Presentation
Fever in aspergillus mycetoma Free Abstract Two patients with aspergillus mycetoma presenting with fever as a major sign are described. [thorax.bmj.com]
It presents as a chronic sinusitis with headache, nasal discharge and obstruction. [aspergillus.org.uk]
The authors present a case of a patient presenting with painful tearing which elicited further evaluation with CT imaging. This revealed a maxillary sinus fungus ball as the cause for the patient's tearing. [ncbi.nlm.nih.gov]
The authors present a case of a patient presenting with painful tearing which elicited further evaluation with CT imaging. This revealed a maxillary sinus fungus ball as the cause for the patient’s tearing. [ingentaconnect.com]
Entire Body System
- Surgical Procedure
After surgical procedure, microscopic examination revealed aspergillosis. Overextension into the maxillary sinus with root canal cements has to be avoided. [ncbi.nlm.nih.gov]
If spillage of fungal infection is anticipated because of the complexity of the surgical procedure, antifungal therapy can be administered in the weeks preceding surgery (SoR A and QoE III). [erj.ersjournals.com]
- Congestive Heart Failure
Further history included moderate pulmonary hypertension, New York Heart Association Class III 2 congestive heart failure and an episode of mycobacterium avium complex that was successfully treated 3 years prior to the initial visit with us. [journal.copdfoundation.org]
Respiratoric
- Cough
They can experience unintended weight loss, a chronic cough that produces mucus, the coughing up of blood, fatigue, and shortness of breath. Less often, fever or night sweats can occur. [rarediseases.org]
The initial manifestations of the disease on admission included cough, dyspnea, hemoptysis, pulmonary infiltrate, and renal failure. [ncbi.nlm.nih.gov]
[…] breath Kidney or liver failure Shock Bloody cough or massive bleeding from the lungs Allergic bronchopulmonary aspergillosis may cause: Coughing accompanied by mucus or blood Wheezing or worsening of asthma Fever Increased mucus or sputum secretions [my.clevelandclinic.org]
– you may cough up blood or lumps of mucus wheezing (a whistling sound when breathing) a high temperature of 38C or above weight loss If you already have a lung condition, your existing symptoms may get worse. a cough for more than 3 weeks a lung condition [nhs.uk]
Sometimes bothersome cough. Unpleasant infection of various internal organs. Fever. [medical-enc.com]
- Hemoptysis
[…] those with hemoptysis due to other causes. [jcm.asm.org]
The initial manifestations of the disease on admission included cough, dyspnea, hemoptysis, pulmonary infiltrate, and renal failure. [ncbi.nlm.nih.gov]
Amongst symptomatic, the most common symptoms include cough and hemoptysis. [thoracicmedicine.org]
Occasionally due to surrounding reactive vascular granulation tissue, hemoptysis may be present. Occasionally, erosion into a bronchial artery may lead to life-threatening hemoptysis 1. [radiopaedia.org]
In such cases surgical resection is indicated if significant hemoptysis occurs. [aacijournal.biomedcentral.com]
- Chronic Cough
They can experience unintended weight loss, a chronic cough that produces mucus, the coughing up of blood, fatigue, and shortness of breath. Less often, fever or night sweats can occur. [rarediseases.org]
A case report • A 71-year-old Chinese male was admitted with complaint of chronic cough and malaise for two months. He had been in Tucson, Arizona, USA, visiting for four months right before the symptoms occurred. [slideshare.net]
- Pulmonary Disorder
Chandler. (2008) The Pathology of Pulmonary Disorders Due to Aspergillus spp. Archives of Pathology & Laboratory Medicine 132 :11, 1713-1714. Online publication date: 1-Oct-2009. [archivesofpathology.org]
- Productive Cough
Patients will usually have very minor symptoms, such as a mild cough, and little evidence of systemic inflammation. When symptoms progress, patients may present with weight loss, productive cough, fatigue and shortness of breath. [journal.copdfoundation.org]
Cardiovascular
- Hypertension
There was no history of diabetes, hypertension, or any other significant disease/ disorder. [priory.com]
There was no history of diabetes, hypertension or any other significant disease/ disorder. The patient had a past history of smear-positive pulmonary tuberculosis 3 years back, for which he was advised antituberculosis drugs (ATT). [thoracicmedicine.org]
Further history included moderate pulmonary hypertension, New York Heart Association Class III 2 congestive heart failure and an episode of mycobacterium avium complex that was successfully treated 3 years prior to the initial visit with us. [journal.copdfoundation.org]
Skin
- Skin Disease
Control and Prevention International Society for Human and Animal Mycology Books about skin diseases See the DermNet NZ bookstore. [dermnetnz.org]
It may be attributed to subtropical and humid climates in North of Iran, so hot and humid climates predispose to fungal, skin diseases. [e-ijd.org]
Neurologic
- Irritability
Fecal transplant is used to treat gut infections and is now being studied as a treatment for obesity, urinary tract infections, irritable bowel syndrome and more. [nytimes.com]
When the lesion irritates the bone surface, a periosteal reaction or diffuse reactive sclerosis may take place. Penetration of the periosteum and cortex leads to formation of bone cavities. [pubs.rsna.org]
Workup
Certain associated atypical symptoms may warrant further workup. The authors present a case of a patient presenting with painful tearing which elicited further evaluation with CT imaging. [ncbi.nlm.nih.gov]
X-Ray
- Atelectasis
FIGURE 2 Simple aspergilloma that developed within a post-tuberculous cicatricial atelectasis of the left upper lobe with saccular bronchiectasis. [erj.ersjournals.com]
Atelectasis. Bronchiectasis. Steroid dependence. Progressive pulmonary fibrosis in severe cases. [patient.info]
Chest radiographs show hazy infiltrates reflecting segmental or lobar atelectasis, and bronchoscopy or postmortem examination reveal extensive plugging of bronchi and smaller airways by large mucoid casts containing fungal masses. [hivinsite.ucsf.edu]
Microbiology
- Aspergillus Fumigatus in the Sputum
Clinical and immunologic significance of Aspergillus fumigatus in the sputum. Am Rev Respir Dis. 1959 Aug;80:167–180. [ncbi.nlm.nih.gov]
Other Pathologies
- Lymphocytic Infiltrate
Figure 4: Photomicrograph showing scattered multinucleated giant cells, some Langhans type in granuloma formations with lymphocytic infiltration (H and E, ×25) Click here to view Figure 5: Photomicrograph of aspergillum organism in granulomas showing [jomfp.in]
Treatment
This treatment resulted in remission of the vasculitis. [ncbi.nlm.nih.gov]
Aspergillus Fumigatus Fungus Ball in the Transplanted Lung after Single Lung Transplantation: Treatment with Cavernostomy and Withdrawal of the Mycetoma. Clin Surg. 2017; 2: 1837. [clinicsinsurgery.com]
After endoscopic treatment, the right maxillary sinus was irrigated using amphotericin B for 2 weeks and then treated by iodine with gentamicin and ketoconazole for 6 weeks. At 1 month after endoscopic treatment, the mycetoma had disappeared. [surgicalcasereports.springeropen.com]
Prognosis
[…] which is a hypersensitive asthmatic reaction to Aspergillus antigens invasive aspergillosis, which is an acute infection that produces septicemia, thrombosis, and infarction of virtually any organ, especially the heart, lungs, brain, and kidneys Varied prognosis [quizlet.com]
Prognosis CNPA has a significant mortality of up to 40%, even if promptly recognised and treated. It is easy to miss and, in such cases, carries a worse prognosis. [patient.info]
Voriconazole (VFEND) With proper treatment, the prognosis is general good as the disease responds well to both antibiotic and antifungal medications. [lymphedemapeople.com]
Treatment and prognosis An asymptomatic aspergilloma does not necessarily require treatment, and the cavity is essentially isolated from any systemic administration of antifungal 3. [radiopaedia.org]
Treatment and prognosis The treatment is chosen only after distinguishing if the disease is an actinomycetoma or a eumycetoma. [afwgonline.com]
Etiology
The etiologic agents range from bacteria to fungi existing free in nature as soil or plant saprophytes gaining entrance into the tissues through abrasion or implantation. Actinomycetoma is caused by aerobic species of actinomycetes. [aspergillus.org.uk]
Aspergillus nidulans is a rare etiological agent, causing pale grain mycetoma. Only 7 cases of Aspergillus nidulans mycetoma have been reported in literature - 1 from India (Rajasthan, 1985), 6 from Africa. [ijidonline.com]
Complete patients' characteristics and etiological agents are reported in Table 1. In 2 cases, the infection was acquired in India, in 2 in Ethiopia, an in 1 case each in Senegal, Tanzania, Honduras, and Italy. [karger.com]
Pseudallescheria boydii is the most common etiologic agent of eumycetoma in the United States. Madurella mycetomatis accounts for most cases worldwide. Madurella grisea is a common etiologic agent in South America. [emedicine.medscape.com]
Epidemiology
Eumycetoma and actinomycetoma–an update on causative agents, epidemiology, pathogenesis, diagnostics and therapy. J Eur Acad Dermatol Venereol 2015;29:1873-1883. van de Sande WW. [afwgonline.com]
Epidemiological profile and spectrum of neglected tropical disease eumycetoma from Delhi, North India. Epidemiol Infect. 2019;147:e294. Chander J. Subcutaneous mycosis mycetoma. In: A Textbook of Medical Mycology. 3rd ed. [jpad.com.pk]
The Conference Theme is: The Holistic management of Mycetoma The following issues will be discussed during the conference: Mycetoma Epidemiology, Control & Eradication Novel Organisms Causing Mycetoma Clinical Presentation of Mycetoma New Diagnostic Tools [aspergillus.org.uk]
The injuries were classified in five categories that pointed injuries such as pricking that had special importance in the epidemiology of mycetoma and the other included cuts, operated injuries, scratch and war injuries. [scialert.net]
Pathophysiology
Stefano Veraldi1, Anna Grancini2, Luigia Venegoni1, Valentina Merlo1, Elena Guanziroli1, Claudia Menicanti1, Gianluca Nazzaro1 and Annamaria Tortorano3 1Department of Pathophysiology and Transplantation, Università degli Studi di Milano, IRCCS Foundation [medicaljournals.se]
[…] accumulation of fungal hyphae Essential features Dense fungal growth with no tissue invasion Fruiting heads (sexual reproduction) may be seen Terminology Fungal ball, mycetoma, chronic noninvasive fungal sinusitis Sites Maxilla is most commonly affected Pathophysiology [pathologyoutlines.com]
Author Contacts Gianluca Nazzaro, MD Department of Pathophysiology and Transplantation Università degli Studi di Milano, I.R.C.C.S. [karger.com]
Pathophysiology The foot is the most common site of infection, and 70% of all mycetomas affect the foot. [emedicine.medscape.com]
Pathophysiology In a healthy, immunocompetent individual, macrophages and neutrophils normally defend against the inhaled fungus. [patient.info]
Prevention
[…] of HIV HIV Transmission and Prevention in Specific Populations Systematic Review of HIV Behavioral Prevention Research in African Americans Lynae A. [hivinsite.ucsf.edu]
These problems are addressed and measures of prevention such as smoking cessation are included. [books.google.com]
Health care providers and researchers believe that wearing shoes might prevent injuries that can lead to mycetoma. [cdc.gov]
Prevention The best prevention of aspergillosis is a healthy way of life that is capable of normal immune system. [medical-enc.com]
Centers for Disease Control and Prevention. Disease condition caused by species of aspergillus and marked by inflammatory granulomatous lesions in the skin, ear, orbit, nasal sinuses, lungs, and sometimes in the bones and meninges. [icd10data.com]