Males present with heterosexual precocious puberty which manifests with pre- or peripubertal onset of gynecomastia, premature growth spurt, accelerated bone maturation resulting in decreased adult stature, and may present mild hypogonadotropic hypogonadism [orpha.net]

Familial hyperestrogenism is a rare clinical condition of unknown etiology in which patients present excessive androgen to estrogen conversion. Excessive aromatization is primarily ascribed to abnormalities in the CYP19. [ncbi.nlm.nih.gov]

In summary, we describe two cases of prepubertal unilateral gynecomastia with a normal endocrine workup. [biocoreopen.org]

Topical dihydrotestosterone is an efficient alternative treatment in men with hyperestrogenism; in addition, second generation aromatase inhibitors are useful in both sexes. [ncbi.nlm.nih.gov]

Make the best clinical decisions with an enhanced emphasis on evidence-based practice and expert opinions on treatment strategies. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography. [books.google.com]

The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. [orpha.net]

Tamoxifen has been shown to be more effective both for prophylaxis and treatment, however. [ 12 ] Prognosis Gynaecomastia is mostly a benign condition. [patient.info]

Because of the limited final height prognosis ( The stepsister (III;9) of the proband was accidentally diagnosed with late-onset adrenal hyperplasia during this study. [doi.org]

Estrone sulfate (E1S), a prognosis marker for tumor aggressiveness in prostate cancer (PCa). J Steroid Biochem Mol Biol. 2008 Mar;109(1-2):158-67. 30. Prins GS, Korach KS. [lifeextension.com]

Familial hyperestrogenism is a rare clinical condition of unknown etiology in which patients present excessive androgen to estrogen conversion. Excessive aromatization is primarily ascribed to abnormalities in the CYP19. [ncbi.nlm.nih.gov]

The root cause of AEXS is not entirely clear, but it has been elucidated that inheritable, autosomal dominant genetic mutations affecting CYP19A1, the gene which encodes aromatase, are involved in its etiology. [en.wikipedia.org]

Cause The root cause of AES is not entirely clear, but it has been elucidated that inheritable, autosomal dominant genetic mutations affecting CYP19A1, the gene which encodes aromatase, are involved in its etiology. [dict.eudic.net]

We can't do much more," Carlo La Vecchia, head of epidemiology at the University of Milan, said in an interview. "It's time to move on to other things." La Vecchia spoke Thursday at a European breast cancer conference in Barcelona. [feliciaenache.blogspot.com]

Epidemiology Gynaecomastia is common and is thought to be present in at least a third of men in the course of their lifetime. [ 2 ] Prevalence of asymptomatic gynaecomastia is reported as 60-90% of neonates, 50-60% of adolescents, and 70% in men aged [patient.info]

Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer. 2002;42(1):1-9. 60. Grainger EM, Schwartz SJ, Wang S, et al. [lifeextension.com]

In this chapter we summarize the clinical characteristics, pathophysiology, differential diagnosis, and treatment of human AD. The implications of AD for the clinical use of aromatase inhibitors are reviewed. [books.google.com]

Treatment for Increased Estrogen and Decreased Testosterone Inappropriate diet is considered the main cause of insulin resistance, which is the primary pathophysiologic feature of metabolic syndrome. [ndnr.com]

[…] receptor blockers (bicalutamide, flutamide), [14] zanoterone, spironolactone, 5-alpha reductase inhibitors, [15] H2 receptor blockers (cimetidine more than ranitidine), [16] proton pump inhibitors (impair testosterone action less than H2 blockers). [17] Pathophysiology [online.epocrates.com]

In addition, extragonadal estrogen biosynthesis plays an important but often underestimated physiological and pathophysiological role, for example in breast cancer and endometriosis. [doi.org]

Conclusion: These two cases illustrate the potential of aromatase inhibitors to effectively prevent short stature in aromatase excess syndrome. [abstracts.eurospe.org]

A 10-year-old girl with gigantomastia has subsequently also been described.[1] Fertility, though usually affected to one degree or another—especially in males—is not always impaired significantly enough to prevent sexual reproduction, as evidenced by [en.wikipedia.org]

In Both Fertility, though usually affected to one degree or another—especially in males—is not always impaired significantly enough to prevent sexual reproduction, as evidenced by vertical transmission of the condition by both sexes. [dict.eudic.net]

Fertility, though usually affected to one degree or anotherâ "especially in malesâ "is not always impaired significantly enough to prevent sexual reproduction, as evidenced by vertical transmission of the condition by both sexes. [monsterologist.blogspot.com]

Fertility, though usually affected to one degree or another--especially in males--is not always impaired significantly enough to prevent sexual reproduction, as evidenced by vertical transmission of the condition by both sexes. [weiodat.blogspot.com]