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Atropa Belladonna
Belladonna

Images

WIKIDATA, Public Domain
WIKIDATA, Public Domain
WIKIDATA, CC BY-SA 4.0
WIKIDATA, CC BY-SA 3.0
WIKIDATA, CC BY-SA 3.0
WIKIDATA, CC BY-SA 4.0
WIKIDATA, CC BY-SA 4.0
WIKIDATA, CC BY-SA 4.0
WIKIDATA, CC BY-SA 4.0

Presentation

We discuss his presentation and review of the literature on this topic. [ncbi.nlm.nih.gov]

For example, Aethusa cynapium L. is not presented in this virtual herbarium because I have not found a specimen, it is nevertheless of course an extremely toxic plant! [herbarium.freehostia.com]

The alkaloids present in Atropa belladonna have toxic anti-cholinergic effects on the body. [omicsonline.org]

The undeveloped fruit, a calyx with an unripe berry, is often present. [henriettesherbal.com]

Entire Body System

  • Fever

    The patient was treated with intravenous benzodiazepines and antibiotics after a full sepsis work up; all the laboratory results were normal and the fever resolved after several hours. [ncbi.nlm.nih.gov]

    Fever : Belladonna might increase the risk of overheating in people with fever. Stomach ulcers : Belladonna might make stomach ulcers worse. [webmd.com]

    These include: the common cold fever whooping cough hay fever earache asthma motion sickness flu a cough and sore throat joint and back pain arthritis pain spasms, or colic-like pain in the stomach or bile ducts nerve problems gout inflammation Parkinson [medicalnewstoday.com]

    […] alternate, simple; flowers axillary, drooping, tubular, 5-lobed, dull red-purple or greenish purple; fruit a glossy, purple-black berry Family: Solanaceae Origin: Eurasia Poison Part: All parts, mainly berries Poison Delivery Mode: Ingestion Symptoms: Fever [plants.ces.ncsu.edu]

  • High Fever

    The 6C dilution relieves high fevers of sudden onset with profuse sweating and can be found as one of the active ingredients in ColdCalm. [boironusa.com]

    Symptoms: Cattle -- high fever, loss of appetite, weight loss, difficult breathing, salivation, ataxia, opisthotonos, convulsions, internal bleeding; often mistaken for anthrax and other infectious diseases of cattle. Death in 4-8 days. [web.archive.org]

  • Painter

    “Woman with a Mirror,” a painting by the Renaissance painter, Titian. Louvre Museum, Paris, France. [fs.fed.us]

  • Rigor

    The ESCOP presents revisions with scientific rigor, very important to validate phytotherapeutic treatments. (more…) García Giménez, Mª Dolores (Spain) Departamento de Farmacología Facultad de Farmacia Universidad de Sevilla (España). [escop.com]

  • Surgical Procedure

    Ancient Greek healers would put it in drinks to induce numbness and drowsiness in patients about to undergo amputations and other rudimentary surgical procedures of the time. [boironusa.com]

Respiratoric

  • Hoarseness

    Throat: larynx dry, sore, very painful; foreign body, + cough; hoarse; voice loss, high, piping. Lungs: cough tickling, short, dry, barking, whooping, < night; respiration oppressed, fast, quick, unequal, laboured, Cheyne-Stokes. [qjure.com]

Gastrointestinal

  • Constipation

    Belladonna can cause serious side effects in babies or young children, including constipation, breathing problems, agitation, and seizures. You should not use this product if you are pregnant or breastfeeding. [drugs.com]

    Common side effects may include: dry mouth; blurred vision; muscle spasms; constipation; decreased urination; or decreased sweating. This is not a complete list of side effects and others may occur. [peacehealth.org]

    The signs of peripheral effects manifested by the parasympathetic block include decreased secretions causing dryness of mouth, flushed skin, mydriasis, vomiting, constipation, urinary retention, fever, tachycardia and hypertension [ 1, 2 ]. [omicsonline.org]

    Symptoms include a depressed level of consciousness, seizure, difficulty or slowed breathing, lethargy, sleepiness, muscle weakness, skin flushing, constipation, difficulty urinating, or agitation. [fda.gov]

    Constipation : Belladonna might make constipation worse. Down syndrome : People with Down syndrome might be extra-sensitive to the potentially toxic chemicals in belladonna and their harmful effects. [webmd.com]

  • Vomiting

    The anti-cholinergic toxidrome affects both central and peripheral nervous system, causing acute delirium, hallucination, tachycardia, dry mouth, flushed skin, vomiting and blurry vision. [omicsonline.org]

    […] palpitations, increased pulse rate and blood pressure, incoordinate movements., incoherent speech, memory disturbed, disorientation, urinary urgency, difficult urination, eye pain, blurred vision, sensitivity to light, dysphagia, great thirst, nausea, vomiting [thenaturopathicherbalist.com]

    Stomach: spasms, empty retching, pain < cough; constriction; nausea and vomiting, uncontrollable; spasmodic hiccough. [qjure.com]

    OVERDOSAGE: The signs and symptoms of overdose are headache, nausea, vomiting, blurred vision, dilated pupils, hot and dry skin, dizziness, dryness of the mouth, difficulty in swallowing, and CNS stimulation. [web.archive.org]

Cardiovascular

  • Tachycardia

    The heart rate increases (tachycardia) with hypertension as a result of parasympathetic block caused by anti-cholinergic agents. [omicsonline.org]

    We also showed that meaningless speech, lethargy, coma, and absence of tachycardia were ominous signs in deadly nightshade intoxication in childhood. [ncbi.nlm.nih.gov]

    Peripheral effects include mydriasis with cycloplegia, dry mucous membranes, hyperreflexia, flushed skin, diminished bowel sounds or ileus, urinary retention, tachycardia, and hypertension or hypotension [ 1 ]. [drugbank.ca]

  • Hypertension

    The heart rate increases (tachycardia) with hypertension as a result of parasympathetic block caused by anti-cholinergic agents. [omicsonline.org]

    Peripheral effects include mydriasis with cycloplegia, dry mucous membranes, hyperreflexia, flushed skin, diminished bowel sounds or ileus, urinary retention, tachycardia, and hypertension or hypotension [ 1 ]. [drugbank.ca]

    The peripheral effect are mydriasis with cycloplegia, dry mucous membranes, hyperreflexia, flushed skin, diminished bowel sounds or ileus, urinary retention, tachycardia, and hypertension or hypotension. [flipper.diff.org]

    Heart: seemed too large; violent palpitation, < least exertion, reverberating, throbbing in head, body; dichrotism; pulse rapid, weak, full, bounding, globular; hypertension; blood-vessels distended. Chest: stitches, < coughing. [qjure.com]

  • Palpitations

    Signs of toxicity : Dry mouth, flushing, skin hot and dry, mydriasis (pupil dilation), increased respiratory rate and volume, increased temperature in children, palpitations, increased pulse rate and blood pressure, incoordinate movements., incoherent [thenaturopathicherbalist.com]

    Various preparations of belladonna are used as lotions, plasters and salves to relieve pain from sciatica, gout, and cardiac palpitations. Did You Know? The oral overdose level for belladonna is only 600 milligrams. [fs.fed.us]

    Heart: seemed too large; violent palpitation, < least exertion, reverberating, throbbing in head, body; dichrotism; pulse rapid, weak, full, bounding, globular; hypertension; blood-vessels distended. Chest: stitches, < coughing. [qjure.com]

    ADVERSE REACTIONS: Adverse reactions may include xerostomia; urinary hesitancy and retention; blurred vision; tachycardia; palpitation; mydriasis; cycloplegia; increased ocular tension; loss of taste sense; headache; nervousness; drowsiness; weakness; [web.archive.org]

Musculoskeletal

  • Back Pain

    Preparations of belladonna plasters came into common usage during the 19th and early 20th centuries for a wide variety of conditions including neuralgia, chronic rheumatism, muscle and back pain, and pulmonary tuberculosis. [fs.fed.us]

    Companies claim it helps with: colds flu fever cough sore throat inflammation joint and back pain earache gout Belladonna should be safe for you if your doctor prescribes it and you take it as directed. [healthline.com]

    These include: the common cold fever whooping cough hay fever earache asthma motion sickness flu a cough and sore throat joint and back pain arthritis pain spasms, or colic-like pain in the stomach or bile ducts nerve problems gout inflammation Parkinson [medicalnewstoday.com]

Eyes

  • Blurred Vision

    Share on Pinterest Blurred vision and hallucinations are potential side effects of belladonna. Belladonna is considered a toxic plant with historical uses as a poison. [medicalnewstoday.com]

    Donnatal Extentabs may produce drowsiness or blurred vision. [web.archive.org]

    The symptoms of poisoning with deadly nightshade include dilated pupils, blurred vision, loss of balance, dry mouth and throat, slurred speech, inability to urinate, confusion, hallucinations and delirium. [woodlands.co.uk]

    vision, sensitivity to light, dysphagia, great thirst, nausea, vomiting, diarrhea, delerium, restlessness, confusion; later: depressed cerebral and neural activity, stupor ,circulatory collapse, coma and death from centric respiratory paralysis. [thenaturopathicherbalist.com]

  • Photophobia

    I began to experience some photophobia, yet my pupils were dilated to a max 3 or 4 (and I was in a light muted room). [erowid.org]

    Eyes: swollen, protruding, staring, glaring, brilliant, wild; shooting, throbbing deep, < lying down; pupils dilated, shining; conjunctiva red, dry, burning; eyelids swollen, squinting, spasms; fundus congested; photophobia; exophthalmus; vision illusions [qjure.com]

    Both locally and internally belladonna is a prompt agent for the relief of photophobia. [henriettesherbal.com]

  • Diplopia

    staring, glaring, brilliant, wild; shooting, throbbing deep, < lying down; pupils dilated, shining; conjunctiva red, dry, burning; eyelids swollen, squinting, spasms; fundus congested; photophobia; exophthalmus; vision illusions, fiery appearance, diplopia [qjure.com]

Skin

  • Flushing

    The anti-cholinergic toxidrome affects both central and peripheral nervous system, causing acute delirium, hallucination, tachycardia, dry mouth, flushed skin, vomiting and blurry vision. [omicsonline.org]

    5-lobed, dull red-purple or greenish purple; fruit a glossy, purple-black berry Family: Solanaceae Origin: Eurasia Poison Part: All parts, mainly berries Poison Delivery Mode: Ingestion Symptoms: Fever, rapid pulse, dilation of pupils, hot and dry flushed [plants.ces.ncsu.edu]

    It was much later, about an hour when I noticed the dry mouth, insatiable thirst, and hardly quenchable (my bladder is nice and flushed). Still experiencing the awareness, everything was brilliantly clear and the auras were resonating. [erowid.org]

    The most common observed symptoms and signs were meaningless speech, tachycardia, mydriasis, and flushing. None of the children required mechanical ventilation or died in our series. [ncbi.nlm.nih.gov]

    Symptoms include a depressed level of consciousness, seizure, difficulty or slowed breathing, lethargy, sleepiness, muscle weakness, skin flushing, constipation, difficulty urinating, or agitation. [fda.gov]

  • Dermatitis

    Handling the plant can expose a person to absorbing toxins through the skin or cause severe dermatitis. Belladonna is also highly toxic to domestic animals causing paralysis and death. [fs.fed.us]

    The sap of the plant can cause dermatitis. Handling the berries can cause eruptions on the face and visual impairment. People have reportedly died after dining on birds and rabbits which have fed on the berries. [hermionesgarden.blogspot.com]

    Related: 14 of the Best Plants for Your Drought-Tolerant Garden istockphoto.com Poison Oak 4 /10 Like poison ivy, poison oak grows three-leaf clusters that can cause severe dermatitis and intense itching. [bobvila.com]

  • Decreased Sweating

    Common side effects of belladonna may include: dry mouth; blurred vision; muscle spasms; constipation; decreased urination; or decreased sweating. This is not a complete list of side effects and others may occur. [drugs.com]

Urogenital

  • Oliguria

    Smaller doses: gastroenteritis, nephrosis, cystitis, and urethritis ( anorexia, soft, and/or mucoid to bloody mucoid feces, intestinal atony, colic dysuria frequent, painful urination, or oliguria to anuria, and hematuria ). [web.archive.org]

Neurologic

  • Confusion

    In addition, the central nervous system effects of atropine include memory disruption, which may lead to severe confusion. [horticultureandsoilscience.wikia.com]

    The risk of poisoning in children is important because of possible confusion with other berries. [ncbi.nlm.nih.gov]

    They are not to be confused with those of bittersweet (Solanum dulcamara) image adjacent, another hedgerow and woodland climber - but this has bright purple flowers with contrasting yellow anthers. [woodlands.co.uk]

    Fitting, because this chemical causes a quickening of the pulse, confusion, seizures, hallucinations and even death when consumed. [motherearthliving.com]

  • Seizure

    We present an infant who suffered serious seizures after ingestion of a homeopathic agent containing A. belladonna. [ncbi.nlm.nih.gov]

    Fitting, because this chemical causes a quickening of the pulse, confusion, seizures, hallucinations and even death when consumed. [motherearthliving.com]

    Symptoms of overdose can include: blurred vision, dilated pupils, rapid heart rate, headache, dry mouth, confusion, hallucinations, and seizures. The name belladonna is derived from the Italian words for "beautiful (bella) woman (donna)." [medicinenet.com]

    The FDA is analyzing adverse events reported to the agency regarding homeopathic teething tablets and gels, including seizures in infants and children who were given these products, since a 2010 safety alert about homeopathic teething tablets. [fda.gov]

    Serious side effects including seizures, breathing problems, and agitation have been reported in infants taking these products, and some have died. [webmd.com]

  • Agitation

    A 36-year-old woman presented to our ophthalmic emergency department with complaints of blurry vision, lightning flashes, disorientation, loss of balance, agitation, and anxiety for 24 hours. [ncbi.nlm.nih.gov]

    Benzodiazepines are frequently used for sedation to control anticholinergic effects including delirium and agitation [ 2 ]. [drugbank.ca]

    Symptoms include a depressed level of consciousness, seizure, difficulty or slowed breathing, lethargy, sleepiness, muscle weakness, skin flushing, constipation, difficulty urinating, or agitation. [fda.gov]

    Serious side effects including seizures, breathing problems, and agitation have been reported in infants taking these products, and some have died. [webmd.com]

  • Neuralgia

    Certain forms of neuralgia, particularly trigeminal neuralgia, are relieved by ordinary doses of belladonna. Intercostal, visceral, and sciatic neuralgias are sometimes amenable to it. [henriettesherbal.com]

    Preparations of belladonna plasters came into common usage during the 19th and early 20th centuries for a wide variety of conditions including neuralgia, chronic rheumatism, muscle and back pain, and pulmonary tuberculosis. [fs.fed.us]

    Belladonna is used in ointments that are applied to the skin for joint pain (rheumatism), leg pain caused by a disc in the backbone pushing on the sciatic nerve ( sciatica ), and nerve pain (neuralgia). [webmd.com]

  • Agitated Delirium

    Benzodiazepines are frequently used for sedation to control anticholinergic effects including delirium and agitation [ 2 ]. [drugbank.ca]

    Atropine crosses the blood brain barrier and patients with central anticholinergic syndrome show loss of memory, confusion, disorientation, hallucination, in-coordinated movements and agitated delirium with acute psychosis [ 1, 2 ]. [omicsonline.org]

    Central nervous effect are ataxia, disorientation, short-term memory loss, confusion, hallucinations, psychosis, agitated delirium, seizures, coma, respiratory failure or cardiovascular collapse. [flipper.diff.org]

    Benzodiazepines are frequently used for sedation to control anticholinergic effects including delirium and agitation 2. [go.drugbank.com]

Treatment

She was admitted in the intensive care unit, the progression was favorable with symptomatic treatment. [ncbi.nlm.nih.gov]

Muscarinic antagonists are known to be used as bronchodilators in asthma treatments. [omicsonline.org]

Berries of belladonna Alternative-medicinal use Edit Belladonna preparations are used in homeopathy as alleged treatments for various conditions. [horticultureandsoilscience.wikia.com]

Prognosis

This content is accurate and true to the best of the author’s knowledge and does not substitute for diagnosis, prognosis, treatment, prescription, and/or dietary advice from a licensed health professional. [owlcation.com]

Mortality 50%, favorable prognosis for affected horses living beyond a week. Treatment: No specific treatment. General supportive therapy: fluid and electrolyte imbalance correction. Broad spectrum antibiotics. [web.archive.org]

Etiology

Therefore, in case of excitability and confusion, as well as somnolence or coma of uncertain etiology, an anticholinergic syndrome caused by ingestion of atropine-containing plants or psychoactive drugs should be included in the differential diagnosis [ncbi.nlm.nih.gov]

Epidemiology

Particular attention is dedicated to the pharmaco/toxicodynamics, pharmaco/toxicokinetics, pathophysiology, epidemiological cases, and animal studies associated with the effects of Atropa belladonna on the nervous system. [ncbi.nlm.nih.gov]

Epidemiology Frequency United States Incidence is sporadic, with clusters of poisoning cases, mostly among adolescents using plants for their hallucinogenic effects. [emedicine.medscape.com]

Pathophysiology

Particular attention is dedicated to the pharmaco/toxicodynamics, pharmaco/toxicokinetics, pathophysiology, epidemiological cases, and animal studies associated with the effects of Atropa belladonna on the nervous system. [ncbi.nlm.nih.gov]

Pathophysiology Toxicity from plants containing tropane alkaloids manifests as classic anticholinergic poisoning. [emedicine.medscape.com]

Prevention

The seedlings need sterile soil to prevent damping off and resent root disturbance during transplanting. This plant is a sign of water nearby. [horticultureandsoilscience.wikia.com]

Drink plenty of water to prevent constipation while using belladonna and opium. Belladonna and opium rectal is most often used 1 or 2 times per day. Do not use the suppositories more than 4 times per day. [cigna.com]

Atropine blocks the muscarinic receptors of the system, preventing the acetylcholine from transmitting nerve impulses. [owlcation.com]

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