Presentation
The COVID-19 patients in the current case series had unusual presenting radiographic findings. This unusual presentation however was associated with devastating outcomes. [jtd.amegroups.com]
Signs and symptoms[edit] The presentation for this condition is as follows:[citation needed] Mental retardation Deafness at birth Obesity Choroideremia Impaired vision Progressive degeneration of the choroid Genetics[edit] Ayazi syndrome's inheritance [en.wikipedia.org]
Western Europe in winter could present conditions nearly as severe as those found in European Russia. But in Russia the winter weather was as vast and endless as the Russian landscape, and it was its endlessness that made it unendurable. [lotsofessays.com]
Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness. [pillintrip.com]
Entire Body System
- Fever
Azi Num Injection is also used to treat patients with the presence of bacteria in the bloodstream that occurs in association with any of these infections, and for the management of patients with low level of neutrophils and fever due to bacterial infection [tabletwise.net]
For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. [ndrugs.com]
Patient 3 On March 21, 2020, a 29-year-old woman presented to the emergency department with 4-day course of low-grade fever and chest pain. [jtd.amegroups.com]
Patients should be instructed to report signs/symptoms of Clostridium difficile (e.g., watery/bloody stools, stomach cramps, fever), for up to 2 months after stopping treatment. [drugs.com]
- Asymptomatic
[…] clinical and radiographic disease severity rapidly worsens around one week after initial onset of symptoms in severe COVID-19 cases (11-13), with ARDS and radiographic severity progressing over one week These patients may have experienced a relatively asymptomatic [jtd.amegroups.com]
- Anemia
[…] delirium depression drug rash with eosinophilia and systemic symptoms dyspnea dysuria epistaxis erythema multiforme fever gastrointestinal disorder gastrointestinal hemorrhage hallucinations heart arrest heart attack heart failure hematuria hemolytic anemia [tabletwise.net]
Respiratoric
- Pneumonia
Uses: -Treatment of mild to moderate community acquired pneumonia due to C pneumoniae, H influenzae, M pneumonia, or S pneumoniae in patients appropriate for oral therapy -Treatment of community-acquired pneumonia due to C pneumoniae, H influenzae, L [drugs.com]
Pneumothorax has been reported as a finding in viral pneumonia as early as during the 1918 H1N1 influenza pandemic (3). [jtd.amegroups.com]
Mild to moderate community-acquired pneumonia (CAP) due to Chlamydia pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, Mycoplasma pneumoniae or Streptococcus pneumoniae. [ndrugs.com]
and CAP Acute otitis media caused by Haemophilus influenzae, Moraxella catarrhalis, or Streptococcus pneumoniae. [powershow.com]
Adverse reactions possibly or probably related to Azi based on clinical trial experience and post-marketing surveillance: Infections and infestations Uncommon: Candidiasis, vaginal infection, pneumonia, fungal infections, bacterial infection, pharyngitis [pillintrip.com]
- Pleural Effusion
effusion pneumonia pulmonary embolus respiratory disorder seizure sepsis shock shortened partial thromboplastin time shortened prothrombin time skin ulcer somnolence swelling in the arms and legs tachycardia toxic epidermal necrolysis vaginal moniliasis [tabletwise.net]
Innate type 2 immunity is associated with eosinophilic pleural effusion in primary spontaneous pneumothorax. Am J Respir Crit Care Med 2013;188:577-85. [Crossref] [PubMed] Bernink JH, Peters CP, Munneke M, et al. [jtd.amegroups.com]
Gastrointestinal
- Dyspepsia
[…] disorders Uncommon: Hot flush Not known: Hypotension Respiratory, thoracic and mediastinal disorders Uncommon: Dyspnoea, epistaxis Gastrointestinal disorders Very common: Diarrhea Common: Vomiting, abdominal pain, nausea Uncommon: Constipation, flatulence, dyspepsia [pillintrip.com]
Gastrointestinal: Anorexia, constipation, dyspepsia, flatulence, vomiting/diarrhea, pseudomembranous colitis, pancreatitis, oral candidiasis, pyloric stenosis, and rare reports of tongue discoloration General: Asthenia, paresthesia, fatigue, malaise and [ndrugs.com]
- Melena
[…] nitrogen increased creatinine increased eosinophils increased lactate dehydrogenase inflammation, pain and swelling at the injection site injection site reaction intestinal obstruction kidney failure leukocytosis leukopenia liver failure lung swelling melena [tabletwise.net]
Cardiovascular
- Hypertension
[…] atrophy Peripheral visual field loss Pituitary hypothyroidism Postnatal growth retardation Progressive night blindness Reduced visual acuity Reticular pigmentary degeneration Stapes ankylosis Visual acuity test abnormality Occasional Dysdiadochokinesis Hypertension [seekhealthz.com]
Advanced age, male sex, hypertension, cardiac disease, diabetes, chronic pulmonary disease, chronic kidney disease, malignancy, and immunocompromised state have all been identified as risk factors (11). [jtd.amegroups.com]
[…] eosinophilia and systemic symptoms dyspnea dysuria epistaxis erythema multiforme fever gastrointestinal disorder gastrointestinal hemorrhage hallucinations heart arrest heart attack heart failure hematuria hemolytic anemia hemoperitoneum hyperbilirubinemia hypertension [tabletwise.net]
Liver, Gall & Pancreas
- Jaundice
Constipation, flatulence, dyspepsia, gastritis, dysphagia, abdominal distension, dry mouth, eructation, mouth ulceration, salivary hypersecretion Not known: Pancreatitis, tongue discoloration Hepatobiliary disorders Rare: Hepatic function abnormal, jaundice [pillintrip.com]
Heart disorders Digestive system disorders Symptoms: abnormally low body weight (anorexia), a decrease in bile flow (cholestatic jaundice), lack of movement in the intestine (ileus), liver failure, intestinal blockage yeast infection of the mouth and [tabletwise.net]
Liver Dose Adjustments Data not available Patients who develop signs/symptoms of cholestatic jaundice, jaundice, or hepatic dysfunction: Discontinue treatment. [drugs.com]
You should not use this medication if you have ever had jaundice or liver problems caused by taking Azi-Once. [ndrugs.com]
Ears
- Hearing Impairment
impairment Frequent Abnormal cochlea morphology Abnormality of the Achilles tendon Ankle clonus Anterior hypopituitarism Ataxia Bilateral sensorineural hearing impairment Conductive hearing impairment Delayed skeletal maturation Dilatated internal auditory [seekhealthz.com]
Symptoms Obesity Sensorineural hearing impairment Deafness at birth Choroideremia Impaired vision Progressive degeneration of the choroid Causes Ayazi syndrome's inheritance pattern is described as x-linked recessive. [checkorphan.org]
Eye Disorders Common (> 1/100, < 1/10) Visual impairment Ear and Labyrinth Disorders Common (> 1/100, < 1/10) Deafness Uncommon (>1/1,000 to <1/100) Hearing impaired, tinnitus Rare (> 1/10000, < 1/1000) Vertigo Cardiac Disorders Uncommon (>1/1,000 to [pillintrip.com]
Although no dosage adjustment of Azi-Once is recommended when administered with nelfinavir, close monitoring for known side effects of Azi-Once, such as liver enzyme abnormalities and hearing impairment, is warranted. [ndrugs.com]
Skin
- Erythema
[…] subcutaneous tissue disorders Uncommon: Rash, pruritus, urticaria, dermatitis, dry skin, hyperhidrosis Rare: Photosensitivity reaction, acute generalised exanthematous pustulosis (AGEP) Not known: Stevens-Johnson syndrome, Toxic epidermal necrolysis, erythema [pillintrip.com]
Inflammatory Disease Chronic Obstructive Pulmonary Disease - Acute Bronchitis Mycobacterium avium-intracellulare - Prophylaxis Mycobacterium avium-intracellulare - Treatment Granuloma Inguinale STD Prophylaxis Pertussis Prophylaxis Pertussis Lyme Disease - Erythema [drugs.com]
[…] anorexia anxiety apnea asthma bradycardia cholestatic jaundice confusion convulsion decreased hematocrit decreased hemoglobin decreased white blood cell delirium depression drug rash with eosinophilia and systemic symptoms dyspnea dysuria epistaxis erythema [tabletwise.net]
Nervous system: Convulsions, dizziness/vertigo, headache, somnolence, hyperactivity, nervousness, agitation and syncope Psychiatric: Aggressive reaction and anxiety Skin/appendages: Pruritus, rash, photosensitivity, serious skin reactions including erythema [ndrugs.com]
- Flushing
[…] vertigo Not known: Hearing impairment including deafness and/or tinnitus Cardiac disorders Uncommon: Palpitations Not known: Torsades de pointes, arrhythmia including ventricular tachycardia, electrocardiogram QT prolonged Vascular disorders Uncommon: Hot flush [pillintrip.com]
If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step. This page provides information for Azi Num Injection. [tabletwise.net]
- Skin Ulcer
Skin Infections Your skin helps protect you from germs, but sometimes it can get ... Urinary Tract Infections The urinary system is the body's drainage system for removing ... [tabletwise.net]
Face, Head & Neck
- Epistaxis
Palpitations Not known: Torsades de pointes, arrhythmia including ventricular tachycardia, electrocardiogram QT prolonged Vascular disorders Uncommon: Hot flush Not known: Hypotension Respiratory, thoracic and mediastinal disorders Uncommon: Dyspnoea, epistaxis [pillintrip.com]
[…] angioedema anorexia anxiety apnea asthma bradycardia cholestatic jaundice confusion convulsion decreased hematocrit decreased hemoglobin decreased white blood cell delirium depression drug rash with eosinophilia and systemic symptoms dyspnea dysuria epistaxis [tabletwise.net]
Neurologic
- Somnolence
[…] reaction Metabolism and nutrition disorders Uncommon: Anorexia Psychiatric disorders Uncommon: Nervousness, insomnia Rare: Agitation Not known: Aggression, anxiety, delirium, hallucination Nervous system disorders Common: Headache Uncommon: Dizziness, somnolence [pillintrip.com]
Nervous system: Convulsions, dizziness/vertigo, headache, somnolence, hyperactivity, nervousness, agitation and syncope Psychiatric: Aggressive reaction and anxiety Skin/appendages: Pruritus, rash, photosensitivity, serious skin reactions including erythema [ndrugs.com]
[…] melena neutropenia oral moniliasis peripheral vascular disorder pharyngitis phlebitis pleural effusion pneumonia pulmonary embolus respiratory disorder seizure sepsis shock shortened partial thromboplastin time shortened prothrombin time skin ulcer somnolence [tabletwise.net]
- Seizure
As a result of this interaction, valproic acid levels may fall below the therapeutic range, therefore increases the risk of sudden seizure attack (breakthrough seizures). [tabletwise.net]
[…] hypothyroidism Postnatal growth retardation Progressive night blindness Reduced visual acuity Reticular pigmentary degeneration Stapes ankylosis Visual acuity test abnormality Occasional Dysdiadochokinesis Hypertension Nystagmus Renal artery stenosis Seizures [seekhealthz.com]
- Forgetful
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Workup
Serum
- Hypoglycemia
[…] epistaxis erythema multiforme fever gastrointestinal disorder gastrointestinal hemorrhage hallucinations heart arrest heart attack heart failure hematuria hemolytic anemia hemoperitoneum hyperbilirubinemia hypertension hypervolemia hypochromic anemia hypoglycemia [tabletwise.net]
Pleura
- Pleural Effusion
effusion pneumonia pulmonary embolus respiratory disorder seizure sepsis shock shortened partial thromboplastin time shortened prothrombin time skin ulcer somnolence swelling in the arms and legs tachycardia toxic epidermal necrolysis vaginal moniliasis [tabletwise.net]
Innate type 2 immunity is associated with eosinophilic pleural effusion in primary spontaneous pneumothorax. Am J Respir Crit Care Med 2013;188:577-85. [Crossref] [PubMed] Bernink JH, Peters CP, Munneke M, et al. [jtd.amegroups.com]
Treatment
There are two main types of clinical studies: Clinical trials determine if a new test or treatment for a disease is effective and safe by comparing groups receiving different tests/treatments. [rarediseases.info.nih.gov]
Skip to content Home About Us Team Log In News All News Finance Treatment People Videos Treatments Clinical Trials Access Programs All Access Programs Diseases Events Networks Research Main Menu Subscribe for Free Newsletter Email * Type * * Required [checkorphan.org]
Uses: -Uncomplicated gonococcal infections of the pharynx, cervix, urethra, and rectum -Treatment of gonococcal conjunctivitis -Treatment of arthritis and arthritis-dermatitis syndrome caused by disseminated gonococcal infection -Treatment of gonococcal [drugs.com]
[…] are resistant to topical treatments. [ndrugs.com]
Epidemiology
In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. [ndrugs.com]
Pathophysiology
An immune response, mediated by respiratory epithelium, eosinophils, and innate lymphoid cells (ILCs), has been proposed as an aspect of pathophysiology in primary spontaneous pneumothorax (16). [jtd.amegroups.com]
Prevention
Mycobacterial Infections Prevention of Disseminated MAC Infections The recommended dose of Azi-Once for the prevention of disseminated Mycobacterium avium complex (MAC) disease is: 1200 mg taken once weekly. [ndrugs.com]
Wuke Tree Adjustable Baby Pillow for Head Shaping Prevent Flat Head Syndrome Blue Breathable Washable,for Newborn Sleeping Toddler Unisex Infant,0-12 Months,17 x27 cm, *Please check turn around times. soft purple and soft green on this one with large [matabad.com]
Use: Prevention of disseminated Mycobacterium avium-intracellulare complex (MAC) disease NIH, IDSA, and ATS Recommendations: Immediate-release: Patients with AIDS and CD4 counts less than 50 cells/mcL: -Primary prophylaxis: 1200 mg orally once a week [drugs.com]
Participating in research helps researchers ultimately uncover better ways to treat, prevent, diagnose, and understand human diseases. What Are Clinical Studies? Clinical studies are medical research involving people as participants. [rarediseases.info.nih.gov]
Oral Anticoagulants Azi Num Injection interacts with oral anti-coagulants, which prevent or reduce the coagulation of blood. The combined use of Azi Num with warfarin may increase its blood clotting effect. [tabletwise.net]