Atrophic glossitis (AG) is a disorder of the tongue mucosa characterized by atrophy of the filiform papillae (and fungiform according to some authors) on the dorsal surface of the tongue [1] [2] [3] [4]. As a result, ulcer-like lesions on the dorsal and lateral tongue appear, and the term "smooth" or "bald" tongue is used to describe the smooth and glossy red-to-pink mucosa [1] [2] [3]. AG is typically seen in adults and elderly individuals, and the most common causes are nutritional deficiencies, (iron, vitamin B12, folic acid, riboflavin, and niacin) and protein malnutrition [1] [2] [5] [6] [7]. In this patient population, pain and a burning sensation of the tongue are frequently reported [4]. In addition to nutritional deficiencies, a number of diseases have been confirmed as possible causes of AG, including amyloidosis, Sjögren syndrome, sarcoidosis, infections (candidiasis, syphilis), bullous dermatoses (pemphigus, bullous pemphigoid), alcohol abuse, exposure to chemical irritants and numerous drugs [1] [2] [3] [5]. Celiac disease, however, a gluten-sensitive enteropathy, is one of the more important causes of AG, in which case chronic diarrhea, vomiting, weight loss, and growth impairment accompany the changes seen on the tongue [2]. Conversely, anemia is a frequent finding in AG due to iron (sideropenic) or vitamin B12 deficiencies (pernicious anemia). Thus symptoms of weakness and fatigue may be present as well [1] [4].

• Sputum

  0.0 % 60 : 100 % Top co-used drugs for these people *: Vitamin B6: 1 person, 100.00% Symbicort: 1 person, 100.00% Erivedge: 1 person, 100.00% Amlodipine: 1 person, 100.00% Acetaminophen: 1 person, 100.00% Top other side effects for these people *: Sputum [ehealthme.com]

• Pleural Disorder

  It is often used in muscle spasms. ( latest outcomes from Baclofen 63,904 users ) Atrophic glossitis Atrophic glossitis (smooth tongue) has been reported by people with basal cell carcinoma, osteoporosis, pleural disorder, vitamin b12 deficiency, asthma [ehealthme.com]

• Lesion of the Tongue

  These patches (lesions) give the tongue a map-like or geographic appearance. The lesions often heal in one area and then migrate to a different part of the tongue. This tongue ailment often arises due to a yeast infection. [naijafoodtherapy.com]

  Glossitis Symptoms Symptoms and signs of glossitis can include: Mouth pain or burning that affects entire mouth Oral lesions Mouth ulcer Tongue pain or tingling sensation Redness of the tongue Swelling of the tongue Hairy tongue – caused by taste buds [healthool.com]

  Further histological findings and the parallel improvement of psoriatic skin lesion and tongue lesion with systemic retinoid treatment supports this hypothesis. [ispub.com]

  "Skin Lesions: Strawberry Tongue". Primary Care Dermatology Module (University of Wisconsin Madison). Retrieved 2007-08-14. Dombi C, Czeglédy A (November 1992). [en.wikipedia.org]

  "Skin Lesions: Strawberry Tongue". Primary Care Dermatology Module (University of Wisconsin Madison). Retrieved 2007-08-14. 1 2 3 Treister NS, Bruch JM (2010). Clinical oral medicine and pathology. New York: Humana Press. p. 149. [ipfs.io]

• Sore Mouth

  Sore tongue and sore mouth: systemic diseases that may cause sore tongue and sore mouth. In: MacBryde CM, Blacklow RS, eds. Signs and symptoms, applied pathologic physiology and clinical interpretation, 5th ed. Philadelphia: J. B. [link.springer.com]

• Heloma

  Heloma Durum, Heloma Molle, Intractable Plantar Keratosis, Tyloma,) Gingival Hypertrophy (29 %) VitaminB2 Deficiency (29 %) ( Ariboflavinosis, Riboflavin Deficiency,) Pustular Psoriasis Of Von Zumbusch (29 %) ( Generalized Pustular Psoriasis,) Waldenstr [gulfdoctor.net]

• Shagreen Patch

  Patch,) Twisted Hairs (29 %) ( Pili Torti,) Central Papillary Atrophy (29 %) ( Median Rhomboid Glossitis,) Angiokeratoma (29 %) Lichen Sclerosus (29 %) ( Lichen Sclerosus Et Atrophicus,) Pseudoxanthoma Elasticum (29 %) ( Gr nblad strandberg Syndrome, [gulfdoctor.net]

• Denial

  Disturbance in the way in which one's body weight or shape is experienced, undue influence of body weight or shape on self-evaluation, or denial of the seriousness of the current low body weight. ‏ [books.google.com]

The diagnosis of atrophic glossitis mandates a thorough clinical and laboratory workup in order to identify the underlying cause, as the list of diseases that can induce atrophic changes is quite long [1]. The distinct red-to-pink and smooth appearance of the tongue and the presence of erythematous and sharply defined ulcer-like lesions should be easily recognized during the physical examination, suggesting that the role of a proper exam is perhaps crucial in making the initial diagnosis. In addition, a comprehensive history taking is equally important, as it may identify additional complaints, assess if preexisting disorders might cause tongue-related symptoms, determine whether proper dietary intake of nutrients is normal (as malnutrition is a common etiology, especially among the elderly), and exclude alcohol abuse [6]. Once the clinical diagnosis of AG is made, the physician should order a full laboratory workup comprising of a complete blood count (CBC) that often reveals anemia, serum levels of iron, ferritin and total iron binding capacity (TIBC), folic acid, several B group vitamins, gastric parietal cell antibodies, and also homocysteine levels, which could also contribute to atrophy of the tongue [3] [7]. If there is a suspicion of celiac disease then, IgA-endomysial, tissue transglutaminase, and antigliadin antibodies should be tested [3].

1. Reamy BV, Derby R, Bunt CW. Common tongue conditions in primary care. Am Fam Physician. 2010;81(5):627-634.
2. Erriu M, Canargiu F, Orrù G, Garau V, Montaldo C. Idiopathic atrophic glossitis as the only clinical sign for celiac disease diagnosis: a case report. J Med Case Rep. 2012;6:185.
3. Erriu M, Pili FMG, Cadoni S, Garau V. Diagnosis of Lingual Atrophic Conditions: Associations with Local and Systemic Factors. A Descriptive Review. Open Dent J. 2016;10:619-635.
4. Ristow Montes G, Duarte Vilella K, Veiga Bonotto D, Compagnoni Martins M, Soares de Lima AA. Atrophic glossitis as a clinical signs of severe anemia – Report of two cases. Polski Przegląd Otorynolaryngologiczny. 2014;3(4):201-204.
5. Gómez-Moyano E, Martínez-Pilar L, Pérez-Belmonte LM, Godoy-Díaz DJ. Erythema and atrophy on the tongue. Cleve Clin J Med. 2014;81(9):523-524.
6. Daley TD, Armstrong JE. Oral manifestations of gastrointestinal diseases. Can J Gastroenterol. 2007;21(4):241-244.
7. Sun A, Lin HP, Wang YP, Chiang CP. Significant association of deficiency of hemoglobin, iron and vitamin B12, high homocysteine level, and gastric parietal cell antibody positivity with atrophic glossitis. J Oral Pathol Med. 2012;41(6):500-504.