Presentation
We discuss his presentation and review of the literature on this topic. [ncbi.nlm.nih.gov]
The active ingredients of this plant are hyoscyamine, atropine, atropamine, belaplomine and scopolamine, present in the whole plant but with higher concentration in the leaves. [europeana.eu]
For example, Aethusa cynapium L. is not presented in this virtual herbarium because I have not found a specimen, it is nevertheless of course an extremely toxic plant! [herbarium.freehostia.com]
The alkaloids present in Atropa belladonna have toxic anti-cholinergic effects on the body. [omicsonline.org]
Entire Body System
- Fever
The patient was treated with intravenous benzodiazepines and antibiotics after a full sepsis work up; all the laboratory results were normal and the fever resolved after several hours. [ncbi.nlm.nih.gov]
Fever : Belladonna might increase the risk of overheating in people with fever. Stomach ulcers : Belladonna might make stomach ulcers worse. [webmd.com]
[…] alternate, simple; flowers axillary, drooping, tubular, 5-lobed, dull red-purple or greenish purple; fruit a glossy, purple-black berry Family: Solanaceae Origin: Eurasia Poison Part: All parts, mainly berries Poison Delivery Mode: Ingestion Symptoms: Fever [plants.ces.ncsu.edu]
These include: the common cold fever whooping cough hay fever earache asthma motion sickness flu a cough and sore throat joint and back pain arthritis pain spasms, or colic-like pain in the stomach or bile ducts nerve problems gout inflammation Parkinson's [medicalnewstoday.com]
- High Fever
The 6C dilution relieves high fevers of sudden onset with profuse sweating and can be found as one of the active ingredients in ColdCalm. [boironusa.com]
Symptoms: Cattle -- high fever, loss of appetite, weight loss, difficult breathing, salivation, ataxia, opisthotonos, convulsions, internal bleeding; often mistaken for anthrax and other infectious diseases of cattle. Death in 4-8 days. [web.archive.org]
- Rigor
The ESCOP presents revisions with scientific rigor, very important to validate phytotherapeutic treatments. (more…) García Giménez, Mª Dolores (Spain) Departamento de Farmacología Facultad de Farmacia Universidad de Sevilla (España). [escop.com]
Respiratoric
- Hoarseness
Throat: larynx dry, sore, very painful; foreign body, + cough; hoarse; voice loss, high, piping. Lungs: cough tickling, short, dry, barking, whooping, < night; respiration oppressed, fast, quick, unequal, laboured, Cheyne-Stokes. [qjure.com]
Gastrointestinal
- Constipation
Belladonna can cause serious side effects in babies or young children, including constipation, breathing problems, agitation, and seizures. You should not use this product if you are pregnant or breastfeeding. [drugs.com]
Common side effects may include: dry mouth; blurred vision; muscle spasms; constipation; decreased urination; or decreased sweating. This is not a complete list of side effects and others may occur. [peacehealth.org]
The signs of peripheral effects manifested by the parasympathetic block include decreased secretions causing dryness of mouth, flushed skin, mydriasis, vomiting, constipation, urinary retention, fever, tachycardia and hypertension [ 1, 2 ]. [omicsonline.org]
Symptoms include a depressed level of consciousness, seizure, difficulty or slowed breathing, lethargy, sleepiness, muscle weakness, skin flushing, constipation, difficulty urinating, or agitation. [fda.gov]
Constipation : Belladonna might make constipation worse. Down syndrome : People with Down syndrome might be extra-sensitive to the potentially toxic chemicals in belladonna and their harmful effects. [webmd.com]
Cardiovascular
- Tachycardia
The heart rate increases (tachycardia) with hypertension as a result of parasympathetic block caused by anti-cholinergic agents. [omicsonline.org]
We also showed that meaningless speech, lethargy, coma, and absence of tachycardia were ominous signs in deadly nightshade intoxication in childhood. [ncbi.nlm.nih.gov]
Peripheral effects include mydriasis with cycloplegia, dry mucous membranes, hyperreflexia, flushed skin, diminished bowel sounds or ileus, urinary retention, tachycardia, and hypertension or hypotension [ 1 ]. [drugbank.ca]
- Hypertension
The heart rate increases (tachycardia) with hypertension as a result of parasympathetic block caused by anti-cholinergic agents. [omicsonline.org]
Peripheral effects include mydriasis with cycloplegia, dry mucous membranes, hyperreflexia, flushed skin, diminished bowel sounds or ileus, urinary retention, tachycardia, and hypertension or hypotension [ 1 ]. [drugbank.ca]
The peripheral effect are mydriasis with cycloplegia, dry mucous membranes, hyperreflexia, flushed skin, diminished bowel sounds or ileus, urinary retention, tachycardia, and hypertension or hypotension. [flipper.diff.org]
Heart: seemed too large; violent palpitation, < least exertion, reverberating, throbbing in head, body; dichrotism; pulse rapid, weak, full, bounding, globular; hypertension; blood-vessels distended. Chest: stitches, < coughing. [qjure.com]
- Palpitations
Signs of toxicity : Dry mouth, flushing, skin hot and dry, mydriasis (pupil dilation), increased respiratory rate and volume, increased temperature in children, palpitations, increased pulse rate and blood pressure, incoordinate movements., incoherent [thenaturopathicherbalist.com]
Various preparations of belladonna are used as lotions, plasters and salves to relieve pain from sciatica, gout, and cardiac palpitations. Did You Know? The oral overdose level for belladonna is only 600 milligrams. [fs.fed.us]
Heart: seemed too large; violent palpitation, < least exertion, reverberating, throbbing in head, body; dichrotism; pulse rapid, weak, full, bounding, globular; hypertension; blood-vessels distended. Chest: stitches, < coughing. [qjure.com]
ADVERSE REACTIONS: Adverse reactions may include xerostomia; urinary hesitancy and retention; blurred vision; tachycardia; palpitation; mydriasis; cycloplegia; increased ocular tension; loss of taste sense; headache; nervousness; drowsiness; weakness; [web.archive.org]
Musculoskeletal
- Leg Pain
Belladonna is used in ointments that are applied to the skin for joint pain (rheumatism), leg pain caused by a disc in the backbone pushing on the sciatic nerve ( sciatica ), and nerve pain (neuralgia). [webmd.com]
Eyes
- Blurred Vision
There is some concern that taking them together might increase the risk for confusion, blurred vision, increased sweating, and increased heart rate. Belladonna contains atropine. Atropine can reduce the effects of cisapride. [webmd.com]
Donnatal Extentabs may produce drowsiness or blurred vision. [web.archive.org]
Risks and side effects Blurred vision and hallucinations are potential side effects of belladonna. Belladonna is considered a toxic plant with historical uses as a poison. [medicalnewstoday.com]
The symptoms of poisoning with deadly nightshade include dilated pupils, blurred vision, loss of balance, dry mouth and throat, slurred speech, inability to urinate, confusion, hallucinations and delirium. [woodlands.co.uk]
vision, sensitivity to light, dysphagia, great thirst, nausea, vomiting, diarrhea, delerium, restlessness, confusion; later: depressed cerebral and neural activity, stupor ,circulatory collapse, coma and death from centric respiratory paralysis. [thenaturopathicherbalist.com]
- Photophobia
I began to experience some photophobia, yet my pupils were dilated to a max 3 or 4 (and I was in a light muted room). [erowid.org]
Eyes: swollen, protruding, staring, glaring, brilliant, wild; shooting, throbbing deep, < lying down; pupils dilated, shining; conjunctiva red, dry, burning; eyelids swollen, squinting, spasms; fundus congested; photophobia; exophthalmus; vision illusions [qjure.com]
Both locally and internally belladonna is a prompt agent for the relief of photophobia. [henriettesherbal.com]
- Diplopia
staring, glaring, brilliant, wild; shooting, throbbing deep, < lying down; pupils dilated, shining; conjunctiva red, dry, burning; eyelids swollen, squinting, spasms; fundus congested; photophobia; exophthalmus; vision illusions, fiery appearance, diplopia [qjure.com]
Skin
- Flushing
The anti-cholinergic toxidrome affects both central and peripheral nervous system, causing acute delirium, hallucination, tachycardia, dry mouth, flushed skin, vomiting and blurry vision. [omicsonline.org]
5-lobed, dull red-purple or greenish purple; fruit a glossy, purple-black berry Family: Solanaceae Origin: Eurasia Poison Part: All parts, mainly berries Poison Delivery Mode: Ingestion Symptoms: Fever, rapid pulse, dilation of pupils, hot and dry flushed [plants.ces.ncsu.edu]
It was much later, about an hour when I noticed the dry mouth, insatiable thirst, and hardly quenchable (my bladder is nice and flushed). Still experiencing the awareness, everything was brilliantly clear and the auras were resonating. [erowid.org]
The most common observed symptoms and signs were meaningless speech, tachycardia, mydriasis, and flushing. None of the children required mechanical ventilation or died in our series. [ncbi.nlm.nih.gov]
Symptoms include a depressed level of consciousness, seizure, difficulty or slowed breathing, lethargy, sleepiness, muscle weakness, skin flushing, constipation, difficulty urinating, or agitation. [fda.gov]
- Decreased Sweating
Common side effects of belladonna may include: dry mouth; blurred vision; muscle spasms; constipation; decreased urination; or decreased sweating. This is not a complete list of side effects and others may occur. [drugs.com]
Urogenital
- Oliguria
Smaller doses: gastroenteritis, nephrosis, cystitis, and urethritis ( anorexia, soft, and/or mucoid to bloody mucoid feces, intestinal atony, colic dysuria frequent, painful urination, or oliguria to anuria, and hematuria ). [web.archive.org]
Neurologic
- Confusion
In addition, the central nervous system effects of atropine include memory disruption, which may lead to severe confusion. [horticultureandsoilscience.wikia.com]
The risk of poisoning in children is important because of possible confusion with other berries. [ncbi.nlm.nih.gov]
They are not to be confused with those of bittersweet (Solanum dulcamara) image adjacent, another hedgerow and woodland climber - but this has bright purple flowers with contrasting yellow anthers. [woodlands.co.uk]
Fitting, because this chemical causes a quickening of the pulse, confusion, seizures, hallucinations and even death when consumed. [motherearthliving.com]
- Seizure
We present an infant who suffered serious seizures after ingestion of a homeopathic agent containing A. belladonna. [ncbi.nlm.nih.gov]
Fitting, because this chemical causes a quickening of the pulse, confusion, seizures, hallucinations and even death when consumed. [motherearthliving.com]
Symptoms of overdose can include: blurred vision, dilated pupils, rapid heart rate, headache, dry mouth, confusion, hallucinations, and seizures. The name belladonna is derived from the Italian words for "beautiful (bella) woman (donna)." [medicinenet.com]
The FDA is analyzing adverse events reported to the agency regarding homeopathic teething tablets and gels, including seizures in infants and children who were given these products, since a 2010 safety alert about homeopathic teething tablets. [fda.gov]
Belladonna can cause serious side effects in babies or young children, including constipation, breathing problems, agitation, and seizures. You should not use this product if you are pregnant or breastfeeding. [drugs.com]
- Agitation
A 36-year-old woman presented to our ophthalmic emergency department with complaints of blurry vision, lightning flashes, disorientation, loss of balance, agitation, and anxiety for 24 hours. [ncbi.nlm.nih.gov]
Benzodiazepines are frequently used for sedation to control anticholinergic effects including delirium and agitation [ 2 ]. [drugbank.ca]
Symptoms include a depressed level of consciousness, seizure, difficulty or slowed breathing, lethargy, sleepiness, muscle weakness, skin flushing, constipation, difficulty urinating, or agitation. [fda.gov]
- Agitated Delirium
Benzodiazepines are frequently used for sedation to control anticholinergic effects including delirium and agitation [ 2 ]. [drugbank.ca]
Atropine crosses the blood brain barrier and patients with central anticholinergic syndrome show loss of memory, confusion, disorientation, hallucination, in-coordinated movements and agitated delirium with acute psychosis [ 1, 2 ]. [omicsonline.org]
Central nervous effect are ataxia, disorientation, short-term memory loss, confusion, hallucinations, psychosis, agitated delirium, seizures, coma, respiratory failure or cardiovascular collapse. [flipper.diff.org]
Despite potential complications, physostigmine can be beneficial in pure anticholinergic overdose with severe symptoms; it can also be useful by controlling agitation and reversing delirium. [ncbi.nlm.nih.gov]
- Slurred Speech
The symptoms of poisoning with deadly nightshade include dilated pupils, blurred vision, loss of balance, dry mouth and throat, slurred speech, inability to urinate, confusion, hallucinations and delirium. [woodlands.co.uk]
The symptoms of belladonna poisoning include dilated pupils, sensitivity to light, blurred vision, tachycardia, loss of balance, staggering, headache, rash, flushing, severely dry mouth and throat, slurred speech, urinary retention, constipation, confusion [horticultureandsoilscience.wikia.com]
They include dryness in the mouth, thirst, difficulty in swallowing and speaking, blurred vision from the dilated pupils, vomiting, excessive stimulation of the heart, drowsiness, slurred speech, hallucinations, confusion, disorientation, delirium, and [thepoisongarden.co.uk]
Sidenote: oh and by the way, I still have blurry vision and slurred speech for the next 24 hours after the end of the visions. [erowid.org]
There are many possible symptoms of poisoning, including: rapid heartbeat dry mouth slurred speech light sensitivity blurred vision inability to urinate loss of balance flushed skin a rash memory loss seizures confusion hallucinations Severe poisoning [owlcation.com]
Treatment
She was admitted in the intensive care unit, the progression was favorable with symptomatic treatment. [ncbi.nlm.nih.gov]
Muscarinic antagonists are known to be used as bronchodilators in asthma treatments. [omicsonline.org]
Berries of belladonna Alternative-medicinal use Edit Belladonna preparations are used in homeopathy as alleged treatments for various conditions. [horticultureandsoilscience.wikia.com]
Prognosis
This content is accurate and true to the best of the author’s knowledge and does not substitute for diagnosis, prognosis, treatment, prescription, and/or dietary advice from a licensed health professional. [owlcation.com]
Mortality 50%, favorable prognosis for affected horses living beyond a week. Treatment: No specific treatment. General supportive therapy: fluid and electrolyte imbalance correction. Broad spectrum antibiotics. [web.archive.org]
Etiology
Therefore, in case of excitability and confusion, as well as somnolence or coma of uncertain etiology, an anticholinergic syndrome caused by ingestion of atropine-containing plants or psychoactive drugs should be included in the differential diagnosis [ncbi.nlm.nih.gov]
Epidemiology
Particular attention is dedicated to the pharmaco/toxicodynamics, pharmaco/toxicokinetics, pathophysiology, epidemiological cases, and animal studies associated with the effects of Atropa belladonna on the nervous system. [ncbi.nlm.nih.gov]
Epidemiology Frequency United States Incidence is sporadic, with clusters of poisoning cases, mostly among adolescents using plants for their hallucinogenic effects. [emedicine.medscape.com]
Pathophysiology
Particular attention is dedicated to the pharmaco/toxicodynamics, pharmaco/toxicokinetics, pathophysiology, epidemiological cases, and animal studies associated with the effects of Atropa belladonna on the nervous system. [ncbi.nlm.nih.gov]
Pathophysiology Toxicity from plants containing tropane alkaloids manifests as classic anticholinergic poisoning. [emedicine.medscape.com]
Prevention
The seedlings need sterile soil to prevent damping off and resent root disturbance during transplanting. This plant is a sign of water nearby. [horticultureandsoilscience.wikia.com]
Drink plenty of water to prevent constipation while using belladonna and opium. Belladonna and opium rectal is most often used 1 or 2 times per day. Do not use the suppositories more than 4 times per day. [cigna.com]
Atropine blocks the muscarinic receptors of the system, preventing the acetylcholine from transmitting nerve impulses. [owlcation.com]