaviour. [ncbi.nlm.nih.gov]

The place in therapy for this treatment is likely to be as an alternative treatment option to the currently available second-generation prolonged-release depot antipsychotics for maintenance treatment of schizophrenia. [nice.org.uk]

Areas covered: This paper reviews the current treatment guidelines for the treatment of bipolar disorder and examines the rationale behind the use of aripiprazole in combination with mood stabilizers for acute and long-term treatment of bipolar disorder [doi.org]

[…] as maintenance treatment in patients with schizophrenia The trial is designed into three treatment phases. [druglib.com]

Tomotaka Suzuki, Masayuki Takase, Toshihiro Moriyama, Hiroyuki Watanabe, Toyoaki Hirata, Makoto Asano and Masaomi Iyo, Impact of dopamine supersensitivity psychosis in treatment-resistant schizophrenia: An analysis of multi-factors predicting long-term prognosis [doi.org]

Given that these medications have substantially improved the long-term prognosis of schizophrenia and that schizophrenia is a disease with significant morbidity, continued use of antipsychotics is clearly still necessary. [ncbi.nlm.nih.gov]

DISCUSSION: The exact etiology of hiccups is unknown but likely involves dopamine and/or γ-butyric acid. [ncbi.nlm.nih.gov]

This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed. [tocris.com]

It is further questionable whether the complexities of treating bipolar disorder (with its unknown etiology and well-known heterogeneity in response to treatment) are accurately portrayed as a reliable, mechanical thermostat. [doi.org]

Recently, one large epidemiological study has confirmed this risk. [ncbi.nlm.nih.gov]

Epidemiology of DSM-5 bipolar I disorder: Results from the national epidemiologic survey on alcohol and related conditions - III. Blanco C, Compton WM, Saha TD et al. J Psychiatr Res 84 (2017) 310-317. National Institute of Mental Health. [globenewswire.com]

The epidemiology of social anxiety disorder in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. J Clin Psychiatry. 2005;66:1351–61. PubMed CrossRef Google Scholar 69. [doi.org]

The epidemiology of major depressive disorder: results from the national comorbidity survey replication (NCS-R). JAMA. June 18 2003;289(23):3095-3105. 3Berman RM, Marcus RN, Swanink R, et al. [news.bms.com]

Although pathophysiological mechanisms are poorly understood, imaging of the present case points toward an involvement of the retinal pigmentary epithelium. [ncbi.nlm.nih.gov]

Abstract Recent imaging studies have indicated that the pathophysiology of schizophrenia is closely related to white matter abnormalities and microglial activation. [schres-journal.com]

E‐mail: [email protected] Abstract The activation of the inflammatory/immunological response system is suggested to be related to the pathophysiology of schizophrenia. [doi.org]

Its efficacy and non-inferiority to oral aripiprazole have been demonstrated in preventing relapse in patients with schizophrenia. [ncbi.nlm.nih.gov]

Acute and long-term treatment of patients with bipolar disorder is mandatory to prevent symptom relapse and episode recurrences. [doi.org]