Presentation
We discuss his presentation and review of the literature on this topic. [ncbi.nlm.nih.gov]
For example, Aethusa cynapium L. is not presented in this virtual herbarium because I have not found a specimen, it is nevertheless of course an extremely toxic plant! [herbarium.freehostia.com]
The undeveloped fruit, a calyx with an unripe berry, is often present. [henriettesherbal.com]
Entire Body System
- Fever
The patient was treated with intravenous benzodiazepines and antibiotics after a full sepsis work up; all the laboratory results were normal and the fever resolved after several hours. [ncbi.nlm.nih.gov]
Fever : Belladonna might increase the risk of overheating in people with fever. Stomach ulcers : Belladonna might make stomach ulcers worse. [webmd.com]
[…] alternate, simple; flowers axillary, drooping, tubular, 5-lobed, dull red-purple or greenish purple; fruit a glossy, purple-black berry Family: Solanaceae Origin: Eurasia Poison Part: All parts, mainly berries Poison Delivery Mode: Ingestion Symptoms: Fever [plants.ces.ncsu.edu]
- Turkish
Dutch beladama Portuguese beladona Portuguese beladona-comum Portuguese erva-midriática Portuguese erva-moura-furiosa Portuguese belladonna Swedish vanlig belladonna Swedish белладонна Russian красавка белладонна Russian galnebær Danish güzelavratotu Turkish [gd.eppo.int]
Death is very rare, with few reports in the literature, including none in a case series of 49 Turkish children who ate fruits, six of whom developed severe symptoms (Caksen et al., 2003). There are generally no sequelae after recovery from overdose. [ndnr.com]
- Rigor
The ESCOP presents revisions with scientific rigor, very important to validate phytotherapeutic treatments. (more…) García Giménez, Mª Dolores (Spain) Departamento de Farmacología Facultad de Farmacia Universidad de Sevilla (España). [escop.com]
Respiratoric
- Hoarseness
Throat: larynx dry, sore, very painful; foreign body, + cough; hoarse; voice loss, high, piping. Lungs: cough tickling, short, dry, barking, whooping, < night; respiration oppressed, fast, quick, unequal, laboured, Cheyne-Stokes. [qjure.com]
Gastrointestinal
- Constipation
Symptoms include a depressed level of consciousness, seizure, difficulty or slowed breathing, lethargy, sleepiness, muscle weakness, skin flushing, constipation, difficulty urinating, or agitation. [fda.gov]
Constipation : Belladonna might make constipation worse. Down syndrome : People with Down syndrome might be extra-sensitive to the potentially toxic chemicals in belladonna and their harmful effects. [webmd.com]
The signs of peripheral effects manifested by the parasympathetic block include decreased secretions causing dryness of mouth, flushed skin, mydriasis, vomiting, constipation, urinary retention, fever, tachycardia and hypertension [ 1, 2 ]. [omicsonline.org]
Cardiovascular
- Tachycardia
We also showed that meaningless speech, lethargy, coma, and absence of tachycardia were ominous signs in deadly nightshade intoxication in childhood. [ncbi.nlm.nih.gov]
The heart rate increases (tachycardia) with hypertension as a result of parasympathetic block caused by anti-cholinergic agents. [omicsonline.org]
Peripheral effects include mydriasis with cycloplegia, dry mucous membranes, hyperreflexia, flushed skin, diminished bowel sounds or ileus, urinary retention, tachycardia, and hypertension or hypotension [ 1 ]. [drugbank.ca]
- Hypertension
The heart rate increases (tachycardia) with hypertension as a result of parasympathetic block caused by anti-cholinergic agents. [omicsonline.org]
Peripheral effects include mydriasis with cycloplegia, dry mucous membranes, hyperreflexia, flushed skin, diminished bowel sounds or ileus, urinary retention, tachycardia, and hypertension or hypotension [ 1 ]. [drugbank.ca]
The peripheral effect are mydriasis with cycloplegia, dry mucous membranes, hyperreflexia, flushed skin, diminished bowel sounds or ileus, urinary retention, tachycardia, and hypertension or hypotension. [flipper.diff.org]
Heart: seemed too large; violent palpitation, < least exertion, reverberating, throbbing in head, body; dichrotism; pulse rapid, weak, full, bounding, globular; hypertension; blood-vessels distended. Chest: stitches, < coughing. [qjure.com]
Skin
- Flushing
5-lobed, dull red-purple or greenish purple; fruit a glossy, purple-black berry Family: Solanaceae Origin: Eurasia Poison Part: All parts, mainly berries Poison Delivery Mode: Ingestion Symptoms: Fever, rapid pulse, dilation of pupils, hot and dry flushed [plants.ces.ncsu.edu]
The anti-cholinergic toxidrome affects both central and peripheral nervous system, causing acute delirium, hallucination, tachycardia, dry mouth, flushed skin, vomiting and blurry vision. [omicsonline.org]
The most common observed symptoms and signs were meaningless speech, tachycardia, mydriasis, and flushing. None of the children required mechanical ventilation or died in our series. [ncbi.nlm.nih.gov]
It was much later, about an hour when I noticed the dry mouth, insatiable thirst, and hardly quenchable (my bladder is nice and flushed). Still experiencing the awareness, everything was brilliantly clear and the auras were resonating. [erowid.org]
Eyes
- Blurred Vision
Symptoms of overdose can include: blurred vision, dilated pupils, rapid heart rate, headache, dry mouth, confusion, hallucinations, and seizures. The name belladonna is derived from the Italian words for "beautiful (bella) woman (donna)." [medicinenet.com]
Risks and side effects Blurred vision and hallucinations are potential side effects of belladonna. Belladonna is considered a toxic plant with historical uses as a poison. [medicalnewstoday.com]
Donnatal Extentabs may produce drowsiness or blurred vision. [web.archive.org]
vision, sensitivity to light, dysphagia, great thirst, nausea, vomiting, diarrhea, delerium, restlessness, confusion; later: depressed cerebral and neural activity, stupor ,circulatory collapse, coma and death from centric respiratory paralysis. [thenaturopathicherbalist.com]
The symptoms of poisoning with deadly nightshade include dilated pupils, blurred vision, loss of balance, dry mouth and throat, slurred speech, inability to urinate, confusion, hallucinations and delirium. [woodlands.co.uk]
- Photophobia
I began to experience some photophobia, yet my pupils were dilated to a max 3 or 4 (and I was in a light muted room). [erowid.org]
Eyes: swollen, protruding, staring, glaring, brilliant, wild; shooting, throbbing deep, < lying down; pupils dilated, shining; conjunctiva red, dry, burning; eyelids swollen, squinting, spasms; fundus congested; photophobia; exophthalmus; vision illusions [qjure.com]
Both locally and internally belladonna is a prompt agent for the relief of photophobia. [henriettesherbal.com]
- Diplopia
staring, glaring, brilliant, wild; shooting, throbbing deep, < lying down; pupils dilated, shining; conjunctiva red, dry, burning; eyelids swollen, squinting, spasms; fundus congested; photophobia; exophthalmus; vision illusions, fiery appearance, diplopia [qjure.com]
Neurologic
- Confusion
The risk of poisoning in children is important because of possible confusion with other berries. [ncbi.nlm.nih.gov]
This anti-cholinergic toxidrome can be confused with post-traumatic brain damage and acute psychosis. [flipper.diff.org]
They are not to be confused with those of bittersweet (Solanum dulcamara) image adjacent, another hedgerow and woodland climber - but this has bright purple flowers with contrasting yellow anthers. [woodlands.co.uk]
- Seizure
We present an infant who suffered serious seizures after ingestion of a homeopathic agent containing A. belladonna. [ncbi.nlm.nih.gov]
Symptoms of overdose can include: blurred vision, dilated pupils, rapid heart rate, headache, dry mouth, confusion, hallucinations, and seizures. The name belladonna is derived from the Italian words for "beautiful (bella) woman (donna)." [medicinenet.com]
Fitting, because this chemical causes a quickening of the pulse, confusion, seizures, hallucinations and even death when consumed. [motherearthliving.com]
Central symptoms, which are dose-dependent and anticholinergic agent-specific, include ataxia, disorientation, short-term memory loss, confusion, hallucinations, psychosis, agitated delirium, seizures, coma, respiratory failure or cardiovascular collapse [drugbank.ca]
- Agitation
A 36-year-old woman presented to our ophthalmic emergency department with complaints of blurry vision, lightning flashes, disorientation, loss of balance, agitation, and anxiety for 24 hours. [ncbi.nlm.nih.gov]
Benzodiazepines are frequently used for sedation to control anticholinergic effects including delirium and agitation [ 2 ]. [drugbank.ca]
Symptoms include a depressed level of consciousness, seizure, difficulty or slowed breathing, lethargy, sleepiness, muscle weakness, skin flushing, constipation, difficulty urinating, or agitation. [fda.gov]
Central nervous effect are ataxia, disorientation, short-term memory loss, confusion, hallucinations, psychosis, agitated delirium, seizures, coma, respiratory failure or cardiovascular collapse. [flipper.diff.org]
- Slurred Speech
The symptoms of poisoning with deadly nightshade include dilated pupils, blurred vision, loss of balance, dry mouth and throat, slurred speech, inability to urinate, confusion, hallucinations and delirium. [woodlands.co.uk]
They include dryness in the mouth, thirst, difficulty in swallowing and speaking, blurred vision from the dilated pupils, vomiting, excessive stimulation of the heart, drowsiness, slurred speech, hallucinations, confusion, disorientation, delirium, and [thepoisongarden.co.uk]
The symptoms of belladonna poisoning include dilated pupils, sensitivity to light, blurred vision, tachycardia, loss of balance, staggering, headache, rash, flushing, severely dry mouth and throat, slurred speech, urinary retention, constipation, confusion [horticultureandsoilscience.wikia.com]
There are many possible symptoms of poisoning, including: rapid heartbeat dry mouth slurred speech light sensitivity blurred vision inability to urinate loss of balance flushed skin a rash memory loss seizures confusion hallucinations Severe poisoning [owlcation.com]
Sidenote: oh and by the way, I still have blurry vision and slurred speech for the next 24 hours after the end of the visions. [erowid.org]
- Agitated Delirium
Benzodiazepines are frequently used for sedation to control anticholinergic effects including delirium and agitation [ 2 ]. [drugbank.ca]
Central nervous effect are ataxia, disorientation, short-term memory loss, confusion, hallucinations, psychosis, agitated delirium, seizures, coma, respiratory failure or cardiovascular collapse. [flipper.diff.org]
Atropine crosses the blood brain barrier and patients with central anticholinergic syndrome show loss of memory, confusion, disorientation, hallucination, in-coordinated movements and agitated delirium with acute psychosis [ 1, 2 ]. [omicsonline.org]
Despite potential complications, physostigmine can be beneficial in pure anticholinergic overdose with severe symptoms; it can also be useful by controlling agitation and reversing delirium. [ncbi.nlm.nih.gov]
Workup
Urine
- Albuminuria
He has likewise found it efficient in acute nephritis, in which it calms the nervous irritation, and at the same time contracts the dilated blood-vessels; in chronic albuminuria, in which it stimulates the kidneys to healthy action, and diminishes the [henriettesherbal.com]
Treatment
She was admitted in the intensive care unit, the progression was favorable with symptomatic treatment. [ncbi.nlm.nih.gov]
Muscarinic antagonists are known to be used as bronchodilators in asthma treatments. [omicsonline.org]
Prognosis
This content is accurate and true to the best of the author’s knowledge and does not substitute for diagnosis, prognosis, treatment, prescription, and/or dietary advice from a licensed health professional. [owlcation.com]
Etiology
Therefore, in case of excitability and confusion, as well as somnolence or coma of uncertain etiology, an anticholinergic syndrome caused by ingestion of atropine-containing plants or psychoactive drugs should be included in the differential diagnosis [ncbi.nlm.nih.gov]
Epidemiology
Particular attention is dedicated to the pharmaco/toxicodynamics, pharmaco/toxicokinetics, pathophysiology, epidemiological cases, and animal studies associated with the effects of Atropa belladonna on the nervous system. [ncbi.nlm.nih.gov]
Epidemiology Frequency United States Incidence is sporadic, with clusters of poisoning cases, mostly among adolescents using plants for their hallucinogenic effects. [emedicine.medscape.com]
Pathophysiology
Particular attention is dedicated to the pharmaco/toxicodynamics, pharmaco/toxicokinetics, pathophysiology, epidemiological cases, and animal studies associated with the effects of Atropa belladonna on the nervous system. [ncbi.nlm.nih.gov]
Pathophysiology Toxicity from plants containing tropane alkaloids manifests as classic anticholinergic poisoning. [emedicine.medscape.com]
Prevention
Atropine blocks the muscarinic receptors of the system, preventing the acetylcholine from transmitting nerve impulses. [owlcation.com]
*This product has not been evaluated by the Food and Drug Administration and is not intended to diagnose, treat, cure or prevent any disease. [hawaiipharm.com]
By blocking these receptors, atropine produces dilatation of the pupil (mydriasis) and prevents the eye from accommodating for near vision (cycloplegia). [web.archive.org]