It can also provide non-invasive ventilation for patients with respiratory insufficiency in the hospital or home. Professional precision Innovative tracking technology ensures accurate and comfortable therapy. [craftopoulos.gr]

However, patients with PPS commonly develop new disabilities that cause significant morbidity, such as orthopedic complications (eg, progressive instability of joints, osteoporosis, fractures, osteoarthrosis, scoliosis, and spondylosis), respiratory insufficiency [emedicine.medscape.com]

muscle weakness of the lower extremities and small hand muscles, hyperreflexia, spastic gait and mild urinary compromise. [orpha.net]

Candidates for diagnostic testing include infants, children, and adults with generalized hypotonia and proximal muscle weakness of unknown etiology. [aetna.com]

muscle weakness of the lower extremities and small hand muscles, hyperreflexia, spastic gait and mild urinary compromise. [orpha.net]

hand muscles, hyperreflexia, spastic gait and mild urinary compromise. [orpha.net]

[…] et al (2011) wrote that nephronophthisis (NPHP) is an autosomal recessive cystic kidney disease and a leading genetic cause of established renal failure in children and young adults; early presenting symptoms in children with NPHP include polyuria, nocturia [aetna.com]

Homepage Rare diseases Search Search for a rare disease Autosomal dominant spastic paraplegia type 41 Disease definition A pure form of hereditary spastic paraplegia characterized by onset in adolescence or early adulthood of slowly progressive spastic [orpha.net]

[…] paraplegia type 41 Disease definition A pure form of hereditary spastic paraplegia characterized by onset in adolescence or early adulthood of slowly progressive spastic paraplegia, proximal muscle weakness of the lower extremities and small hand muscles, hyperreflexia [orpha.net]

Affiliated tissues include globus pallidus, skin and bone, and related phenotypes are babinski sign and lower limb hyperreflexia Disease Ontology : 12 A hereditary spastic paraplegia that has material basis in mutation in the CYP2U1 gene on chromosome [malacards.org]

Examination at the age of 22 years after a traffic accident revealed failure of abduction of the left eye, hyperreflexia in all four extremities and Babinski sign. [journals.plos.org]

[…] whether the disorder is a pure spastic paraplegia or a more complex syndrome with other associated features. 1 Autosomal dominant pure spastic paraplegia (ADPSP) is clinically characterised by slowly progressive spasticity and weakness of the legs, hyperreflexia [jnnp.bmj.com]

The key diagnostic findings are lower limb weakness, increased muscle tone, hyperreflexia, extensor plantar responses, and gait spasticity [ 2 ]. [bmcneurol.biomedcentral.com]

gait and mild urinary compromise. [orpha.net]

If symptoms begin during the teenage years or later, then spastic gait disturbance usually progresses over many years. [ipfs.io]

Grade 2 refers to a patient with spastic gait, able to walk independently with or without support. Grade 3 refers to a chairbound or bedridden patient. [jnnp.bmj.com]

Winner B, Uyanik G, Gross C et al. (2004) Clinical progression and genetic analysis in hereditary spastic paraplegia with thin corpus callosum in spastic gait gene 11 (SPG11). Archives of Neurology 61: 117–121. [els.net]

[…] identified specialty as the volume and complexity of data became too much for the general pediatician or the adult neurologist to master, the discipline has now continued to evolve into so many subspecialties, such as epilepsy, neuromuscular disease, stroke [books.google.ro]

The BSE undergoes a large conformational change upon GTP hydrolysis that has been described as the power stroke of dynamin [ 29, 30 ]. [bmcneurol.biomedcentral.com]

Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan Kunihiro Yoshida Department of Human Genetics, Graduate School of Medicine, Yokohama City University, Yokohama, Japan Hiroshi Doi Department of Neurology and Stroke [nature.com]

Focal muscle vibration in the treatment of upper limb spasticity: a pilot randomized controlled trial in patients with chronic stroke. Arch Phys Med Rehabil. 93(9):1656-61. 2012. . Casale R1, Damiani C, Maestri R, Fundarò C, Chimento P, Foti C. [en.wikipedia.org]

He was a quick player with a decent shooting stroke. Despite his size, he was able to score at a reasonably efficient clip over the course of his career. [bleacherreport.com]

The diagnosis was made on the basis of a well documented family history and the diagnostic criteria of Harding 1 and Bruyn and Scheltens. 12 Minimal criteria for diagnosis were spasticity of the lower limbs, usually more pronounced than weakness, hyperactive [jnnp.bmj.com]

Introduction The hereditary spastic paraplegias (HSP) are clinically and genetically heterogeneous disorders characterized by the triad of progressive spastic paraparesis, hyperactive bladder and mild sensory dysfunction in the lower limbs [1] – [4]. [journals.plos.org]

[…] dysfunctions no no dysarthria no no Leg Spasticity Muscle contracture - - - - Muscle weakness (MRC scale): Knee flexion 3.5 2.5 2 2 4 Knee extention 3.5 3 2 2 4.5 Ankle flexion 4 3 1.5 2.5 5 Ankle extention 3.5 3.5 1.5 2 5 Toes 3 3 1 1.5 3 Muscle wasting - - Hyperactive [bmcneurol.biomedcentral.com]

Primary lateral sclerosis The age of onset for primary lateral sclerosis (PLS) is usually between 40 and 60 years, with spasticity in the legs accompanied by hyperactive deep tendon reflexes, clonus, and Babinski sign. [emedicine.medscape.com]

Gilbert directs the Movement Disorders and Tourette's Syndrome Clinics, which specialize in evaluation and pharmacologic treatment of tics, chorea, tremor, dystonia, stereotypies, ataxia, and other movement disorders . Dr. [books.google.com]