loss Meldrum et al. 1973 Prolonged epileptic seizures in primates: ischemic cell change and its relation to ictal physiological events Earnest et al. 1983 Complications of intravenous phenytoin for acute treatment of seizures: recommendations for usage [google.nl]

Thrombasthenia is one of the few forms of platelet dysfunction in which hemorrhage is severe and disabling. [doctorlib.info]

Use: Closure time is indicated when a disorder of platelet function is suspected by a personal or family history of easy bruising, nosebleeds, menorrhagia or post-operative bleeding. It is not recommended as a screen for potential bleeding risk. [labguide.fairview.org]

A hereditary cause is suspected if there is a lifelong history of easy bruising; bleeding after tooth extractions, surgery, childbirth, or circumcision; or heavy menstruation. [merckmanuals.com]

bruising Prolonged or heavy menstrual periods. [healthcommunities.com]

These patients have a mild bleeding tendency, the most frequent symptoms being gingival bleeding after brushing teeth, epistaxis, easy bruising, and menorrhagia. Bleeding symptoms appear early in childhood, but hearing loss appears later. [doctorlib.info]

The bleeding manifestations are predominantly skin-related and mucocutaneous (ie, easy bruising, epistaxis, GI hemorrhage). Most bleeding episodes occur following trauma or surgery. [emedicine.medscape.com]

The PFA-100 ( P latelet F unction A ssay [1] or P latelet F unction A nalyser [2] ) is a platelet function analyser that aspirates blood in vitro from a blood specimen into disposable test cartridges through a microscopic aperture cut into a biologically [en.wikipedia.org]

Bone marrow aspiration is indicated if the smear shows abnormalities other than thrombocytopenia, such as nucleated RBCs or abnormal or immature WBCs. [merckmanuals.com]

Platelet Function Testing: PFA-100 Introduction The PFA-100 is a system for analysing platelet function in which citrated whole blood is aspirated at high shear rates through disposable cartridges containing an aperture within a membrane coated with either [practical-haemostasis.com]

A bone marrow aspiration and biopsy (removal of tissue through a needle inserted into the hip or thigh) may be necessary to determine whether adequate numbers of platelets are being manufactured. [healthcommunities.com]

Recommended triggers for the use of platelet concentrate: 10,000 /uL Stable oncohematological recipient, lumbar puncture in stable pediatric leukemia, thrombocytopenia 2 to GPIIb/IIIa receptor inhibitors 20,000 /uL Bone marrow aspiration and biopsy 20 [uab.edu]

Hemoptysis, hematemesis, hematuria, hematochezia, and melena are rarely the initial symptoms of a bleeding disorder. However, these may be exacerbated by an underlying bleeding disorder. Menstrual history is important. [emedicine.medscape.com]

The term Henoch-Schönlein purpura is applied when the condition is accompanied by transient arthralgia, nephritis, abdominal pain, and purpuric skin lesions, which are frequently confused with the hemorrhagic rash of immune thrombocytopenic purpura. 2 [doctorlib.info]

ADP receptor defect Aggregation defect P2YR12 n/a Bernard-Soulier syndrome Adhesion disorder with deficiency or dysfunction of platelet glycoprotein Ib/IX/V complex GP1BA, GP1BB, GP9 Epistaxis, ecchymoses, menorrhagia, gingival hemorrhage, gastrointestinal [arupconsult.com]

A year before this admission with malena, she had her first bleeding episode with epistaxis following septoplasty at which time APTT was 40s, PT 20s. [medcraveonline.com]

Clinical manifestations usually include purpura, epistaxis, menorrhagia, gingival and gastrointestinal bleeding. The syndrome is transmitted as an autosomal recessive trait. [askhematologist.com]

Mild bleeding such as epistaxis may occur in early childhood, but severe postoperative hemorrhage has been observed. [doctorlib.info]

Glanzmann's thrombasthenia is an inherited autosomal recessive disorder in which patients present with mucosal type bleeding (epistaxis, gingival bleeding, and menorrhagia). [quizlet.com]