Presentation
The present study deals with the successful screening of potent microorganisms producing l-asparaginase. 47 microorganisms were screened including bacteria, fungi, and yeasts. [ncbi.nlm.nih.gov]
Entire Body System
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Thyroid Nodule
We report the first two cases of hyperthyroidism associated with thyroid nodule following L-asparaginase therapy for acute lymphoblastic leukemia (ALL). [ncbi.nlm.nih.gov]
Eyes
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Esotropia
Ocular motor examination revealed esotropia with a right abduction deficit, consistent with a sixth nerve palsy, and funduscopy revealed bilateral optic disc edema. [ncbi.nlm.nih.gov]
Neurologic
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Focal Seizure
Intracranial hemorrhage and focal seizures secondary to use of l-asparaginase during induction therapy of acute lymphocytic leukemia. J Pediatr. 1980; 97:829-33. [PubMed 6933231] 101. Priest JR, Ramsay NKC, Steinherz PG et al. [web.archive.org]
Workup
Serum
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Glutamine Increased
The substitution of Ser-254 with either an asparagine or a glutamine increases the l-asparagine specificity but only when combined with the E63Q mutation. [ncbi.nlm.nih.gov]
Other Pathologies
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Pancreatic Necrosis
Computed tomography scan demonstrated extensive pancreatic necrosis involving 90% of the gland. He underwent surgical debridement of his necrotic pancreas and wide drainage of the lesser sac. [ncbi.nlm.nih.gov]
Treatment
Treatment Adult Acute Lymphocytic Leukemia 3 4 Completed Treatment Lymphoma, Lymphoblastic 1 4 Recruiting Treatment Acute Lymphobkastic Leukemia 1 4 Recruiting Treatment Acute Lymphoblastic Leukaemias (ALL) 1 4 Recruiting Treatment Peripheral T Cell [drugbank.ca]
An 8-year-old girl with acute lymphoblastic leukaemia developed acute pancreatitis following treatment with asparaginase. Clinical and laboratory improvements were evident after treatment with somatostatin, with no complications of pancreatitis. [ncbi.nlm.nih.gov]
Prognosis
Abstract Aggressive nature killer cell leukemia (ANKL) is a mature NK-T cell lymphoma with worse prognosis, but optimal treatment is unclear. Therefore, we analyzed the efficacy of L-asparaginase-based regimens for ANKL patients. [ncbi.nlm.nih.gov]
ALL in children has a much better prognosis than in adults, with over 90% of children going into remission and an 80% cure rate with chemotherapy. [encyclopedia.com]
Etiology
Reversible posterior leukoencephalopathy syndrome (RPLS) is being increasingly described with various etiologies even in the absence of hypertension. [ncbi.nlm.nih.gov]
Pathophysiology
Notably, more than half of the CVTs were diagnosed prior the administration of asparaginase which accentuates the role of other risk factors on the pathophysiology of CVT compared to truncal or central venous line (CVL) VTs in adult ALL patients. 2017 [ncbi.nlm.nih.gov]
We review the previously reported cases and discuss the clinical presentation, pathophysiology, and suggested treatment of this syndrome. 1988 by the American Academy of Neurology AAN Members: Sign in with your AAN member credentials (e-mail or 6-digit [neurology.org]
Effective strategies to prevent and treat AD remain elusive despite major efforts to understand its basic biology and clinical pathophysiology. Significant investments in therapeutic ... [doi.org]
Prevention
Octreotide 100 μg subcutaneously 3 times/day, utilized as a chemoprotectant, was found to prevent pancreatitis recurrence. [ncbi.nlm.nih.gov]