Presentation
All patients presented normal thyroid hormone levels. [ncbi.nlm.nih.gov]
One or more associated symptoms were often present: faintness, syncope, headache, dizziness, insomnia, increased perspiration, difficulty in swallowing, tremor, flushing and pallor. [jamanetwork.com]
Entire Body System
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Fatigue
BACKGROUND: Asthenia fatigue syndrome (AFS) is a common symptom perceived by patients with cancer and consists of reported pathologic fatigue, poor endurance, and impaired motor and cognitive function. [ncbi.nlm.nih.gov]
[…] lisuride Fatigue lithium Fatigue lithium carbonate Fatigue lodoxamide Fatigue lodoxamide tromethamine Fatigue lomefloxacin Asthenia Fatigue lomitapide Asthenia Fatigue loperamide Fatigue: postmarketing loratadine Fatigue: 3.36% - 9.02% lorazepam Asthenia [sideeffects.embl.de]
Types[edit] Muscle fatigue can be central, neuromuscular, or peripheral muscular. [en.wikipedia.org]
What should be emphasized is that in the majority of persons complaining of fatigue, ... [accessmedicine.mhmedical.com]
Routine screening for fatigue is essential for optimal assessment of fatigue and history and investigations should always be individualized. [oxfordmedicine.com]
Workup
Microbiology
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Giardia Lamblia
In-patient children who had Giardia lamblia infection were compared with non Giardia-infected children, focusing only on 4 clinical manifestations: diarrhoea, abdominal pain, asthenia and vomiting. [ncbi.nlm.nih.gov]
Treatment
CONCLUSIONS: Even when asthenia is widely diagnosed in cancer patients in Spain, there is a laxity in its assessment and treatment. [ncbi.nlm.nih.gov]
The stage, location, and body structure involved all help to determine the best course of treatment. Treatment options for cancer include: chemotherapy radiation treatment surgery Chemotherapy and other cancer treatments can also cause asthenia. [healthline.com]
Published on Jul 5, 2017 Symptomatic treatment of Anxiety & Asthenia Symptomatic treatment of Anxiety & Asthenia 1. [slideshare.net]
Prognosis
Previous research has shown that patients with neurocirculatory asthenia have a good prognosis, unless their disturbances are part of an affective disorder [14]. [onlinelibrary.wiley.com]
A randomized group of subjects was formed in the period after the ophthalmologic intervention and determination of the volume and prognosis of visual impairment. [e-medjournal.com]
Etiology
‘Diagnosis begins with a patient history distinguishing weakness from fatigue or asthenia, separate conditions with different etiologies that can coexist with, or be confused for, weakness.’ [en.oxforddictionaries.com]
‘the asthenia of chronic respiratory disease’ ‘Diagnosis begins with a patient history distinguishing weakness from fatigue or asthenia, separate conditions with different etiologies that can coexist with, or be confused for, weakness.’ [lexico.com]
Fatigue in older cancer patients: etiology, assessment, and treatment. Semin Oncol. 2008;35(6):633-642. Breitbart W, Alici Y. Pharmacologic treatment options for cancer-related fatigue: current state of clinical research. [managingmyeloma.com]
The results therefore lend support to previous uncontrolled literature [16], suggesting an etiological role for life events in neurocirculatory asthenia. Retrospective studies have obvious inherent risks. [onlinelibrary.wiley.com]
Jo Nijs, Kenny De Meirleir, Mira Meeus, Neil R McGregor and Patrick Englebienne, Chronic fatigue syndrome: intracellular immune deregulations as a possible etiology for abnormal exercise response, Medical Hypotheses, 62, 5, (759), (2004). [doi.org]
Epidemiology
Author information 1 Municipal Centre of Hygiene, Epidemiology and Microbiology, Havana, Cuba. Abstract Giardiasis is a disease with worldwide distribution, although its prevalence differs from country to country. [ncbi.nlm.nih.gov]
Forlenza MJ, Hall P, Lichtenstein P et al (2005) Epidemiology of cancer-related fatigue in the Swedish twin registry. Cancer. 104:2022–2031 PubMed CrossRef Google Scholar 13. [link.springer.com]
Tolu Osoba, Derek Pheby, Selena Gray and Luis Nacul, The Development of an Epidemiological Definition for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Journal of Chronic Fatigue Syndrome, 14, 4, (61), (2007). [doi.org]
Pathophysiology
We do not understand this pathophysiology well at all. There are some correctable causes of asthenia that are familiar to most clinicians. [mywhatever.com]
Google Scholar Alexander HR, Norton JA : Pathophysiology of cancer cachexia. In: Doyle D, Hanks G, MacDonald E, eds. Oxford Textbook of Palliative Medicine. London: Oxford University Press, 1993:316-329. [journals.sagepub.com]
• Sympathetic nervous system overactivity, increased muscle tension and hyperventilation are the common pathophysiological mechanisms. [slideshare.net]
Pathophysiology[edit] Muscle cells work by detecting a flow of electrical impulses from the brain, which signals them to contract through the release of calcium by the sarcoplasmic reticulum. [en.wikipedia.org]
Prevention
Prevention & Expectations What can be done to prevent the condition? Prevention depends on the cause. For example, weakness due to lack of exercise can be prevented with regular exercise. [medicineonline.com]
Taking care of your physical health is a good preventive measure. Drinking plenty of fluids, getting adequate rest, and exercising regularly can help your recover from weakness and also prevent it. [healthline.com]
How to Prevent Asthenia? Maintain an active lifestyle- Making proper schedules of the day including free leisure time and some physical exercises can help prevent asthenia. Try to spend at least 30 minutes outdoors. [medindia.net]
Even if the first drug that prevents calcium leaks does not work in patients, Dr. McClellan added, the important advance is to understand the molecular events underlying fatigue. “Then,” he said, “you can design therapies.” [nytimes.com]