Symptoma

B-Cell Prolymphocytic Leukemia

B-PLL

Our results suggest that PLL usually presents with cytogenetic abnormalities. The finding of translocation (11;14) is noteworthy; chromosomes 1 and 3 are also involved. [ncbi.nlm.nih.gov]

  • Fishing

    Three cases showed additional signals for the MYC gene by fluorescence in situ hybridization (FISH), and two cases demonstrated t(8;14) MYC/IGH by karyotyping or FISH. [ajcp.oxfordjournals.org]

    Three cases showed additional signals for the MYC gene by fluorescence in situ hybridization (FISH), and two cases demonstrated t(8;14)MYC/IGH by karyotyping or FISH. [ncbi.nlm.nih.gov]

    FISH FISH was performed as previously described. 18 The two non-commercial probes were labeled by nick translation with biotin-16-deoxyuridine triphosphate (Boehringer Mannheim, Manheim, Germany). [dx.doi.org]

  • Fatigue

    An 86-year-old man underwent a medical examination for lumbago and general fatigue at another hospital in June 2007. A compressed lumbar fracture and splenomegaly were found using computed tomography (CT). [ncbi.nlm.nih.gov]

    We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition. Last updated: May 13, 2019 [patientslikeme.com]

    The side effects of chemotherapy depend on the individual and the dose used, but they can include fatigue, risk of infection, nausea and vomiting, hair loss, loss of appetite, and diarrhea. [cancer.net]

    Common leukemia symptoms are: persistent fatigue, weakness; frequent infections; weight loss without trying; swollen lymph nodes, enlarged liver or spleen; easy bleeding or bruising; tiny red spots in the skin (petechiae); and bone pain or tenderness. [publichealth.va.gov]

  • Pelvic Mass

    Abdominal pain aggravated despite chemotherapy, and pelvic computed tomography (CT) revealed a huge lobular pelvic mass which had increased in size on the follow-up CT. Total hysterectomy with bilateral adnexectomy was performed. [jpatholtm.org]

  • Subcutaneous Nodule

    The patient was then treated with single-agent rituximab and returned in 16 months with relapse as a right chest wall subcutaneous nodule. A subsequent positron emission tomography scan revealed widespread bony lesions. [ajcp.oxfordjournals.org]

  • Subcutaneous Mass

    Recurrence as nodal disease was seen in one patient (case 2) with MYC amplification (more than five signals), and recurrence as a subcutaneous mass was seen in another patient (case 5) with MYC rearrangement. [ajcp.oxfordjournals.org]

  • Polyradiculoneuropathy

    A 52 year old man with a 10-month history of B-cell prolymphocytic leukemia (PLL) died of an apparent acute fulminant polyradiculoneuropathy, a condition generally attributed to paraneoplastic complication. [ncbi.nlm.nih.gov]

    B-cell prolymphocytic leukemia. ( 3509770 ) Brito-Babapulle V....Catovsky D. 1987 38 Fulminant leukemic polyradiculoneuropathy in a case of B-cell prolymphocytic leukemia. [malacards.org]

Further workup revealed splenomegaly and liver cirrhosis, with no B symptoms or lymphadenopathy per imaging studies. Peripheral blood flow cytometric analysis was consistent with B-cell leukemia. [ajcp.oxfordjournals.org]

Talk with your doctor about the goals of each treatment and what you can expect while receiving the treatment. Learn more about making treatment decisions. [cancer.net]

We could not identify any correlation between CD20-expression and efficacy of rituximab treatment. [ncbi.nlm.nih.gov]

For all those patients, we have clinical and biological data, including age, sex, lymphocytosis, Hb, Platelets, date of diagnosis, date of treatment, type of treatment, immunophenotype, cytogenetics, IGHV status. [icgc.org]

Although the therapeutic strategy for B-PLL should be determined based on the severity of the disease, RIC with allo-HSCT may be a therapeutic option for indolent B-PLL when the long-term prognosis of patients is markedly poor. [ncbi.nlm.nih.gov]

Sub-classification PLL can transform from CLL. de novo cases of PLL must be distinguished from CLL transformation, as the latter has a worse prognosis. [wiki.clinicalflow.com]

This difference in the spectrum of p53 mutations may reflect the etiologic contribution of distinct exogenous or endogenous factors to B-PLL pathogenesis. [bloodjournal.org]

All blood cultures remained negative for bacterial or fungal etiology. Bronchoalveolar lavage confirmed evidence of PCP as well as CMV by PCR with no evidence of fungal elements. His blood CMV viral titers were over 3.9 10 6 copies/ml. [ehoonline.biomedcentral.com]

10 Codes C91.3 Prolymphocytic Leukemia Corresponding ICD-10-CM Codes (U.S. only) C91.3 Prolymphocytic leukemia of B-cell type (effective October 01, 2015) Diagnostic Exams Immunophenotyping Peripheral blood smear Progression and Transformation None Epidemiology [seer.cancer.gov]

Case Name (click on case name to open) Comments Size Epidemiology B-PLL is an extremely rare disease, comprising approximately 1% of lymphocytic leukemias. [wiki.clinicalflow.com]

About this book Introduction Neoplastic Diseases of the Blood integrates the history, epidemiology, pathology, pathophysiology, and therapeutics of modern neoplastic hematopathology. [doi.org]

[…] distinct from B-CLL cells in that they express bright surface immunoglobulin, unfrequently express CD5, fail to form rosettes with mouse erythrocytes and react strongly with FMC7; expression of CD22 is often observed whereas CD23 is usually not expressed Epidemiology [atlasgeneticsoncology.org]

About the journal Japanese Journal of Clinical Oncology is an online only (from Jan 2018), multidisciplinary journal for clinical oncologists which publishes high quality articles on medical oncology, clinical trials, radiology, surgery, basic research, epidemiology [jjco.oxfordjournals.org]

About this book Introduction Neoplastic Diseases of the Blood integrates the history, epidemiology, pathology, pathophysiology, and therapeutics of modern neoplastic hematopathology. [doi.org]

Pathophysiology CLL is a lymphoproliferative disorder that arises from mature B cells and leads to the development of functionally incompetent, clonal malignant cells. [cancertherapyadvisor.com]

Pathophysiology T-PLL is a malignancy of post thymic T-cells with the cytogenetic abnormalities listed above. [oncologynurseadvisor.com]

This “alert” generally prevents other cells from becoming infected. Unfortunately, many viruses can outsmart this protective strategy, and they continue to spread the infection. [primaryimmune.org]

The degradation of the cyclin is essential for the replication of DNA because acute overexpression of cyclin D1 in fibroblasts prevented S-phase entry [ 38, 39 ]. [doi.org]

Once in the blood, leukemia cells can spread to other organs, where they can prevent other cells in the body from functioning normally. [cancer.org]

Other therapies: Prophylactic measures to prevent tumor lysis syndrome Prophylactic antimicrobials when using alemtuzumab Monitoring for Cytomegalovirus (CMV) reactivation with use of alemtuzumab What should you tell the patient and the family about prognosis [oncologynurseadvisor.com]

Similarly, although pentamidine was used to prevent PCP pneumonitis, it was ineffective in this case. Trimethoprim/sulfisoxazole, although may lead to prolonged neutropenia, may be more effective and should be considered. [ehoonline.biomedcentral.com]