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Arterial Thrombosis


Presentation

  • Here, we present a 36-year-old man with active ulcerative colitis presenting via digital arterial thrombosis and digital necrosis that was not associated with a surgical procedure.[ncbi.nlm.nih.gov]
  • The patient, who underwent emergency percutaneous coronary intervention, suffered from thrombocytopenia presenting with cerebral infarction and myocadial reinfarction during haparin exposure.[ncbi.nlm.nih.gov]
  • We present this case with a brief review of the literature.[ncbi.nlm.nih.gov]
  • Cushing's syndrome is known to present with a characteristic set of clinical manifestations and complications, well described in literature. However, hypercoagulability remains an under recognised entity in Cushing's syndrome.[ncbi.nlm.nih.gov]
  • However, symptoms of claudication were present only in 1 case and clinical significant legs growth retardation ( 15 mm) was present in 1%.[ncbi.nlm.nih.gov]
Chest Discomfort
  • You may experience: a crushing central chest pain or mild chest discomfort shortness of breath a clammy, sweaty and grey complexion dizziness nausea and vomiting If you suspect you or someone you know is having a heart attack, dial 999 immediately.[nhsinform.scot]
Noncompliance
  • A 50-year-old chronically noncompliant woman with a known unresected pheochromocytoma presented to the emergency department with ataxia. Imaging confirmed a right-sided ischemic stroke.[ncbi.nlm.nih.gov]
Pleural Effusion
  • In another case, massive ascites, pleural effusion, and variceal changes of the mesenteric veins owing to portal hypertension were identified, and surgical closure of the shunt was performed 152 days after partial portal arterialization.[ncbi.nlm.nih.gov]
Left Upper Quadrant Pain
  • A 31-year-old woman from Southern India presented with history of fever, left upper quadrant pain and progressive breathing difficulty for 3 weeks. Clinical examination revealed discriminatory features of Cushing's syndrome.[ncbi.nlm.nih.gov]
Liver Dysfunction
  • However, the patient worsened steadily and died of liver dysfunction due to multiple liver metastases.[ncbi.nlm.nih.gov]
Vascular Disease
  • Author information 1 Department of Vascular Diseases, Ljubljana University Medical Centre, Ljubljana, Slovenia - pavel.poredos@kclj.si. Abstract In the past, arterial and venous thrombosis have been accepted as two completely different diseases.[ncbi.nlm.nih.gov]
  • It's important that you don't wait and do treat these symptoms as an emergency. symptoms of a stroke Peripheral vascular disease If you have a narrowing of an artery in one or both of your legs (peripheral vascular disease) you may: be more susceptible[nhsinform.scot]
  • SEARCH METHODS: The Cochrane Peripheral Vascular Diseases Group Trials Search Co-ordinator searched the Specialised Register (last searched November 2013) and CENTRAL (2013, Issue 10).[ncbi.nlm.nih.gov]
  • Search strategy: The Cochrane Peripheral Vascular Diseases Group Trials Search Co-ordinator searched the Specialised Register (last searched November 2013) and CENTRAL (2013, Issue 10).[cochrane.org]
  • disease (PVD) – when the blood flow in the legs is affected Heart attack and stroke are leading causes of death in the UK.[your.md]
Leg Pain
  • The patient complained of acute leg pain after chemotherapy, and computed tomography revealed multiple thrombi from the thoracic to popliteal arteries.[ncbi.nlm.nih.gov]
Episodic Headache
  • The symptoms and signs of pheochromocytoma include the classic triad of episodic headache, increased sweating, and palpitations. These are as a result of an uncontrolled release of catecholamines.[ncbi.nlm.nih.gov]
Ataxia
  • A 50-year-old chronically noncompliant woman with a known unresected pheochromocytoma presented to the emergency department with ataxia. Imaging confirmed a right-sided ischemic stroke.[ncbi.nlm.nih.gov]

Workup

  • Hypercoagulability workup was negative. Pathology samples revealed vasculitis.[ncbi.nlm.nih.gov]
  • A hypercoagulability workup revealed the presence of an anticardiolipin antibody.[ncbi.nlm.nih.gov]
  • By extensive workup, no other known causes of arterial thrombosis were found. To our knowledge, this is the first case describing arterial thrombosis occurring as a complication of carboplatin therapy.[ncbi.nlm.nih.gov]
  • Patients presenting with an incomplete occlusion are usually with systemic anticoagulation and a medical workup investigating the cause of the thrombosis [2] .[ijcasereportsandimages.com]
  • Autoimmune workup to look for vasculitis is reasonable if this workup is negative. Hypercoagulable workup should be really limited to the ones that cause arterial thrombosis – see below. II.[errolozdalga.com]
Pleural Effusion
  • In another case, massive ascites, pleural effusion, and variceal changes of the mesenteric veins owing to portal hypertension were identified, and surgical closure of the shunt was performed 152 days after partial portal arterialization.[ncbi.nlm.nih.gov]

Treatment

  • Warfarin treatment was started in the level of INR 2-2,5. ASA with a dose of 100 mg/day was added to the treatment.[ncbi.nlm.nih.gov]
  • To report a case of arterial thrombosis in a 63-year-old female undergoing treatment with multiagent chemotherapy for breast cancer. An overview of the prevalence and pathogenesis of the disorder, clinical diagnosis, and treatment are discussed.[ncbi.nlm.nih.gov]
  • The hand surgeon may be called upon to direct management in cases of acute arterial thrombosis of the hand and should have an understanding of the available diagnostic tools and treatment modalities.[ncbi.nlm.nih.gov]
  • treatment of this complication.[ncbi.nlm.nih.gov]
  • Thrombolytic therapy is a well-defined treatment option for arterial and venous thrombosis in adults.[ncbi.nlm.nih.gov]

Prognosis

  • It is a dreaded complication and has a dismal prognosis if not promptly recognized and treated.[ncbi.nlm.nih.gov]
  • The goal of this study was to evaluate the effect of tirofiban use on the early and 6-month prognosis of patients with knee and below-knee arterial thrombosis who were treated with percutaneous thrombosuction (PT) within 24 h.[ncbi.nlm.nih.gov]
  • Outcomes after treatment of arterial thrombosis of the hand are variable, and prognosis may be related to whether isolated thrombosis or diffuse intravascular injury is present. Copyright 2015 American Society for Surgery of the Hand.[ncbi.nlm.nih.gov]
  • Prognosis Prognosis is severe in homozygous or compound heterozygous patients. Prognosis is good for heterozygous patients. With adequate treatment and monitoring, the risk of thromboembolic disease is markedly reduced.[orpha.net]
  • […] leg, the limb may have to be amputated. [1] Limb amputation is in itself usually remarkably well tolerated, but is associated with a substantial mortality ( 50%), primarily because of the severity of the diseases in patients where it is indicated. [1] Prognosis[en.wikipedia.org]

Etiology

  • In conclusion, this side effect of the use of thalidomide should be taken into consideration while doing examinations with respect to the etiology in arterial thromboembolism and because of this vascular complication that threatens life; we suggest stopping[ncbi.nlm.nih.gov]
  • Etiology Protein S deficiency is caused by mutations in the PROS1 gene (3q11-q11.2). Diagnostic methods Diagnosis is based on the measurement of protein S antigen levels (total protein S or free protein S) and anticoagulant activity.[orpha.net]
  • There are few case reports and case series in literature focussing on etiology and management (5-9). A Canadian registry reported 97 cases of neonatal thrombosis over a three-year period, from 29 centres.[medichub.ro]
  • OVERVIEW OF ANTIPHOSPHOLIPID SYNDROME Etiologies: 1) Primary (Idiopathic) 2) Secondary – associated with Autoimmune Disorders (especially SLE), Malignancy (both solid and heme tumors), Infections (bacterial, virla, and parasites), and Drug Reactions Diagnostic[errolozdalga.com]
  • Metabolic syndrome and risk of venous thromboembolism: Longitudinal Investigation of Thromboembolism Etiology (LITE). J Thromb Haemost 2009; 7: 746-751. 15.[ghrnet.org]

Epidemiology

  • A plasma-based global fibrinolysis assay, which is sensitive to plasma levels of plasminogen, regulators of fibrinolysis, and proteins involved in coagulation, has been used in large epidemiological studies to assess the role of fibrinolysis in thrombosis[ncbi.nlm.nih.gov]
  • FH of premature arterial thrombosis was any thrombotic event [IS, myocardial infarction or other arterial events event] KEYWORDS: Stroke in young adults; cohort studies; risk factors in epidemiology[ncbi.nlm.nih.gov]
  • Epidemiological studies have detected elevated γA/γ' fibrinogen in patients with arterial thrombosis, suggesting that this isoform promotes thrombosis.[ncbi.nlm.nih.gov]
  • This section focuses on the role of atherosclerosis in the formation of arterial thrombi and discusses their risk factors, epidemiology and associated complications In this section: Arterial thrombi Risk factors Incidence and prevalence Complications[thrombosisadviser.com]
Sex distribution
Age distribution

Pathophysiology

  • The pathophysiology, risk factors, diagnosis, and treatment options for this complication are discussed.[ncbi.nlm.nih.gov]
  • Pathophysiological studies indicated that etiopathogenetic mechanisms of both diseases are similar and that coagulation and platelet activation participate in both venous and arterial thrombogenesis.[ncbi.nlm.nih.gov]
  • Taken together, these findings indicated that palladin is involved in platelet activation and arterial thrombosis, implying a potent role of palladin in pathophysiology of thrombotic diseases. Copyright 2016 Elsevier Ltd. All rights reserved.[ncbi.nlm.nih.gov]
  • […] wound healing. 3 In addition, scientific development over the last 10 years indicates that the properties of the endothelium may even govern the physiological balance of haemostasis/fibrinolysis and that endothelial derangement can account for numerous pathophysiological[eurheartj.oxfordjournals.org]
  • In the progressed stage of our research. our focus was shifted to the pathophysiology of the ADAMTS13 molecule.[ginmu.naramed-u.ac.jp]

Prevention

  • In contrast, clopidogrel did not prevent coronary reocclusion and increased bleeding time.[ncbi.nlm.nih.gov]
  • Abstract P2Y12 inhibitors are a critical component of dual antiplatelet therapy (DAPT), which is the superior strategy to prevent arterialthrombosis in patients with acute coronary syndromes (ACS) and undergoing stent implantation..[ncbi.nlm.nih.gov]
  • Here, we report characterization of transgenic mice expressing recombinant human ADAMTS13 (rADAMTS13) in platelets and its efficacy in inhibiting arterial thrombosis and preventing hereditary and acquired antibody-mediated TTP in murine models.[ncbi.nlm.nih.gov]
  • […] high-dose ( 100 units/kg) unfractionated heparin administered as an intravenous bolus at the time of initiation of cardiac catheterization (that is, immediately after arterial puncture), with or without subsequent heparin maintenance doses, for the prevention[ncbi.nlm.nih.gov]
  • A narrative review of the literature on arterial access site thrombosis in children was carried out with a special focus on current evidence that supports preventive and treatment strategies.[ncbi.nlm.nih.gov]

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