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Atropa Belladonna


Presentation

  • We discuss his presentation and review of the literature on this topic.[ncbi.nlm.nih.gov]
  • For example, Aethusa cynapium L. is not presented in this virtual herbarium because I have not found a specimen, it is nevertheless of course an extremely toxic plant![herbarium.freehostia.com]
  • The child presented essentially a central anti-cholinergic syndrome. She was admitted in the intensive care unit, the progression was favorable with symptomatic treatment.[ncbi.nlm.nih.gov]
  • A 36-year-old woman presented to our ophthalmic emergency department with complaints of blurry vision, lightning flashes, disorientation, loss of balance, agitation, and anxiety for 24 hours.[ncbi.nlm.nih.gov]
  • Patients may present to the emergency department with a psychotic picture [ 3 ].[ncbi.nlm.nih.gov]
Fever
  • The patient was treated with intravenous benzodiazepines and antibiotics after a full sepsis work up; all the laboratory results were normal and the fever resolved after several hours.[ncbi.nlm.nih.gov]
  • Fever : Belladonna might increase the risk of overheating in people with fever. Stomach ulcers : Belladonna might make stomach ulcers worse.[webmd.com]
  • These include: the common cold fever whooping cough hay fever earache asthma motion sickness flu a cough and sore throat joint and back pain arthritis pain spasms, or colic-like pain in the stomach or bile ducts nerve problems gout inflammation Parkinson's[medicalnewstoday.com]
High Fever
  • Symptoms: Cattle -- high fever, loss of appetite, weight loss, difficult breathing, salivation, ataxia, opisthotonos, convulsions, internal bleeding; often mistaken for anthrax and other infectious diseases of cattle. Death in 4-8 days.[web.archive.org]
Rigor
  • The ESCOP presents revisions with scientific rigor, very important to validate phytotherapeutic treatments. (more…) García Giménez, Mª Dolores (Spain) Departamento de Farmacología Facultad de Farmacia Universidad de Sevilla (España).[escop.com]
Constipation
  • Constipation : Belladonna might make constipation worse. Down syndrome : People with Down syndrome might be extra-sensitive to the potentially toxic chemicals in belladonna and their harmful effects.[webmd.com]
  • The signs of peripheral effects manifested by the parasympathetic block include decreased secretions causing dryness of mouth, flushed skin, mydriasis, vomiting, constipation, urinary retention, fever, tachycardia and hypertension [ 1, 2 ].[esciencecentral.org]
Tachycardia
  • We also showed that meaningless speech, lethargy, coma, and absence of tachycardia were ominous signs in deadly nightshade intoxication in childhood.[ncbi.nlm.nih.gov]
  • Within 6 h he experienced phases of disorientation, aggressiveness, and tachycardia. He was initially treated with diazepam, an intravenous infusion of physostigmine and activated charcoal.[ncbi.nlm.nih.gov]
  • Some tachycardia, no worse than my near lightening hit, max about 150bpm for about 5 minutes at its worse. It was much later, about an hour when I noticed the dry mouth, insatiable thirst, and hardly quenchable (my bladder is nice and flushed).[erowid.org]
  • The heart rate increases (tachycardia) with hypertension as a result of parasympathetic block caused by anti-cholinergic agents.[esciencecentral.org]
Hypertension
  • The heart rate increases (tachycardia) with hypertension as a result of parasympathetic block caused by anti-cholinergic agents.[esciencecentral.org]
  • Peripheral effects include mydriasis with cycloplegia, dry mucous membranes, hyperreflexia, flushed skin, diminished bowel sounds or ileus, urinary retention, tachycardia, and hypertension or hypotension [ 1 ] .[drugbank.ca]
  • The peripheral effect are mydriasis with cycloplegia, dry mucous membranes, hyperreflexia, flushed skin, diminished bowel sounds or ileus, urinary retention, tachycardia, and hypertension or hypotension.[flipper.diff.org]
  • The peripheral effects that are common to anticholinergic agents include mydriasis with cycloplegia, dry mucous membranes, hyperreflexia, flushed skin, diminished bowel sounds or ileus, urinary retention, tachycardia, and hypertension or hypotension [[ncbi.nlm.nih.gov]
Long Arm
  • They had big heads, tall, skinny, long arms and legs. These creatures studied me but not with equipment with their large eyes. I also remember seeing transparent spirits among earth then a bright light and the most beautiful music I've ever heard.[erowid.org]
Flushing
  • The most common observed symptoms and signs were meaningless speech, tachycardia, mydriasis, and flushing. None of the children required mechanical ventilation or died in our series.[ncbi.nlm.nih.gov]
  • It was much later, about an hour when I noticed the dry mouth, insatiable thirst, and hardly quenchable (my bladder is nice and flushed). Still experiencing the awareness, everything was brilliantly clear and the auras were resonating.[erowid.org]
  • , 5-lobed, dull red-purple or greenish purple; fruit a glossy, purple-black berry Family: Solanaceae Origin: Eurasia Poison Part: All parts, mainly berries Poison Delivery Mode: Ingestion Symptoms: Fever, rapid pulse, dilation of pupils, hot and dry flushed[plants.ces.ncsu.edu]
  • Signs of toxicity : Dry mouth, flushing, skin hot and dry, mydriasis (pupil dilation), increased respiratory rate and volume, increased temperature in children, palpitations, increased pulse rate and blood pressure, incoordinate movements., incoherent[thenaturopathicherbalist.com]
  • The anti-cholinergic toxidrome affects both central and peripheral nervous system, causing acute delirium, hallucination, tachycardia, dry mouth, flushed skin, vomiting and blurry vision.[esciencecentral.org]
Blurred Vision
  • ., incoherent speech, memory disturbed, disorientation, urinary urgency, difficult urination, eye pain, blurred vision, sensitivity to light, dysphagia, great thirst, nausea, vomiting, diarrhea, delerium, restlessness, confusion; later: depressed cerebral[thenaturopathicherbalist.com]
  • Symptoms of overdose can include: blurred vision, dilated pupils, rapid heart rate, headache, dry mouth, confusion, hallucinations, and seizures. The name belladonna is derived from the Italian words for "beautiful (bella) woman (donna)."[medicinenet.com]
  • Risks and side effects Blurred vision and hallucinations are potential side effects of belladonna. Belladonna is considered a toxic plant with historical uses as a poison.[medicalnewstoday.com]
  • Donnatal Extentabs may produce drowsiness or blurred vision.[web.archive.org]
  • Side effects can include dry mouth, enlarged pupils, blurred vision, red dry skin, fever, fast heartbeat, inability to urinate or sweat, hallucinations, spasms, mental problems, convulsions, and coma.[webmd.com]
Photophobia
  • I began to experience some photophobia, yet my pupils were dilated to a max 3 or 4 (and I was in a light muted room).[erowid.org]
  • Both locally and internally belladonna is a prompt agent for the relief of photophobia.[henriettesherbal.com]
Oliguria
  • Smaller doses: gastroenteritis, nephrosis, cystitis, and urethritis ( anorexia, soft, and/or mucoid to bloody mucoid feces, intestinal atony, colic dysuria frequent, painful urination, or oliguria to anuria, and hematuria ).[web.archive.org]
Confusion
  • The risk of poisoning in children is important because of possible confusion with other berries.[ncbi.nlm.nih.gov]
  • The risk of poisoning in children is important because of possible confusion of black/dark blue belladonna fruit berries with other edible berries.[ncbi.nlm.nih.gov]
  • This anti-cholinergic toxidrome can be confused with post-traumatic brain damage and acute psychosis.[flipper.diff.org]
  • When we got back to Isa's I was in a worse state than ever, I thought I was fine but I was swaying, I couldn't stand, sit, kneel or move without seeing something or getting confused.[erowid.org]
Seizure
  • We present an infant who suffered serious seizures after ingestion of a homeopathic agent containing A. belladonna.[ncbi.nlm.nih.gov]
  • Symptoms of overdose can include: blurred vision, dilated pupils, rapid heart rate, headache, dry mouth, confusion, hallucinations, and seizures. The name belladonna is derived from the Italian words for "beautiful (bella) woman (donna)."[medicinenet.com]
  • Fitting, because this chemical causes a quickening of the pulse, confusion, seizures, hallucinations and even death when consumed.[motherearthliving.com]
  • The toxicity associated with physostigmine consists mostly of seizures and cardiac arrhythmia, and occurs when used in the absence of anticholinergic symptoms.[ncbi.nlm.nih.gov]
  • Central symptoms, which are dose-dependent and anticholinergic agent-specific, include ataxia, disorientation, short-term memory loss, confusion, hallucinations, psychosis, agitated delirium, seizures, coma, respiratory failure or cardiovascular collapse[drugbank.ca]
Agitation
  • A 36-year-old woman presented to our ophthalmic emergency department with complaints of blurry vision, lightning flashes, disorientation, loss of balance, agitation, and anxiety for 24 hours.[ncbi.nlm.nih.gov]
  • Benzodiazepines are frequently used for sedation to control anticholinergic effects including delirium and agitation [ 2 ] .[drugbank.ca]
  • Benzodiazepines may be used for sedation if the patient is very agitated [ 2 ].[ncbi.nlm.nih.gov]
  • Symptoms include a depressed level of consciousness, seizure, difficulty or slowed breathing, lethargy, sleepiness, muscle weakness, skin flushing, constipation, difficulty urinating, or agitation.[fda.gov]
  • Central nervous effect are ataxia, disorientation, short-term memory loss, confusion, hallucinations, psychosis, agitated delirium, seizures, coma, respiratory failure or cardiovascular collapse.[flipper.diff.org]
Agitated Delirium
  • Central symptoms, which are dose-dependent and anticholinergic agent-specific, include ataxia, disorientation, short-term memory loss, confusion, hallucinations, psychosis, agitated delirium, seizures, coma, respiratory failure or cardiovascular collapse[drugbank.ca]
  • Central nervous effect are ataxia, disorientation, short-term memory loss, confusion, hallucinations, psychosis, agitated delirium, seizures, coma, respiratory failure or cardiovascular collapse.[flipper.diff.org]
  • Atropine crosses the blood brain barrier and patients with central anticholinergic syndrome show loss of memory, confusion, disorientation, hallucination, in-coordinated movements and agitated delirium with acute psychosis [ 1, 2 ].[esciencecentral.org]
  • Central effects are dose-dependent and agent-dependent [ 5 ], Patients with central anti-cholinergic syndrome may present with ataxia, disorientation, short-term memory loss, confusion, hallucinations, psychosis, agitated delirium, seizures, coma, respiratory[ncbi.nlm.nih.gov]
Slurred Speech
  • Sidenote: oh and by the way, I still have blurry vision and slurred speech for the next 24 hours after the end of the visions.[erowid.org]
  • They include dryness in the mouth, thirst, difficulty in swallowing and speaking, blurred vision from the dilated pupils, vomiting, excessive stimulation of the heart, drowsiness, slurred speech, hallucinations, confusion, disorientation, delirium, and[thepoisongarden.co.uk]
  • The symptoms of belladonna poisoning include dilated pupils, sensitivity to light, blurred vision, tachycardia, loss of balance, staggering, headache, rash, flushing, severely dry mouth and throat, slurred speech, urinary retention, constipation, confusion[horticultureandsoilscience.wikia.com]

Treatment

  • She was admitted in the intensive care unit, the progression was favorable with symptomatic treatment.[ncbi.nlm.nih.gov]
  • Additionally, we discuss the influence of active tropane alkaloids in Atropa belladonna and other similar plants on FDA-approved therapeutic drugs for treatment of neurological disorders. Copyright 2018. Published by Elsevier Ltd.[ncbi.nlm.nih.gov]
  • Physostigmine treatment was ineffective.[ncbi.nlm.nih.gov]
  • It is important to recognize the anticholinergic syndrome caused by such intoxication in order to make a proper diagnosis, avoid unnecessary testing, and provide expedient appropriate treatment when required.[ncbi.nlm.nih.gov]
  • The main outcome was the proportion of subjects who had proved in each treatment group.[ncbi.nlm.nih.gov]

Prognosis

  • Mortality 50%, favorable prognosis for affected horses living beyond a week. Treatment: No specific treatment. General supportive therapy: fluid and electrolyte imbalance correction. Broad spectrum antibiotics.[web.archive.org]

Etiology

  • Therefore, in case of excitability and confusion, as well as somnolence or coma of uncertain etiology, an anticholinergic syndrome caused by ingestion of atropine-containing plants or psychoactive drugs should be included in the differential diagnosis[ncbi.nlm.nih.gov]

Epidemiology

  • Particular attention is dedicated to the pharmaco/toxicodynamics, pharmaco/toxicokinetics, pathophysiology, epidemiological cases, and animal studies associated with the effects of Atropa belladonna on the nervous system.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • Particular attention is dedicated to the pharmaco/toxicodynamics, pharmaco/toxicokinetics, pathophysiology, epidemiological cases, and animal studies associated with the effects of Atropa belladonna on the nervous system.[ncbi.nlm.nih.gov]

Prevention

  • *This product has not been evaluated by the Food and Drug Administration and is not intended to diagnose, treat, cure or prevent any disease.[hawaiipharm.com]
  • Antispasmodic Some of the antispasmodic benefits were explained earlier, but another important effect of this particular quality of Atropa belladonna is its prevention of muscle spasms, which protects the entire body, including the heart (irregularities[organicfacts.net]
  • By blocking these receptors, atropine produces dilatation of the pupil (mydriasis) and prevents the eye from accommodating for near vision (cycloplegia).[web.archive.org]

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