Here we report a rare case of arsenical keratosis presented with multiple polymorphic eruptions combined with chloracne. [tandfonline.com]

On the palms and soles, numerous, yellow, firm, hyperkeratotic papules and plaques with surrounding collarettes of scale were present. [escholarship.org]

Clinical Presentation: Lorem ipsum dolor sit amet, consectetur adipiscing elit. Mauris non arcu. Morbi mi. Donec nibh. Nullam convallis sodales lorem. Quisque dui. [dermpedia.org]

Arsenicism is a systemic disease that can present with cutaneous, neurologic, and/or gastrointestinal symptoms. Acute arsenic toxicity most commonly presents with gastrointestinal symptoms with nausea, vomiting, and diarrhea. [clinicaladvisor.com]

• Weakness

  StatPearls will help you identify your weaknesses so that when you are ready to study for a board or certification exam in Family Medicine-Medical Student, you will already be prepared. [knowledge.statpearls.com]

  The prevalence of pigmentation and keratosis, hepatomegaly, chronic respiratory disease and weakness rose significantly with increasing arsenic concentrations in drinking water. [dermatologyadvisor.com]

  […] deposits across the bed of the fingernails (Mee's lines) Hair Arsenic deposits in hair Nervous system Sensory changes, numbness and tingling in a “stocking-glove” distribution (sensory peripheral neuropathy) A headache, drowsiness, confusion The distal weakness [dermnetnz.org]

• Anemia

  Acute and chronic exposures can cause ANEMIA; KIDNEY and LIVER damage; PULMONARY EDEMA; MEMORY LOSS and behavioral changes; bone deformities in children; and MISCARRIAGE or PREMATURE LABOR in pregnant women. [bioportfolio.com]

  Skin lesions, peripheral neuropathy, and anemia are hallmarks of chronic arsenic exposure. [atsdr.cdc.gov]

  Extracutaneous manifestations are protean and include weakness, anemia, burning sensation of eyes, solid swelling of legs, liver fibrosis, chronic lung disease, gangrene of toes, neuropathy. [dermatologyadvisor.com]

  Use of medications with arsenic, like Fowler's solution, Donovan's solution, and asiatic pills, were previously used to treat leukemia, psoriasis, asthma, pemphigus, pernicious anemia, and Hodgkin's disease. [clinicaladvisor.com]

• Constitutional Symptom

  As a rule, except in some of the cases ofgeneralized erythematous rashes, the constitutional symptoms arerarely marked in dermatitis medicamentosa, and are not infrequentlywanting. [diarrhea.medicclub.info]

• Diarrhea

  Chronic arsenic poisoning may also result in many nonspecific gastrointestinal symptoms such as diarrhea and cramping, hematological effects such as leucopenia and neutropenia, and neurologic diseases, most notably peripheral neuropathy. [doi.org]

  Acute arsenic toxicity most commonly presents with gastrointestinal symptoms with nausea, vomiting, and diarrhea. [clinicaladvisor.com]

  Medicinal arsenic Inorganic arsenic has been used in medicine for at least 2500 years, particularly since the 18th century, when it was used to treat a great variety of illnesses (eg, acne, diarrhea, gastric ulcer, asthma, malaria, lupus, psoriasis, neurodermatitis [emedicine.medscape.com]

• Abdominal Pain

  Gastrointestinal (GI): Hypersalivation, abdominal pain, vomiting, diarrhoea leading to hypovolaemic shock. Trivalent arsenic is corrosive - may cause oral burns, dysphagia and GI bleeding. Cardiovascular: Myocardial depression. [patient.info]

• Palmoplantar Keratosis

  PUVA can be used for eczematized palmoplantar keratosis treatment. Suggestions Surgery and CO2 laser can treat local severe palmoplantar keratosis [waitall.com]

  Herein, we report a suspected case of palmoplantar arsenical keratosis in a patient from Newfoundland, Canada. [doi.org]

• Palmar Keratosis

  Keratotic nodular size will be measured of each patient to draw a conclusion about the effect of antimicrobials in patients with palmar arsenical keratosis. [clinicaltrials.gov]

  Role of linoleic acid in arsenical palmar keratosis. Int J Dermatol. 2016 Mar. 55 (3):289-95. [QxMD MEDLINE Link]. WashingtonDeceit. Dermatopathology of arsenical keratosis. YouTube. Available at http://www.youtube.com/watch?v=xBreXMMHmLU. [emedicine.medscape.com]

• Peripheral Neuropathy

  Peripheral neuropathy may occur and present similarly to the Guillain-Barré syndrome, with an asymmetric peripheral neuropathy. [clinicaladvisor.com]

  Chronic exposure is associated with mucosal irritation, desquamating rash, myalgias, peripheral neuropathy, and white transverse (Mees) lines in the fingernails. [bioportfolio.com]

• Tingling

  Exfoliative dermatitis Arsenic-induced skin cancers (especially Bowen disease) Nails Transverse white bands of arsenic deposits across the bed of the fingernails (Mee's lines) Hair Arsenic deposits in hair Nervous system Sensory changes, numbness and tingling [dermnetnz.org]

• Headache

  Nails Transverse white bands of arsenic deposits across the bed of the fingernails (Mee's lines) Hair Arsenic deposits in hair Nervous system Sensory changes, numbness and tingling in a “stocking-glove” distribution (sensory peripheral neuropathy) A headache [dermnetnz.org]

• Seizure

  Acute oral ingestion is associated with gastrointestinal symptoms and an encephalopathy which may manifest as SEIZURES, mental status changes, and COMA. [bioportfolio.com]

  Seizures. Haematological: Acute haemolysis. Bone marrow suppression. Basophilic stippling and rouleaux formation may be seen on a blood film. Skin: rashes. [patient.info]

• Neurologic Manifestation

  Other Medscape articles related to arsenic include Neurological Manifestations of Arsenic Intoxication and Arsenic Toxicity in Emergency Medicine. Pathophysiology The carcinogenic mechanism of arsenic is not well understood. [emedicine.medscape.com]

Workup may include: CBC with differential, liver function tests, renal function tests, blood and urine arsenic levels. Arsenic levels in tissue, hair and nails can be performed, but may be normal if only distant exposure. [wiydx.com]

A thorough history and physical examination should be performed and further imaging and workup should be based on these findings. [clinicaladvisor.com]

[…] have elevated linoleic acid levels in lipid extracts from the lesions when compared to patients with arsenic exposure but no lesions and to a control group with no arsenic exposure. [5] Imaging studies Imaging studies are not recommended in a standard workup [emedicine.medscape.com]

• Leukopenia

  […] system Sensory changes, numbness and tingling in a “stocking-glove” distribution (sensory peripheral neuropathy) A headache, drowsiness, confusion The distal weakness of small muscles of the. hands and feet Blood and urine Haemolytic anaemia (moderate) leukopenia [dermnetnz.org]

  The complete blood cell count may reveal anemia, leukopenia, and thrombocytopenia. Red blood cells may show cloverleaf nuclei when systemic symptoms are present. [emedicine.medscape.com]

Read more about this topic: Arsenical Keratosis Other articles related to " treatment, treatments ": Sleep Disorder - General Principles of Treatment ... [liquisearch.com]

There is no such study where effects of antimicrobials have been evaluated as the treatment of arsenical keratosis. [clinicaltrials.gov]

The recommended dosing regime is several treatment pulses, which are separated by several 4-day periods without treatment. PUVA can be used for eczematized palmoplantar keratosis treatment. [waitall.com]

Side effects associated with these treatments are inflammation, oozing, ulceration, crusting, pain, hypo/hyperpigmentation, and treatment failure. Surgical excision can be performed for arsenical keratoses. [dermatologyadvisor.com]

The prognosis of Arsenical Keratosis is generally excellent with suitable early treatment Who gets Arsenical Keratosis? (Age and Sex Distribution) Arsenical Keratosis usually forms over many decades (20-30 years). [dovemed.com]

Pregnancy and breast-feeding: arsenic is probably transferred to the baby via the placenta and breast milk. [ 2 ] Prognosis [ 2 ] The prognosis varies with the amount and rate of arsenic ingestion. [patient.info]

Prognosis and Clinical Course ArKs and arsenical-induced BD tend to persist for many years, and progression to invasive SCC is believed to be relatively rare. [dermaamin.com]

Léčba this psoriázy arrow-down Epidemiology Pustcular a rozsáhlá ložisková psoriáza Visual třetí arrow-down Presentation arrow-down Differential diagnosis arrow-down Psoriázy arrow-down Complications arrow-down Prognosis arrow-down Palmoplantar pustulosis [omycoricy.ga]

Epithelioma of the back of the hand is usually responsive to proper measures, but the prognosis is not so favorable as with the ordinary face cases, and axillary gland involve ment sometimes presents early. [doctortreatments.com]

Bowen's precancerous dermatosis and multiple benign superficial epithelioma; evidence of arsenic as an etiological agent Anderson, Anderson Arsenical epitheliomas of medicinal origin Arhelger, Arhelger; Kremen, Kremen Radio‐autographic studies of the [deepdyve.com]

(This article gives a thorough review of the literature regarding the etiology, epidemiology, and most common clinical presentations of chronic arsenic exposure. [clinicaladvisor.com]

(Etiology) Arsenical Keratosis is caused when skin cells (the keratinocytes that form the epidermis) are damaged from prolonged and frequently severe exposure to arsenic or arsenic-based compounds, over many decades Study research indicate that chronic [dovemed.com]

The rapid cell-growth requires increased 1 In a paper in which the possible etiologic factors are gone over, and carefully considered, Hartzell (“Etiology and Pathology of Malignant Diseases of the Skin Affecting Epithelial Tissue,” Jour. Cutan. [doctortreatments.com]

No global epidemiologic studies have been performed, and no direct predilection has been found among persons of different races. [emedicine.medscape.com]

[…] mechanisms of one of the most toxic minerals in the world • Helps readers understand potential health effects of arsenic, using population studies, mammalian and invertebrate models, and pharmacokinetic and toxicokinetic models • Discusses outcomes, epidemiology [books.google.com]

Case Overview arsenical keratosis Member Rated 0 Patient case no. 2022 Date added 18 May 2003 Patient details Age --Undetermined-- Localisation Upper limbs / hands / palms Description Primary Lesions Papule / hyperpigmented Hyperkeratosis Pathophysiology [dermquest.com]

Pathophysiology[edit] Arsenite impairs nucleotide excision repair,[6] and it may also affect gene expression by increasing or decreasing DNA methylation. [en.wikipedia.org]

Pathophysiology The exact mechanism for chromosomal damage has yet to be fully elucidated. [clinicaladvisor.com]

OBJECTIVE: For early detection and prevention of the arsenic-induced malignancies, the authors analyzed the clinical characteristics of arsenic-induced skin diseases. [koreamed.org]

The article reports treatment and preventative measures based on a review of the literature.) [clinicaladvisor.com]

Systemic Implications and Complications It’s important to treat squamous cell carcinomas early on to prevent the risk of metastasis. [dermatologyadvisor.com]

Medical treatment of PCOS is tailored to the patient's goals ... insulin levels Restoration of fertility Treatment of hirsutism or acne Restoration of regular menstruation, and prevention of endometrial hyperplasia and ... reasons for this is the lack [liquisearch.com]

Commencing early treatment can help prevent a progressive deterioration of Arsenical Keratosis and avoid complications. Several management measures are available and these include: Use of topical ointments, lotions, and creams. [dovemed.com]