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Atopic Cataract

Atopic Cataract Syndrome


Presentation

  • Lenticular opacities were present in the posterior subcapsule in 50%, in the anterior subcapsule in 25% and throughout the lens in 12.5%. 2 patients with total lens opacities had shown rapid progression at the time of exacerbation of the skin lesions.[ncbi.nlm.nih.gov]
  • We discuss in detail about the presentation, clinical features, and surgical management of these patients presenting with RD, cataracts and related clinical problems secondary to severe AD.[nature.com]
  • Two cases involving retinal detachment caused by breaks in the pars plicata of the ciliary body are presented. In both, retinal detachment developed following surgery for atopic cataract.[ncbi.nlm.nih.gov]
  • The frequency of breaks or detachment that occurred postoperatively (approximately 5%) was lower than that present preoperatively.[ncbi.nlm.nih.gov]
  • Positive association of cataract with dermatitis is still uncommon in present day medical knowledge.[jamanetwork.com]
Vascular Disease
  • Master the latest advances in ophthalmology: radical changes in the management of macular disease, including the widespread introduction of VEGF inhibitor therapy; recent developments in the investigation and treatment of retinal vascular disease; new[books.google.com]
Facial Skin Lesion
  • In a study of 41 patients, Nagaki et al. (20) showed that cataract progression was statistically significantly related to facial skin lesions.[medicaljournals.se]

Workup

  • Infants with bilateral cataracts and failure to thrive should receive a full metabolic workup in conjunction with a pediatrician and geneticist, if possible.[aao.org]
  • […] syndrome, with affected males presenting with dense visually significant cataracts. 20 Investigations Although 60% of pediatric cataracts are idiopathic, 40 based on the antenatal history, family history, and the type of cataract, a baseline laboratory workup[dovepress.com]

Treatment

  • Apply the latest best practices through new and updated treatment algorithms. Find therapeutic drug information more easily with guidance incorporated into each chapter.[books.google.com]
  • Despite much current research interest, the pathophysiology of these disorders and their optimum treatment remain uncertain.[books.google.com]
  • Treatment. The only known effective treatment for cataract is surgical removal of the lens (lens extraction or cataract extraction). The procedure of choice was formerly intracapsular extraction, with total removal of the lens within its capsule.[medical-dictionary.thefreedictionary.com]
  • Master the latest advances in ophthalmology: radical changes in the management of macular disease, including the widespread introduction of VEGF inhibitor therapy; recent developments in the investigation and treatment of retinal vascular disease; new[books.google.com]

Prognosis

  • Only an estimated 10% of patients older than 20 years continue to be symptomatic. [5] Prognosis The prognosis is good if the inflammation can be kept under control with therapy.[emedicine.medscape.com]
  • . – Visual prognosis: Visual prognosis is worse for AKC. – Peri-orbital skin and eyelid: There is increased peri-orbital and eyelid skin involvement in AKC as compared to VKC which generally spare skin. – Papillae: AKC usually presents with micro-papillae[aimu.us]
  • It can rarely deteriorate to symptomatic keratoconjunctivitis that may have a poor prognosis. Statistical methods Continuous variables were expressed as mean and standard deviation. Categorical variables were expressed as percentages.[medicaljournals.se]
  • What is the prognosis of cataracts? The rate of progression of cataracts is usually predictable and surgery is successful in restoring vision in a large majority of cases.[medicinenet.com]
  • The presence of extensor distribution in older children and adults indicates a poor prognosis for ultimate cure. 8 View/Print Figure FIGURE 2. Typical facial rash of atopic dermatitis in a white infant. FIGURE 2.[aafp.org]

Etiology

  • The etiology, and therefore the basic pathophysiology, of childhood cataract varies widely; in many children, the etiology may not be determined.[aao.org]
  • Etiological factors in keratoconus.Ophthalmology. 1995;102(suppl):156 57) Zadnik K, Barr JT, Edrington TB, et al.[gatinel.com]
  • Slit lamp appearance of the eyes is shown below: What type of cataract is this and what is the etiology? These cataracts have an unusual appearance because of the refractile intralenticular crystals, which are cholesterol deposits.[ophthalmologyweb.com]
  • Complete retinal detachment (both eyes): with special reference to allergy as a possible primary etiologic factor . Am J Ophthalmol 1937; 20 : 580–582. 2. Ingram RM . Retinal detachment associated with atopic dermatitis and cataract .[nature.com]
  • In fact, the etiology of allergic cataract has not been fully elucidated until recently. 2,6 We now know that the allergic process itself causes the cataract, with allergy as the probable initiating factor.[crstodayeurope.com]

Epidemiology

  • American journal of epidemiology, 137(3), 342-354 Winter DA, Patla AE, Frank JS, Walt SE. Biomechanical walking pattern changes in the fit and healthy elderly. Phys Ther. 1990;70(6):340–347. Elble RJ, Thomas SS, Higgins C, Colliver J.[en.wikipedia.org]
  • Robertson, LS (2015) Injury Epidemiology: Fourth Edition. Free online at www.nanlee.net "Occupational Injury and Illness Classification System". Centers for Disease Control and Prevention. Retrieved 2014-03-24. Rae, K; Orchard, J (May 2007).[en.wikipedia.org]
  • J Dermatol 1999;26:658-65. [ PUBMED ] [Table 1], [Table 2] This article has been cited by 1 Epidemiology and clinical features of atopic dermatitis in India Kanwar, A., De, D.[ijdvl.com]
  • Trends in the epidemiology and prescribing of medication for eczema in England . J R Soc Med 2009; 102 (3): 108–117. 4. Eiseman AS . The ocular manifestations of atopic dermatitis and rosacea . Curr Allergy Asthma Rep 2006; 6 (4): 292–298. 5.[nature.com]
  • Nonetheless, patients frequently have a history of food or inhalant allergies or eventually develop them. [3] Epidemiology Frequency United States An estimated 3-12% of the population will be affected at some point during their lifetime.[emedicine.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • Despite much current research interest, the pathophysiology of these disorders and their optimum treatment remain uncertain.[books.google.com]
  • Conclusions: : Our results suggested that PAI-1 and TGF-β1 synergistically play some roles for the pathophysiology of atopic cataracts.[iovs.arvojournals.org]
  • Allergic conjunctivitis: Update on pathophysiology and prospects for future treatment. J Allergy Clin Immunol. 2005; 115:118-22. Bielory L. Allergic and Immunologic Disorders of the Eye. Part II: Ocular Allergy.[verywell.com]
  • Atopic dermatitis: therapeutic concepts evolving from new pathophysiologic insights. J Allergy Clin Immunol. 2008 Dec. 122(6):1074-81. [Medline]. Bezan DJ. Eye itch. Bezan DJ, Larussa FP, Nishimoto JH, et al, eds.[emedicine.medscape.com]
  • The etiology, and therefore the basic pathophysiology, of childhood cataract varies widely; in many children, the etiology may not be determined.[aao.org]

Prevention

  • This case seems to suggest that prompt control of severe dermatitis on the face in patients with atopic dermatitis is important for prevention of atopic cataract, whether the dermatitis on the face is atopic or nonatopic in nature.[ncbi.nlm.nih.gov]
  • This case seems to suggest that prompt control of severe dermatitis on the face in patients with atopic dermatitis is important for prevention of atopic cataract, whether the dermatitis on the face is atopic or nonatopic in nature. 1986 S.[karger.com]
  • […] for Disease Control and Prevention Preventing Falls: What Works―A CDC Compendium of Effective Community-based Interventions from Around the World US Centers for Disease Control and Prevention (PDF) Preventing Falls: How to Develop Community-based Fall[en.wikipedia.org]
  • The end result is a decrease in degranulation of mast cells, which prevents release of histamine and other chemotactic factors that are present in the preformed and newly formed state.[emedicine.medscape.com]

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