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Atrophic Retina

Retinal Atrophy


Presentation

  • In this volume, the seminars on surgical retina presented by renowned experts during ESASO’s activities are collected. Many specialists have contributed their knowledge to make this volume a device to give practical support.[books.google.com]
  • Macular edema is commonly present and posterior subcapsular cataracts requiring surgery are common.[disorders.eyes.arizona.edu]
  • The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.[orpha.net]
  • Table 2 Vision threatening events/diagnoses during follow up in the fellow eye The visual acuity data are presented in table 3.[bjo.bmj.com]
  • High myopia was present in 19 pts.[omicsonline.org]
Falling
  • (these RARELY occur in accidental trauma like falls or bumps to head) extraocular: bradycardia, hypothermia, lethargy, seizures, failure to thrive, spiral fractures of long bones, bulging fontanelles Type of photic damage in: 1. solar retinopathy 2. phototoxicity[brainscape.com]
Progressive Loss of Vision
  • People suffering from gyrate atrophy of the choroid (the thin coating of the eye) and retina face a progressive loss of vision, with total blindness usually occurring between the ages of 40 and 60. The disease is an inborn error of metabolism.[ncbi.nlm.nih.gov]
Alopecia
  • Fine, straight hairs have been observed with patches of alopecia. Slow wave background changes on EEG have been described in about one-third of patients and peripheral neuropathy is sometimes a feature. Hearing loss has been described as well.[disorders.eyes.arizona.edu]
Confusion
  • This is known as a vitreous detachment , which is quite common and should not be confused with a retinal detachment , which is much more rare and much more serious.[waterdownoptometric.ca]
  • It is characterized by a smooth, dome-shaped elevation of the inner layer of the schisis cavity in the peripheral fundus and may be confused with a RD.[reviewofophthalmology.com]
Peripheral Neuropathy
  • Slow wave background changes on EEG have been described in about one-third of patients and peripheral neuropathy is sometimes a feature. Hearing loss has been described as well.[disorders.eyes.arizona.edu]

Workup

Gliosis
  • Ophthalmologically and morphologically, his retina was severely atrophic and scarred by a dense fibrillary gliosis while photoreceptor cells had completely disappeared, cells of the bipolar layer had decreased in number and had become atrophic beyond[ncbi.nlm.nih.gov]

Treatment

  • After five weeks of treatment, there was improvement in the visual function of one eye which had been severely impaired without improvement for 3 years.[ncbi.nlm.nih.gov]
  • Death of retinal cells 18.3% of CATT Patients ( Comparison of Age-related macular degeneration Treatment Trials ) developed geographic atrophy.[healingtheeye.com]
  • Put the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques to work in your practice.[books.google.de]
  • The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.[orpha.net]
  • This in itself is not particularly dangerous or uncommon, and requires no treatment, except to see an eyecare practitioner to rule out more serious problems.[waterdownoptometric.ca]

Prognosis

  • Prognosis The ocular prognosis is poor because constriction of the visual field and visual loss are progressive and can cause blindness. Early diagnosis and successful diet treatment are important prognostic factors.[orpha.net]
  • Prognosis The prognosis for atrophic retinal holes is good. There is a low risk of retinal detachments in patient with round holes, and the incidence of atrophic holes in the general population is low as well. American Academy of Ophthalmology.[eyewiki.aao.org]
  • The prognosis of retinal detachment due to lattice degeneration. Ann Ophthalmol 1978 ; Sept : 1197 –200. Byer NE . Lattice degeneration of the retina. Surv Ophthalmol 1979 ; 23 : 213 . Byer NE .[bjo.bmj.com]
  • It is considered an Ophthalmological Emergency as there is a poor prognosis if untreated. SYMPTOMS The portion of the retina that is detached will not work properly and a curtain, blurring or blind spot in the vision appears.[oftalmedic.es]

Etiology

  • Etiology GACR is caused by homozygous or compound heterozygous mutations in the ornithine aminotransferase OAT gene (10q26) which codes for the ornithine-degrading, pyridoxal phosphate-dependent enzyme ornithine aminotransferase.[orpha.net]
  • These cases are usually associated with a worse prognosis compared to breaks of other etiologies. RRD is a common feature in several genetic syndromes.[institut-vision.org]
  • P athophysiology The etiology of lattice is questionable. It appears to be due to dropout of peripheral retinal capillaries with resulting ischemia, which induces thinning of all retinal layers.[eyecaretrust.org.uk]
  • According to the description from ClinicalTrials.gov, "While the etiology of GA is not completely understood, inflammatory processes involving the activation of resident immune cells of the retina called microglia is likely to contribute.[webrn-maculardegeneration.com]
  • Furthermore, consideration must be given to the risk of recurrence or involvement of the fellow eye based on the etiology (as described above).[asams.org]

Epidemiology

  • Summary Epidemiology Prevalence has been estimated to be 1/50,000 in Finland. More than 200 biochemically-confirmed cases have been reported in the international literature.[orpha.net]
  • Jpn J Clin Ophthalmol 35:1347–1352 Google Scholar Ohba N, Murakami F (1982) An epidemiological study of lattice degeneration of the retina.[link.springer.com]
  • Generally, myopia is the result of elongated axial length in the region of 25.5 or 26.5mm. (1,2) Degenerative myopia is also known as other terminology including: High Myopia Degenerative Myopia Pernicious Myopia Malignant Myopia EPIDEMIOLOGY The epidemiology[optometrystudents.com]
  • EPIDEMIOLOGY AND PATHOGENESIS The pioneering works of ophthalmic giants such as deWecker, Leber, and Gonin pointed out the significance of retinal breaks in the pathophysiology of rhegmatogenous retinal detachment.[medtextfree.wordpress.com]
Sex distribution
Age distribution

Pathophysiology

  • Comprehensively updated to reflect everything you need to know regarding retinal diagnosis, treatment, development, structure, function, and pathophysiology, this monumental ophthalmology reference work equips you with expert answers to virtually any[books.google.de]
  • Pathophysiology Retinal holes are the result of chronic atrophy of the sensory retina. These lesions often take a round or oval shape.[eyewiki.aao.org]
  • Pathophysiology: Ornithine is a non-essential amino acid that plays an important role in the metabolism of urea, creatinine and polyamines, and in the exchange of molecules between the urea and Kreb's cycles.[path.upmc.edu]
  • EPIDEMIOLOGY AND PATHOGENESIS The pioneering works of ophthalmic giants such as deWecker, Leber, and Gonin pointed out the significance of retinal breaks in the pathophysiology of rhegmatogenous retinal detachment.[medtextfree.wordpress.com]

Prevention

  • The topics range from prevention to state-of-the-art diagnostic techniques and the latest surgical treatment options for many eye conditions such as diabetic retinopathy and rhegmatogenous retinal detachment.This publication provides the ophthalmologist[books.google.com]
  • الصفحة 593 - Branch Vein Occlusion Study Group: Argon laser scatter photocoagulation for prevention of neovascularization and vitreous hemorrhage in branch vein occlusion: A randomized clinical trial. ‏[books.google.com]
  • Unfortunately, there is very little that one can do on a preventive basis to avoid atrophic retinal holes or lattice degeneration, but regular eye examinations and immediate evaluation of any unusual visual symptoms are the best way to avoid further damage[waterdownoptometric.ca]
  • Chapter 106 Prevention of Retinal Detachment Rhegmatogenous retinal detachment continues to be an important cause of reduced visual acuity and blindness.[clinicalgate.com]

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