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Aspirin

Acetylsalicylic Acid


Presentation

  • Unique, relevant, and unexpected findings from the platelet function testing are presented.[ncbi.nlm.nih.gov]
  • Health care workers must be cognizant of the simultaneous presentation of both IgG4-RD and AERD.[ncbi.nlm.nih.gov]
  • , and ECG presentation) characteristics.[circ.ahajournals.org]
  • The findings of the present study may provide novel guidance to the clinical treatment of IUA.[ncbi.nlm.nih.gov]
  • However, clinical studies demonstrated that patients that regularly took aspirin presented recurrence of cardiovascular events.[ncbi.nlm.nih.gov]
Pain
  • Patients who reported any type of chest pain were assessed for the presence of cardiac risk factors, eosinophilia, and response of chest pain to a variety of treatments.[ncbi.nlm.nih.gov]
  • There is no consensus to stop aspirin therapy before interventional chronic pain procedures. CASE REPORT: A 73-year-old woman with postlaminectomy pain syndrome and lumbar radiculopathy underwent percutaneous spinal cord stimulator lead placement.[ncbi.nlm.nih.gov]
  • Aspirin.ca - (Canada) The official Canadian Aspirin website providing information on back pain and arthritis pain relief using Bayer Inc.'s acetylsalicylic acid. Bayer Aspirin Information about heart attack prevention and the pain reliever.[curlie.org]
  • Joseph What this drug is used for Aspirin relieves pain and reduces fever. It is used for headaches, toothaches, and the minor aches and pains of arthritis, colds, and flu.[web.archive.org]
  • Do not take delayed-release tablets for fever or pain that must be relieved quickly.[nlm.nih.gov]
Fever
  • We conclude that naproxen is as effective, is easier to use, and is safer than aspirin in the treatment of the arthritis of rheumatic fever.[ncbi.nlm.nih.gov]
  • Do not take delayed-release tablets for fever or pain that must be relieved quickly.[nlm.nih.gov]
  • It works by reducing substances in the body that cause pain, fever, and inflammation. Aspirin is used to treat mild to moderate pain, and also to reduce fever or inflammation.[web.archive.org]
  • Do not take aspirin for more than 10 days for pain or 3 days for fever without your doctor's approval.[web.archive.org]
  • An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature.[ebi.ac.uk]
Anemia
  • […] associated with asthma, sarcoidosis, thrombocytopenia, ulcerative colitis Relative Appendicitis, asthma (bronchial), chronic diarrhea, bowel outlet obstruction (for enteric-coated formulations), dehydration, erosive gastritis, hypoparathyroidism Cautions Anemia[reference.medscape.com]
  • […] rivaroxaban) Aspirin alcohol/food interactions There are 2 alcohol/food interactions with aspirin Aspirin disease interactions There are 9 disease interactions with aspirin which include: coagulation asthma GI toxicity renal dysfunction Reye's syndrome anemia[drugs.com]
  • Your doctor may tell you that you should not take aspirin. tell your doctor if you often have heartburn, upset stomach, or stomach pain and if you have or have ever had ulcers, anemia, bleeding problems such as hemophilia, or kidney or liver disease.[nlm.nih.gov]
Fatigue
  • Side effects The most common side effects of aspirin are: dizziness, ringing in the ears, blurred vision drowsiness, fatigue, depression thirst, sweating, fluid retention, swollen ankles abdominal discomfort or bloating nausea, heartburn, diarrhoea, constipation[adf.org.au]
  • Post-Viral Fatigue Syndrome - How To Live With It (1989) It is also possible to unintentionally combine aspirin based drugs with other medicines and this could be dangerous.[collinsdictionary.com]
  • One subject taking a daily dose of 324 mg of aspirin reported mild fatigue on days 14 and 17. Two subjects reported episodes of headache.[jnci.oxfordjournals.org]
Easy Bruising
  • Notify your doctor promptly if you develop a persistent ringing in the ears, difficulty hearing, dark urine, yellowing eyes, easy bruising, persistent stomach pain or presence of black stools.[web.archive.org]
  • Notify your doctor promptly if you develop: persistent ringing in the ears, difficulty hearing, dark urine, yellowing eyes, easy bruising, persistent stomach pain, black stools.[web.archive.org]
  • However, regular use of aspirin may eventually cause: anaemia (low red blood cell count) easy bruising and abnormal bleeding inflamed stomach lining, stomach bleeding and peptic ulcers vomiting blood that may look like coffee grounds and bowel motions[adf.org.au]
  • Bleeding that won't stop Pale skin with easy bruising Black, tarry, or bloody stools Bad headache Ringing in the ears Swelling or pain in one or both legs Sudden numbness, weakness, confusion, dizziness, or headache Signs of allergic reaction: - rash[childrensmn.org]
  • Easy bruising (common). Tinnitus (ringing in the ears, a rare side effect). Potential significant exacerbation of asthma. Anaphylaxis.[allergy.org.au]
Hyperpnea
  • Methemoglobinemia makes mucous membranes brown or muddy in color and is usually accompanied by tachycardia, hyperpnea, weakness, and lethargy.[merckmanuals.com]
  • Symptoms of acute systemic toxicity include hyperpnea, tachypnea, tinnitus, deafness, hyperpyrexia, diaphoresis, lethargy, confusion, coma, and seizures.[doi.org]
  • […] distress, heartburn, anorexia, GI bleeding Hematologic: thrombocytopenia, hemolytic anemia, leukopenia, agranulocytosis, shortened red blood cell life span Hepatic: hepatotoxicity Metabolic: hyponatremia, hypokalemia, hypoglycemia Respiratory: wheezing, hyperpnea[medical-dictionary.thefreedictionary.com]
  • References Physical Pulmonary Hyperventilation (common) Hyperpnea Noncardiogenic pulmonary edema Respiratory arrest Apnea Aspiration pneumonitis Auditory Ototoxicity Tinnitus: Tinnitus is commonly encountered when serum salicylate concentrations exceed[misc.medscape.com]
Tachypnea
  • Symptoms of acute systemic toxicity include hyperpnea, tachypnea, tinnitus, deafness, hyperpyrexia, diaphoresis, lethargy, confusion, coma, and seizures.[doi.org]
  • The chronic ingestion of salicylates may produce the appearance of anxiety with its associated tachypnea, difficulty concentrating, and hallucinations; agitated delirium also may be observed.[misc.medscape.com]
Nausea
  • Other nonsteroidal anti-inflammatory drugs are effective antipyretics and are not associated with the constellation of symptoms seen in Reye syndrome, which includes nausea, vomiting, headache, excitability, delirium, combativeness, and coma.[ncbi.nlm.nih.gov]
  • Exposure Routes inhalation, ingestion, skin and/or eye contact Symptoms irritation eyes, skin, upper respiratory system; increased blood clotting time; nausea, vomiting; liver, kidney injury Target Organs Eyes, skin, respiratory system, blood, liver,[cdc.gov]
  • Check with your doctor immediately if the child has a severe sore throat that lasts for more than 2 days, or has a sore throat accompanied or followed by fever, headache, rash, nausea, or vomiting.[web.archive.org]
  • […] child LDLo oral 104mg/kg (104mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA BLOOD: HEMORRHAGE GASTROINTESTINAL: NAUSEA OR VOMITING Lancet.[chem.nlm.nih.gov]
Abdominal Pain
  • Long-term risks from daily aspirin therapy may include abdominal pain or bleeding of the stomach or stomach ulcers.[aerd.partners.org]
  • Symptoms of this type of severe bleed include upper abdominal pain, passing blood or black stools, or vomiting blood. If this happens, seek urgent medical attention. Severe bleeds may also occur in the brain, leading to a stroke.[bhf.org.uk]
  • Since the effects of nonsteroidal anti-inflammatory drugs (NSAID) intolerance are by no means always severe or life-endangering but may just as well present as oligosymptomatic or local disorders (e.g. abdominal pain, diarrhea, we decided to evaluate[ncbi.nlm.nih.gov]
  • An acute single ingestion of 100–125 mg/kg can lead to vomiting, diarrhea, nausea, abdominal pain, and anorexia. Renal failure may follow dosages of 175–300 mg/kg.[merckmanuals.com]
Melena
  • The most common of these manifestations are mild, such as skin hemorrhages as petechiae or microscopic hematuria, but may also include epistaxis, bleeding gums, hematemesis, and melena.[web.archive.org]
  • […] listed in the Anti-platelet Trialists Collaboration, in which a direct aspirin–placebo comparison was possible, found a pooled odds ratios (OR) of 1.5 to 2.0 for categories of gastrointestinal bleeding with aspirin use (for example, hematemesis and melena[doi.org]
  • NSAID-induced GI bleeding may be occult, leading to iron-deficiency anemia, or be more severe, resulting in vomiting, hematemesis, and melena.[merckvetmanual.com]
  • Dosages of 5.6–11.1 mg/kg, PO, for 3–7 days have caused melena, frequent vomiting, abdominal pain, perforating duodenal ulcer, weakness, stumbling, pale mucous membranes, regenerative anemia, neutrophilia with a left shift, increased BUN and creatinine[merckmanuals.com]
Dyspepsia
  • […] example, patients with a family history of myocardial infarction at an early age and patients who smoke or have multiple cardiovascular risk factors may be most likely to benefit, whereas those with risk factors for gastrointestinal bleeding such as dyspepsia[mdedge.com]
  • Adverse reactions EENT: hearing loss, tinnitus, ototoxicity GI: nausea, vomiting, abdominal pain, dyspepsia, epigastric distress, heartburn, anorexia, GI bleeding Hematologic: thrombocytopenia, hemolytic anemia, leukopenia, agranulocytosis, shortened[medical-dictionary.thefreedictionary.com]
  • —possible problems with enteric coating and, since aspirin is likely to be the least-tolerated component, benefits of other well-tolerated components may be lost if treatment is stopped due to dyspepsia (author favours giving aspirin separately) Need[doi.org]
  • Some sources recommend that patients with hyperthyroidism avoid aspirin because it elevates T4 levels. [2] Common side effects Gastrointestinal complaints (stomach upset, dyspepsia, heartburn, small blood loss).[newworldencyclopedia.org]
  • Reproductive systemand mammary disorders Rare: Menorrhagia Gastrointestinal disorders Common: Dyspepsia. Rare: Severe gastrointestinal haemorrhage, nausea, vomiting. Not known: Gastric or duodenal ulcers and perforation, diarrhoea.[medicines.org.uk]
Hematemesis
  • The most common of these manifestations are mild, such as skin hemorrhages as petechiae or microscopic hematuria, but may also include epistaxis, bleeding gums, hematemesis, and melena.[web.archive.org]
  • […] placebo-controlled trials listed in the Anti-platelet Trialists Collaboration, in which a direct aspirin–placebo comparison was possible, found a pooled odds ratios (OR) of 1.5 to 2.0 for categories of gastrointestinal bleeding with aspirin use (for example, hematemesis[doi.org]
  • NSAID-induced GI bleeding may be occult, leading to iron-deficiency anemia, or be more severe, resulting in vomiting, hematemesis, and melena.[merckvetmanual.com]
  • Hematemesis, epistaxis, melena, ataxia, paresis, seizures, and sudden death have also been observed. Treatment : If the exposure has occurred within the last 24 hours, emetics, activated charcoal, and cathartics are warranted.[ansci.cornell.edu]
Tinnitus
  • Vol. 7, Pg. 365, 1984. human TDLo oral 480mg/kg/7D-I (480mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR Arzneimittel-Forschung. Drug Research.[chem.nlm.nih.gov]
  • Very high doses of aspirin may cause confusion or ringing in the ears (tinnitus). Aspirin should be avoided in children, as it can trigger Reye's syndrome, a condition with liver inflammation and brain swelling.[allergy.org.au]
  • Angioedema Bronchospasm CNS alteration Dermatologic problems GI pain, ulceration, bleeding Hepatotoxicity Hearing loss Nausea Platelet aggregation inhibition Premature hemolysis Pulmonary edema (salicylate-induced, noncardiogenic) Rash Renal damage Tinnitus[reference.medscape.com]
  • Its primary undesirable side effects, especially in stronger doses, are gastrointestinal distress (including ulcers and stomach bleeding) and tinnitus.[medical-dictionary.thefreedictionary.com]
  • However, the site and the mechanism of generation of tinnitus induced by salicylate remains unclear. Here, we developed a behavioral procedure to measure tinnitus in rats.[jneurosci.org]
Urticaria
  • No appearance of urticaria or bronchospastic reactions was registered in any subject, confirming the safe use of IS in aspirin-sensitive patients.[ncbi.nlm.nih.gov]
  • We enrolled 67 subjects with documented intolerance to aspirin, pyrazolones or NSAIDs, clinically manifested as urticaria/angioedema (68%), asthma, and/or rhinitis (32%).[doi.org]
  • KEYWORDS: AERD; anti-IgE therapy; chronic idiopathic urticaria; pulmonology[ncbi.nlm.nih.gov]
  • Dietary salicylates in aspirin-sensitive patients Some people who have urticaria or asthma and nasal polyps suffer symptoms if they eat foods that have high levels of natural salicylates.[allergy.org.au]
  • Vomiting Warnings Contraindications Hypersensitivity to aspirin or NSAIDs; aspirin-associated hypersensitivity reactions include aspirin-induced urticaria (HLA-DRB1*1302-DQB1*0609 haplotype), aspirin-intolerant asthma (HLA-DPB1*0301) Allergy to tartrazine[reference.medscape.com]
Pruritus
  • SAFETY AND ADVERSE EFFECTS At therapeutically equivalent doses, different narcotics are likely to produce similar levels of side effects such as constipation, respiratory and cardiovascular depression, nausea, and pruritus.[aafp.org]
Sparse Hair
  • In this study, we report a Japanese female diagnosed with PROS, who presented with hyperplasia of the lower extremities, macrodactyly, multiple lipomatosis, and sparse hair.[ncbi.nlm.nih.gov]
Epistaxis
  • Abstract Objectives/Hypothesis: Epistaxis represents a very common emergency in any ear, nose, and throat (ENT) department around the world.[doi.org]
  • […] entradas: In the Spanish description: ácido acetilsalicílico English: aspirin Forum discussions with the word(s) "aspirina" in the title: A Carlos le dolía la muela y se tomó una aspirina. arrticles - Los medicamentos común como la aspirina - grammar Epistaxis[wordreference.com]
  • Minor bleeding episodes (epistaxis, bruising, etc.) are also increased. A well-conducted meta-analysis of primary and secondary prevention trials found a moderately increased relative risk of hemorrhagic stroke in aspirin users.[care.diabetesjournals.org]
  • The most common of these manifestations are mild, such as skin hemorrhages as petechiae or microscopic hematuria, but may also include epistaxis, bleeding gums, hematemesis, and melena.[web.archive.org]
  • Not known: Cases of bleeding with prolonged bleeding time such as epistaxis, gingival bleeding. Symptoms may persist for a period of 4–8 days after acetylsalicylic acid discontinuation.[medicines.org.uk]
Hematuria
  • Neonatal hemostatic abnormalities included numerous petechiae over the presenting part, hematuria, a cephalhematoma, subconjunctival hemorrhage, and bleeding from a circumcision.[ncbi.nlm.nih.gov]
  • Vol. 33, Pg. 631, 1983. infant TDLo oral 120mg/kg (120mg/kg) KIDNEY, URETER, AND BLADDER: HEMATURIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION British Medical Journal.[chem.nlm.nih.gov]
  • Gastrointestinal bleeding and hematuria in the patients’ history were recorded. Subjects were categorized into current cigarette smokers and nonsmokers.[doi.org]
  • The most common of these manifestations are mild, such as skin hemorrhages as petechiae or microscopic hematuria, but may also include epistaxis, bleeding gums, hematemesis, and melena.[web.archive.org]
  • In addition to serious gastrointestinal bleeding events, episodes of peptic ulcer, self-reported hematuria, easy bruising, and epistaxis were significantly more common among the women randomly assigned to receive aspirin than among those randomly assigned[doi.org]
Seizure
  • Other symptoms such as fever or seizures are treated as necessary.[msdmanuals.com]
  • Other symptoms such as fever or seizures are treated as necessary. Generic Name Select Brand Names Sodium bicarbonate No US brand name acetaminophen TYLENOL ibuprofen ADVIL, MOTRIN IB[merckmanuals.com]
  • Overdose symptoms may include temporary hearing loss, seizure (convulsions), or coma. What should I avoid while taking aspirin? Avoid drinking alcohol while you are taking aspirin. Heavy drinking can increase your risk of stomach bleeding.[drugs.com]
  • Symptoms of overdose may include nausea, vomiting, burning pain in the throat and stomach, loss of appetite, fever, tremors, confusion, headache, dizziness, weakness, ringing in the ears, fast or slow breathing, agitation, constipation, seizures, fainting[web.archive.org]
Dizziness
  • Others include heartburn, loss of appetite or dizziness. Notify your doctor if any of these symptoms persist or worsen.[web.archive.org]
  • This drug may make you dizzy or drowsy. Alcohol or marijuana ( cannabis ) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages.[webmd.com]
  • Side effects The most common side effects of aspirin are: dizziness, ringing in the ears, blurred vision drowsiness, fatigue, depression thirst, sweating, fluid retention, swollen ankles abdominal discomfort or bloating nausea, heartburn, diarrhoea, constipation[adf.org.au]
  • Bleeding that won't stop Pale skin with easy bruising Black, tarry, or bloody stools Bad headache Ringing in the ears Swelling or pain in one or both legs Sudden numbness, weakness, confusion, dizziness, or headache Signs of allergic reaction: - rash[childrensmn.org]
Vertigo
  • Nervous system disorders Rare: Intracranial haemorrhage Not known: Headache, vertigo. Ear and labyrinth disorders Not known: Reduced hearing ability; tinnitus. Vascular disorders Rare: Hemorrhagic vasculitis.[medicines.org.uk]
  • . • Stay alert for signs and symptoms of acute toxicity, such as diplopia, ECG abnormalities, generalized seizures, hallucinations, hyperthermia, oliguria, acute renal failure, incoherent speech, irritability, restlessness, tremor, vertigo, confusion,[medical-dictionary.thefreedictionary.com]
  • Other side effects include: Rash, kidney impairment, vertigo, and dizziness.[medicinenet.com]
Neglect
  • While the explanation for this observation is not obvious, it may be that physicians focus on high-technology interventions in high-risk patients and inadvertently neglect the simple use of aspirin.[circ.ahajournals.org]
  • ., child abuse or neglect) should be expeditiously transported to an emergency department regardless of the dose ingested.[doi.org]

Treatment

  • To estimate the risk of hemorrhagic stroke associated with aspirin treatment.[ncbi.nlm.nih.gov]
  • Their chest pain did not improve with typical antianginal treatments but did respond to corticosteroid therapy.[ncbi.nlm.nih.gov]
  • Aspirin (ASA) is the mainstay of treatment in cerebrovascular and systemic vascular disease. ASA hypersensitivity can pose a challenge to achieving optimum medical management prior to and after neurointerventional treatment.[ncbi.nlm.nih.gov]
  • Patients, investigators, and others involved in treatment or data analysis were masked to treatment allocation.[ncbi.nlm.nih.gov]
  • .— To estimate the risk of hemorrhagic stroke associated with aspirin treatment.[doi.org]

Prognosis

  • In rare occasions, simultaneous thrombosis of 2 coronary arteries occurs, which is usually associated with a worse prognosis.[ncbi.nlm.nih.gov]
  • In conclusion, postoperative combination therapy with transdermal estrogen gel and oral aspirin may be more efficacious in enhancing endometrial receptivity by increasing uterine blood and angiogenesis, contributing to improved fertility prognosis.[ncbi.nlm.nih.gov]
  • Survival bias is of concern for diseases characterised by poor prognosis, including lung cancer.[dx.doi.org]
  • Prognosis is excellent, with clinical signs abating within 72 hours. However, if the weedkiller was dipyridyl type(paraquat, diquat), then the prognosis is not very good.[web.archive.org]

Etiology

  • OBJECTIVE: There are various etiologies of erectile dysfunction (ED), including endothelial dysfunction, atherosclerosis, and chronic inflammation.[ncbi.nlm.nih.gov]
  • Clinical and epidemiologic features support an infectious cause, but the etiology remains unknown four decades after KD was first identified by Tomisaku Kawasaki. Finding the cause of KD is a pediatric research priority.[doi.org]
  • There were no long-term data supporting the analgesic effectiveness of any drug and the etiology of the neuropathy did not predict treatment outcome.[doi.org]
  • Dengue shoul d be considered as the possible etiology where influenza, rubella, or measles is suspected in a dengue-receptive area, i.e., at a time and place where vector mosquito populations are abundant and active.[web.archive.org]
  • Methods We conducted a hospital-based case-control study to evaluate the role of regular aspirin use in lung cancer etiology.[biomedcentral.com]

Epidemiology

  • In summary, current epidemiologic evidence does not indicate that use of aspirin or NSAIDs lowers the risk of pancreatic cancer.[dx.doi.org]
  • This paper will provide a brief biographical background on Max Samter, MD, followed by an epidemiologic overview, clinical presentation and diagnosis, and management strategies, which highlight patient counseling and educational needs.[ncbi.nlm.nih.gov]
  • Abstract Epidemiological studies have suggested that aspirin may have a protective effect against prostate cancer, but the evidence is still limited and inconsistent.[dx.doi.org]
  • Author information 1 Centre for Health Informatics, Biostatistics and Epidemiology, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka. dileepa@kln.ac.lk. 2 Ministry of Health, Colombo, Sri Lanka.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • The pathophysiological basis of this syndrome is not well understood and currently a consensus has not been reached on its optimal treatment.[ncbi.nlm.nih.gov]
  • METHODS: We systematically reviewed the pathophysiology of ED, physiological effect of prostaglandins, pharmacological action of NSAIDs, and clinical and basic research studies that evaluated the effect of aspirin or non-aspirin NSAIDs on ED.[ncbi.nlm.nih.gov]
  • Aspirin sensitive asthma occurs in Pathophysiology Why an individual becomes sensitive to aspirin is not completely understood.[care.american-rhinologic.org]
  • COX-2 is regarded as an inducible enzyme involved in the pathophysiology of inflammation and pain.[doi.org]
  • Favorites PDF Get Content & Permissions Buy Obstetrics Physiology & Pathophysiology of Pregnancy, Labor, and the Puerperium Maternal and Paternal Thrombophilia: Risk Factors for Perinatal Mortality de Galan-Roosen, Agnes E.M.; Kuijpers, Johan C.; Rosendaal[journals.lww.com]

Prevention

  • Preventive Services Task Force Aspirin for the prevention of cardiovascular disease: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 2009 150 396 404 ,, ,, ,.[doi.org]
  • Although the benefit of low-dose aspirin for secondary prevention of CVD is well established, its role for primary prevention remains inconclusive and controversial in diabetes patients.[ncbi.nlm.nih.gov]
  • Preventive Services Task Force (USPSTF) recommendations on aspirin for the prevention of cardiovascular disease.[web.archive.org]
  • Primary prevention trials consistently demonstrated effectiveness of aspirin in preventing nonfatal MI and stroke.[doi.org]

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