The distinction was historically considered important, as it differentiated those more likely to present with "typical" respiratory symptoms and lobar pneumonia from those more likely to present with "atypical" generalized symptoms (such as fever, headache [en.wikipedia.org]

PURPOSE OF REVIEW: We present the key advances in the infections that clinicians conventionally associate with atypical pneumonia: legionellosis, Mycoplasma pneumonia, Chlamydophila species pneumonia and Q fever. [ncbi.nlm.nih.gov]

If the process extends to the pleural space, associated empyema may be present. [emedicine.medscape.com]

• Fever

  Clinical findings Incubation ± 3 weeks; insidious onset of fever, malaise, headache, myalgia, low-grade fever, cough, chest pain and respiratory disease, from asymptomatic to rhinitis, pharyngitis, tracheobronchitis and pneumonia. [medical-dictionary.thefreedictionary.com]

  Coxiella burnetii Causes Q fever. Francisella tularensis Causes tularemia. Legionella pneumophila Causes a severe form of pneumonia with a relatively high mortality rate, known as legionellosis or Legionnaires' disease. [en.wikipedia.org]

  During the later stages of the illness, symptoms may worsen, the fever may become higher, and coughing may yield discolored phlegm (sputum). [my.clevelandclinic.org]

  Coxiella burnetii infection ( Q fever pneumonia ) is associated with exposure to livestock 4. The presentation of atypical pneumonia is often similar to the presentation of more typical bacterial pneumonia. [radiopaedia.org]

• Malaise

  All are marked by extensive but short-lived pulmonary infiltration, fever, malaise, muscle pains, sore throat, and coughing. Copyright 2007. An Elsevier publication. All rights reserved. [web.archive.org]

  Atypical bacterial pneumonia generally is characterised by a symptom complex that includes headache, low-grade fever, cough, and malaise. Constitutional symptoms often predominate over respiratory findings. [bestpractice.bmj.com]

  None had received the seasonal influenza vaccine; they had cough (92%), fever (86.8%), and malaise (73.7%). The median time from disease onset to hospital admission was 6 days (range 0-8 days). [ncbi.nlm.nih.gov]

  Clinical findings Incubation ± 3 weeks; insidious onset of fever, malaise, headache, myalgia, low-grade fever, cough, chest pain and respiratory disease, from asymptomatic to rhinitis, pharyngitis, tracheobronchitis and pneumonia. [medical-dictionary.thefreedictionary.com]

• Cough

  It develops gradually with a dry cough and low-grade fever as opposed to sudden fever and coughing up mucus in bacterial pneumonia [1]. [ehealthstar.com]

  During the later stages of the illness, symptoms may worsen, the fever may become higher, and coughing may yield discolored phlegm (sputum). [my.clevelandclinic.org]

  […] pri·mar·y a·typ·i·cal pneu·mo·ni·a an older term referring to an acute systemic disease with involvement of the lungs, usually caused by Mycoplasma pneumoniae and marked by fever, cough, relatively few physical signs, and scattered densities on x-rays [medical-dictionary.thefreedictionary.com]

  DO NOT take cough medicines without first talking to your provider. Cough medicines may make it harder for your body to cough up the extra sputum. Drink plenty of fluids to help loosen secretions and bring up phlegm. Get a lot of rest. [medlineplus.gov]

• Pertussis

  This review will discuss the epidemiology, clinical manifestations, and laboratory diagnosis of Mycoplasma pneumoniae, Chlamydia sp., Legionella sp., Bordetella pertussis, and Coxiella bumetii, the most common agents associated with atypical pneumonia [ncbi.nlm.nih.gov]

  The Mycoplasma pneumoniae PCR assay was tested for cross reactivity against Bordetella pertussis, Bordetella parapertussis, Bordetella bronchiseptica, all relevant species of Chlamydophila, all relevant species of Legionella as well as human herpes viruses [viracor-eurofins.com]

  There may also be dyspnea and, in some cases, the cough may take on a pertussis-like character. Some children may develop inflammation of the throat, cervical adenopathy, conjunctivitis, and myringitis. [phac-aspc.gc.ca]

  An epidemic of a pertussis-like illness caused by Chlamydia pneumoniae. Pediatr Infect Dis J 1999; 18: 271-275. 21. Thom DH, Grayston JT, Wang SP, Kuo CC, Altamn J. [indianpediatrics.net]

• Rales

  As pneumonia progresses, rales appear in the chest, C. penumoniae is known to be associated with hyper-reactive airway. Infec-tion with C. pneumoniae can trigger acute epidosde of wheezing in children with asthma. [indianpediatrics.net]

  Harsh breath sounds from the larger airways that are transmitted through the inflamed lung are termed bronchial breathing and are heard on auscultation with a stethoscope.[20] Crackles (rales) may be heard over the affected area during inspiration.[20 [en.wikipedia.org]

• Chest Pain

  Herein we report a 44-year-old male patient displaying atypical pneumonia symptoms of intermittent fever, dry cough, chest pain, dyspnea, headache, hepatitis, and hyponatremia. He had two sick cockatiels, one of which had died a month previously. [ncbi.nlm.nih.gov]

  Symptoms include cough, shortness of breath, fevers, chills, chest pain, headache, sweating, and weakness. Definition (CSP) inflammation of the lungs with consolidation and exudation. [fpnotebook.com]

  Clinical findings Incubation ± 3 weeks; insidious onset of fever, malaise, headache, myalgia, low-grade fever, cough, chest pain and respiratory disease, from asymptomatic to rhinitis, pharyngitis, tracheobronchitis and pneumonia. [medical-dictionary.thefreedictionary.com]

• Headache

  Despite general symptoms and problems with the upper respiratory tract (such as high fever, headache, a dry irritating cough followed later by a productive cough with radiographs showing consolidation), there are in general few physical signs. [en.wikipedia.org]

  Herein we report a 44-year-old male patient displaying atypical pneumonia symptoms of intermittent fever, dry cough, chest pain, dyspnea, headache, hepatitis, and hyponatremia. He had two sick cockatiels, one of which had died a month previously. [ncbi.nlm.nih.gov]

  Atypical bacterial pneumonia generally is characterised by a symptom complex that includes headache, low-grade fever, cough, and malaise. Constitutional symptoms often predominate over respiratory findings. [bestpractice.bmj.com]

  The key symptoms of atypical pneumonia are fever, headache, sweating and myalgia along with bronchopneumonia. Atypical pneumonia is treated with macrolide class of antibiotics like clarithromycin or erythromycin. [differencebetween.net]

Challenges in Community-Acquired Pneumonia American Family Physician Atypical pneumonia General Practice Notebook Bono MJ, Mycoplasmal pneumonia Emedicine Bono MJ, Mycoplasmal pneumonia, clinical presentation Emedicine Bono MJ, Mycoplasmal pneumonia, workup [ehealthstar.com]

• Atelectasis

  Subsegmental and sometimes segmental atelectasis from small airway obstruction may occur. The radiographic features are often more extensive than what is suggested clinically. [radiopaedia.org]

  Other findings that suggest the presence of pneumonia include air bronchograms; the silhouette sign; parapneumonic effusions; and complications of pneumonia, such as lung abscesses, and atelectasis. [emedicine.medscape.com]

  Children treated as outpatients should have a follow-up examination within 24 to 72 hours. 31 View/Print Table TABLE 3 Conditions that May Mimic Community-Acquired Pneumonia Acute respiratory distress syndrome Atelectasis Bronchiolitis obliterans with [aafp.org]

In the azithromycin treatment group, Mycoplasma pneumoniae was identified in 65, Chlamydia spp. in 9 and Coxiella burnetti in 1 patient. [ncbi.nlm.nih.gov]

Treatment failure: as defined in study, with and without treatment modifications. 21. Mechanical ventilation. 22. Adverse events: life‐threatening events, events necessitating specific medical treatment, events requiring cessation of treatment. [doi.org]

CONCLUSION: This analysis of pneumonia in the Al-Qassim area indicates the pattern and prognosis of acute bacterial and atypical pneumonia that requires admission to hospital in the central region of Saudi Arabia. [ncbi.nlm.nih.gov]

Prognosis for the AD adult subtype is good with a reasonable life expectancy. [radiopaedia.org]

Prognosis. Chlamydia pneumoniae infection is usually mild, but may last for several weeks or months; in older individuals, it may be life-threatening; mortality among individuals treated with antibiotics is ~5% [9,11]. [ehealthstar.com]

M. pneumoniae was an important microorganism in the etiology of atypical pneumonia of childhood in our community. [ncbi.nlm.nih.gov]

Noninfectious etiologies must be considered in atypical and nonresolving pneumonias. [emedicine.medscape.com]

SUMMARY: There are few advances in our knowledge of the epidemiology of atypical pathogens or the effectiveness of antimicrobial therapy--empirical or pathogen specific. [ncbi.nlm.nih.gov]

There are few advances in our knowledge of the epidemiology of atypical pathogens or the effectiveness of antimicrobial therapy - empirical or pathogen specific. [journals.lww.com]

Amongst pathophysiological causes, tachypnea can be a symptom of sepsis, compensation for diabetic ketoacidosis or other metabolic acidosis, pneumonia, pleural effusion, carbon monoxide poisoning, pulmonary embolism, asthma, COPD, laryngospasm, allergic [en.wikipedia.org]

References Cheng AC, BartJC (2005) Melioidosis: Epidemiology, Pathophysiology, andManagement, Clinical Microbiology Review 12: 383-416. [omicsonline.org]

Pathophysiology The organism responsible for mycoplasmal pneumonia, M pneumoniae, is a pleomorphic organism that, unlike bacteria, lacks a cell wall, and unlike viruses, does not need a host cell for replication. [emedicine.com]

Centers of Disease Control and Prevention [ehealthstar.com]

In order to prevent loss of time with beta-lactamase antibiotics, which are usually started in severe pneumonia, serologic tests and PCR must be done during the initial evaluation of the patient for the reliable diagnosis of M. pneumoniae, which will [ncbi.nlm.nih.gov]

Preventing pneumonia is always better than treating it. Vaccines are available to prevent pneumococcal pneumonia and the flu. Other preventive measures include washing your hands frequently and not smoking. [fpnotebook.com]