Severe autoimmune enteropathy manifests with intractable secretory diarrhea leading to malabsorption, electrolyte disturbance and failure to thrive. Vomiting, ileus, gastritis or colitis can also be observed. [orpha.net]

Failure to thrive led to initiation of total parenteral nutrition and transfer to our institution. Figure 1. [acgcasereports.gi.org]

Ten of fourteen (71%) patients were diagnosed with failure to thrive and required parenteral nutritional support. The time interval from presentation to diagnosis varied from 1 month to 1.2 years (median, 4.2 months; mean 6.3 months). [nature.com]

Recurrent diarrhea, morning nausea, and intermittent abdominal pain occurred from age 9, and he became Cushingoid because of frequent stress doses of hydrocortisone. [pediatrics.aappublications.org]

Our results suggest that the detection of the autoantibody against the 75-kD antigen has a diagnostic value in AIE and that the autoimmune reaction against the 75-kD antigen may be implicated in the development of intestinal and renal tissue damage in [ncbi.nlm.nih.gov]

The pathophysiology of AIE likely involves a hyperactive immune state in the setting of a T-cell regulatory defect, resulting in destruction of the enterocyte. [ncbi.nlm.nih.gov]

The pathophysiology of AIE is not completely understood, but the available evidence suggests a hyperactive immune state caused by a defect in regulatory T-cell homeostasis.3 AIE must be distinguished from refractory sprue, which is a form of celiac disease [kundoc.com]

A 13-year-old celiac girl was admitted because of vomiting, weight loss, diarrhea, hypoproteinemia, and neurological disturbances such as head tremors, vertical nystagmus, and lower limb hyperesthesia. [ncbi.nlm.nih.gov]

A 13-year-old celiac girl was admitted because of vomiting, weight loss, diarrhea, hypoproteinemia, and neurological disturbances such as head tremors, vertical nystagmus, and lower limb hyperesthesia. [ncbi.nlm.nih.gov]

Lymphocyte subsets and immunoglobulin concentrations were normal, but in vitro testing showed no activation in response to phytohaemagglutinin, Candida, or purified protein derivative, although the response to interleukin (IL)-2 was intact. [ncbi.nlm.nih.gov]