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Atrophic Vaginitis


Presentation

The following are the various signs and symptoms of atrophic vaginitis:

Recurrent Infection
  • The vaginal epithelium may become inflamed, contributing to urinary symptoms such as frequency, urgency, dysuria, incontinence, and/or recurrent infections.[ncbi.nlm.nih.gov]
  • Candidiasis: a fungal culture may be ordered to help guide treatment with persistent or recurrent infections and can be used to identify which yeast is present.[labtestsonline.org]
Pathologist
  • Cytotechnologists are more likely than pathologists are to label it negative for intraepithelial lesion or malignancy (NILM) and are equally likely to mistake it for a high-grade lesion.[ncbi.nlm.nih.gov]
Increased Susceptibility to Infections
  • susceptibility to infections decreased vaginal lubrication urinary tract infections painful urination difficulty sitting difficulty wiping Since women can have signs and symptoms that could be attributed to other causes, diagnosis is based upon the symptoms[en.wikipedia.org]
Difficulty Walking
  • These problems include: Infections Nerve damage from diabetes or stroke Heart problems Medicines Feeling depressed Difficulty walking or moving A very common kind of bladder control problem for older women is urge incontinence.[neilbaum.wordpress.com]
Neglect
  • Tampons, condoms, neglected diaphragms, and irritating douches or deodorant sprays can upset the vagina's environmental balance and produce abnormal vaginal discharge. Hyperglycemia and antibiotics can also disturb this balance.[medical-dictionary.thefreedictionary.com]
Vaginal Dryness
  • Approximately 50% of women in the menopausal state to develop vaginal dryness. However, breast feeding mothers also complain of vaginal dryness. Simple treatment regimes help in effective management of the condition.[symptoma.com]
  • RESULTS: The Vaginal Maturation Index, vaginal pH, and vaginal dryness rating improved significantly at 3 and 6 months compared with baseline.[ncbi.nlm.nih.gov]
  • Vaginal dryness can also be linked to Sjögrens syndrome, or vaginal disorders such as lichens sclerosis or vulvodynia.[project-aware.org]
  • Vaginal moisturizers and lubricants also provide symptomatic relief for vaginal dryness and dyspareunia, respectively. 2010 Wiley Periodicals, Inc.[ncbi.nlm.nih.gov]
Vaginal Discharge
  • Symptoms of Vaginitis Profuse vaginal discharge.[wgurology.com]
  • Women with atrophic vaginitis may also experience vaginal itching, burning, frequent urination, or vaginal discharge.[health.harvard.edu]
  • Those symptoms may include: vaginal dryness, painful intercourse, vaginal itching, and abnormal vaginal discharge. Also, women may experience urinary symptoms such as painful urination, urinary urgency or frequency of urination.[mmgyn.com]
Vaginal Bleeding
  • Vaginal bleeding H. Haemorrhage requiring return to theatre To filter your results, tick the boxes above and hit the search button. If you want to clear the results untick your choices and hit the search button again.[rcog.org.uk]
  • Women receiving hormonal treatment should all be advised to contact their doctor if they experience any vaginal bleeding.[patient.info]
  • When To Call A Professional Schedule an appointment with your doctor if you experience any vaginal bleeding, vaginal dryness, burning or itching, or if painful sexual intercourse is not relieved with a water-soluble lubricant.[drugs.com]
  • Vaginal estrogen may have the following rare side effects: vulvar itching or irritation, vaginal discharge, and vaginal bleeding; however, a switch to a different dosage or preparation may reduce or eliminate these problems.[mmgyn.com]
Dysuria
  • The vaginal epithelium may become inflamed, contributing to urinary symptoms such as frequency, urgency, dysuria, incontinence, and/or recurrent infections.[ncbi.nlm.nih.gov]
  • Declining estrogen also affects the urinary tract, leading to thinning of the bladder and urethral linings and potentially resulting in chronic dysuria and an increased incidence of urinary tract infections.[medscape.com]
  • RESULTS: Fractional CO2 laser treatment was effective to improve VVA symptoms (vaginal dryness, vaginal burning, vaginal itching, dyspareunia, dysuria; p 0.001) at 12-week follow-up, as well as the VHIS (13.1 2.5 at baseline vs. 23.1 1.9; p 0.001).[ncbi.nlm.nih.gov]
  • […] vulval dryness Vaginal or vulval itching ( pruritus vulvae ) Vaginal burning Painful sex ( dyspareunia ) Skin splitting (fissuring) of the entrance to the vagina ( posterior fourchette) Vaginal spotting (bleeding) Deficiency of oestrogen may also lead to dysuria[dermnetnz.org]
Sexual Dysfunction
  • Levine et al. 8 reported that postmenopausal sexually active women with sexual dysfunction were nearly four times more likely to have vulvovaginal symptoms than those without sexual dysfunction.[doi.org]
  • [ 1 ] Hayes, R. and Dennerstein, L. (2005) The Impact of Aging on Sexual Function and Sexual Dysfunction in Women: A Review of Population-Based Studies.[dx.doi.org]
  • Estrogen deficiency also interferes with many physiologic responses associated with sexual arousal, including smooth muscle relaxation, vasocongestion, and vaginal lubrication. 5 One epidemiologic study found that women experiencing sexual dysfunction[clinicaladvisor.com]

Workup

Diagnosis of the condition starts with a medical history of the patient. Medical history would include information regarding medications, past surgical procedures and diseases if any. In addition, the following methods would be employed for diagnosing atrophic vaginitis:

  • Pelvic examination to check for the signs of vaginal dryness [6]. A visual examination of the vagina is also necessary. An examination for vaginal prolapsed would also be required.
  • Urinary examination to detect signs of infection.
  • Acid balance test is done to examine the vagina for the acid balance. The vaginal fluids are taken for the test or an indicative strip is placed in the vagina for examination. Atrophic vaginitis secretion will present with acidic pH in the tests [7]. 
  • Pelvic ultrasound can demonstrate the diminished endometrial thickness with atrophic vaginitis [8].
Estrogen Increased
  • A lack of estrogen increases the pH value, rendering the body susceptible to vaginal/urinary infections. It also thins the vaginal walls, making it inelastic and dry.[dovemed.com]
Progesterone Increased
  • Serum preinsertion progesterone increased but returned to baseline preinsertion levels at month 6, and preinsertion levels were significantly less at month 6 compared with month 3.[ncbi.nlm.nih.gov]

Treatment

Lubricants and drugs often form the first line of treatment for atrophic vaginitis. The following are various topical agents and lubricants suggested for treating vaginal dryness:

  • Water based lubricants and vaginal moisturizers with vitamin E are advised to improve lubrication [9]. If these work then, topical agents would not be necessary. However these only help improve the dryness, but are not very effective in treating the burning and irritation caused due to the condition. Topical creams may also be applied to relieve pruritus [10].
  • Vaginal estrogen is very effective as it provides controlled release of estrogen to the vagina. Vaginal estrogen is available in various forms such as estrogen creams, estrogen rings and estrogen tablets. Estrogen rings are basically soft flexible rings containing the hormone inserted into the upper part of the vagina. Many women benefit from this method. In the beginning, any one of these therapies is advised on regular basis, and after the first few weeks, weekly application is necessary.

Prognosis

The prognosis of the condition is favorable if women seek treatment. With hormone replacement therapy and lubricating agents women often experience less discomfort.

Complications

Atrophic vaginitis if not treated on time can cause the following complications:

  • Urinary problems such as increased frequency of urination or burning sensation while urinating can be experienced. This is so because atrophic vaginitis contributes significantly to genitourinary atrophy giving rise to several urinary problems. In addition, women may also complain of incontinence or urinary tract infections.
  • Vaginal infections are the second most common complication of atrophic vaginitis. Decreased production of estrogen disrupts the acid base balance making the vagina susceptible to infections.

Etiology

Decrease in the production of estrogen levels causes development of atrophic vaginitis. The following are the various factors that are known to decrease the production of the hormone estrogen:

  • After menopause
  • Perimenopause
  • During breast feeding
  • Cancer treatments such as radiation therapy and chemotherapy
  • Removal of ovaries
  • Hormonal treatment for breast cancer
  • Chronic tricyclic antidepressant use [3]

The condition of atrophic vaginitis is a common one; however not all women in the menopausal stage develop this condition.

Epidemiology

It has been estimated that about 20 to 50% of postmenopausal women suffer from atrophic vaginitis. Of these, only 25% seek medical help. The condition is far more common than what has been reported. Women often feel embarrassed and do not report symptoms to their doctor.

Sex distribution
Age distribution

Pathophysiology

The vaginal epithelium is subject to change during various phases of life. At birth the vagina is rich in glycogen due to estrogen supply from the mother. During childhood phase, the epithelium is thin which then thickens during puberty due to increased production of estrogen.

A sufficient supply of this hormone keeps the vagina lubricated and also maintains the pH levels 3.5 – 4.5. Such level helps protect the vagina against bacterial infections. When the pH goes beyond this level, the vagina gets susceptible to urinary tract infections. During early years of menopause and post menopause, the ovaries secrete less of estrogen that causes the vagina to get dry and inflamed.

Prevention

It is advised that women begin applying lubricants and vaginal estrogens to help prevent the condition from turning severe. In addition, sexual activity has also been known to improve the vaginal elasticity and lubrication. Topical treatments in the form of tablets and creams should also be practiced as this increases the vaginal epithelium proliferation.

Summary

Atrophic vaginitis is a common condition affecting majority of the women after menopause. It is a condition characterized by inflammation of the vagina accompanied by dryness and therefore the condition is also known as vaginal dryness. Such a condition arises due to low levels of estrogen, the production of which is significantly reduced once woman reach menopause [1].

Approximately 50% of women in the menopausal state to develop vaginal dryness [2]. However, breast feeding mothers also complain of vaginal dryness. Simple treatment regimes help in effective management of the condition.

Patient Information

Definition

Atrophic vaginitis is a condition characterized by inflammation of the vagina accompanied by dryness and itching. Decrease in estrogen levels gives rise to such a situation. Such condition is more common in women who are in the menopausal stage. Also, women who have undergone surgery to remove the ovaries also develop atrophic vaginitis

Cause

Decrease in the production of estrogen is the major cause that leads to development of atrophic vaginitis. The several factors causing lowered production of estrogen include menopause, cancer treatments, surgical removal of ovaries and lactation.

Symptoms

Symptoms of atrophic vaginitis include vaginal dryness, burning sensation, frequent urination, incontinence, and pain during intercourse, vaginal discharge, bleeding during intercourse, decreased lubrication, urinary tract infections and shortening of the vaginal canal.

Diagnosis

A thorough physical examination to study the vagina for signs of inflammation and dryness is carried out. In addition, pelvic examination is done to check for pelvic prolapse. The vagina is also tested to check for its acid base balance. Various laboratory tests are also required for analyzing the levels of serum hormone levels. A decrease in the levels of estrogen confirms atrophic vaginitis.

Treatment

Treatment of atrophic vaginitis includes application of moisturizing vaginal creams and lubricants to improve the dryness and lubrication. However, estrogen creams would also be required to relieve other symptoms of itching, burning sensation and irritation. These include insertion of estrogen tablets or application of estrogen creams to facilitate a controlled release of estrogen to the organ.

References

Article

  1. Bachmann GA, Nevadunsky NS. Diagnosis and treatment of atrophic vaginitis. Am Fam Physician. 2000; 61:3090-3096.
  2. Stenberg A, Heimer G, Ulmsten U, et al. Prevalence of genitourinary and other climacteric symptoms in 61 year old women. Mauritas. 1996; 24:31-36.
  3. Nactigall L. Vaginal estrogen in the controversial patient. Menopause Management. 2006; March/April: 19-22.
  4. Simuniæ V, Banoviæ I, Ciglar S, Jeren L, Paviciæ Baldani D, Sprem M. Local estrogen treatment in patients with urogenital symptoms. Int J Gynaecol Obstet. 2003; 82:187-197.
  5. Goldstein I, Alexander JL. Practical aspects in the management of vaginal atrophy and sexual dysfunction in perimenopausal and postmenopausal women. J Sex Med. 2005; 2:154-165.
  6. Bachmann GA, Ebert GA, Burd ID. Vulvovaginal complaints. In Lobo RA ed. Treatment of the Postmenopausal Woman: Basic and Clinical Aspects. 2nd ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 1999:195-201.
  7. Semmens JP, Tsai CC, Semmens EC, et al. Effects of estrogen therapy on vaginal physiology during menopause. Obstet Gynecol. 1985; 66:15-18.
  8. Weisberg E, Ayton R, Darling G, et al. Endometrial and vaginal effects of low dose estradiol delivered by vaginal ring or vaginal tablet. Climacteric. 2005; 8:83-92.
  9. North American Menopause Society. The role of local vaginal estrogen for treatment of vaginal atrophy in postmenopausal women: 2007 position statement of the North American Menopause Society. Menopause. 2007; 14:355-369
  10. Sobel JD, Chaim W, Nagappan V, Leaman D. Treatment of vaginitis caused by Candida glabrata: use of topical boric acid and flucytosine. Am J Obstet Gynecol. Nov 2003; 189(5):1297-300.

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Last updated: 2018-06-22 05:03