Children with severe combined immunodeficiency (SCID) have profoundly diminished humoral and cellular immunity resulting in death during infancy unless immune reconstitution occurs by bone marrow transplantation (BMT). [ncbi.nlm.nih.gov]

A decrease in platelets can result in easy bruising, bleeding gums, and internal bleeding. ITP may be acute and resolve in less than 6 months, or chronic and last longer than 6 months. [hopkinsmedicine.org]

The low platelet count causes easy bruising and bleeding, which may be seen as purple areas in the skin, mucous membranes, and outer linings of organs. [icd10data.com]

A decrease in platelets can result in easy bruising, bleeding gums and internal bleeding. "Idiopathic" means the cause is unknown. "Thrombocytopenia" means a decreased number of platelets in the blood. [chop.edu]

The clinical manifestations of bleeding were generally mild, such as easy bruising and, in the majority of patients the thrombocytopenia was detected incidentally. [scirp.org]

Patients with chronic autoimmune thrombocytopenia typically present with petechiae and mucosa bleeding. Symptoms may be present for months, or some patients may experience more acute manifestations. [asmscience.org]

CASE REPORT: A 70-year-old woman was admitted with rectal bleeding accompanied by widespread petechiae, bruising, tongue and buccal mucosa bleeding, and epistaxes and proved refractory to HLA- and HPA-matched PLTs. [ncbi.nlm.nih.gov]

References • Nachman RL, Rafii S: Platelets, petechiae, and preservation of the vascular wall, N Engl J Med 359:1261–1270, 2008. • Donato H, Picón A, Martinez M, et al. [slideshare.net]

These bruises may also appear as pinpoint-sized red or purple dots on the skin called petechiae. Petechiae often look like a rash. ITP can occur in both children and adults. [healthline.com]

You may have small red or purple spots called petechiae on your lower legs, or bruising that is purple, red, or brown (known as purpura). [my.clevelandclinic.org]

Veien NK (2010): Bullous pemphigoid masquerading as recurrent vesicular hand eczema. Acta Derm Venereol 90: 4–5., 10 10. Malik M, Gürcan HM & Ahmed AR (2010): Coexistence of mucous membrane pemphigoid and connective-tissue disease. [peertechz.com]

In March 2003 the patient received high doses IVIg but during that treatment, aggravation of the haemorrhagic diathesis with epistaxis, menorrhea and secondary anaemia (Hb 8.2 g/dl) was observed. [springerlink.com]

Treatment-related complications included transient hemorrhagic cystitis (1 patient), vaginal bleeding (2 patients), gastrointestinal bleeding (1 patient), epistaxis (1 patient), and antibiotic-responsive febrile neutropenia (all patients). [ncbi.nlm.nih.gov]

Severe: – Bleeding episodes—menorrhagia, epistaxis, melena—requiring transfusion or hospitalization - Symptoms interfering seriously with the quality of life 1/25/2015 Idiopathic Thrombocytopenic Purpura Prof.Dr. [slideshare.net]

Therefore, our goal is to ameliorate the petechiae and nosebleeds (epistaxis) and not necessarily get one’s hemostatic platelet count up to 100,000. [hopkinsarthritis.org]

In the early stages of pregnancy there is generally no need to treat ITP unless the platelet count drops below 10,000-20,000/ul, or there is associated minor bleeding such as epistaxis and bruising. [cancertherapyadvisor.com]

Additional laboratory evaluation should be performed as clinically indicated, and a trial of discontinuing agents known to decrease platelet counts is recommended. [aafp.org]

The resulting shortened life span of platelets in the circulation, together with incomplete compensation by increased platelet production by bone marrow megakaryocytes, results in a decreased platelet count. [emedicine.medscape.com]

The case of a young woman with autoimmune thrombocytopenia, complete IgA deficiency and anti-IgA antibodies is presented and the role of the AH 8-1 supratype (HLA B8, DR3) is discussed. [ncbi.nlm.nih.gov]