In the present report, we present a case with chronic HCV infection in which autoimmune thrombocytopenia developed at week 7 of PEG-IFN alpha 2b plus ribavirin therapy. The patient subsequently received ursodeoxycholic acid (UDCA) treatment. [ncbi.nlm.nih.gov]

• Easy Bruising

  A decrease in platelets can result in easy bruising, bleeding gums, and internal bleeding. ITP may be acute and resolve in less than 6 months, or chronic and last longer than 6 months. [hopkinsmedicine.org]

  The low platelet count causes easy bruising and bleeding, which may be seen as purple areas in the skin, mucous membranes, and outer linings of organs. [icd10data.com]

  A decrease in platelets can result in easy bruising, bleeding gums and internal bleeding. "Idiopathic" means the cause is unknown. "Thrombocytopenia" means a decreased number of platelets in the blood. [chop.edu]

  A hereditary cause is suspected if there is a lifelong history of easy bruising; bleeding after tooth extractions, surgery, childbirth, or circumcision; or heavy menstruation. [merckmanuals.com]

• Petechiae

  Patients with chronic autoimmune thrombocytopenia typically present with petechiae and mucosa bleeding. Symptoms may be present for months, or some patients may experience more acute manifestations. [asmscience.org]

  CASE REPORT: A 70-year-old woman was admitted with rectal bleeding accompanied by widespread petechiae, bruising, tongue and buccal mucosa bleeding, and epistaxes and proved refractory to HLA- and HPA-matched PLTs. [ncbi.nlm.nih.gov]

  References • Nachman RL, Rafii S: Platelets, petechiae, and preservation of the vascular wall, N Engl J Med 359:1261–1270, 2008. • Donato H, Picón A, Martinez M, et al. [slideshare.net]

  People may have tiny purple spots on their skin (petechiae) and bleed easily. Diagnosis is with blood tests to measure the number of platelets. Corticosteroids or other drugs are given to block the destruction of platelets. [merckmanuals.com]

• Eczema

  Veien NK (2010): Bullous pemphigoid masquerading as recurrent vesicular hand eczema. Acta Derm Venereol 90: 4–5., 10 10. Malik M, Gürcan HM & Ahmed AR (2010): Coexistence of mucous membrane pemphigoid and connective-tissue disease. [peertechz.com]

• Epistaxis

  In March 2003 the patient received high doses IVIg but during that treatment, aggravation of the haemorrhagic diathesis with epistaxis, menorrhea and secondary anaemia (Hb 8.2 g/dl) was observed. [springerlink.com]

  Treatment-related complications included transient hemorrhagic cystitis (1 patient), vaginal bleeding (2 patients), gastrointestinal bleeding (1 patient), epistaxis (1 patient), and antibiotic-responsive febrile neutropenia (all patients). [ncbi.nlm.nih.gov]

  Severe: – Bleeding episodes—menorrhagia, epistaxis, melena—requiring transfusion or hospitalization - Symptoms interfering seriously with the quality of life 1/25/2015 Idiopathic Thrombocytopenic Purpura Prof.Dr. [slideshare.net]

  In the early stages of pregnancy there is generally no need to treat ITP unless the platelet count drops below 10,000-20,000/ul, or there is associated minor bleeding such as epistaxis and bruising. [cancertherapyadvisor.com]

  Therefore, our goal is to ameliorate the petechiae and nosebleeds (epistaxis) and not necessarily get one’s hemostatic platelet count up to 100,000. [hopkinsarthritis.org]

[…] future reference, as corticosteroids can change marrow morphology Biopsy is performed before splenectomy to evaluate for possible hypoplasia or fibrosis Unresponsiveness to standard treatment after 6 months is an indication for bone marrow aspiration See Workup [emedicine.medscape.com]

• Decreased Platelet Count

  Additional laboratory evaluation should be performed as clinically indicated, and a trial of discontinuing agents known to decrease platelet counts is recommended. [aafp.org]

  The resulting shortened life span of platelets in the circulation, together with incomplete compensation by increased platelet production by bone marrow megakaryocytes, results in a decreased platelet count. [emedicine.medscape.com]

• HLA-B8

  The case of a young woman with autoimmune thrombocytopenia, complete IgA deficiency and anti-IgA antibodies is presented and the role of the AH 8-1 supratype (HLA B8, DR3) is discussed. [ncbi.nlm.nih.gov]

Conservative methods of treatment using steroids, dietotherapy, antibiotics or immunosuppressive agents are not particularly effective in treating fistulas. [ncbi.nlm.nih.gov]

Prognosis • Severe bleeding is rare ( 20. [slideshare.net]

Although there is no known cause of ITP and there is no cure, the prognosis for a child with ITP is very good. Usually, the body stops making the antibodies that are attacking the platelets and the disorder resolves on its own. [chop.edu]

Immune thrombocytopenia (ITP) in adults: Initial treatment and prognosis. https://www.uptodate.com/contents/search. Accessed March 13, 2019. George JN, et al. [mayoclinic.org]

Therefore, patients suffering from B-CLL in association with ITP should have a personalized treatment program. 87 Any association of NHL and ITP which changes the prognosis of the patients should be studied carefully. [haematologica.org]

Secondary idiopathic thrombocytopenic purpura Secondary ITP due to other autoimmune or viral processes has a prognosis directly related to the underlying disorder. [cancertherapyadvisor.com]

A greater understanding of the pathogenesis and treatment options can only be definitively clarified by analyses of settings such as the present case, as autoimmune thrombocytopenia is uncommon in patients with malignant lymphoma and the etiology and [ncbi.nlm.nih.gov]

No plausible alternative etiology such as drug-mediated thrombocytopenia, marrow failure syndrome or thrombocytopenia related to viral or bacterial infection. [clinicaltrials.gov]

Common Etiologies of Thrombocytopenia with Clinical Findings and Suggested Treatment Etiology Severity Clinical presentation Evaluation Treatment Comments Bone marrow suppression by irradiation, chemotherapy, or neoplasia Moderate to severe History of [aafp.org]

Loftus EV, Sandborn WJ (2002) Epidemiology of inflammatory bowel disease. Gastroenterol Clin N Am 31: 1 – 20. ]. [peertechz.com]

Epidemiology of incident immune thrombocytopenia: a nationwide population-based study in France. Blood. 2014 Nov 20. 124(22):3308-15. [Medline]. Danese MD, Lindquist K, Gleeson M, Deuson R, Mikhael J. [emedicine.medscape.com]

"Epidemiology of immune thrombocytopenic purpura in the General Practice Research Database". Br. J. Haematol. 145 (2): 235–44. doi : 10.1111/j.1365-2141.2009.07615.x. PMID 19245432. ^ a b Roback et al. AABB Technical Manual, 16th Ed. [en.wikipedia.org]

In fact, the decision to define as ITP a platelet count between 100 × 10 9 /l and 150 × 10 9 /l in an otherwise healthy individual is not supported by recent epidemiological studies. [journals.plos.org]

Br J Haematol 128 (5): 698–702 PubMed CrossRef Google Scholar Sloand EM, Klein HG, Banks SM, Vareldzis B, Merritt S, Pierce P (1992) Epidemiology of thrombocytopenia in HIV infection. [link.springer.com]

HCV-associated thrombocytopenia may be considered complex and multifactorial in origin, since different mechanisms have been implicated in its pathophysiology. [ncbi.nlm.nih.gov]

This book provides a concise yet comprehensive summary of the current state of knowledge concerning the pathophysiology, differential diagnosis and treatment options that support day-to-day patient management. [books.google.com]

ITP (Pathophysiology)(cont.) skperdon.hubpages.com 1/25/2015 Idiopathic Thrombocytopenic Purpura Prof.Dr. Saad S Al Ani Khorfakkan Hospital 7 8. [slideshare.net]

Bleeding can be prevented if the platelet count can be kept above 10,000 microL. [ncbi.nlm.nih.gov]

The National Heart, Lung, and Blood Institute (NHLBI) leads or sponsors many studies aimed at preventing, diagnosing, and treating heart, lung, blood, and sleep disorders. [nhlbi.nih.gov]

IVIG may be administered to the mother during the pregnancy or platelet transfusion may be given to the developing fetus to prevent severe bleeding. Cesarean section is recommended for delivery to prevent bleeding. Thanks for your feedback! [verywell.com]

When treatment is necessary, the two most common forms of treatment are: Steroids, which help prevent bleeding by decreasing the rate of platelet destruction. [chop.edu]