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B-Cell Chronic Lymphocytic Leukemia


B-cell chronic lymphocytic leukemia (BCLL) is a lymphoproliferative disorder typically following an indolent or mild course. Patients may be asymptomatic or the disease may manifest in generalized lymphadenopathy, malaise and weakness, fever, night sweats, and weight loss. Due to the advanced age of most patients, comorbidities frequently contribute to a complex clinical picture. Notwithstanding, watchful waiting is the general approach to early, asymptomatic BCLL, and treatment is not usually initiated until symptoms do interfere with life quality. To date, most patients have a favorable prognosis, although the histological transformation into an aggressive type of lymphoma may negatively impact on the outcome.


BCLL patients may be asymptomatic for prolonged periods of time, and about one-third of all diagnoses are made incidentally [1] [2]. If symptoms manifest, they are non-specific. Constitutional B-symptoms, such as fever, night sweats, and weight loss, are common and may be accompanied by general malaise and weakness. The clinical examination of BCLL patients may reveal generalized lymphadenopathy, hepatomegaly, and splenomegaly.

Additional symptoms may arise from bone marrow failure due to marrow crowding or autoimmune destruction. Hematological studies may confirm anemia, leukocytopenia, and/or thrombocytopenia [1]. Those suffering from anemia will appear pale, and their tolerance to exercise will be reduced. They may claim headaches and palpitations. Leukocytopenia, in turn, is associated with an increased risk of infection. The incidence of cutaneous, respiratory, and urinary infections is particularly high in BCLL patients, and they may give rise to life-threatening pneumonia and sepsis [3]. Low platelet counts may induce a predisposition to bleeding, causing easy bruisability, epistaxis, bleeding gums, and hemorrhages of the gastrointestinal tract. As implied above, autoimmune processes may trigger autoimmune hemolytic anemia and immune-mediated thrombocytopenia, and these conditions may exacerbate the consequences of bone marrow failure.

Moreover, solid tumors may compress adjacent tissues and produce further symptoms related to organ dysfunction. The primary involvement of non-lymphoid organs is rare, but has been described. In this regard, the skin and central nervous system are most frequently affected [4].

  • In contrast, no grade 3 or 4 infusion-related dyspnea, hypoxemia, or hypotension was noted in the 7 patients receiving stepped-up dosing with a lower dose (50 mg/m 2 ) on day 1 of therapy.[doi.org]
Black Stools
  • Tell your healthcare provider if you have any signs of bleeding, including: blood in your stools or black stools (looks like tar), pink or brown urine, unexpected bleeding, or bleeding that is severe or that you cannot control, vomit blood or vomit looks[imbruvica.com]
Muscle Spasm
  • spasms nausea tiredness mouth sores (stomatitis) pneumonia bruising muscle spasms diarrhea nausea Diarrhea is a common side effect in people who take IMBRUVICA .[imbruvica.com]
  • We report a case of a 65-year-old woman with B-cell chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) who presented with multiple, tender, firm pink papules on the face, upper trunk and upper extremities 6 years after diagnosis of CLL[ncbi.nlm.nih.gov]
  • On exam, there were erythematous papules and plaques studded with vesicles on the neck, trunk, and upper extremities. Two skin biopsies showed common features of a perivascular and periadnexal lymphocytic infiltrate in the superficial to mid-dermis.[ncbi.nlm.nih.gov]
  • The authors present the case of a 77-year-old female patient, referred to the dermatology clinic for red, erythematous, pruritic papules, which had suddenly appeared on her left hemithorax, along the C6 dermatome, with a 4-week duration.[ncbi.nlm.nih.gov]
Cutaneous Manifestation
  • We report on a 69-year-old female patient with specific cutaneous manifestations of B-cell chronic lymphocytic leukemia that arose at the site of erythema chronicum migrans due to Borrelia burgdorferi infection.[ncbi.nlm.nih.gov]
  • Cutaneous manifestations are an uncommon presentation of subclinical B-CLL.[ncbi.nlm.nih.gov]
  • We conducted a retrospective case series analysis of 3 patients with unusual cutaneous clinicopathologic presentations of B-cell chronic lymphocytic leukemia, including erythematous plaques, angiomatosis/telangiectasia, and erosive skin changes, respectively[ncbi.nlm.nih.gov]
  • Biopsy revealed both palisading granulomatous dermatitis consistent with actinic granuloma and a dense perivascular lymphocytic infiltrate consistent with the patient's known history of leukemia.[ncbi.nlm.nih.gov]
  • As we have seen before, CAL-101 has the ability to flush CLL cells out of their comfortable and safe niches in the lymph nodes, where they are hard to reach and even harder to kill.[web.archive.org]
Guillain-Barré Syndrome
  • We report a case of Guillain-Barré Syndrome (GBS) which appeared after mobilization therapy in a patient with B-cell chronic lymphocytic leukemia (B-CLL).[ncbi.nlm.nih.gov]


Hematological studies revealing lymphocytosis and variable cytopenias are usually the first indication of a lymphoproliferative disorder like BCLL. The final diagnosis of BCLL requires the presence of at least 5,000 B cells per µl in the peripheral blood and proof of a clonal B-cell population. Flow cytometric analyses of lymph node biopsy samples are generally carried out to this end and show B cells positive for light chain restriction, CD5, CD23, CD79b, and surface immunoglobulins. CD20 expression is low. Microscopically, tumor cells have a typical appearance of smudge cells, which are artifacts produced during the slide preparation. The share of phenotypically or immunophenotypically atypical cells is generally <15% [2]. A bone marrow biopsy is not required to diagnose BCLL but may become necessary to confirm the histological transformation of tumor cells [5].

With regards to the molecular characteristics of tumor cells, the following features should be determined [6] [7]:

  • Cytogenetic abnormalities, e.g., del(17p), del(13q), del(11q), trisomy 12, and complex karyotype (poor response to chemoimmunotherapy; increased risk for histological transformation)
  • Inactivation of TP53 or CDKN2A/B tumor suppressor genes; activation of C-MYC oncogene (unsatisfactory response to chemoimmunotherapy)
  • Mutation of immunoglobulin heavy-chain variable (IGHV; unmutated IGHV as a predictive biomarker for lack of benefit from chemoimmunotherapy but not from ibrutinib)
  • Impairment of NOTCH signaling (predicting resistance to rituximab and ofatumumab, but not obinutuzumab; augments the risk of Richter transformation)

During follow-ups, the patient's response to treatment is assessed by clinical, radiological, and laboratory criteria. A complete response to therapy comprises the total reduction of lymphadenopathy and organomegaly, the decrease of bone marrow lymphocytes <4,000 per µl and the stabilization of peripheral blood lymphocytes at values <30%. Furthermore, hemoglobin, neutrophil and platelet counts should rise to near-physiological ranges. Patients should also be tested for minimal residual disease, whereby the threshold is set at 1 tumor cell detectable per 10,000 leukocytes. Patients with <0.01% of tumor cells are considered negative for minimal residual disease [8].

Normocytic Anemia
  • Pure red cell aplasia (PRCA) is a rare syndrome characterized by a normochromic normocytic anemia and the absence of mature erythroid precursors in an otherwise normocellular bone marrow.[ncbi.nlm.nih.gov]
Staphylococcus Aureus
  • Additionally we determined the influence of lipopolysaccharide Escherichia coli - TLR4-ligand (LPS) and Staphylococcus aureus strain Cowan I - TLR2-ligand (SAC) on TIR-domain-containing adaptor protein, also called MyD88 adaptor-like (TIRAP) and myeloid[ncbi.nlm.nih.gov]
  • Söderberg, Thunberg, Weigelt, Christiansen, Tötterman, Carlsson, Sällström and Nilsson, Staphylococcus aureus Cowan Strain 1 Activation of B‐Chronic Lymphocytic Leukaemia Cells Augments the Response to CD40 Stimulation, Scandinavian Journal of Immunology[doi.org]


About one-third of BCLL patients is not expected ever to develop sequelae that require treatment or affect survival [1]. These patients may, however, suffer from side effects by drugs used in the management of BCLL. Accordingly, the current consensus is to not start treatment until required to reduce or delay the imminent onset of symptoms due to BCLL. In the face of comorbidities, however, it may not be easy to attribute signs and symptoms to leukemia.

Front-line treatments of BCLL include cytotoxic chemoimmunotherapy and small molecule inhibitors, although corticosteroids may suffice to control autoimmune hemolytic anemia and immune-mediated thrombocytopenia. In any case, treatment decisions are based on the patient's general condition, on clinical and molecular factors [7].

  • Chemotherapy generally uses purine analogs and alkylators. The efficacy of chemotherapy can be significantly enhanced by the addition of anti-CD20 monoclonal antibodies, such as rituximab, ofatumumab, and obinutuzumab. It should be considered, though, that the likelihood of adverse events is greater with the application of anti-CD20 monoclonal antibodies [1]. For patients aged <65 years, the standard treatment regimen comprises fludarabine, cyclophosphamide, and rituximab, while the elderly bendamustine and rituximab are usually preferred in the elderly [9].
  • Ibrutinib is an inhibitor of Bruton's tyrosine kinase and may be administered to diminish B-cell signaling and maturation. Similarly, idelalisib, a reversible kinase inhibitor which targets the phosphatidylinositol 3 kinases, has been shown to suppress the proliferation, migration, activation, and survival of B cells [9].
  • Venetoclax is one of the small molecule inhibitors used in BCLL therapy. Venetoclax promotes B-cell apoptosis by antagonizing BCL-2, an inhibitor of programmed cell death.

Several mechanisms of resistance have been described for small molecule inhibitors [6]. If the molecular characterization of tumor cells implies resistance to certain compounds, they are not to be used in the respective patient - to reduce the overall toxicity of therapy and to minimize costs. Indeed, the introduction of small molecule inhibitors has been accompanied by an exponential increase in medical expenses.


For a long time, BCLL has been deemed incurable, and any therapy merely aimed at the maintenance of life quality and the prolongation of survival times. Considerable advances in BCLL therapy, however, made this condition manageable and often even curable: In the absence of minimal residual disease, 10-year progression-free survival rates amount to 65% and overall survival is about 70%. Positivity for minimal residual disease is associated with a reduction of 10-year progression-free and overall survival to 10 and 30%, respectively [8].

The patient's prognosis considerably worsens upon the histological transformation of BCLL into more aggressive lymphomas. In this context, Richter transformation into diffuse large B-cell lymphoma or classical Hodgkin lymphoma is observed in 2-10% of all cases. These patients hardly respond to therapy, and median survival times are estimated at 5 to 8 months [5].


First-degree family members of BCLL patients are at higher risks of developing CLL than the general population [1]. This argues in favor of a genetic component in the etiology of BCLL, but the contribution of hereditary factors to the development of the disease remains incompletely understood. In this context, a series of single nucleotide polymorphisms have been shown to confer a modest but significant increase in BCLL risk [10]. In general, the successive acquisition and progressive accumulation of mutations of oncogenes and tumor suppressor genes are assumed to result in leukemia. Mutations and chromosomal aberrations affecting more than 40 driver genes have been identified in BCLL:

  • The majority of BCLL patients harbors at least one of the four most common chromosomal abnormalities, namely del(13q14), del(11q22-23), del(17p12), and trisomy 12 [6].
  • Notch 1 (NOTCH1, 9q34.3), ATM serine/threonine kinase (ATM, 11q22.3), splicing factor 3b subunit 1 (SF3B1, 2q33.1), baculoviral IAP repeat-containing protein 3 (BIRC3, 11q22.2), chromodomain-helicase-DNA-binding protein 1 (CHD2, 15q26.1), tumor protein p53 (TP53, 17p13.1), and myeloid differentiation primary response protein 88 (MYD88) are among the most frequently mutated genes [11].

To date, there is no evidence of occupational or environmental risk factors contributing to the risk of developing CLL. Still, multiple factors have been discussed as possible promoters of the disease, e.g., live in rural areas, hepatitis C, exposure to Agent Orange, lack of exposure to sunlight [2].


In the western world, BCLL is the most common type of adult leukemia, accounting for up to 30% of newly diagnosed cases of leukemia [9]. In the United States, the overall incidence of BCLL has been estimated at 5 per 100,000 people. Men are affected about twice as often as women, and patients of Caucasian origin and Ashkenazi Jews are predisposed to the disease. The median age at the time of diagnosis is 72 years, with two-thirds of patients being over the age of 65 when BCLL is recognized [2]. Notwithstanding, BCLL has been described in young adults and pediatric patients.

Sex distribution
Age distribution


BCLL is characterized by the uncontrolled proliferation and accumulation of degenerated CD5+ B cells in the bone marrow, blood, lymph nodes, liver, and spleen. Tumor cells don't mature appropriately and are unable to fulfill their function in the immune system. They do, however, displace functional cells and form solid tumors that interfere with organ function. These cells' reduced ability to undergo apoptosis accelerates this process. Accordingly, BCLL patients may develop bone marrow failure with cytopenias, lymphadenopathy and immunodeficiency, as well as hepatomegaly and splenomegaly.

Mutations and chromosomal aberrations inducing the degeneration of B cells generally affect key regulators of cell cycle and apoptosis, and these gene defects facilitate the persistence of additional mutations. The typical genome of BCLL has been estimated to include about 2,000 molecular lesions, with only a few mutations occurring at a relatively high frequency [6].


Considerable knowledge gaps regarding the etiology of BCLL hamper the development of prevention guidelines. Metaprophylaxis, however, does play a major role in the management of BCLL. Most patients suffer from immune dysregulation and propensity to infections, and complications of infections account for as much as 60% of disease-related deaths [12]. In this context, the following recommendations can be given:

  • Evaluation of status of relevant viral infections (e.g., hepatitis B and C, HIV, CMV) before starting BCLL therapy
  • Provision of pneumococcal and influenza vaccination for all patients
  • Avoidance of vaccines containing live pathogens
  • Neutropenic fever should prompt the administration of G-CSF
  • Antibiotic prophylaxis in symptomatic patients with recurrent infections or serum immunoglobulin G levels <500 mg/dl, possibly complementation with immunoglobulin therapy

Treatment-specific recommendations have been elaborated, too. The interested reader is referred to the respective review published by Tadmor et al. [3].


According to the classification of the World Health Organization, BCLL is a type of non-Hodgkin lymphoma and mature B-cell neoplasm [13] [14]. It tends to follow an indolent course, and diagnoses are often made incidentally. Nevertheless, life-threatening complications may arise from disease-related bone marrow failure and transformation into an aggressive lymphoma. Although the clinical outcome has been associated with a series of parameters, the search for useful prognostic markers with high predictive power has not yet been concluded [2]. At the same time, intense research is focused on the development of drugs that allow for long-term disease control and even cure while minimizing the impact of side effects [6] [11].

As of today, treatment is generally delayed until the onset of symptoms, but essential time may be lost in cases of high-risk BCLL: Here, patients might benefit from an early initiation of therapy. One major challenge is to identify these patients; another one consists in the provision of effective and well-tolerated treatment to the majority of those affected by BCLL.

Patient Information

B-cell chronic lymphocytic leukemia (BCLL) is one of the most common types of leukemia and thus a form of blood cancer. It is mostly diagnosed in the elderly and tends to follow an indolent course. Accordingly, BCLL patients may remain asymptomatic for prolonged periods of time. Incidental diagnoses are common and are usually based on hematological studies yielding abnormal results.

Therapy may not be required before the onset of symptoms. In this context, it is important to thoroughly characterize tumor cells, to carry out a detailed risk assessment in order to prepare a personalized treatment plan. Most patients respond well to therapy and experience partial or even complete relief from symptoms.



  1. Samples LS, Graf SA. On the front line: first choice pharmacotherapeutics for chronic lymphocytic leukemia. Expert Opin Pharmacother. 2018; 19(15):1675-1684.
  2. Strati P, Jain N, O'Brien S. Chronic Lymphocytic Leukemia: Diagnosis and Treatment. Mayo Clin Proc. 2018; 93(5):651-664.
  3. Tadmor T, Welslau M, Hus I. A review of the infection pathogenesis and prophylaxis recommendations in patients with chronic lymphocytic leukemia. Expert Rev Hematol. 2018; 11(1):57-70.
  4. Ratterman M, Kruczek K, Sulo S, Shanafelt TD, Kay NE, Nabhan C. Extramedullary chronic lymphocytic leukemia: systematic analysis of cases reported between 1975 and 2012. Leuk Res. 2014; 38(3):299-303.
  5. Wierda WG, Byrd JC, Abramson JS, et al. NCCN Guidelines Insights: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 2.2019. J Natl Compr Canc Netw. 2019; 17(1):12-20.
  6. Condoluci A, Rossi D. Genetic mutations in chronic lymphocytic leukemia: impact on clinical treatment. Expert Rev Hematol. 2019.
  7. Baliakas P, Jeromin S, Iskas M, et al. Cytogenetic complexity in chronic lymphocytic leukemia: definitions, associations and clinical impact. Blood. 2019.
  8. Kwok M, Rawstron AC, Varghese A, et al. Minimal residual disease is an independent predictor for 10-year survival in CLL. Blood. 2016; 128(24):2770-2773.
  9. O'Reilly A, Murphy J, Rawe S, Garvey M. Chronic Lymphocytic Leukemia: A Review of Front-line Treatment Options, With a Focus on Elderly CLL Patients. Clin Lymphoma Myeloma Leuk. 2018; 18(4):249-256.
  10. Crowther-Swanepoel D, Corre T, Lloyd A, et al. Inherited genetic susceptibility to monoclonal B-cell lymphocytosis. Blood. 2010; 116(26):5957-5960.
  11. Tripathi R, Lee-Verges E, Higashi M, et al. New drug discovery approaches targeting recurrent mutations in chronic lymphocytic leukemia. Expert Opin Drug Discov. 2017; 12(10):1041-1052.
  12. Morrison VA. Infections in patients with leukemia and lymphoma. Cancer Treat Res. 2014; 161:319-349.
  13. Campo E, Swerdlow SH, Harris NL, Pileri S, Stein H, Jaffe ES. The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Blood. 2011; 117(19):5019-5032.
  14. Swerdlow SH, Campo E, Pileri SA, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016; 127(20):2375-2390.

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Last updated: 2019-07-11 20:02