Presentation
The authors report the case of a 33-year-old woman who presented with spontaneous intraparenchymal hemorrhage. The collective radiographic data suggested the presence of a cavernous malformation. [ncbi.nlm.nih.gov]
Entire Body System
- Plethora
Unlike conventional low-grade tumors, high-grade tumors associate a plethora of factors when they metastasize to other areas of the body. [en.wikipedia.org]
Gastrointestinal
- Episodic Vomiting
A 12-year-old girl child presented with episodes of generalized tonic-clonic seizures for 6 months and headache and episodic vomiting for 2 months. Neurological examination did not reveal any significant abnormality. [pediatricneurosciences.com]
Eyes
- Hemianopsia
39 ] 39; F TL Aphasia + ++ LG Salvati et al. (2009) [ 39 ] 43; F FL Hemiparesis Circular lesion with a ring-shaped contrast enhancement + ++ LG Salvati et al. (2009) [ 39 ] 33; M Rolandic area Hemiparesis + ++ HG Salvati et al. (2009) [ 39 ] 50; F OL Hemianopsia [dx.doi.org]
Musculoskeletal
- Leg Weakness
A 41-year-old man presented to us with left arm and leg weakness and mild word finding difficulties. [ncbi.nlm.nih.gov]
- Long Arm
Molecular analysis using 17 microsatellite markers on chromosomes 9, 10, 11, 17, 19, and 22 showed loss of heterozygosity at the D19S412 locus on the long arm of chromsome 19. [ncbi.nlm.nih.gov]
Neurologic
- Papilledema
The neurological examination showed right 6 th nerve paresis with papilledema. [ncbi.nlm.nih.gov]
Her neurological examination revealed 6th nerve palsy and papilledema. [medresearch.in]
The neurological examination showed right sixth nerve paresis with bilateral papilledema. [cancerjournal.net]
Bilateral papilledema was detected on fundoscopy. Routine blood and biochemical investigations were within normal limits. [pediatricneurosciences.com]
- Motor Symptoms
Case Description: We present the case of a 9-year-old girl who presented with headache, motor symptoms, and seizures few days before she was admitted to our institution. [surgicalneurologyint.com]
- Throbbing Headache
headache or nausea for the patient. [en.wikipedia.org]
Workup
Full pathologic workup later revealed the patient had two distinct tumors occurring simultaneously, anaplastic astrocytoma and astroblastoma. [ncbi.nlm.nih.gov]
Afterwards, metastatic workup of the patient including x-ray chest and ultrasound abdomen and pelvis did not revealed any spread of the disease. [synapse.koreamed.org]
Serum
- Karyotype Abnormal
Further cytogenetic studies will also help to identify if there are consistent karyotypic abnormalities in these enigmatic tumors. [ncbi.nlm.nih.gov]
Biopsy
- Foam Cell
Foam cells were frequently infiltrated around blood vessels and among tumor cells. In some areas, a solid growth pattern of plump tumor cells with abundant inclusion-like eosinophilic cytoplasm showing rhabdoid appearance was observed. [ncbi.nlm.nih.gov]
Treatment
[…] subtyping, treatment details and a follow-up of at least 12 months. [ncbi.nlm.nih.gov]
Astroblastoma - a rare and challenging tumor: a case report and review of the literature. ( 29678196 ) 2018 2 Co-occurrence of astrocytoma and astroblastoma: Case report and literature review. ( 29939429 ) Sali G....Sughrue M.E. 2018 3 Patterns of care and treatment [malacards.org]
Chemotherapy is the preferred secondary treatment after resection. The treatment kills astroblastoma cells left behind after surgery and induces a non-dividing, benign state for remaining tumor cells. [en.wikipedia.org]
Prognosis
Prognosis, however, sometimes is in contradiction with the pathological appearance and seems to be more closely related to the grade of surgical resection. [ncbi.nlm.nih.gov]
Prognosis The prognosis of astroblastoma has not been characterized, though the presence of high-grade features is thought to be a poor prognostic finding. [prod.wiki.cns.org]
[…] most commonly include headaches and seizures Because these tumors are rare, there is little known regarding their behavior and how they should be managed Gross total resection (complete removal) of the tumor is recommended and is associated with a good prognosis [dovemed.com]
Etiology
Hemorrhagic appearance is not uncommon; there are three reported cases in which radiologic presentation was confused with vascular etiologies because the initial presentation was acute hemorrhage.[ 1 22 31 ] Differential diagnoses in imaging are ependymoma [surgicalneurologyint.com]
Epidemiology
Epidemiology Reliable epidemiological data regarding astroblastoma are not available. These lesions are most common in young adults, but may occur in infants and children. [prod.wiki.cns.org]
Definition / general Rare ( < 3% of primary brain gliomas), compact glial neoplasm with perivascular pseudorosettes formed of GFAP+ cells arranged around central, often sclerotic, blood vessels Controversial entity - relationship with ependymoma is not clear Epidemiology [pathologyoutlines.com]
Astroblastomas: a Surveillance, Epidemiology, and End Results (SEER)-based patterns of care analysis. [futuremedicine.com]
Astroblastomas: a Surveillance, Epidemiology, and End Results (SEER)-based patterns of care analysis. World Neurosurg 2014; 82 (01) (02) e291-e297 10 Asha U, Mahadevan A, Sathiyabama D. et al. [thieme-connect.com]
Epidemiological, clinical, radiologic, and immunohistochemical characteristics and grading are summarized in Table 1. [dx.doi.org]
Pathophysiology
We report two patients with astroblastoma who presented with hemorrhage and discuss the natural history, radiological findings, pathophysiology of hemorrhage and histopathological characteristics. [ncbi.nlm.nih.gov]
It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of childhood cancers, including aspects important in optimal supportive care. [books.google.com]
Prevention
There are no guidelines or methods available for the prevention of Astroblastoma, since the exact cause or risk factors are not known Active research is currently being performed to explore the possibilities for treatment and prevention of disorders such [dovemed.com]
Its rarity has prevented evidenced-based treatment stratification. An 8-year-old boy presented with signs and symptoms of raised intracranial pressure. [ncbi.nlm.nih.gov]
Prophylactic anticonvulsants for prevention of immediate and early postcraniotomy seizures. [n.neurology.org]
At that point, January 2009, it was time to begin radiation to prevent regrowth of the tumor, which required 6 more long weeks of treatment. We had a great deal of love and support from the people around us and God used them to carry us through. [caringbridge.org]
Franklin’s fraternity, the Krazy Kappa chapter of Omega Psi Phi Fraternity Inc., presented a discussion on rape culture and the role men can play in preventing sexual violence last fall. [watertowndailytimes.com]