Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. [malacards.org]

Related phenotypes are spasticity and polyneuropathy Disease Ontology : 12 A hereditary spastic paraplegia that has material basis in mutation in the ARL6IP1 gene on chromosome 16p12. [malacards.org]

Genetic epidemiology of sensorimotor polyneuropathy with or without agenesis of the corpus callosum in northeastern Quebec. Hum Genet. 1993 ; 91 : 223 – 7. 56. Battistella, P, Drigo, P, Laverda, A, Casara, G, De Martin, P, Condini, A, et al. [cambridge.org]