We present the case of a middle-aged Caucasian patient, who presented with fever and headache within a few hours of starting cetuximab therapy and was diagnosed with cetuximab-induced aseptic meningitis after a complete workup. [ncbi.nlm.nih.gov]

• Sepsis

  METHODS: During the study period, 356 CSF samples were collected from patients with sepsis-like illness and/or aseptic meningitis. [ncbi.nlm.nih.gov]

  Finnish melko harvinaiset: sepsis, meningiitti English uncommon: sepsis, meningitis Last Update: 2012-04-10 Usage Frequency: 4 Quality: Reference: IATE Finnish nekrotisoiva faskiitti, virusperäinen meningiitti, divertikuliitti English necrotising fasciitis [mymemory.translated.net]

• Disability

  Long-term sequelae of meningitis include neuromuscular impairments, learning disabilities and hearing loss. Prompt diagnosis and treatment are essential to improved outcome. [ncbi.nlm.nih.gov]

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  If infants are diagnosed, medical professionals will order regular check-ins for hearing and learning disabilities. Aseptic meningitis was first described by Wallgren in 1925. Aseptic meningitis cases have varied historically. [en.wikipedia.org]

• Anorexia

  A variety of patients notice a change in body temperatures (higher than normal temperatures 38-40*C), marked with the possibility of vomiting, headaches, firm neck pain, and even anorexia. [en.wikipedia.org]

• Diarrhea

  Meanwhile, vomiting occurred in majority of the patients and diarrhea in parts of them. White blood cells in cerebrospinal fluid (CSF) exceeded normal range in all patients. Protein levels in CSF were above normal range in half of the patients. [ncbi.nlm.nih.gov]

  The next set of age group, like children, have similar but varying symptoms of sore throat, rashes, and diarrhea. In adults, symptoms and the harshness of them tend to be less in duration. [en.wikipedia.org]

• Neck Pain

  Fever, headache, neck pain, and altered mental status were the most common findings reported in TSIAM reactions. Severe reactions ranged from hypotension to seizure and unconsciousness or coma. [ncbi.nlm.nih.gov]

  A variety of patients notice a change in body temperatures (higher than normal temperatures 38-40*C), marked with the possibility of vomiting, headaches, firm neck pain, and even anorexia. [en.wikipedia.org]

• Irritability

  Drug-induced aseptic meningitis (DIAM) may be due to two mechanisms: (i) a direct meningeal irritation caused by the intrathecal administration of drugs and (ii) an immunologic hypersensitivity reaction to a systemic administration. [ncbi.nlm.nih.gov]

  Bacteria Lyme disease Syphilis Leptospirosis Fungi Cryptococcal infection Coccidioidal infection Drug-induced aseptic meningitis (DIAM) Irritation of the meninges from drugs administered directly to the spinal canal or subarachnoid space. [en.wikipedia.org]

• Altered Mental Status

  A 49-year-old man presented with episodes of altered mental status. He had two surgeries for a recurrent suprasellar arachnoid cyst. [ncbi.nlm.nih.gov]

  Older patients are less likely to have headache and neck stiffness, and more likely to have altered mental status and focal neurologic deficits11,13 (Table 311–13 ). [aafp.org]

• Confusion

  Focal central nervous system infections, such as occur in the spinal cord with viral myelitis, are much less common and may be confused with noninfectious disorders that cause acute flaccid paralysis. [ncbi.nlm.nih.gov]

  However other symptoms may be confusing and often appear similar. Herpes infections. This could be herpes simplex infections or a recurrence of chicken pox lesions called Herpes zoster. [news-medical.net]

  Physical examination showed fever, confusion, meningismus, papilledema and no focal signs. CT scan showed diffuse cerebral oedema. Because of signs of cranial hypertension CSF was obtained only 24 hours later. [scielo.br]

• Focal Neurological Deficit

  In serious cases, a multiple organ failure can also signal aseptic meningitis and oftentimes, in babies, seizures and focal neurological deficits can be early symptoms of aseptic meningitis. In fact, in newborns, the mortality rate is 70%. [en.wikipedia.org]

  HSV meningitis can present with or without cutaneous lesions and should be considered as an etiology in persons presenting with altered mental status, focal neurologic deficits, or seizure.15 The time from symptom onset to presentation for medical care [aafp.org]

We present the case of a middle-aged Caucasian patient, who presented with fever and headache within a few hours of starting cetuximab therapy and was diagnosed with cetuximab-induced aseptic meningitis after a complete workup. [ncbi.nlm.nih.gov]

• Herpes Simplex Virus Type 2

  We describe the case of a 49-year-old Caucasian man who developed recurrent episodes of herpes simplex virus type 2-associated aseptic meningitis in the setting of heat exposure and bicycling. [ncbi.nlm.nih.gov]

• Hepatic Necrosis

  In younger patients, like babies, a meningeal inflammation can be noticed along with the possibility of hepatic necrosis and myocarditis. [en.wikipedia.org]

DIAM has been recognized with various treatments including non-steroidal anti-inflammatory drugs, monoclonal antibodies and some antibiotics. [ncbi.nlm.nih.gov]

Clinicians need to consider syphilis in the differential diagnosis of macular or papular rashes with neurological conditions, particularly aseptic meningitis, as early diagnosis and treatment lead to a better prognosis. [ncbi.nlm.nih.gov]

KEYWORDS: aseptic meningitis; cerebrospinal fluid; etiology; signs and symptoms [ncbi.nlm.nih.gov]

Abstract We reviewed the epidemiological and clinical characteristics of 927 aseptic meningitis patients in Shandong in 2014, and the phylogeny of predominant enterovirus (EV) types causing this disease was analyzed. [ncbi.nlm.nih.gov]

[…] for Disease Control and Prevention, Jinan, People's Republic of China; Academy of Preventive Medicine, Shandong University, Jinan, People's Republic of China. 3 Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Shandong [ncbi.nlm.nih.gov]