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Autoimmune Pangastritis


Presentation

  • Microabscesses may be present in the gastric glands. There may also be areas of overt ulceration. These patients are not hypergastrinemic and do not develop neuroen-docrine cell lesions.[humpath.com]
  • The 8 patients presented ranged from 1 to 75 years and showed a slight female predominance (5F:3M).[journals.lww.com]
  • Results The presenting features of the 160 patients studied are described in Table 1. Table 1.[bloodjournal.org]
  • [ncbi.nlm.nih.gov] We present a 47-year-old woman from southeast Asia with dyspepsia and mild anemia. [symptoma.com] We present a 47-year-old woman from southeast Asia with dyspepsia and mild anemia.[symptoma.com]
Anemia
  • All patients have systemic autoimmune diseases that include autoimmune enterocolitis, systemic lupus erythematosus, refractory sprue, autoimmune hemolytic anemia, and disabling fibromyalgia.[humpath.com]
  • All had systemic autoimmune and/or connective tissue diseases including autoimmune enterocolitis (4 cases), systemic lupus erythematosus, refractory sprue, autoimmune hemolytic anemia, and disabling fibromyalgia.[journals.lww.com]
Weakness
  • […] gets worse or moves to the lower right belly (appendix area) Chest pain that appears or gets worse, or spreads to the back, neck, shoulder, or arm Frequent vomiting (can’t keep down liquids) Blood in the stool or vomit (red or black in color) Feeling weak[fairview.org]
  • ) Backflow of bile into the stomach (bile reflux) Cocaine abuse Eating or drinking caustic or corrosive substances (such as poisons) Extreme stress Viral infection, such as cytomegalovirus and herpes simplex virus (more often occurs in people with a weak[nlm.nih.gov]
  • Weakness in your stomach lining allows digestive juices to damage and inflame it, causing gastritis. Having a thin or damaged stomach lining raises your risk for gastritis. A gastrointestinal bacterial infection can also cause gastritis.[healthline.com]
  • Signs and Symptoms of Autoimmune Gastritis: Abdominal pain Anemia, which is characterized by the following symptoms: Weakness Trouble concentrating Shortness of breath Leg cramps Headache Heart palpitations Insomnia Paleness In severe cases, severe B12[beyondtype1.org]
  • Early clinical presentation is often insidious; consequently, the diagnosis may be missed clinically, endoscopically, and pathologically The symptoms may be nonspecific, such as dyspepsia (abdominal discomfort) or anemia (weakness, decreased mental concentration[dovemed.com]
Weight Loss
  • Center Bascom Palmer Eye Institute Font Size Group 30 Group 30 Contrast logo Menu Search University of Miami Health System Close Search Find a Doctor Treatments Page 1 Featured Treatments For Allergy and Immunology Arthritis (Rheumatology) Bariatrics (Weight[uhealthsystem.com]
  • loss Fever of 100.4ºF (38ºC) or higher, or as directed by your healthcare provider 2000-2018 The StayWell Company, LLC. 800 Township Line Road, Yardley, PA 19067.[fairview.org]
  • Other symptoms can include: nausea and vomiting bloating and gas weight loss and/or loss of appetite Chronic Gastritis Symptoms In the vast majority of cases, chronic gastritis causes no symptoms.[ddc.musc.edu]
  • Gastritis and an ulcer are conditions that affect the stomach and small intestine, and they share many symptoms, such as abdominal pain, nausea, vomiting, loss of appetite and weight loss. There are many differences, though.[tmphysiciannetwork.org]
  • Autoimmune atrophic gastritis is characterized by megaloblastic anemia, anorexia with weight loss, neurologic changes such as numbness and paresthesias.[patientslikeme.com]
Disability
  • All patients have systemic autoimmune diseases that include autoimmune enterocolitis, systemic lupus erythematosus, refractory sprue, autoimmune hemolytic anemia, and disabling fibromyalgia.[humpath.com]
  • All had systemic autoimmune and/or connective tissue diseases including autoimmune enterocolitis (4 cases), systemic lupus erythematosus, refractory sprue, autoimmune hemolytic anemia, and disabling fibromyalgia.[journals.lww.com]
  • "Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013".[en.wikipedia.org]
  • This can predispose patients to urinary tract infections Reproductive system Infertility Abnormalities in infants and children Developmental delay or regression, permanent disability The patient does not smile Feeding difficulties Hypotonia, lethargy,[wjgnet.com]
Pallor
  • [casesjournal.biomedcentral.com] Pallor [gastroenterologistpaloalto.com] Pallor His physical examination revealed splenomegaly and pallor. [casesjournal.biomedcentral.com] Pallor, sweating, and rapid (or "racing") heartbeat.[symptoma.com]
  • Pallor, sweating, and rapid (or "racing") heartbeat.[emedicinehealth.com]
  • […] insidious; consequently, the diagnosis may be missed clinically, endoscopically, and pathologically The symptoms may be nonspecific, such as dyspepsia (abdominal discomfort) or anemia (weakness, decreased mental concentration, headache, palpitations, pallor[dovemed.com]
  • In acute gastritis, the faeces may be blackened by blood lost from the stomach; in chronic gastritis, slow blood loss may lead to anaemia, resulting in symptoms such as pallor, tiredness and breathlessness.[enetmd.com]
Dyspnea
  • […] photosensitivity, "V-neck" sign, "shawl" sign, calcinosis, ulcers and vasculitis - skin biopsy: histopathological analysis with perivascular lymphocytic infiltrate), articular involvement (arthralgia and / or arthritis), high dysphagia, pulmonary involvement (dyspnea[medicalexpress.net.br]
Nausea
  • [tmphysiciannetwork.org] Nausea [ncbi.nlm.nih.gov] After completing 2 cycles of chemotherapy, the patient had epigastric pain, nausea, and vomiting. [ncbi.nlm.nih.gov] Common gastritis symptoms include stomach pain, nausea and vomiting.[symptoma.com]
  • These are the most common symptoms of gastritis: Nausea Vomiting Abdominal pain Black or bloody stools But having these symptoms doesn’t necessarily mean you have gastritis. Many other conditions have similar symptoms.[rush.edu]
  • Other symptoms can include: nausea and vomiting bloating and gas weight loss and/or loss of appetite Chronic Gastritis Symptoms In the vast majority of cases, chronic gastritis causes no symptoms.[ddc.musc.edu]
  • Gastritis and an ulcer are conditions that affect the stomach and small intestine, and they share many symptoms, such as abdominal pain, nausea, vomiting, loss of appetite and weight loss. There are many differences, though.[tmphysiciannetwork.org]
  • Marshmallow may help aid in fighting nausea and vomiting. These are just some of the natural treatments you can utilize to ease symptoms of gastritis.[belmarrahealth.com]
Dyspepsia
  • […] the hypothesis that dyspepsia associated to AG is quite different from functional dyspepsia.[journals.lww.com]
  • Gastritis (also called dyspepsia) is an inflammation (swelling and irritation) of the lining of the stomach. It can occur suddenly (acute) or gradually (chronic).[my.clevelandclinic.org]
  • However, gastritis can cause indigestion (dyspepsia). See the separate leaflet called Indigestion (Dyspepsia). Gastritis may start suddenly (acute) or may develop slowly and last for a long period of time (chronic).[patient.info]
  • Many cases are asymptomatic, but dyspepsia and GI bleeding sometimes occur. Diagnosis is by endoscopy. Treatment is directed at the cause but often includes acid suppression and, for Helicobacter pylori infection, antibiotics.[merckmanuals.com]
  • The causes of dyspepsia include peptic ulcer disease (30%), gastroesophageal reflux (29%), and nonulcer (functional) dyspepsia (40%).[nature.com]
Diarrhea
  • However, side effects can include diarrhea or constipation, depending on the type of antacid used.[news-medical.net]
  • Gastroenteritis symptoms may include diarrhea in addition to nausea or vomiting. While the prevalence of chronic gastritis has decreased in developing countries in recent years, acute gastritis is still common.[healthline.com]
  • The presence and the frequency of GI symptoms (heartburn, regurgitation, early satiety, nausea, vomiting, postprandial fullness, epigastric pain, abdominal pain, constipation, diarrhea, and bloating) were assessed at the time of the first visit through[journals.lww.com]
  • There is cramping stomach pain, accompanied by diarrhea and vomiting. The vomitus may be bloody. The victim may collapse.[medical-dictionary.thefreedictionary.com]
Gastric Pain
  • When symptoms do occur, they may include anorexia nervosa, gastric pain, nausea, and vomiting. Other forms of gastritis Less common forms of gastritis may result from a number of generalized diseases, or from complications of chronic gastritis.[encyclopedia.com]
  • When symptoms do occur, they may include anorexia nervosa, gastric pain, nausea and vomiting. Other forms of gastritis Less common forms of gastritis may result from a number of generalized diseases or from complications of chronic gastritis.[medical-dictionary.thefreedictionary.com]
Palpitations
  • Signs and Symptoms of Autoimmune Gastritis: Abdominal pain Anemia, which is characterized by the following symptoms: Weakness Trouble concentrating Shortness of breath Leg cramps Headache Heart palpitations Insomnia Paleness In severe cases, severe B12[beyondtype1.org]
  • […] presentation is often insidious; consequently, the diagnosis may be missed clinically, endoscopically, and pathologically The symptoms may be nonspecific, such as dyspepsia (abdominal discomfort) or anemia (weakness, decreased mental concentration, headache, palpitations[dovemed.com]
  • […] appetite unexpected weight loss stomach ulcers iron deficiency anemia (a low level of healthy red blood cells) Autoimmune AG may lead to a B-12 deficiency, which can cause symptoms of anemia, including: weakness lightheadedness dizziness chest pain heart palpitations[healthline.com]
Blurred Vision
  • Neurologic complications that may be attributed to Cbl deficiency including paresthesia (4), confusion (1), impaired memory (1), and blurred vision (1) were encountered in 9% of the macrocytic and normocytic but in none of the microcytic subjects.[bloodjournal.org]
Paresthesia
  • Autoimmune atrophic gastritis is characterized by megaloblastic anemia, anorexia with weight loss, neurologic changes such as numbness and paresthesias.[patientslikeme.com]
  • , which is characterized by the following symptoms: Weakness Trouble concentrating Shortness of breath Leg cramps Headache Heart palpitations Insomnia Paleness In severe cases, severe B12 deficiency, which is characterized by the following symptoms: Paresthesia[beyondtype1.org]
  • Iron-deficiency anemia due to low hydrochloric acid is more common in Autoimmune Gastritis, than pernicious anemia due to vitamin B12 deficiency In some patients, severe vitamin B12 deficiency may result in neurological symptoms, such as paresthesia ([dovemed.com]
  • […] gastric cancers References: [1] [3] Clinical features Intensity of symptoms may be inconsistent and vary widely Hematemesis ; ( coffee-ground appearance or bright red in color), possibly melena Epigastric pain is possible Nausea, vomiting Abdominal paresthesia[amboss.com]
  • […] spasticity (hyperreflexia) Positive Romberg sign Lhermitte’s sign Segmental cutaneous sensory level Autonomic nervous system Postural hypotension Incontinence Impotence Peripheral nervous system Cutaneous sensory loss Hyporeflexia symmetric weakness Paresthesias[wjgnet.com]
Confusion
  • […] symptoms of anemia, including: weakness lightheadedness dizziness chest pain heart palpitations tinnitus (ringing in the ears) A B-12 deficiency can also cause nerve damage, which can lead to: limb numbness and tingling unsteadiness when walking mental confusion[healthline.com]
  • Symptoms can include: Confusion Short-term memory loss Depression Loss of balance Numbness and tingling in the hands and feet Problems concentrating Irritability Hallucinations Delusions Optic nerve atrophy The goal of treatment is to increase your vitamin[medlineplus.gov]
  • Description Gastritis should not be confused with common symptoms of upper abdominal discomfort. Gastritis has been associated with resulting ulcers, particularly peptic ulcers.[encyclopedia.com]
  • Description Gastritis should not be confused with common symptoms of upper abdominal discomfort. It has been associated with resulting ulcers, particularly peptic ulcers. And in some cases, chronic gastritis can lead to more serious complications.[medical-dictionary.thefreedictionary.com]
  • Neurologic complications that may be attributed to Cbl deficiency including paresthesia (4), confusion (1), impaired memory (1), and blurred vision (1) were encountered in 9% of the macrocytic and normocytic but in none of the microcytic subjects.[bloodjournal.org]
Peripheral Neuropathy
  • neuropathy Dementia Getting a Diagnosis Many different factors can contribute to a doctor’s diagnosis of autoimmune gastritis.[beyondtype1.org]
  • Methylmalonic acid accumulation and the development of peripheral neuropathy (IN1-1.010) Neurology. 2012; 78 (1 suppl):IN1–IN1. [ Google Scholar ] 70. Ralapanawa DM, Jayawickreme KP, Ekanayake EM, Jayalath WA.[ncbi.nlm.nih.gov]
  • Evidence of additional autoimmune disease was present in a total of six female patients classified as positive ( n 3) or indeterminate for AG ( n 3), two of whom had multiple autoimmune processes: Sjögren’s syndrome ( n 3), inflammatory peripheral neuropathy[nature.com]
Dizziness
  • […] worse or moves to the lower right belly (appendix area) Chest pain that appears or gets worse, or spreads to the back, neck, shoulder, or arm Frequent vomiting (can’t keep down liquids) Blood in the stool or vomit (red or black in color) Feeling weak or dizzy[fairview.org]
  • […] and vomiting loss of appetite unexpected weight loss stomach ulcers iron deficiency anemia (a low level of healthy red blood cells) Autoimmune AG may lead to a B-12 deficiency, which can cause symptoms of anemia, including: weakness lightheadedness dizziness[healthline.com]
  • Case 2 A 17-year-old girl with a history of menorrhagia, fatigue and dizziness, and no previous personal or family history of autoimmune disease, was referred to our hospital to evaluate an IDA (Hb 6.7 g/dl; MCV 56 fl; MCH 16.1 pg; MCHC 288 g/l; iron[frontiersin.org]
Headache
  • Signs and Symptoms of Autoimmune Gastritis: Abdominal pain Anemia, which is characterized by the following symptoms: Weakness Trouble concentrating Shortness of breath Leg cramps Headache Heart palpitations Insomnia Paleness In severe cases, severe B12[beyondtype1.org]
  • […] presentation is often insidious; consequently, the diagnosis may be missed clinically, endoscopically, and pathologically The symptoms may be nonspecific, such as dyspepsia (abdominal discomfort) or anemia (weakness, decreased mental concentration, headache[dovemed.com]

Workup

  • Discussion and Conclusions In the cases reported here, AIG was a late and unexpected discovery in the diagnostic workup of a refractory anemia.[frontiersin.org]
  • Provides all the necessary tools to make a comprehensive diagnostic workup including data from ancillary techniques and molecular findings whenever appropriate.[books.google.it]
  • Laboratory workup All patients had a complete blood count, serum iron, total iron-binding capacity (TIBC), serum ferritin, serum B 12 and folate, sedimentation rate, fibrinogen, and CRP studies performed.[bloodjournal.org]
  • [symptoma.com] Workup Laboratory tests Complete blood count Coagulation profile Urea breath test Liver function test Renal function test Stool for occult blood Gastric biopsy Pregnancy test Helicobacter pylori stool antigen test Test for gall bladder[symptoma.com]
Abnormal Schilling Test
  • Definite diagnosis of PA required an abnormal Schilling test or anti-intrinsic factor positivity in combination with 3 additional abnormal parameters.[bloodjournal.org]
Microcytic Anemia
  • Of the 83 subjects with microcytic anemia, only 18 (22%) were men compared with 35 of 77 (46%) for all other groups combined (χ 2 0.0001).[bloodjournal.org]
  • The study of Hershko et al. has also shown a high prevalence of H. pylori positivity in young patients with AIG and microcytic anemia.[frontiersin.org]
  • As expected, the prevalence of microcytic anemia decreased whereas that of macrocytic PA increased with increasing age of patients (data not shown).[jamanetwork.com]
  • In a study by Hershko et al[ 24 ] low serum vitamin B12 levels were found in 100% macrocytic, 92% normocytic and 46% microcytic patients with CAAG, whereas iron deficiency was found in all the patients with microcytic anemia, but also in 50% of the normocytic[wjgnet.com]
  • anemia ( 9 ).[nature.com]
Gastrin Increased
  • As a significant event we point out that affected members with CAG had the highest levels of Gastrin, but three showed Gastrin increases without decreases in Pepsinogen I, which is showing that despite the process itself is not affected, there is some[primarycare.imedpub.com]
Normocytic Anemia
  • Among subjects with normocytic indices, the only feature distinguishing anemic from nonanemic patients was the lower value of serum iron ( P .029) and serum ferritin ( P .018) in anemic subjects, implying that the apparently normocytic anemia was in fact[bloodjournal.org]

Treatment

  • Treatment of erosive gastritis Since few people with this form of gastritis show symptoms, treatment may depend upon severity of symptoms.[encyclopedia.com]
  • Treatment of Acute Gastritis The most important part of acute gastritis treatment obviously is to remove the irritant when found.[ddc.musc.edu]
  • Gastritis treatment varies from person to person and depends on what's causing the inflammation. Treatments generally focus on fixing the problem that's actually causing the gastritis, like clearing up an infection, says Marrero.[everydayhealth.com]
  • UHealth Sylvester Comprehensive Cancer Center Bascom Palmer Eye Institute Font Size Group 30 Group 30 Contrast logo Menu Search University of Miami Health System Close Search Find a Doctor Treatments Page 1 Featured Treatments For Allergy and Immunology[uhealthsystem.com]

Prognosis

  • What Is the Prognosis for Gastritis? Most people with gastritis improve quickly once treatment has begun.[webmd.com]
  • Prognosis The discovery of H. pylori has improved the prognosis for persons with gastritis and ulcers. Since treatment exists with the potential to eradicate the infection, recurrence is much less common.[encyclopedia.com]
  • Prognosis The discovery of H. pylori has improved the prognosis for patients with gastritis and ulcers. Since treatment exists to eradicate the infection, recurrence is much less common.[medical-dictionary.thefreedictionary.com]

Etiology

  • These differ in their topographical distribution in the stomach, histologic features, and etiology.[journals.lww.com]
  • Depends on the etiology (see below). asymptomatic epigastric pain/tenderness nausea and vomiting loss of appetite Etiology infection: H. pylori (most common) systemic illness: trauma and burns pharmacological/medication: NSAIDS autoimmune caustic ingestion[radiopaedia.org]
  • Etiology The cause could be infective or non-infective. The infective causes could be bacteria, Helicobacter pylori is the commonest of this group. It is also the commonest cause of gastritis.[symptoma.com]

Epidemiology

  • It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels.[books.google.it]
  • Sci, 1934) Several epidemiologic studies have shown equal prevalence in various ethnic groups in the US. (Carmel et al, N. Engl. J. Med. 1978; Arch. Intern. Med. 1987; Arch. Intern.[informdx.com]
  • Epidemiology of Helicobacter pylori infection. Helicobacter 13 (Suppl. 1), 1–6 (2008). 10. Malaty, H. M. Epidemiology of Helicobacter pylori infection. Best Pract. Res. Clin. Gastroenterol. 21, 205–214 (2007). 11. Graham, D. Y.[nature.com]
  • Prevention Epidemiologic studies of H pylori –associated chronic gastritis show that acquisition of the infection is associated with large crowded households and lower socioeconomic status.[emedicine.medscape.com]
  • Epidemiology Prevalence in the general population: References: [1] [2] [3] Epidemiological data refers to the US, unless otherwise specified.[amboss.com]
Sex distribution
Age distribution

Pathophysiology

  • No classification scheme matches perfectly with the pathophysiology; a large degree of overlap exists. Some forms of gastritis involve acid-peptic and H. pylori disease (see also Overview of Acid Secretion ).[merckmanuals.com]
  • Unlike others on this topic, this text demonstrates how the endoscope incorporates pathophysiology, diagnostic, and treatment modalities into endoscopic practice.[books.google.it]
  • Pathophysiology The gastric mucosa is usually kept intact by an equilibrium of the aggressive stomach acid forces and the forces of the protective gastric mucosal barrier.[symptoma.com]
  • Special varieties Histopathological level of inflammation : acute, chronic, or chronic active Grading Non- metaplastic Mild (G1) Moderate (G2) Severe (G3) Metaplastic Mild (G1) Moderate (G2) Severe (G3) Pathophysiology AMAG Autoimmune destruction of the[amboss.com]

Prevention

  • […] binding of intrinsic factor to Vitamin B12 Type 2 antibody reacts with free or complexed Vitamin B12 to prevent its biological activity Microscopic (histologic) description Glandular atrophy predominantly in gastric body / fundus with deep or diffuse[pathologyoutlines.com]
  • How can gastritis be prevented? People may be able to reduce their chances of getting gastritis by preventing H. pylori infection. No one knows for sure how H. pylori infection spreads, so prevention is difficult.[niddk.nih.gov]
  • Foods to avoid to prevent gastritis Here is a list of foods you should avoid to prevent gastritis.[belmarrahealth.com]
  • Prevention The widespread detection and treatment of H. pylori as a preventive measure in gastritis has been discussed but not resolved.[encyclopedia.com]
  • The mainstay of gastritis prevention is to avoid those things that irritate or inflame the stomach's lining.[emedicinehealth.com]

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