TMC1 appears to be a common cause of recessive deafness in consanguineous Indian, Pakistani, Turkish, and Tunisian families. Recessive mutations of TMC1 all result in a prelingual severe-to-profound SNHL. [entokey.com]

Four novel TMC1 (DFNB7/DFNB11) mutations in Turkish patients with congenital autosomal recessive nonsyndromic hearing loss. Hum Mutat. 2005; 26 (6): 591[ DOI ][ PubMed ] 15. Kitajiri S, Makishima T, Friedman TB, Griffith AJ. [ircmj.com]

seizures, hypertonia, developmental delay, ataxia) & visual problems Some degree of HL is present in 75% of children who become symptomatic Cutaneous features (e.g., skin rash, alopecia, conjunctivitis) Neurologic & cutaneous manifestations resolve [ncbi.nlm.nih.gov]

Pro R32L G to T at 95 Arg at 32 into Leu V84L G to C at 250 Val at 84 into Leu K15T A to C at 44 Lys at 15 into Thr V95M G to A at 283 Val at 95 into Met K122I A to T at 365 Lys at 122 into Ile N206S A to G at 617 Gln at 206 into Ser delE120 del of GAG [entokey.com]

The primers used in sequencing Cx26 were: CxG4352 -µ/5º-TCG GCC CCA GTG GTA CAG-3º (Mar.F)-forward; Cx873-4 /5º-CTG GGC AAT GCC TTA AAC TGG-3º (Mar.R)-reverse; Cx26A-µ (5º-TCT TTT CCA GAG CAA ACC GC-3º (Mar. [ejo.eg.net]