Edit concept Question Editor Create issue ticket

Arsenic-Induced Polyneuropathy

Polyneuropathy Arsenic Ind


Presentation

  • Leading authorities and up-and-coming clinical neurotoxicologists present their expertise on wide-ranging, global subjects and debate controversies in the specialty, including Gulf War Syndrome.[books.google.com]
  • Improve your interpretation of presenting symptoms with 38 new topics and 40 new images in the Differential Diagnosis section, and optimize patient care with more than 250 new figures and tables.[books.google.com]
  • Improve your interpretation of presenting symptoms with 39 new topics in the Differential Diagnosis section, and optimize patient care with 12 new tables in the Clinical Practice Guidelines section.[books.google.com]
  • In developing its educational products ATSDR has made a diligent effort to ensure the accuracy and the currency of the presented information.[atsdr.cdc.gov]
  • Acute arsenic intoxication presenting as Guillain-Barre-like syndrome . Muscle and Nerve , 10 (2), 114-120. DOI: 10.1002/mus.880100203 Acute arsenic intoxication presenting as Guillain-Barre-like syndrome. / Donofrio, P. D.; Wilbourn, A.[experts.umich.edu]
Physician
  • Journal of the Association of Physicians of India, 40 (4), 268-269 (1992). Massey, E. W., Arsenic neuropathy. Neurology, 31 (8), 1057-1058 (1981). Ott, M. G., Holder, B. B. and Gordon, H.[consultox.com]
  • The products are intended for educational use to build the knowledge of physicians and other health professionals in assessing the conditions and managing the treatment of patients potentially exposed to hazardous substances.[atsdr.cdc.gov]
  • Am Fam Physician. 1998 Feb 15;57(4):755-764. The diagnosis of peripheral neuropathies can be frustrating, time consuming and costly.[aafp.org]
  • These medications may have side effects and should be closely monitored by a physician. Physical therapy can enhance your balance, strength and safety. Braces may be needed to help with extreme muscle weakness and instability.[oncolink.org]
  • (e.g. arsenic trioxide) is present in air, usually due to volcanic eruption and purposeful human activities Arsenic also found as sulphuric compound in lead, copper, nickel and ferrous ores; also in soil in small quantities Also a medicinal used by physicians[pathologyoutlines.com]
Disability
  • This market-leading text covers everything from basic examination and psychological assessment to electrodiagnosis, therapeutic exercise, orthotics and assistive devices, and in-depth clinical management of the full range of childhood disabilities and[books.google.com]
  • The disorder does not usually cause life-threatening complications, but it can be uncomfortable or disabling.[medlineplus.gov]
  • According to US governmental agencies, mercury and other heavy metals cause adverse health effects and learning disabilities in millions of people in the United States each year. The elderly and children are especially susceptible.[nervedoctor.info]
  • If the cause cannot be corrected, treatment focuses on minimizing disability and pain. Physical and occupational therapists can recommend useful assistive devices.[merckmanuals.com]
  • Some cases are seemingly asymptomatic but the most severe cases might have severe physical disability.[synapse.koreamed.org]
Malnutrition
  • Malnutrition When we think of malnutrition, we typically think of third-world countries, where hunger and starvation run rampant. We don’t commonly think of America, the land of abundance, as being a country stricken with malnutrition, but it is.[nervedoctor.info]
  • ., chemotherapeutic agents ) Malnutrition /intestinal malabsorption Inflammatory Vasculitis Connective tissue disorders Granulomatous diseases Radiation exposure Guillain-Barre syndrome Critical illness polyneuropathy Infectious Environmental Prolonged[amboss.com]
  • Physical injury, disease, poisoning, or malnutrition can cause the damage (1). Figure 1. Peripheral Nervous System (3) Peripheral Neuropathy, also known as peripheral neuritis, is a neurological disorder that has many causes.[faculty.virginia.edu]
  • VITAMIN B12 DEFICIENCY NEUROPATHY Peripheral neuropathy can be caused by malnutrition as described above and a lack of vitamin B12, an essential dietary nutrient, is clearly associated with peripheral neuropathy [ 19 ].[synapse.koreamed.org]
  • These may be caused by metabolic diseases such as diabetes and renal failure, deficiency syndromes (such as malnutrition and alcoholism), or the direct effects of toxins or drugs.[diamondhead.net]
Burning Feet
  • feet syndrome with worsening of symptoms at night Cranial nerve involvement is very common (especially of the oculomotor and abducens nerve ) Trophic skin changes ; (due to autonomic neuropathy ): anhidrosis ;, edema, ulcers Autonomic features: erectile[amboss.com]
  • Tricyclic antidepressants such as amitriptyline or anticonvulsants such as gabapentin are useful for relief of neuropathic pain (eg, diabetic burning feet).[merckmanuals.com]
Anosmia
  • […] unusually rapid heart beat (tachycardia); low levels of iron within the red blood cells (anemia); bluish discoloration (cyanosis) of the skin and mucous membranes due to insufficient oxygen supply to these tissues; and/or an impaired sense of smell (anosmia[rarediseases.org]
Failure to Thrive
  • Fred Ferri’s popular "5 books in 1" format provides quick guidance on menorrhagia, Failure to Thrive (FTT), Cogan’s syndrome, and much more.[books.google.com]
Myalgia
  • Chronic exposure is associated with mucosal irritation, desquamating rash, myalgias, peripheral neuropathy, and white transverse (Mees) lines in the fingernails. (Adams et al., Principles of Neurology, 6th ed, p1212)[xmri.com]
  • Chronic exposure is associated with mucosal irritation, desquamating rash, myalgias, peripheral neuropathy, and white transverse (Mees) lines in the fingernails.[connects.catalyst.harvard.edu]
Tinnitus
  • COBALT POISONING Cobalt, used in making jet engines, may cause nausea, vomiting, lack of appetite (anorexia), ear ringing (tinnitus), nerve damage, respiratory diseases, an unusually large thyroid gland (goiter), and/or heart and/or kidney damage.[rarediseases.org]
Desquamating Rash
  • Chronic exposure is associated with mucosal irritation, desquamating rash, myalgias, peripheral neuropathy, and white transverse (Mees) lines in the fingernails. (Adams et al., Principles of Neurology, 6th ed, p1212)[xmri.com]
  • Chronic exposure is associated with mucosal irritation, desquamating rash, myalgias, peripheral neuropathy, and white transverse (Mees) lines in the fingernails.[connects.catalyst.harvard.edu]
Peripheral Neuropathy
  • Features of Textbook of Peripheral Neuropathy Include : ̈ Practical yet comprehensiveóan accessible ìgo-toî reference for clinicians ̈ Covers all clinically relevant peripheral neuropathies ̈ Clinical Pearls and Key Points are set off from the text for[books.google.com]
  • Chronic exposure is associated with mucosal irritation, desquamating rash, myalgias, peripheral neuropathy, and white transverse (Mees) lines in the fingernails. (Adams et al., Principles of Neurology, 6th ed, p1212)[xmri.com]
  • Peripheral neuropathy definition and facts Peripheral neuropathy is a condition in which the nerves in the peripheral nervous system become damaged. Peripheral neuropathy symptoms and signs depend upon the cause.[medicinenet.com]
  • Peripheral neuropathy that is caused by drugs is called drug-induced peripheral neuropathy or secondary peripheral neuropathy. Many of the chemotherapy drugs used to treat cancer are highly toxic and can kill neurons.[livestrong.com]
  • Sniffing glue or other toxic compounds can also cause peripheral neuropathy. Certain herbal medicines, especially Chinese herbal medicines, are particularly rich in mercury and arsenic and taking them can lead to peripheral neuropathy.[foundationforpn.org]
Seizure
  • Acute oral ingestion is associated with gastrointestinal symptoms and an encephalopathy which may manifest as SEIZURES, mental status changes, and COMA.[xmri.com]
  • Overexposure may cause headaches, drowsiness, confusion, seizures, and life-threatening complications.[rarediseases.org]
  • Phenytoin, which is prescribed to prevent seizures, and disulfiram, which is given to fight alcohol addition, both have been linked to peripheral neuropathy.[livestrong.com]
Encephalopathy
  • Acute oral ingestion is associated with gastrointestinal symptoms and an encephalopathy which may manifest as SEIZURES, mental status changes, and COMA.[xmri.com]
  • — Arsenic EncephalopathiesEncephalopathies, Arsenic — Encephalopathy, Arsenic[mesh.kib.ki.se]
  • Overexposure to aluminum may cause brain damage (encephalopathy).[rarediseases.org]
Mononeuropathy
  • Reviewing the full spectrum of clinically significant neuropathies, the book contains chapterson common and rare forms including mononeuropathy in the upper and lower extremities, mononeuritismultiplex, diffuse and symmetric polyneuropathies, brachial[books.google.com]
  • In cases of mononeuropathy, just one nerve is affected. Polyneuropathy can affect nerves responsible for feeling (sensory neuropathy ), movement (motor neuropathy), or both (sensorimotor neuropathy).[medicalnewstoday.com]
  • This category of nerve damage (called mononeuropathy multiplex or multifocal mononeuropathy) is when isolated nerves in different areas are damaged.[verywell.com]
  • Causes of Peripheral Neuropathy Based on Clinical Presentation Conditions causing mononeuropathy Acute (trauma-related) Chronic (nerve entrapment) Disorders causing mononeuropathy multiplex Acute Diabetes mellitus* Multifocal motor neuropathy Vasculitic[aafp.org]
  • For example, some disorders involve single individual peripheral nerves— mononeuropathies —and some involve numerous individual peripheral nerves, the mononeuritis multiplex syndrome.[clevelandclinicmeded.com]
Dysesthesia
  • The common symptoms are as follows: numbness and/or tingling of extremities; burning or electric pain; dysesthesia; trouble with balance; dizziness; vision changes; and so on.[synapse.koreamed.org]
  • Small-fiber neuropathies often present with burning pain, lightning-like or lancinating pain, aching, or uncomfortable paresthesias (dysesthesias).[aafp.org]
  • In addition to sensory loss, patients often complain of paresthesias and dysesthesias, often characterized by a sense of numbness, tingling, prickling, and pins-and-needles sensations.[clevelandclinicmeded.com]

Treatment

  • The textbookprovides an evidence-based approach to testing, differential diagnosis, and treatment, and should serveas a trusted resource for healthcare professionals confronting the many manifestations of peripheralneuropathy in clinical practice.[books.google.com]
  • What is the treatment for peripheral neuropathy and its symptoms? Can peripheral neuropathy be cured? The treatment for peripheral neuropathy depends on its cause. The first step in treatment is, therefore, to look for the cause.[medicinenet.com]
  • Despite treatment with succimer meso-2,3-dimercaptosuccinic acid, her neuropathy progressed to ventilator dependence and quadriplegia.[ncbi.nlm.nih.gov]
  • For the treatment of DN, tight glucose control should be preceded [ 5 ].[synapse.koreamed.org]
  • Treatment Definitive therapy : treat the underlying disease![amboss.com]

Prognosis

  • Prognosis varies depending on the severity of nerve damage done by the medication. Conclusions As described in this review, there are many different kinds of polyneuropathies although their symptoms and signs might look similar.[synapse.koreamed.org]
  • Pregnancy and breast-feeding: arsenic is probably transferred to the baby via the placenta and breast milk. [ 2 ] Prognosis [ 2 ] The prognosis varies with the amount and rate of arsenic ingestion.[patient.info]
  • Lancet I: 791–794 Google Scholar Juntunen J, Antti-Poika M, Tola S, et al. (1982) Clinical prognosis of patients with diagnosed chronic solvent intoxication.[link.springer.com]
  • Classifications More than 100 types of peripheral neuropathy have been identified, each having a characteristic set of symptoms, a pattern of development, and prognosis.[verywell.com]

Etiology

  • Diagnostic tests, usually beginning electrodiagnostic testing, are indicated in patients with atypical clinical features, unknown etiology, and/or severe or rapidly progressive symptoms.[amboss.com]
  • Code First Code First Help Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology.[icd10data.com]
  • Though the etiological agent could not be confirmed with investigations, probable toxin induced polyneuropathy due to arsenic still remains the most likely diagnosis.[annalsofneurosciences.org]
  • We conducted an open label study of patients with peripheral neuropathy of multiple etiologies.[practicalpainmanagement.com]
  • With a systematic approach to the evaluation of these disorders, approximately 75% of patients have a specific etiologic diagnosis.[clevelandclinicmeded.com]

Epidemiology

  • Epidemiologic Reviews, 16 (2), 184-209 (1994). Enterline, P. E. and Marsh, G. M., Cancers among workers exposed to arsenic and other substances in a copper smelter. American Journal of Epidemiology, 116 (6), 895-911 (1982). Falk, H., Caldwell, G.[consultox.com]
  • […] table Free element of arsenic appears in two allotropic forms: grey and yellow (crystalline) Can also exist in various oxidation states, inorganic and organic forms, exposure to inorganic arsenic is associated with most cases of arsenic induced toxicity Epidemiology[pathologyoutlines.com]
  • Causation and causal inference in epidemiology. Am J Public Health 95 (Suppl 1): S144–50, 2005. Dalakas MC. Peripheral neuropathy and antiretroviral drugs. J Periph N Syst 6:14-20, 2001. Gaist D, Jeppesen U, Anderson M, et al.[now.aapmr.org]
  • Epidemiology In Victorian times arsenic was famous as a homicidal or suicidal poison; it is now thankfully much harder to obtain. Health and safety at work have also improved so that, in the UK, both acute and chronic arsenic poisoning are rare.[patient.info]
  • Epidemiology of peripheral neuropathy. J Neurol Neurosurg Psychiatry. 1997;62(4):310–318. ... 2. Hughes RA. Peripheral neuropathy. BMJ. 2002;324(7335):466–469. 3. Davies M, Brophy S, Williams R, Taylor A.[aafp.org]
Sex distribution
Age distribution

Pathophysiology

  • […] is present in air, usually due to volcanic eruption and purposeful human activities Arsenic also found as sulphuric compound in lead, copper, nickel and ferrous ores; also in soil in small quantities Also a medicinal used by physicians for 2000 years Pathophysiology[pathologyoutlines.com]
  • Our grasp of the pathophysiologic basis of the clinical PN has increased rapidly, but these advances are primarily descriptive and little progress has been made in understanding the fundamental pathogenic events that underlie the polyneuropathies.[practicalpainmanagement.com]
  • Because pathophysiology and symptoms are related, polyneuropathies are often classified by area of dysfunction: Myelin Vasa nervorum Axon Polyneuropathies may be acquired or inherited.[merckmanuals.com]
  • Pathophysiology Although peripheral neuropathy has multiple etiologies, the nerve has a limited number of ways to respond to injury. 4, 5 The damage can occur at the level of the axon (i.e., axonopathy).[aafp.org]
  • Back to Top Pathophysiology and Natural History Despite the diverse array of medical disorders that cause peripheral neuropathies, peripheral nerves exhibit only a few distinct pathologic reactions to an insult or disease: wallerian degeneration, axonal[clevelandclinicmeded.com]

Prevention

  • Rapidly find the answers you need with separate sections on diseases and disorders, differential diagnosis, clinical algorithms, laboratory results, and clinical preventive services, plus an at-a-glance format that uses cross-references, outlines, bullets[books.google.com]
  • SLIDESHOW Diabetic Peripheral Neuropathy: Improve Diabetes Nerve Pain See Slideshow Can peripheral neuropathy be prevented? Certain forms of peripheral neuropathy can be prevented.[medicinenet.com]
  • Phenytoin, which is prescribed to prevent seizures, and disulfiram, which is given to fight alcohol addition, both have been linked to peripheral neuropathy.[livestrong.com]
  • Prevention and outlook Preventing polyneuropathy involves limiting the risk factors and managing underlying conditions. A person with polyneuropathy may not be able to avoid all risk factors, but some lifestyle choices may reduce the risk.[medicalnewstoday.com]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!