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Autoimmune Vasculitis


Presentation

  • CNS involvement is uncommon in RA and presents vasculitis-like symptoms, such as stroke, seizures, and meningitis (probably due to rheumatoid nodules).[ncbi.nlm.nih.gov]

Treatment

  • Treatment PubMed The neurologic manifestations of systemic lupus erythematosus Greenberg BM (2009) Review Treatment PubMed The involvement of the peripheral nervous system in biopsy proven active giant cell arteritis Pfadenhauer K, Roesler A and Golling[ncbi.nlm.nih.gov]

Prognosis

  • A combination of steroids and pulse cyclophosphamide is recommended for patients with a poor prognosis. ( 24, 25 ) With a relapse rate of 25% and reduced survival rate, a close follow-up of suspected PACNS is mandatory.[ncbi.nlm.nih.gov]

Etiology

  • ) Variable vessel vasculitis Behçet disease and Cogan's syndrome Single-organ vasculitis Primary central nervous system vasculitis Vasculitis associated with systemic disease Lupus vasculitis Rheumatoid vasculitis Vasculitis associated with probable etiology[ncbi.nlm.nih.gov]

Pathophysiology

  • CONCLUSION The vasculitides and connective tissue diseases associated to them provide an avenue for investigating the pathophysiology of immune system among the vasculature of the central and peripheral nervous system.[ncbi.nlm.nih.gov]

Prevention

  • A randomized controlled trial of 44 patients showed that maintenance therapy with infliximab failed to show more efficacy in disease control than that of steroids, and it did not allow a reduction in the dose of steroids required to prevent relapse. ([ncbi.nlm.nih.gov]

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